Imbalanced intrahepatic expression of interleukin 12, interferon gamma, and interleukin 10 in fulminant hepatitis B

Hepatology

Volumn 36, Issue 4I, 2002, Pages 1001-1008

  Leifeld, Ludger ^a   Cheng, Silvia ^a   Ramakers, Jan ^a   Dumoulin, Franz Ludwig ^a   Trautwein, Christian ^b   Sauerbruch, Tilman ^a   Spengler, Ulrich ^a  

^a UNIVERSITY OF BONN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; MESSENGER RNA;

ADOLESCENT; ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BILE DUCT; CHRONIC LIVER DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; EXPLANT; FEMALE; GENE OVEREXPRESSION; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KUPFFER CELL; LIVER INJURY; LIVER PROTECTION; LYMPHOCYTE; MALE; POLYMERASE CHAIN REACTION; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; STELLATE CELL;

ACUTE DISEASE; ADOLESCENT; ADULT; FEMALE; GENE EXPRESSION; HEPATITIS B; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; LIVER; MALE; MIDDLE AGED; RNA, MESSENGER;

EID: 0036787682     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2002.35532     Document Type: Article

References (38)

1. Myers KJ, Eppihimer MJ, Hall L, Wolitzky B. Interleukin-12-induced adhesion molecule expression in murine liver. Am J Pathol 1998;152:457-468.
2. Gately MK, Warrier RR, Honasoge S, Carvajal DM, Faherty DA, Connaughton SE, Anderson TD, et al. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo. Int Immunol 1994;6:157-167.
3. Okuno K, Jinnai H, Lee YS, Kaneda K, Yasutomi M. Interleukin 12 augments the liver-associated immunity and reduces liver metastases. Hepatogastroenterology 1996;43:1196-1202.
4. Nicoletti F, Di Marco R, Zaccone P, Salvaggio A, Magro G, Bendtzen K, Meroni P. Murine concanavalin A-induced hepatitis is prevented by interleukin 12 (IL-12) antibody and exacerbated by exogenous IL-12 through an interferon-gamma-dependent mechanism. Hepatology 2000;32:728-733.
5. Tanaka Y, Takahashi A, Watanabe K, Takayama K, Yahata T, Habu S, Nishimura T. A pivotal role of IL-12 in Th1-dependent mouse liver injury. Int Immunol 1996;8:569-576.
6. Ando K, Moriyama T, Guidotti LG, Wirth S, Schreiber RD, Schlicht HJ, Huang SN, et al. Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis. J Exp Med 1993;178:1541-1554.
7. Ohta A, Sekimoto M, Sato M, Koda T, Nishimura S, Iwakura Y, Sekikawa K, et al. Indispensable role for TNF-alpha and IFN-gamma at the effector phase of liver injury mediated by Thl cells specific to hepatitis B virus surface antigen. J Immunol 2000;165:956-961.
8. Kusters S, Gantner F, Kunstle G, Tiegs G. Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology 1996;111:462-471.
9. Nicoletti F, Zaccone P, Xiang M, Magro G, Di Mauro M, Di Marco R, Garotta G, et al. Essential pathogenetic role for interferon (IFN-)gamma in concanavalin A-induced T cell-dependent hepatitis: exacerbation by exogenous IFN-gamma and prevention by IFN-gamma receptor-immunoglobulin fusion protein. Cytokine 2000;12:315-323.
10. Louis H, Le Moine O, Peny MO, Quertinmont E, Fokan D, Goldman M, Deviere J. Production and role of interleukin-10 in concanavalin A-induced hepatitis in mice. Hepatology 1997;25:1382-1389.
11. Di Marco R, Xiang M, Zaccone P, Leonardi C, Franco S, Meroni P, Nicoletti F. Concanavalin A-induced hepatitis in mice is prevented by interleukin (IL)-10 and exacerbated by endogenous IL-10 deficiency. Autoimmunity 1999;31:75-83.
12. Kato M, Ikeda N, Matsushita E, Kaneko S, Kobayashi K. Involvement of IL-10, an anti-inflammatory cytokine in murine liver injury induced by concanavalin A. Hepatol Res 2001;20:232-243.
13. Louis H, Le Moine O, Peny MO, Gulbis B, Nisol F, Goldman M, Deviere J. Hepatoprotective role of interleukin 10 in galactosamine/lipopolysaccharide mouse liver injury. Gastroenterology 1997;112:935-942.
14. Santucci L, Fiorucci S, Chiorean M, Brunori PM, Di Matteo FM, Sidoni A, Migliorati G, et al. Interleukin 10 reduces lethality and hepatic injury induced by lipopolysaccharide in galactosamine-sensitized mice. Gastroenterology 1996;111:736-744.
15. Nagaki M, Tanaka M, Sugiyama A, Ohnishi H, Moriwaki H. Interleukin-10 inhibits hepatic injury and tumor necrosis factor-alpha and interferon-gamma mRNA expression induced by staphylococcal enterotoxin B or lipopolysaccharide in galactosamine-sensitized mice. J Hepatol 1999;31:815-824.
16. O'Grady JG, Alexander GJ, Hayllar KM, Williams R. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology 1989;97:439-445.
17. Fogler WE, Volker K, Watanabe M, Wigginton JM, Roessler P, Brunda MJ, Ortaldo JR, et al. Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas. J Immunol 1998;161:6014-6021.
18. Matsushita T, Ando K, Kimura K, Ohnishi H, Imawari M, Muto Y, Moriwaki H. IL-12 induces specific cytotoxicity against regenerating hepatocytes in vivo. Int Immunol 1999;11:657-665.
19. Fantuzzi G, Reed DA, Dinarello CA. IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor. J Clin Invest 1999;104:761-767.
20. Yoshida A, Koide Y, Uchijima M, Yoshida TO. IFN-gamma induces IL-12 mRNA expression by a murine macrophage cell line, J774. Biochem Biophys Res Commun 1994;198:857-861.
21. Yasoshima M, Kono N, Sugawara H, Katayanagi K, Harada K, Nakanuma Y. Increased expression of interleukin-6 and tumor necrosis factor-alpha in pathologic biliary epithelial cells: in situ and culture study. Lab Invest 1998;78:89-100.
22. Loffreda S, Rai R, Yang SQ, Lin HZ, Diehl AM. Bile ducts and portal and central veins are major producers of tumor necrosis factor alpha in regenerating rat liver. Gastroenterology 1997;112:2089-2098.
23. Morland CM, Fear J, McNab G, Joplin R, Adams DH. Promotion of leukocyte transendothelial cell migration by chemokines derived from human biliary epithelial cells in vitro. Proc Assoc Am Physicians 1997;109:372-382.
24. Tsuneyama K, Harada K, Yasoshima M, Hiramatsu K, Mackay CR, Mackay IR, Gershwin ME, et al. Monocyte chemotactic protein-1,-2, and-3 are distinctively expressed in portal tracts and granulomata in primary biliary cirrhosis: implications for pathogenesis. J Pathol 2001;193:102-109.
25. Leifeld L, Trautwein C, Dumoulin FL, Manns MP, Sauerbruch T, Spengler U. Enhanced expression of CD80 (137-1), CD86 (B7-2), and CD40 and their ligands CD28 and CD154 in fulminant hepatic failure. Am J Pathol 1999;154:1711-1720.
26. Nelson DR, Lauwers GY, Lau JY, Davis GL. Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders. Gastroenterology 2000;118:655-660.
27. Knolle P, Schlaak J, Uhrig A, Kempf P, Meyer zum Buschenfelde KH, Gerken G. Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge. J Hepatol 1995;22:226-229.
28. Knolle PA, Schmitt E, Jin S, Germann T, Duchmann R, Hegenbarth S, Gerken G, et al. Induction of cytokine production in naive CD4(+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells. Gastroenterology 1999;116:1428-1440.
29. Thompson KC, Trowern A, Fowell A, Marathe M, Haycock C, Arthur MJ, Sheron M. Primary rat and mouse hepatic stellate cells express the macrophage inhibitor cytokine interleukin-10 during the course of activation in vitro. Hepatology 1998;28:1518-1524.
30. Wang SC, Ohata M, Schrum L, Rippe RA, Tsukamoto H. Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells. J Biol Chem 1998;273:302-308.
31. Quiroga JA, Martin J, Navas S, Carreno V. Induction ofinterleukin-12 production in chronic hepatitis C virus infection correlates with the heparocellular damage. J Infect Dis 1998;178:247-251.
32. Laso FJ, Iglesias MC, Lopez A, Ciudad J, San Miguel JF, Orfao A. Increased interleukin-12 serum levels in chronic alcoholism. J Hepatol 1998;28:771-777.
33. Lee M, Lee M, Lee SK, Son M, Cho SW, Park S, Kim HI. Expression of Th1 and Th2 type cytokines responding to HBsAg and HBxAg in chronic hepatitis B patients. J Korean Med Sci 1999;14:175-181.
34. Kimura K, Ando K, Tomita E, Ohnishi H, Ishikawa T, Kakumu S, Muto Y, et al. Elevated intracellular IFN-gamma levels in circulating CD8+ lymphocytes in patients with fulminant hepatitis. J Hepatol 1999;31:579-583.
35. Jung MC, Hartmann B, Gerlach JT, Diepolder H, Gruber R, Schraut W, Grüner N, et al. Virus-specific lymphokine production differs quantitatively but not qualitatively in acute and chronic hepatitis B infection. Virology 1999;261:165-172.
36. Nagaki M, Iwai H, Naiki T, Ohnishi H, Muro Y, Moriwaki H. High levels of serum interleukin-10 and tumor necrosis factor-alpha are associated with fatality in fulminant hepatitis. J Infect Dis 2000;182:1103-1108.
37. Leifeld L, Ramakers J, Schneiders A, Dumoulin F, Sterneck M, Müller A, Sauerbruch T, et al. Intrahepatic MxA expression in correlation to interferon-a expression in chronic and fulminant hepatitis. J Pathol 2001;194:477-482.
38. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U, Brenner D, et al. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Gastroenterology 2000;119:446-460.