A mutant HBs antigen (HBsAg)183-191 epitope elicits specific cytotoxic T lymphocytes in acute hepatitis B patients

Clinical and Experimental Immunology

Volumn 151, Issue 3, 2008, Pages 441-447

  Liu, H G ^a,c   Fan, Z P ^b   Chen, W W ^b   Yang, H Y ^b   Liu, Q F ^b   Zhang, H ^b   Tien, P ^a   Wang, F S ^a,b,d  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b BEIJING 302 HOSPITAL   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d Institute of Infectious Diseases   (China)

Author keywords

Cytotoxic T lymphocyte; Epitope; Hepatitis B virus; Mutation

Indexed keywords

ARGININE; EPITOPE; HEPATITIS B SURFACE ANTIGEN; HLA A2 ANTIGEN; LYSINE;

ANTIGEN DETECTION; ARTICLE; CHINA; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HEPATITIS B; HUMAN; IN VIVO STUDY; MOUSE; NONHUMAN; PREVALENCE; PRIORITY JOURNAL;

ACUTE DISEASE; ANIMALS; ANTIGEN PRESENTATION; CROSS REACTIONS; EPITOPES; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HISTOCOMPATIBILITY TESTING; HLA-A2 ANTIGEN; HUMANS; MICE; MICE, TRANSGENIC; MUTATION; PROTEIN FOLDING; T-LYMPHOCYTES, CYTOTOXIC;

EID: 38549182325     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2007.03570.x     Document Type: Article

References (51)

1. Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Annu Rev Immunology 1995 13 : 29 60.
2. Sobao Y, Sugi K, Tomiyama H et al. Identification of hepatitis B virus-specific CTL epitopes presented by HLA-A*2402, the most common HLA class I allele in East Asia. J Hepatol 2001 34 : 922 9.
3. Boettler T, Spangenberg HC, Neumann-Haefelin C et al. T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol 2005 79 : 7860 7.
4. Rehermann B, Fowler P, Sidney J et al. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. J Exp Med 1995 181 : 1047 58.
5. Webster GJ, Reignat S, Maini MK et al. Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology 2000 32 : 1117 24.
6. Lohr HF, Krug S, Herr W et al. Quantitative and functional analysis of core-specific T-helper cell and CTL activities in acute and chronic hepatitis B. Liver 1998 18 : 405 13.
7. Zhang H-R, Tang G-I, Sun M et al. Molecular biological features and clinical significance of hepatitis B virus genotype in Nanjin. World J Infect 2004 4 : 232 4.
8. Yan L, Hou J-L, Jiang S et al. A study on the relationship between HBV genotype and outcome of hepatitis B virus infection. J Chin Physicians 2004 6 : 1347 8.
9. Kao JH. Hepatitis B viral genotypes: clinical relevance and molecular characteristics. J Gastroenterol Hepatol 2002 17 : 643 50.
10. Grandjacques C, Pradat P, Stuyver L et al. Rapid detection of genotypes and mutations in the pre-core promoter and the pre-core region of hepatitis B virus genome: correlation with viral persistence and disease severity. J Hepatol 2000 33 : 430 9.
11. Bertoletti A, Costanzo A, Chisari FV et al. Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope. J Exp Med 1994 180 : 933 43.
12. Bertoletti A, Sette A, Chisari FV et al. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 1994 369 : 407 10.
13. Klenerman P, Zinkernagel RM. Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes. Nature 1998 394 : 482 5.
14. Phillips RE, Rowland-Jones S, Nixon DF et al. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 1991 354 : 453 9.
15. Thimme R, Wieland S, Steiger C et al. CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol 2003 77 : 68 76.
16. Westland CE, Yang H, Delaney WEt et al. Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B. Hepatology 2003 38 : 96 103.
17. Nayersina R, Fowler P, Guilhot S et al. HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection. J Immunol 1993 150 : 4659 71.
18. Bertoletti A, Chisari FV, Penna A et al. Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein. J Virol 1993 67 : 2376 80.
19. Chung MK, Yoon H, Min SS et al. Induction of cytotoxic T lymphocytes with peptides in vitro: identification of candidate T-cell epitopes in hepatitis B virus X antigen. J Immunother 1999 22 : 279 87.
20. Hwang YK, Kim NK, Park JM et al. HLA-A2 1 restricted peptides from the HBx antigen induce specific CTL responses in vitro and in vivo. Vaccine 2002 20 : 3770 7.
21. Davis MM, Bjorkman PJ. T-cell antigen receptor genes and T-cell recognition. Nature 1988 334 : 395 402.
22. Okamoto H, Tsuda F, Sakugawa H et al. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J Gen Virol 1988 69 : 2575 83.
23. Norder H, Courouce AM, Magnius LO. Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes. Virology 1994 198 : 489 503.
24. Stuyver L, De Gendt S, Van Geyt C et al. A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. J Gen Virol 2000 81 : 67 74.
25. Arauz-Ruiz P, Norder H, Robertson BH, Magnius LO. Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America. J Gen Virol 2002 83 : 2059 73.
26. Bertoni R, Sidney J, Fowler P, Chesnut RW, Chisari FV, Sette A. Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis. J Clin Invest 1997 100 : 503 13.
27. Rehermann B, Pasquinelli C, Mosier SM, Chisari FV. Hepatitis B virus (HBV) sequence variation of cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection. J Clin Invest 1995 96 : 1527 34.
28. Xu D, Fu J, Jin L et al. Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol 2006 177 : 739 47.
29. Kuhrober A, Wild J, Pudollek HP, Chisari FV, Reimann J. DNA vaccination with plasmids encoding the intracellular (HBcAg) or secreted (HBeAg) form of the core protein of hepatitis B virus primes T cell responses to two overlapping Kb- and Kd-restricted epitopes. Int Immunol 1997 9 : 1203 12.
30. Passoni L, Scardino A, Bertazzoli C et al. ALK as a novel lymphoma-associated tumor antigen: identification of 2 HLA-A2.1-restricted CD8+ T-cell epitopes. Blood 2002 99 : 2100 6.
31. Wang B, Chen H, Jiang X et al. Identification of an HLA-A*0201- restricted CD8+ T-cell epitope SSp-1 of SARS-CoV spike protein. Blood 2004 104 : 200 6.
32. Ju DW, Tao Q, Lou G et al. Interleukin 18 transfection enhances antitumor immunity induced by dendritic cell-tumor cell conjugates. Cancer Res 2001 61 : 3735 40.
33. Altman JD, Moss PA, Goulder PJ et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 1996 274 : 94 6.
34. Kuzushima K, Hayashi N, Kudoh A et al. Tetramer-assisted identification and characterization of epitopes recognized by HLA A*2402-restricted Epstein-Barr virus-specific CD8+ T cells. Blood 2003 101 : 1460 8.
35. Lechner F, Wong DK, Dunbar PR et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 2000 191 : 1499 512.
36. Vitiello A, Marchesini D, Furze J, Sherman LA, Chesnut RW. Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex. J Exp Med 1991 173 : 1007 15.
37. Yasutomi Y, Palker TJ, Gardner MB, Haynes BF, Letvin NL. Synthetic peptide in mineral oil adjuvant elicits simian immunodeficiency virus-specific CD8+ cytotoxic T lymphocytes in rhesus monkeys. J Immunol 1993 151 : 5096 105.
38. Zhou M, Xu D, Li X et al. Screening and identification of severe acute respiratory syndrome-associated coronavirus-specific CTL epitopes. J Immunol 2006 177 : 2138 45.
39. Li H, Zhou M, Han J et al. Generation of murine CTL by a hepatitis B virus-specific peptide and evaluation of the adjuvant effect of heat shock protein glycoprotein 96 and its terminal fragments. J Immunol 2005 174 : 195 204.
40. Sette A, Vitiello A, Reherman B et al. The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes. J Immunol 1994 153 : 5586 92.
41. Regner M, Claesson MH, Bregenholt S, Ropke M. An improved method for the detection of peptide-induced upregulation of HLA-A2 molecules on TAP-deficient T2 cells. Exp Clin Immunogenet 1996 13 : 30 5.
42. Kuzushima K, Hayashi N, Kimura H, Tsurumi T. Efficient identification of HLA-A*2402-restricted cytomegalovirus-specific CD8(+) T-cell epitopes by a computer algorithm and an enzyme-linked immunospot assay. Blood 2001 98 : 1872 81.
43. Penna A, Del Prete G, Cavalli A et al. Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B. Hepatology 1997 25 : 1022 7.
44. Penna A, Chisari FV, Bertoletti A et al. Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen. J Exp Med 1991 174 : 1565 70.
45. Bertoletti A, Southwood S, Chesnut R et al. Molecular features of the hepatitis B virus nucleocapsid T-cell epitope 18-27: interaction with HLA and T-cell receptor. Hepatology 1997 26 : 1027 34.
46. Madden DR, Garboczi DN, Wiley DC. The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell 1993 75 : 693 708.
47. Ogg GS, McMichael AJ. HLA-peptide tetrameric complexes. Curr Opin Immunol 1998 10 : 393 6.
48. Maini MK, Reignat S, Boni C et al. T cell receptor usage of virus-specific CD8 cells and recognition of viral mutations during acute and persistent hepatitis B virus infection. Eur J Immunol 2000 30 : 3067 78.
49. Pircher H, Moskophidis D, Rohrer U, Burki K, Hengartner H, Zinkernagel RM. Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature 1990 346 : 629 33.
50. Ding YH, Smith KJ, Garboczi DN, Utz U, Biddison WE, Wiley DC. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 1998 8 : 403 11.
51. Riedl P, Bertoletti A, Lopes R, Lemonnier F, Reimann J, Schirmbeck R. Distinct, cross-reactive epitope specificities of CD8 T cell responses are induced by natural hepatitis B surface antigen variants of different hepatitis B virus genotypes. J Immunol 2006 176 : 4003 11.