Thermolytic CpG-containing DNA oligonucleotides as potential immunotherapeutic prodrugs

Nucleic Acids Research

Volumn 33, Issue 11, 2005, Pages 3550-3560

  Grajkowski, Andrzej ^b   Pedras Vasconcelos, Joao ^a   Wang, Vivian ^a   Ausín, Cristina ^a   Hess, Sonja ^b   Verthelyi, Daniela ^a   Beaucage, Serge L ^a  

^a Center for Drug Evaluation and Research   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (N FORMYL N METHYL)AMINOETHYLTHIOPHOSPHATE; CPG ODN 1555; CPG ODN FMA 1555; IMMUNOGLOBULIN M; IMMUNOMODULATING AGENT; INTERLEUKIN 12; INTERLEUKIN 6; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; PRODRUG; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; CPG OLIGONUCLEOTIDE; CPG-OLIGONUCLEOTIDE; CYTOKINE; IMMUNOLOGICAL ADJUVANT; OLIGODEOXYRIBONUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARENAVIRUS; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DRUG MECHANISM; DRUG SYNTHESIS; LEISHMANIA MAJOR; LEISHMANIASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMASTIGOTE; RNA VIRUS INFECTION; SURVIVAL RATE; TREATMENT OUTCOME; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMISTRY; FEMALE; HEAT; SKIN LEISHMANIASIS;

LEISHMANIA MAJOR; TACARIBE VIRUS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTI-INFECTIVE AGENTS; CYTOKINES; FEMALE; HEAT; LEISHMANIASIS, CUTANEOUS; MICE; MICE, INBRED BALB C; OLIGODEOXYRIBONUCLEOTIDES; PRODRUGS;

EID: 21344471386     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gki657     Document Type: Article

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