Release of DNA oligonucleotides and their conjugates from controlled-pore glass under thermolytic conditions

Current Protocols in Nucleic Acid Chemistry

Volumn , Issue SUPPL. 35, 2008, Pages

  Grajkowski, Andrzej ^a   Cieślak, Jacek ^a   Freedberg, Darón I ^b   Kauffman, Jon S ^c   Duff, Robert J ^c   Beaucage, Serge L ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c Lancaster Laboratories   (United States)

Author keywords

Deoxyribonucleoside phosphorodiamidites; DNA oligonucleotides conjugates; Modified CPG support; Solid phase synthesis; Thermolytic conditions

Indexed keywords

2N ISOBUTYRYL 5' O (4,4' DIMETHOXYTRITYL) 3' O BIS(N,N DIISOPROPYLAMINO)PHOSPHINYL 2' DEOXYGUANOSINE; 4N BENZOYL 5' O (4,4' DIMETHOXYTRITYL) 3' O BIS(N,N DIISOPROPYLAMINO)PHOSPHINYL 2' DEOXYCYTIDINE; 5' O (4,4' DIMETHOXYTRITYL) 3' O BIS(N,N DIISOPROPYLAMINO)PHOSPHINYL 2' DEOXYTHYMIDINE; 6N BENZOYL 5' O (4,4' DIMETHOXYTRITYL) 3' O BIS(N,N DIISOPROPYLAMINO)PHOSPHINYL 2' DEOXYADENOSINE; GLASS; OLIGONUCLEOTIDE; PHOSPHORAMIDOUS ACID DERIVATIVE; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; CONJUGATE; DEPROTECTION REACTION; DNA SYNTHESIS; ELECTROPHORESIS; ELIMINATION REACTION; OXIDATION; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REVIEW; SOLID PHASE SYNTHESIS; TEMPERATURE DEPENDENCE; TEMPERATURE SENSITIVITY;

PHOS;

EID: 58849095800     PISSN: 19349270     EISSN: 19349289     Source Type: Journal    
DOI: 10.1002/0471142700.nc0317s35     Document Type: Review

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