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Volumn 3, Issue 5, 2009, Pages 253-262

An immunological overview of allergen specific immunotherapy — subcutaneous and sublingual routes

Author keywords

allergy; asthma; atopy; regulatory T cell sublingual immunotherapy; subcutaneous immunotherapy

Indexed keywords

ALLERGEN; CD4 ANTIGEN; CORTICOSTEROID; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G4; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PLACEBO; T LYMPHOCYTE RECEPTOR;

EID: 70449901330     PISSN: 17534658     EISSN: None     Source Type: Journal    
DOI: 10.1177/1753465809349522     Document Type: Review
Times cited : (19)

References (99)
  • 2
    • 70349967915 scopus 로고    scopus 로고
    • Efficacy of sublingual specific immunotherapy in intermittent and persistent allergic rhinitis in children: an observational case-control study on 171 patients. The EFESO-children Multicenter Trial
    • [Epub ahead of print]
    • Acquistapace, F., Agostinis, F., Castella, V., Kantar, A., Novembre, E., Perrone, M.R. et al. (2009) Efficacy of sublingual specific immunotherapy in intermittent and persistent allergic rhinitis in children: an observational case-control study on 171 patients. The EFESO-children Multicenter Trial. Pediatr Allergy Immunol Mar 23 [Epub ahead of print].
    • (2009) Pediatr Allergy Immunol Mar , vol.23
    • Acquistapace, F.1    Agostinis, F.2    Castella, V.3    Kantar, A.4    Novembre, E.5    Perrone, M.R.6
  • 3
    • 53049107609 scopus 로고    scopus 로고
    • New insights into mechanisms of immunoregulation in 2007
    • Akdis, C.A. (2008) New insights into mechanisms of immunoregulation in 2007. J Allergy Clin Immunol 122: 700-709.
    • (2008) J Allergy Clin Immunol , vol.122 , pp. 700-709
    • Akdis, C.A.1
  • 4
    • 63449090874 scopus 로고    scopus 로고
    • Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
    • quiz, 747, 738
    • Akdis, C.A. and Akdis, M. (2009) Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J Allergy Clin Immunol 123: 735-746, quiz 747-738.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 735-746
    • Akdis, C.A.1    Akdis, M.2
  • 5
    • 33744771363 scopus 로고    scopus 로고
    • Immunological mechanisms of sublingual immunotherapy
    • Suppl, 81
    • Akdis, C.A., Barlan, I.B., Bahceciler, N. and Akdis, M. (2006) Immunological mechanisms of sublingual immunotherapy. Allergy 61 Suppl 81: 11-14.
    • (2006) Allergy , vol.61 , pp. 11-14
    • Akdis, C.A.1    Barlan, I.B.2    Bahceciler, N.3    Akdis, M.4
  • 7
    • 33750336249 scopus 로고    scopus 로고
    • Healthy immune response to allergens: T regulatory cells and more
    • Akdis, M. (2006) Healthy immune response to allergens: T regulatory cells and more. Curr Opin Immunol 18: 738-744.
    • (2006) Curr Opin Immunol , vol.18 , pp. 738-744
    • Akdis, M.1
  • 8
    • 58149468461 scopus 로고    scopus 로고
    • Immunologic responses to sublingual allergen immunotherapy
    • Akdis, M. (2008a) Immunologic responses to sublingual allergen immunotherapy. Clin Allergy Immunol 21: 71-86.
    • (2008) Clin Allergy Immunol , vol.21 , pp. 71-86
    • Akdis, M.1
  • 9
    • 45549107012 scopus 로고    scopus 로고
    • T-cell tolerance to inhaled allergens: mechanisms and therapeutic approaches
    • Akdis, M. (2008b) T-cell tolerance to inhaled allergens: mechanisms and therapeutic approaches. Expert Opin Biol Ther 8: 769-777.
    • (2008) Expert Opin Biol Ther , vol.8 , pp. 769-777
    • Akdis, M.1
  • 10
    • 34047163404 scopus 로고    scopus 로고
    • Mechanisms of allergen-specific immunotherapy
    • Akdis, M. and Akdis, C.A. (2007) Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 119: 780-791.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 780-791
    • Akdis, M.1    Akdis, C.A.2
  • 11
    • 0032983759 scopus 로고    scopus 로고
    • Effect of formoterol on clinical parameters and lung functions in patients with bronchial asthma: a randomised controlled trial
    • Akpinarli, A., Tuncer, A., Saraclar, Y., Sekerel, B.E. and Kalayci, O. (1999) Effect of formoterol on clinical parameters and lung functions in patients with bronchial asthma: a randomised controlled trial. Arch Dis Child 81: 45-48.
    • (1999) Arch Dis Child , vol.81 , pp. 45-48
    • Akpinarli, A.1    Tuncer, A.2    Saraclar, Y.3    Sekerel, B.E.4    Kalayci, O.5
  • 12
    • 0037661991 scopus 로고    scopus 로고
    • Characterization of dendritic cells from human oral mucosa: a new Langerhans’ cell type with high constitutive FcepsilonRI expression
    • Allam, J.P., Novak, N., Fuchs, C., Asen, S., Berge, S., Appel, T. et al. (2003) Characterization of dendritic cells from human oral mucosa: a new Langerhans’ cell type with high constitutive FcepsilonRI expression. J Allergy Clin Immunol 112: 141-148.
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 141-148
    • Allam, J.P.1    Novak, N.2    Fuchs, C.3    Asen, S.4    Berge, S.5    Appel, T.6
  • 13
    • 42549119146 scopus 로고    scopus 로고
    • Distribution of Langerhans cells and mast cells within the human oral mucosa: new application sites of allergens in sublingual immunotherapy?
    • Allam, J.P., Stojanovski, G., Friedrichs, N., Peng, W., Bieber, T., Wenzel, J. et al. (2008) Distribution of Langerhans cells and mast cells within the human oral mucosa: new application sites of allergens in sublingual immunotherapy? Allergy 63: 720-727.
    • (2008) Allergy , vol.63 , pp. 720-727
    • Allam, J.P.1    Stojanovski, G.2    Friedrichs, N.3    Peng, W.4    Bieber, T.5    Wenzel, J.6
  • 14
    • 0035523295 scopus 로고    scopus 로고
    • Oral tolerance and gut-oriented immune response to dietary proteins
    • Alpan, O. (2001) Oral tolerance and gut-oriented immune response to dietary proteins. Curr Allergy Asthma Rep 1: 572-577.
    • (2001) Curr Allergy Asthma Rep , vol.1 , pp. 572-577
    • Alpan, O.1
  • 15
    • 0035871627 scopus 로고    scopus 로고
    • The role of dendritic cells, B cells, and M cells in gut-oriented immune responses
    • Alpan, O., Rudomen, G. and Matzinger, P. (2001) The role of dendritic cells, B cells, and M cells in gut-oriented immune responses. J Immunol 166: 4843-4852.
    • (2001) J Immunol , vol.166 , pp. 4843-4852
    • Alpan, O.1    Rudomen, G.2    Matzinger, P.3
  • 16
    • 0030855386 scopus 로고    scopus 로고
    • Absorption and distribution kinetics of the major parietaria judaica allergen (Par J 1) administered by noninjectable routes in healthy human beings
    • Bagnasco, M., Mariani, G., Passalacqua, G., Motta, C., Bartolomei, M., Falagiani, P. et al. (1997) Absorption and distribution kinetics of the major parietaria judaica allergen (Par J 1) administered by noninjectable routes in healthy human beings. J Allergy Clin Immunol 100: 122-129.
    • (1997) J Allergy Clin Immunol , vol.100 , pp. 122-129
    • Bagnasco, M.1    Mariani, G.2    Passalacqua, G.3    Motta, C.4    Bartolomei, M.5    Falagiani, P.6
  • 17
    • 33847200758 scopus 로고    scopus 로고
    • Immunologic aspects of sublingual immunotherapy in the treatment of allergy and asthma
    • Bahceciler, N.N., Ozdemir, C. and Barlan, I.B. (2007) Immunologic aspects of sublingual immunotherapy in the treatment of allergy and asthma. Curr Med Chem 14: 265-269.
    • (2007) Curr Med Chem , vol.14 , pp. 265-269
    • Bahceciler, N.N.1    Ozdemir, C.2    Barlan, I.B.3
  • 18
    • 34548237449 scopus 로고    scopus 로고
    • Sublingual immunotherapy induces Il-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation
    • Bohle, B., Kinaciyan, T., Gerstmayr, M., Radakovics, A., Jahn-Schmid, B. and Ebner, C. (2007) Sublingual immunotherapy induces Il-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation. J Allergy Clin Immunol 120: 707-713.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 707-713
    • Bohle, B.1    Kinaciyan, T.2    Gerstmayr, M.3    Radakovics, A.4    Jahn-Schmid, B.5    Ebner, C.6
  • 19
    • 0031736285 scopus 로고    scopus 로고
    • Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper
    • Bousquet, J., Lockey, R. and Malling, H.J. (1998) Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper. J Allergy Clin Immunol 102: 558-562.
    • (1998) J Allergy Clin Immunol , vol.102 , pp. 558-562
    • Bousquet, J.1    Lockey, R.2    Malling, H.J.3
  • 20
    • 0033006767 scopus 로고    scopus 로고
    • Sublingual-swallow immunotherapy (SLIT) in patients with asthma due to house-dust mites: a double-blind, placebo-controlled study
    • Bousquet, J., Scheinmann, P., Guinnepain, M.T., Perrin-Fayolle, M., Sauvaget, J., Tonnel, A.B. et al. (1999) Sublingual-swallow immunotherapy (SLIT) in patients with asthma due to house-dust mites: a double-blind, placebo-controlled study. Allergy 54: 249-260.
    • (1999) Allergy , vol.54 , pp. 249-260
    • Bousquet, J.1    Scheinmann, P.2    Guinnepain, M.T.3    Perrin-Fayolle, M.4    Sauvaget, J.5    Tonnel, A.B.6
  • 22
    • 42049096075 scopus 로고    scopus 로고
    • Effect of sublingual immunotherapy with grass monomeric allergoid on allergen-specific T-Cell proliferation and interleukin 10 production
    • Burastero, S.E., Mistrello, G., Falagiani, P., Paolucci, C., Breda, D., Roncarolo, D. et al. (2008) Effect of sublingual immunotherapy with grass monomeric allergoid on allergen-specific T-Cell proliferation and interleukin 10 production. Ann Allergy Asthma Immunol 100: 343-350.
    • (2008) Ann Allergy Asthma Immunol , vol.100 , pp. 343-350
    • Burastero, S.E.1    Mistrello, G.2    Falagiani, P.3    Paolucci, C.4    Breda, D.5    Roncarolo, D.6
  • 24
    • 33748289993 scopus 로고    scopus 로고
    • Efficacy of sublingual immunotherapy in asthma: systematic review of randomized-clinical trials using the Cochrane Collaboration method
    • Calamita, Z., Saconato, H., Pela, A.B. and Atallah, A.N. (2006) Efficacy of sublingual immunotherapy in asthma: systematic review of randomized-clinical trials using the Cochrane Collaboration method. Allergy 61: 1162-1172.
    • (2006) Allergy , vol.61 , pp. 1162-1172
    • Calamita, Z.1    Saconato, H.2    Pela, A.B.3    Atallah, A.N.4
  • 25
    • 33744721092 scopus 로고    scopus 로고
    • Sublingual immunotherapy in the treatment of adult allergic rhinitis patients
    • (Suppl.,):
    • Canonica, G.W. and Passalacqua, G. (2006) Sublingual immunotherapy in the treatment of adult allergic rhinitis patients. Allergy 61(Suppl. 81): 20-23.
    • (2006) Allergy , vol.61 , Issue.81 , pp. 20-23
    • Canonica, G.W.1    Passalacqua, G.2
  • 26
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor FoxP3
    • Chen, W., Jin, W., Hardegen, N., Lei, K.J., Li, L., Marinos, N. et al. (2003) Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor FoxP3. J Exp Med 198: 1875-1886.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6
  • 27
    • 0031864005 scopus 로고    scopus 로고
    • Clinical efficacy of sublingual-swallow immunotherapy: a double-blind, placebo-controlled trial of a standardized five-grass-pollen extract in rhinitis
    • Clavel, R., Bousquet, J. and Andre, C. (1998) Clinical efficacy of sublingual-swallow immunotherapy: a double-blind, placebo-controlled trial of a standardized five-grass-pollen extract in rhinitis. Allergy 53: 493-498.
    • (1998) Allergy , vol.53 , pp. 493-498
    • Clavel, R.1    Bousquet, J.2    Andre, C.3
  • 28
    • 33644746130 scopus 로고    scopus 로고
    • Sublingual immunotherapy with dermatophagoides monomeric allergoid down-regulates allergen-specific immunoglobulin E and increases both interferon-gamma- and interleukin-10-production
    • Cosmi, L., Santarlasci, V., Angeli, R., Liotta, F., Maggi, L., Frosali, F. et al. (2006) Sublingual immunotherapy with dermatophagoides monomeric allergoid down-regulates allergen-specific immunoglobulin E and increases both interferon-gamma- and interleukin-10-production. Clin Exp Allergy 36: 261-272.
    • (2006) Clin Exp Allergy , vol.36 , pp. 261-272
    • Cosmi, L.1    Santarlasci, V.2    Angeli, R.3    Liotta, F.4    Maggi, L.5    Frosali, F.6
  • 29
    • 42149163526 scopus 로고    scopus 로고
    • Sublingual immunotherapy and allergic rhinitis
    • Cox, L. (2008) Sublingual immunotherapy and allergic rhinitis. Curr Allergy Asthma Rep 8: 102-110.
    • (2008) Curr Allergy Asthma Rep , vol.8 , pp. 102-110
    • Cox, L.1
  • 30
    • 56349093347 scopus 로고    scopus 로고
    • Il-4 inhibits TGF-beta-induced FoxP3+ T cells and, together with TGF-beta, generates Il-9+ Il-10+ FoxP3(-) effector T cells
    • Dardalhon, V., Awasthi, A., Kwon, H., Galileos, G., Gao, W., Sobel, R.A. et al. (2008) Il-4 inhibits TGF-beta-induced FoxP3+ T cells and, together with TGF-beta, generates Il-9+ Il-10+ FoxP3(-) effector T cells. Nat Immunol 9: 1347-1355.
    • (2008) Nat Immunol , vol.9 , pp. 1347-1355
    • Dardalhon, V.1    Awasthi, A.2    Kwon, H.3    Galileos, G.4    Gao, W.5    Sobel, R.A.6
  • 31
    • 0030903223 scopus 로고    scopus 로고
    • Immunotherapy with a standardized dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children
    • Des Roches, A., Paradis, L., Menardo, J.L., Bouges, S., Daures, J.P. and Bousquet, J. (1997) Immunotherapy with a standardized dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children. J Allergy Clin Immunol 99: 450-453.
    • (1997) J Allergy Clin Immunol , vol.99 , pp. 450-453
    • Des Roches, A.1    Paradis, L.2    Menardo, J.L.3    Bouges, S.4    Daures, J.P.5    Bousquet, J.6
  • 32
  • 33
    • 0029156326 scopus 로고
    • Tryptase and histamine release due to a sting challenge in bee venom allergic patients treated successfully or unsuccessfully with hyposensitization
    • Eberlein-Konig, B., Ullmann, S., Thomas, P. and Przybilla, B. (1995) Tryptase and histamine release due to a sting challenge in bee venom allergic patients treated successfully or unsuccessfully with hyposensitization. Clin Exp Allergy 25: 704-712.
    • (1995) Clin Exp Allergy , vol.25 , pp. 704-712
    • Eberlein-Konig, B.1    Ullmann, S.2    Thomas, P.3    Przybilla, B.4
  • 34
    • 0029061834 scopus 로고
    • Expression and biological activities of bovine interleukin 4: Effects of recombinant bovine interleukin 4 on T cell proliferation and B cell differentiation and proliferation in vitro
    • Estes, D.M., Hirano, A., Heussler, V.T., Dobbelaere, D.A. and Brown, W.C. (1995) Expression and biological activities of bovine interleukin 4: Effects of recombinant bovine interleukin 4 on T cell proliferation and B cell differentiation and proliferation in vitro. Cell Immunol 163: 268-279.
    • (1995) Cell Immunol , vol.163 , pp. 268-279
    • Estes, D.M.1    Hirano, A.2    Heussler, V.T.3    Dobbelaere, D.A.4    Brown, W.C.5
  • 36
    • 0036170440 scopus 로고    scopus 로고
    • Activation and inhibition of lymphocytes by costimulation
    • Frauwirth, K.A. and Thompson, C.B. (2002) Activation and inhibition of lymphocytes by costimulation. J Clin Invest 109: 295-299.
    • (2002) J Clin Invest , vol.109 , pp. 295-299
    • Frauwirth, K.A.1    Thompson, C.B.2
  • 37
    • 0027767762 scopus 로고
    • Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation
    • Freeman, G.J., Gribben, J.G., Boussiotis, V.A., Ng, J.W., Restivo Jr, V.A., Lombard, L.A. et al. (1993) Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 262: 909-911.
    • (1993) Science , vol.262 , pp. 909-911
    • Freeman, G.J.1    Gribben, J.G.2    Boussiotis, V.A.3    Ng, J.W.4    Restivo, V.A.5    Lombard, L.A.6
  • 38
    • 0029883629 scopus 로고    scopus 로고
    • Induction of anergy in Th1 lymphocytes by oral tolerance. importance of antigen dosage and frequency of feeding
    • Friedman, A. (1996) Induction of anergy in Th1 lymphocytes by oral tolerance. importance of antigen dosage and frequency of feeding. Ann N Y Acad Sci 778: 103-110.
    • (1996) Ann N Y Acad Sci , vol.778 , pp. 103-110
    • Friedman, A.1
  • 39
    • 0025913662 scopus 로고    scopus 로고
    • Immunotherapy decreases antigen-induced eosinophil cell migration into the nasal cavity
    • Immunotherapy decreases antigen-induced eosinophil cell migration into the nasal cavity. J Allergy Clin Immunol 88: 27-32.
    • J Allergy Clin Immunol , vol.88 , pp. 27-32
  • 41
    • 0029563257 scopus 로고
    • Role of B7 Signaling in the Differentiation of naive CD4+ T Cells to effector interleukin-4-producing T helper cells
    • Gause, W.C., Urban, J.F., Linsley, P. and Lu, P. (1995) Role of B7 Signaling in the Differentiation of naive CD4+ T Cells to effector interleukin-4-producing T helper cells. Immunol Res 14: 176-188.
    • (1995) Immunol Res , vol.14 , pp. 176-188
    • Gause, W.C.1    Urban, J.F.2    Linsley, P.3    Lu, P.4
  • 42
    • 0018174365 scopus 로고
    • T cell growth factor: parameters of production and a quantitative microassay for activity
    • Gillis, S., Ferm, M.M., Ou, W. and Smith, K.A. (1978) T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol 120: 2027-2032.
    • (1978) J Immunol , vol.120 , pp. 2027-2032
    • Gillis, S.1    Ferm, M.M.2    Ou, W.3    Smith, K.A.4
  • 43
    • 9144219649 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T Cells
    • Huber, S., Schramm, C., Lehr, H.A., Mann, A., Schmitt, S., Becker, C. et al. (2004) Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T Cells. J Immunol 173: 6526-6531.
    • (2004) J Immunol , vol.173 , pp. 6526-6531
    • Huber, S.1    Schramm, C.2    Lehr, H.A.3    Mann, A.4    Schmitt, S.5    Becker, C.6
  • 45
    • 52249095519 scopus 로고    scopus 로고
    • T-cell regulatory mechanisms in specific immunotherapy
    • Jutel, M. and Akdis, C.A. (2008) T-cell regulatory mechanisms in specific immunotherapy. Chem Immunol Allergy 94: 158-177.
    • (2008) Chem Immunol Allergy , vol.94 , pp. 158-177
    • Jutel, M.1    Akdis, C.A.2
  • 46
    • 0038363534 scopus 로고    scopus 로고
    • Il-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    • Jutel, M., Akdis, M., Budak, F., Aebischer-Casaulta, C., Wrzyszcz, M., Blaser, K. et al. (2003) Il-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 33: 1205-1214.
    • (2003) Eur J Immunol , vol.33 , pp. 1205-1214
    • Jutel, M.1    Akdis, M.2    Budak, F.3    Aebischer-Casaulta, C.4    Wrzyszcz, M.5    Blaser, K.6
  • 47
    • 0029850382 scopus 로고    scopus 로고
    • Influence of bee venom immunotherapy on degranulation and leukotriene generation in human blood basophils
    • Jutel, M., Muller, U.R., Fricker, M., Rihs, S., Pichler, W.J. and Dahinden, C. (1996) Influence of bee venom immunotherapy on degranulation and leukotriene generation in human blood basophils. Clin Exp Allergy 26: 1112-1118.
    • (1996) Clin Exp Allergy , vol.26 , pp. 1112-1118
    • Jutel, M.1    Muller, U.R.2    Fricker, M.3    Rihs, S.4    Pichler, W.J.5    Dahinden, C.6
  • 48
    • 0348135024 scopus 로고    scopus 로고
    • Dendritic-cell control of pathogen-driven T-cell polarization
    • Kapsenberg, M.L. (2003) Dendritic-cell control of pathogen-driven T-cell polarization. Nat Rev Immunol 3: 984-993.
    • (2003) Nat Rev Immunol , vol.3 , pp. 984-993
    • Kapsenberg, M.L.1
  • 49
    • 45549122275 scopus 로고    scopus 로고
    • Il-13 as a therapeutic target for respiratory disease
    • Kasaian, M.T. and Miller, D.K. (2008) Il-13 as a therapeutic target for respiratory disease. Biochem Pharmacol 76: 147-155.
    • (2008) Biochem Pharmacol , vol.76 , pp. 147-155
    • Kasaian, M.T.1    Miller, D.K.2
  • 50
    • 39449087338 scopus 로고    scopus 로고
    • Th17 cells: effector T cells with inflammatory properties
    • Korn, T., Oukka, M., Kuchroo, V. and Bettelli, E. (2007) Th17 cells: effector T cells with inflammatory properties. Semin Immunol 19: 362-371.
    • (2007) Semin Immunol , vol.19 , pp. 362-371
    • Korn, T.1    Oukka, M.2    Kuchroo, V.3    Bettelli, E.4
  • 51
  • 53
    • 33749016485 scopus 로고    scopus 로고
    • Immunological mechanisms of allergen-specific immunotherapy
    • Larche, M., Akdis, C.A. and Valenta, R. (2006) Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol 6: 761-771.
    • (2006) Nat Rev Immunol , vol.6 , pp. 761-771
    • Larche, M.1    Akdis, C.A.2    Valenta, R.3
  • 54
    • 65549141754 scopus 로고    scopus 로고
    • (2009) Administration regimens for sublingual immunotherapy to pollen allergens: what do we know?
    • Lombardi, C., Incorvaia, C., Braga, M., Senna, G., Canonica, G.W. and Passalacqua, G. (2009) Administration regimens for sublingual immunotherapy to pollen allergens: what do we know? Allergy 64: 849-854.
    • Allergy , vol.64 , pp. 849-854
    • Lombardi, C.1    Incorvaia, C.2    Braga, M.3    Senna, G.4    Canonica, G.W.5    Passalacqua, G.6
  • 55
    • 10044225592 scopus 로고    scopus 로고
    • Combination therapy in asthma - fixed or variable dosing in different patients?
    • Lotvall, J. (2004) Combination therapy in asthma - fixed or variable dosing in different patients? Curr Med Res Opin 20: 1711-1727.
    • (2004) Curr Med Res Opin , vol.20 , pp. 1711-1727
    • Lotvall, J.1
  • 56
    • 38549166301 scopus 로고    scopus 로고
    • Gata3-driven Th2 responses inhibit TGF-beta1-induced FoxP3 expression and the formation of regulatory T cells
    • Mantel, P.Y., Kuipers, H., Boyman, O., Rhyner, C., Ouaked, N., Ruckert, B. et al. (2007) Gata3-driven Th2 responses inhibit TGF-beta1-induced FoxP3 expression and the formation of regulatory T cells. PLoS Biol 5: e329.
    • (2007) PLoS Biol , vol.5 , pp. e329
    • Mantel, P.Y.1    Kuipers, H.2    Boyman, O.3    Rhyner, C.4    Ouaked, N.5    Ruckert, B.6
  • 59
    • 50649122989 scopus 로고    scopus 로고
    • Oral dendritic cells mediate antigen-specific tolerance by stimulating Th1 and regulatory CD4+ T cells
    • Mascarell, L., Lombardi, V., Louise, A., Saint-Lu, N., Chabre, H., Moussu, H. et al. (2008) Oral dendritic cells mediate antigen-specific tolerance by stimulating Th1 and regulatory CD4+ T cells. J Allergy Clin Immunol 122: 603-609e605.
    • (2008) J Allergy Clin Immunol , vol.122 , pp. 603-609e605
    • Mascarell, L.1    Lombardi, V.2    Louise, A.3    Saint-Lu, N.4    Chabre, H.5    Moussu, H.6
  • 60
    • 53749096798 scopus 로고    scopus 로고
    • Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors
    • Meiler, F., Klunker, S., Zimmermann, M., Akdis, C.A. and Akdis, M. (2008) Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors. Allergy 63: 1455-1463.
    • (2008) Allergy , vol.63 , pp. 1455-1463
    • Meiler, F.1    Klunker, S.2    Zimmermann, M.3    Akdis, C.A.4    Akdis, M.5
  • 61
    • 58149306013 scopus 로고    scopus 로고
    • In vivo switch to Il-10-secreting T regulatory cells in high dose allergen exposure
    • Meiler, F., Zumkehr, J., Klunker, S., Ruckert, B., Akdis, C.A. and Akdis, M. (2008) In vivo switch to Il-10-secreting T regulatory cells in high dose allergen exposure. J Exp Med 205: 2887-2898.
    • (2008) J Exp Med , vol.205 , pp. 2887-2898
    • Meiler, F.1    Zumkehr, J.2    Klunker, S.3    Ruckert, B.4    Akdis, C.A.5    Akdis, M.6
  • 63
    • 0036170801 scopus 로고    scopus 로고
    • Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study)
    • Moller, C., Dreborg, S., Ferdousi, H.A., Halken, S., Host, A., Jacobsen, L. et al. (2002) Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J Allergy Clin Immunol 109: 251-256.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 251-256
    • Moller, C.1    Dreborg, S.2    Ferdousi, H.A.3    Halken, S.4    Host, A.5    Jacobsen, L.6
  • 64
    • 0043264799 scopus 로고    scopus 로고
    • Allergen-specific immunotherapy with a monophosphoryl lipid a-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies
    • Mothes, N., Heinzkill, M., Drachenberg, K.J., Sperr, W.R., Krauth, M.T., Majlesi, Y. et al. (2003) Allergen-specific immunotherapy with a monophosphoryl lipid a-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies. Clin Exp Allergy 33: 1198-1208.
    • (2003) Clin Exp Allergy , vol.33 , pp. 1198-1208
    • Mothes, N.1    Heinzkill, M.2    Drachenberg, K.J.3    Sperr, W.R.4    Krauth, M.T.5    Majlesi, Y.6
  • 65
    • 0024324363 scopus 로고
    • Predictive value of venom-specific IgE, IgG and IgG subclass antibodies in patients on immunotherapy with honey bee venom
    • Muller, U., Helbling, A. and Bischof, M. (1989) Predictive value of venom-specific IgE, IgG and IgG subclass antibodies in patients on immunotherapy with honey bee venom. Allergy 44: 412-418.
    • (1989) Allergy , vol.44 , pp. 412-418
    • Muller, U.1    Helbling, A.2    Bischof, M.3
  • 66
    • 16244421980 scopus 로고    scopus 로고
    • Advances in upper airway diseases and allergen immunotherapy
    • Nelson, H.S. (2005) Advances in upper airway diseases and allergen immunotherapy. J Allergy Clin Immunol 115: 676-684.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 676-684
    • Nelson, H.S.1
  • 67
    • 4944266011 scopus 로고    scopus 로고
    • Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis
    • Novembre, E., Galli, E., Landi, F., Caffarelli, C., Pifferi, M., De Marco, E. et al. (2004) Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol 114: 851-857.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 851-857
    • Novembre, E.1    Galli, E.2    Landi, F.3    Caffarelli, C.4    Pifferi, M.5    De Marco, E.6
  • 68
    • 60549101976 scopus 로고    scopus 로고
    • (2009) Regulation of the FoxP3 gene by the Th1 cytokines: the role of Il-27-induced STAT1
    • et al
    • Ouaked, N., Mantel, P.Y., Bassin, C., Burgler, S., Siegmund, K., Akdis, C.A. et al. (2009) Regulation of the FoxP3 gene by the Th1 cytokines: the role of Il-27-induced STAT1. J Immunol 182: 1041-1049.
    • J Immunol , vol.182 , pp. 1041-1049
    • Ouaked, N.1    Mantel, P.Y.2    Bassin, C.3    Burgler, S.4    Siegmund, K.5    Akdis, C.A.6
  • 69
    • 64649093157 scopus 로고    scopus 로고
    • (2009) T regulatory cells and their counterparts: masters of immune regulation
    • Ozdemir, C., Akdis, M. and Akdis, C.A. (2009) T regulatory cells and their counterparts: masters of immune regulation. Clin Exp Allergy 39: 626-639.
    • Clin Exp Allergy , vol.39 , pp. 626-639
    • Ozdemir, C.1    Akdis, M.2    Akdis, C.A.3
  • 70
    • 34547639714 scopus 로고    scopus 로고
    • Efficacy of long-term sublingual immunotherapy as an adjunct to pharmacotherapy in house dust mite-allergic children with asthma
    • Ozdemir, C., Yazi, D., Gocmen, I., Yesil, O., Aydogan, M., Semic-Jusufagic, A. et al. (2007) Efficacy of long-term sublingual immunotherapy as an adjunct to pharmacotherapy in house dust mite-allergic children with asthma. Pediatr Allergy Immunol 18: 508-515.
    • (2007) Pediatr Allergy Immunol , vol.18 , pp. 508-515
    • Ozdemir, C.1    Yazi, D.2    Gocmen, I.3    Yesil, O.4    Aydogan, M.5    Semic-Jusufagic, A.6
  • 71
    • 34250836330 scopus 로고    scopus 로고
    • Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: a randomized, double-blind, placebo-controlled study
    • Pajno, G.B., Caminiti, L., Vita, D., Barberio, G., Salzano, G., Lombardo, F. et al. (2007) Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: a randomized, double-blind, placebo-controlled study. J Allergy Clin Immunol 120: 164-170.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 164-170
    • Pajno, G.B.1    Caminiti, L.2    Vita, D.3    Barberio, G.4    Salzano, G.5    Lombardo, F.6
  • 72
    • 0032574206 scopus 로고    scopus 로고
    • Randomised controlled trial of local allergoid immunotherapy on allergic inflammation in mite-induced rhinoconjunctivitis
    • Passalacqua, G., Albano, M., Fregonese, L., Riccio, A., Pronzato, C., Mela, G.S. et al. (1998) Randomised controlled trial of local allergoid immunotherapy on allergic inflammation in mite-induced rhinoconjunctivitis. Lancet 351: 629-632.
    • (1998) Lancet , vol.351 , pp. 629-632
    • Passalacqua, G.1    Albano, M.2    Fregonese, L.3    Riccio, A.4    Pronzato, C.5    Mela, G.S.6
  • 73
    • 0032713995 scopus 로고    scopus 로고
    • Clinical and immunologic effects of a rush sublingual immunotherapy to parietaria species: a double-blind, placebo-controlled trial
    • Passalacqua, G., Albano, M., Riccio, A., Fregonese, L., Puccinelli, P., Parmiani, S. et al. (1999) Clinical and immunologic effects of a rush sublingual immunotherapy to parietaria species: a double-blind, placebo-controlled trial. J Allergy Clin Immunol 104: 964-968.
    • (1999) J Allergy Clin Immunol , vol.104 , pp. 964-968
    • Passalacqua, G.1    Albano, M.2    Riccio, A.3    Fregonese, L.4    Puccinelli, P.5    Parmiani, S.6
  • 74
    • 34047161743 scopus 로고    scopus 로고
    • Allergic rhinitis and its impact on asthma update: allergen immunotherapy
    • Passalacqua, G. and Durham, S.R. (2007) Allergic rhinitis and its impact on asthma update: allergen immunotherapy. J Allergy Clin Immunol 119: 881-891.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 881-891
    • Passalacqua, G.1    Durham, S.R.2
  • 76
    • 40549140165 scopus 로고    scopus 로고
    • Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age
    • Penagos, M., Passalacqua, G., Compalati, E., Baena-Cagnani, C.E., Orozco, S., Pedroza, A. et al. (2008) Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age. Chest 133: 599-609.
    • (2008) Chest , vol.133 , pp. 599-609
    • Penagos, M.1    Passalacqua, G.2    Compalati, E.3    Baena-Cagnani, C.E.4    Orozco, S.5    Pedroza, A.6
  • 78
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
    • Read, S., Malmstrom, V. and Powrie, F. (2000) Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 192: 295-302.
    • (2000) J Exp Med , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 79
    • 1542511733 scopus 로고    scopus 로고
    • Immunologic influences on allergy and the Th1/Th2 balance
    • Romagnani, S. (2004) Immunologic influences on allergy and the Th1/Th2 balance. J Allergy Clin Immunol 113: 395-400.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 395-400
    • Romagnani, S.1
  • 80
    • 0024549594 scopus 로고
    • Presentation of exogenous protein antigens by dendritic cells to T cell clones. intact protein is presented best by immature, epidermal Langerhans cells
    • Romani, N., Koide, S., Crowley, M., Witmer-Pack, M., Livingstone, A.M., Fathman, C.G. et al. (1989) Presentation of exogenous protein antigens by dendritic cells to T cell clones. intact protein is presented best by immature, epidermal Langerhans cells. J Exp Med 169: 1169-1178.
    • (1989) J Exp Med , vol.169 , pp. 1169-1178
    • Romani, N.1    Koide, S.2    Crowley, M.3    Witmer-Pack, M.4    Livingstone, A.M.5    Fathman, C.G.6
  • 81
    • 33845301687 scopus 로고    scopus 로고
    • Evaluation of serum IgG4 antibodies specific to grass pollen allergen components in the follow up of allergic patients undergoing subcutaneous and sublingual immunotherapy
    • Rossi, R.E., Monasterolo, G., Coco, G., Silvestro, L. and Operti, D. (2007) Evaluation of serum IgG4 antibodies specific to grass pollen allergen components in the follow up of allergic patients undergoing subcutaneous and sublingual immunotherapy. Vaccine 25: 957-964.
    • (2007) Vaccine , vol.25 , pp. 957-964
    • Rossi, R.E.1    Monasterolo, G.2    Coco, G.3    Silvestro, L.4    Operti, D.5
  • 82
    • 66749106297 scopus 로고    scopus 로고
    • (2009) Targeting the allergen to oral dendritic cells with mucoadhesive chitosan particles enhances tolerance induction
    • et al
    • Saint-Lu, N., Tourdot, S., Razafindratsita, A., Mascarell, L., Berjont, N., Chabre, H. et al. (2009) Targeting the allergen to oral dendritic cells with mucoadhesive chitosan particles enhances tolerance induction. Allergy 64: 1003-1013.
    • Allergy , vol.64 , pp. 1003-1013
    • Saint-Lu, N.1    Tourdot, S.2    Razafindratsita, A.3    Mascarell, L.4    Berjont, N.5    Chabre, H.6
  • 83
    • 70349216591 scopus 로고    scopus 로고
    • Allergen content of grass pollen preparations for skin prick testing and sublingual immunotherapy
    • Apr 6 [Epub ahead of print]
    • Sander, I., Fleischer, C., Meurer, U., Bruning, T. and Raulf-Heimsoth, M. (2009) Allergen content of grass pollen preparations for skin prick testing and sublingual immunotherapy. Allergy Apr 6 [Epub ahead of print].
    • (2009) Allergy
    • Sander, I.1    Fleischer, C.2    Meurer, U.3    Bruning, T.4    Raulf-Heimsoth, M.5
  • 84
    • 33748294181 scopus 로고    scopus 로고
    • Sublingual immunotherapy in children modulates allergen-induced in vitro expression of cytokine mRNA in PBMC
    • Savolainen, J., Jacobsen, L. and Valovirta, E. (2006) Sublingual immunotherapy in children modulates allergen-induced in vitro expression of cytokine mRNA in PBMC. Allergy 61: 1184-1190.
    • (2006) Allergy , vol.61 , pp. 1184-1190
    • Savolainen, J.1    Jacobsen, L.2    Valovirta, E.3
  • 85
    • 0026755576 scopus 로고
    • Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects
    • Sehmi, R., Wardlaw, A.J., Cromwell, O., Kurihara, K., Waltmann, P. and Kay, A.B. (1992) Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects. Blood 79: 2952-2959.
    • (1992) Blood , vol.79 , pp. 2952-2959
    • Sehmi, R.1    Wardlaw, A.J.2    Cromwell, O.3    Kurihara, K.4    Waltmann, P.5    Kay, A.B.6
  • 88
    • 7444226349 scopus 로고    scopus 로고
    • Pharmacologic approaches to daytime and nighttime symptoms of allergic rhinitis
    • Storms, W.W. (2004) Pharmacologic approaches to daytime and nighttime symptoms of allergic rhinitis. J Allergy Clin Immunol 114: S146-153.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. S146-S153
    • Storms, W.W.1
  • 89
    • 0028143625 scopus 로고
    • Immunologic evaluation of 24 month course of sublingual immunotherapy
    • Madr
    • Tari, M.G., Mancino, M., Madonna, F., Buzzoni, L. and Parmiani, S. (1994) Immunologic evaluation of 24 month course of sublingual immunotherapy. Allergol Immunopathol (Madr) 22: 209-216.
    • (1994) Allergol Immunopathol , vol.22 , pp. 209-216
    • Tari, M.G.1    Mancino, M.2    Madonna, F.3    Buzzoni, L.4    Parmiani, S.5
  • 91
    • 58149475502 scopus 로고    scopus 로고
    • Changes in serum specific IgG4 and IgG4/IgE ratio in mite-sensitized Taiwanese children with allergic rhinitis receiving short-term sublingual-swallow immunotherapy: a multicenter, randomized, placebo-controlled trial
    • Tseng, S.H., Fu, L.S., Nong, B.R., Weng, J.D. and Shyur, S.D. (2008) Changes in serum specific IgG4 and IgG4/IgE ratio in mite-sensitized Taiwanese children with allergic rhinitis receiving short-term sublingual-swallow immunotherapy: a multicenter, randomized, placebo-controlled trial. Asian Pac J Allergy Immunol 26: 105-112.
    • (2008) Asian Pac J Allergy Immunol , vol.26 , pp. 105-112
    • Tseng, S.H.1    Fu, L.S.2    Nong, B.R.3    Weng, J.D.4    Shyur, S.D.5
  • 92
    • 1642265044 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled birch allergy vaccination study: inhibition of CD23-mediated serum-immunoglobulin E-facilitated allergen presentation
    • Van Neerven, R.J., Arvidsson, M., Ipsen, H., Sparholt, S.H., Rak, S. and Wurtzen, P.A. (2004) A double-blind, placebo-controlled birch allergy vaccination study: inhibition of CD23-mediated serum-immunoglobulin E-facilitated allergen presentation. Clin Exp Allergy 34: 420-428.
    • (2004) Clin Exp Allergy , vol.34 , pp. 420-428
    • Van Neerven, R.J.1    Arvidsson, M.2    Ipsen, H.3    Sparholt, S.H.4    Rak, S.5    Wurtzen, P.A.6
  • 93
    • 0033197966 scopus 로고    scopus 로고
    • Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibiting serum-IgE-facilitated allergen presentation
    • Van Neerven, R.J., Wikborg, T., Lund, G., Jacobsen, B., Brinch-Nielsen, A., Arnved, J. et al. (1999) Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibiting serum-IgE-facilitated allergen presentation. J Immunol 163: 2944-2952.
    • (1999) J Immunol , vol.163 , pp. 2944-2952
    • Van Neerven, R.J.1    Wikborg, T.2    Lund, G.3    Jacobsen, B.4    Brinch-Nielsen, A.5    Arnved, J.6
  • 94
    • 56749156137 scopus 로고    scopus 로고
    • When to initiate immunotherapy in children with allergic disease? Lessons from the paediatric studies
    • Van Wijk, R.G. (2008) When to initiate immunotherapy in children with allergic disease? Lessons from the paediatric studies. Curr Opin Allergy Clin Immunol 8: 565-570.
    • (2008) Curr Opin Allergy Clin Immunol , vol.8 , pp. 565-570
    • Van Wijk, R.G.1
  • 95
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-beta ‘reprograms’ the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • Veldhoen, M., Uyttenhove, C., Van Snick, J., Helmby, H., Westendorf, A., Buer, J. et al. (2008) Transforming growth factor-beta ‘reprograms’ the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol 9: 1341-1346.
    • (2008) Nat Immunol , vol.9 , pp. 1341-1346
    • Veldhoen, M.1    Uyttenhove, C.2    Van Snick, J.3    Helmby, H.4    Westendorf, A.5    Buer, J.6
  • 96
    • 9644281044 scopus 로고    scopus 로고
    • Interleukin-13 in asthma pathogenesis
    • Wills-Karp, M. (2004) Interleukin-13 in asthma pathogenesis. Immunol Rev 202: 175-190.
    • (2004) Immunol Rev , vol.202 , pp. 175-190
    • Wills-Karp, M.1
  • 98
    • 0035725164 scopus 로고    scopus 로고
    • Grass pollen immunotherapy inhibits seasonal increases in basophils and eosinophils in the nasal epithelium
    • Wilson, D.R., Irani, A.M., Walker, S.M., Jacobson, M.R., Mackay, I.S., Schwartz, L.B. et al. (2001) Grass pollen immunotherapy inhibits seasonal increases in basophils and eosinophils in the nasal epithelium. Clin Exp Allergy 31: 1705-1713.
    • (2001) Clin Exp Allergy , vol.31 , pp. 1705-1713
    • Wilson, D.R.1    Irani, A.M.2    Walker, S.M.3    Jacobson, M.R.4    Mackay, I.S.5    Schwartz, L.B.6


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