The 4-[N-methyl-N-(2,2,2-trifiuoroacetyl)amino]butyl group as an alternative to the 2-cyanoethyl group for phosphate protection in the synthesis of oligodeoxyribonucleotides

Journal of Organic Chemistry

Volumn 64, Issue 20, 1999, Pages 7515-7522

  Wilk, Andrzej ^a   Grajkowski, Andrzej ^a,c   Phillips, Lawrence R ^b   Beaucage, Serge L ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLONITRILE; ALKALINE PHOSPHATASE; AMMONIA; AMMONIUM DERIVATIVE; DEOXYRIBONUCLEOSIDE; NUCLEIC ACID BASE; OLIGODEOXYRIBONUCLEOTIDE; PHOSPHATE; PHOSPHORAMIDIC ACID DERIVATIVE; PROPIONITRILE; PYRROLIDINE DERIVATIVE; SNAKE VENOM; TRIFLUOROACETIC ACID;

ALKYLATION; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; ESTERIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

EID: 0033215350     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo990835w     Document Type: Article

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