Sublingual Immunotherapy in Children: An Updated Review

Pediatrics and Neonatology

Volumn 50, Issue 2, 2009, Pages 44-49

  Kuo, Chang Hung ^a   Wang, Wei Li ^a   Chu, Yu Te ^a   Lee, Min Sheng ^a   Hung, Chih Hsing ^a,b,c  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c Faculty of Internal Medicine   (Taiwan)

Author keywords

allergic disease; clinical efficacy; mechanism; sublingual immunotherapy

Indexed keywords

ALLERGEN; ANTIASTHMATIC AGENT; CORTICOSTEROID; FLUTICASONE PROPIONATE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 10; POLLEN ANTIGEN; POLLEN EXTRACT; RECOMBINANT ALLERGEN; VACCINE;

ABDOMINAL PAIN; ALLERGIC DISEASE; ALLERGIC RHINITIS; ANAPHYLAXIS; ANTIGEN PRESENTING CELL; ASTHMA; CHILD; CLINICAL PROTOCOL; CLINICAL TRIAL; CONJUNCTIVITIS; CYTOKINE PRODUCTION; DIARRHEA; DISEASE COURSE; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; GASTROINTESTINAL SYMPTOM; HUMAN; IMMUNE RESPONSE; IMMUNOTHERAPY; MOUTH EDEMA; MOUTH MUCOSA; NAUSEA; NONHUMAN; ORAL PRURITUS; PATIENT COMPLIANCE; REGULATORY T LYMPHOCYTE; REVIEW; RHINOCONJUNCTIVITIS; SUBLINGUAL IMMUNOTHERAPY; TABLET FORMULATION; THROAT IRRITATION; VOMITING;

ADMINISTRATION, SUBLINGUAL; ADOLESCENT; ALLERGENS; CHILD; CHILD, PRESCHOOL; DOUBLE BIND INTERACTION; HUMANS; HYPERSENSITIVITY; IMMUNOTHERAPY; RANDOM ALLOCATION;

EID: 65549138795     PISSN: 18759572     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1875-9572(09)60031-0     Document Type: Review

References (48)

1. Wills-Karp M., Santeliz J., and Karp C.L. The germless theory of allergic disease: revisiting the hygiene hypothesis. Nat Rev Immunol 1 (2001) 69-75
2. Bousquet J., Van Cauwenberge P., and Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 108 (2001) S147-S334
3. Johnstone D.E., and Crump L. Value of hyposensitization therapy for perennial bronchial asthma in children. Pediatrics 27 (1961) 39-44
4. Canonica G.W., and Passalacqua G. Noninjection routes for immunotherapy. J Allergy Clin Immunol 111 (2003) 437-448
5. Niu C.K., Chen W.Y., Huang J.L., Lue K.H., and Wang J.Y. Efficacy of sublingual immunotherapy with high-dose mite extracts in asthma: a multi-center, double-blind, randomized, and placebo-controlled study in Taiwan. Respir Med 100 (2006) 1374-1383
6. Lue K.H., Lin Y.H., Sun H.L., Lu K.H., Hsieh J.C., and Chou M.C. Clinical and immunologic effects of sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, randomized, placebo-controlled study. Pediatr Allergy Immunol 17 (2006) 408-415
7. Wilson D.R., Lima M.T., and Durham S.R. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy 60 (2005) 4-12
8. Penagos M., Compalati E., Tarantini F., et al. Efficacy of sub-lingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials. Ann Allergy Asthma Immunol 97 (2006) 141-148
9. Calamita Z., Saconato H., Pela A.B., and Atallah A.N. Efficacy of sublingual immunotherapy in asthma: systematic review of randomized-clinical trials using the Cochrane Collaboration method. Allergy 61 (2006) 1162-1172
10. Ibanez M.D., Kaiser F., Knecht R., et al. Safety of specific sub-lingual immunotherapy with SQ standardized grass allergen tablets in children. Pediatr Allergy Immunol 18 (2007) 516-522
11. La Grutta S., Arena A., D'Anneo W.R., et al. Evaluation of the antiinflammatory and clinical effects of sublingual immu-notherapy with carbamylated allergoid in allergic asthma with or without rhinitis: a 12-month prospective randomized, controlled trial. Eur Ann Allergy Clin Immunol 39 (2007) 40-44
12. Ozdemir C., Yazi D., Gocmen I., et al. Efficacy of long-term sublingual immunotherapy as an adjunct to pharmacother-apy in house dust mite-allergic children with asthma. Pediatr Allergy Immunol 18 (2007) 508-515
13. Pham-Thi N., Scheinmann P., Fadel R., Combebias A., and Andre C. Assessment of sublingual immunotherapy efficacy in children with house dust mite-induced allergic asthma optimally controlled by pharmacologic treatment and mite-avoidance measures. Pediatr Allergy Immunol 18 (2007) 47-57
14. Pajno G.B., Vita D., Parmiani S., Caminiti L., La Grutta S., and Barberio G. Impact of sublingual immunotherapy on seasonal asthma and skin reactivity in children allergic to Pari-etaria pollen treated with inhaled fluticasone propionate. Clin Exp Allergy 33 (2003) 1641-1647
15. Moller C., Dreborg S., Ferdousi H.A., et al. Pollen immuno-therapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J Allergy Clin Immunol 109 (2002) 251-256
16. Jacobsen L., Niggemann B., Dreborg S., et al. Specific immu-notherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study. Allergy 62 (2007) 943-948
17. Novembre E., Galli E., Landi F., et al. Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol 114 (2004) 851-857
18. Durham S.R., Walker S.M., Varga E.M., et al. Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med 341 (1999) 468-475
19. Di Rienzo V., Marcucci F., Puccinelli P., et al. Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10-year prospective study. Clin Exp Allergy 33 (2003) 206-210
20. Marcucci F., Sensi L., Di Cara G., et al. Three-year follow-up of clinical and inflammation parameters in children mono-sensitized to mites undergoing sub-lingual immunotherapy. Pediatr Allergy Immunol 16 (2005) 519-526
21. Moingeon P., Batard T., Fadel R., Frati F., Sieber J., and Van Overtvelt L. Immune mechanisms of allergen-specific sub-lingual immunotherapy. Allergy 61 (2006) 151-165
22. Allam J.P., Novak N., Fuchs C., et al. Characterization of dendritic cells from human oral mucosa: a new Langerhans' cell type with high constitutive FcepsilonRI expression. J Allergy Clin Immunol 112 (2003) 141-148
23. Bousquet J., Scheinmann P., Guinnepain M.T., et al. Sublingual-swallow immunotherapy (SLIT) in patients with asthma due to house-dust mites: a double-blind, placebo-controlled study. Allergy 54 (1999) 249-260
24. La Rosa M., Ranno C., Andre C., Carat F., Tosca M.A., and Canonica G.W. Double-blind placebo-controlled evaluation of sublin-gual-swallow immunotherapy with standardized Parietaria judaica extract in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol 104 (1999) 425-432
25. Bahceciler N.N., Arikan C., Taylor A., et al. Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites. Int Arch Allergy Immunol 136 (2005) 287-294
26. Rolinck-Werninghaus C., Kopp M., Liebke C., Lange J., Wahn U., and Niggemann B. Lack of detectable alterations in immune responses during sublingual immunotherapy in children with seasonal allergic rhinoconjunctivitis to grass pollen. Int Arch Allergy Immunol 136 (2005) 134-141
27. Akdis M., Verhagen J., Taylor A., et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 199 (2004) 1567-1575
28. Jutel M., Akdis M., Budak F., et al. IL-10 and TGF-beta co operate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 33 (2003) 1205-1214
29. Vourdas D., Syrigou E., Potamianou P., et al. Double-blind, placebo-controlled evaluation of sublingual immunotherapy with standardized olive pollen extract in pediatric patients with allergic rhinoconjunctivitis and mild asthma due to olive pollen sensitization. Allergy 53 (1998) 662-672
30. Ciprandi G., Fenoglio D., Cirillo I., et al. Induction of interleukin 10 by sublingual immunotherapy for house dust mites: a preliminary report. Ann Allergy Asthma Immunol 95 (2005) 38-44
31. Fenoglio D., Puppo F., Cirillo I., et al. Sublingual specific immunotherapy reduces PBMC proliferations. Eur Ann Allergy Clin Immunol 37 (2005) 147-151
32. Pajno G.B., Morabito L., Barberio G., and Parmiani S. Clinical and immunologic effects of long-term sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, placebo-controlled study. Allergy 55 (2000) 842-849
33. Durham S.R., Yang W.H., Pedersen M.R., Johansen N., and Rak S. Sublingual immunotherapy with once-daily grass allergen tablets: a randomized controlled trial in seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol 117 (2006) 802-809
34. Passalacqua G., Guerra L., Pasquali M., Lombardi C., and Canonica G.W. Efficacy and safety of sublingual immunotherapy. Ann Allergy Asthma Immunol 93 (2004) 3-12
35. Winther L., Arnved J., Malling H.J., Nolte H., and Mosbech H. Side-effects of allergen-specific immunotherapy: a prospective multi-centre study. Clin Exp Allergy 36 (2006) 254-260
36. Gidaro G.B., Marcucci F., Sensi L., Incorvaia C., Frati F., and Ciprandi G. The safety of sublingual-swallow immunotherapy: an analysis of published studies. Clin Exp Allergy 35 (2005) 565-571
37. Cox L.S., Linnemann D.L., Nolte H., Weldon D., Finegold I., and Nelson H.S. Sublingual immunotherapy: a comprehensive review. J Allergy Clin Immunol 117 (2006) 1021-1035
38. Andre C., Vatrinet C., Galvain S., Carat F., and Sicard H. Safety of sublingual-swallow immunotherapy in children and adults. Int Arch Allergy Immunol 121 (2000) 229-234
39. Valenta R. The future of antigen-specific immunotherapy of allergy. Nat Rev Immunol 2 (2002) 446-453
40. Jutel M., Jaeger L., Suck R., Meyer H., Fiebig H., and Cromwell O. Allergen-specific immunotherapy with recombinant grass pollen allergens. J Allergy Clin Immunol 116 (2005) 608-613
41. Caffarelli C., Sensi L.G., Marcucci F., and Cavagni G. Preseasonal local allergoid immunotherapy to grass pollen in children: a double-blind, placebo-controlled, randomized trial. Allergy 55 (2000) 1142-1147
42. Bahceciler N.N., Isik U., Barlan I.B., and Basaran M.M. Efficacy of sublingual immunotherapy in children with asthma and rhinitis: a double-blind, placebo-controlled study. Pediatr Pulmonol 32 (2001) 49-55
43. Ippoliti F., De Santis W., Volterrani A., et al. Immunomodulation during sublingual therapy in allergic children. Pediatr Allergy Immunol 14 (2003) 216-221
44. Marcucci F., Sensi L., Frati F., et al. Effects on inflammation parameters of a double-blind, placebo controlled one-year course of SLIT in children monosensitized to mites. Allergy 58 (2003) 657-662
45. Wuthrich B., Bucher C., Jorg W., et al. Double-blind, placebo-controlled study with sublingual immunotherapy in children with seasonal allergic rhinitis to grass pollen. J Investig Allergol Clin Immunol 13 (2003) 145-148
46. Bufe A., Ziegler-Kirbach E., Stoeckmann E., et al. Efficacy of sublingual swallow immunotherapy in children with severe grass pollen allergic symptoms: a double-blind placebo-controlled study. Allergy 59 (2004) 498-504
47. Rolinck-Werninghaus C., Wolf H., Liebke C., et al. A prospective, randomized, double-blind, placebo-controlled multi-centre study on the efficacy and safety of sublingual immunotherapy (SLIT) in children with seasonal allergic rhinoconjunctivitis to grass pollen. Allergy 59 (2004) 1285-1293
48. Valovirta E., Jacobsen L., Ljorring C., Koivikko A., and Savolainen J. Clinical efficacy and safety of sublingual immunotherapy with tree pollen extract in children. Allergy 61 (2006) 1177-1183