Thermolytic 4-Methylthio-1-butyl Group for Phosphate/Thiophosphate Protection in Solid-Phase Synthesis of DNA Oligonucleotides

Journal of Organic Chemistry

Volumn 69, Issue 7, 2004, Pages 2509-2515

  Cieślak, Jacek ^a,c   Grajkowski, Andrzej ^a   Livengood, Victor ^b   Beaucage, Serge L ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATES; REACTION KINETICS; SYNTHESIS (CHEMICAL);

OLIGONUCLEOTIDES; SOLID-PHASE TECHNIQUES;

DNA;

DEOXYRIBONUCLEOSIDE; DNA; NUCLEIC ACID BASE; OLIGONUCLEOTIDE; PHOSPHATE; PHOSPHORAMIDIC ACID DERIVATIVE; PHOSPHOROTHIOIC ACID; PHOSPHOROTHIOIC ACID DERIVATIVE; SULFONIUM DERIVATIVE;

ARTICLE; DNA MICROARRAY; ESTERIFICATION; HEATING; MASS SPECTROMETRY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SYNTHESIS;

BASE SEQUENCE; CATALYSIS; DEOXYRIBONUCLEOSIDES; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HEAT; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOTHIOPHOSPHORUS COMPOUNDS; PHOSPHATES; THIONUCLEOTIDES;

EID: 12144287950     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo035861f     Document Type: Article

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