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Volumn 3, Issue , 2009, Pages 159-168

Ustekinumab in the therapy of chronic plaque psoriasis

Author keywords

Plaque; Psoriasis; Ustekinumab

Indexed keywords


EID: 70449712998     PISSN: 11775475     EISSN: 11775491     Source Type: Journal    
DOI: 10.2147/BTT.S3498     Document Type: Review
Times cited : (25)

References (87)
  • 2
    • 0016029730 scopus 로고
    • Natural history of psoriasis in 61 twin pairs
    • Farber EM, Nall ML, Watson W. Natural history of psoriasis in 61 twin pairs. Arch Dermatol. 1974;109:207-211.
    • (1974) Arch Dermatol. , vol.109 , pp. 207-211
    • Farber, E.M.1    Nall, M.L.2    Watson, W.3
  • 4
    • 0018321051 scopus 로고
    • Cyclosporine A for psoriasis
    • Mueller W, Herrmann B. Cyclosporine A for psoriasis. N Engl J Med. 1979;301:555.
    • (1979) N Engl J Med. , vol.301 , pp. 555
    • Mueller, W.1    Herrmann, B.2
  • 6
    • 1542313881 scopus 로고    scopus 로고
    • Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha
    • Boyman O, Hefti HP, Conrad C, Nickoloff BJ, Suter M, Nestle FO. Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha. J Exp Med. 2004;199:731-736.
    • (2004) J Exp Med. , vol.199 , pp. 731-736
    • Boyman, O.1    Hefti, H.P.2    Conrad, C.3    Nickoloff, B.J.4    Suter, M.5    Nestle, F.O.6
  • 7
    • 0032729645 scopus 로고    scopus 로고
    • The majority of epidermal T cells in psoriasis vulgaris lesions can produce type I cytokines, IFN-γ, IL-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: A Type I differentiation bias is also measured in circulating blood T cells in psoriatic patients
    • Austin LM, Ozawa M, Kikuchi T, et al. The majority of epidermal T cells in psoriasis vulgaris lesions can produce type I cytokines, IFN-γ, IL-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a Type I differentiation bias is also measured in circulating blood T cells in psoriatic patients. J Invest Dermatol. 1999;113:752-759.
    • (1999) J Invest Dermatol. , vol.113 , pp. 752-759
    • Austin, L.M.1    Ozawa, M.2    Kikuchi, T.3
  • 9
    • 42049083573 scopus 로고    scopus 로고
    • Efalizumab: Results of a 3-year continuous dosing study for the longterm control of psoriasis
    • Leonardi C, Menter A, Hamilton T, Caro I, Xing B, Gottlieb AB. Efalizumab: results of a 3-year continuous dosing study for the longterm control of psoriasis. Br J Dermatol. 2008;158:1107-1116.
    • (2008) Br J Dermatol. , vol.158 , pp. 1107-1116
    • Leonardi, C.1    Menter, A.2    Hamilton, T.3    Caro, I.4    Xing, B.5    Gottlieb, A.B.6
  • 10
    • 34250761386 scopus 로고    scopus 로고
    • Long-term safety and efficacy of 50 mg of etanercept twice weekly in patients with psoriasis
    • Tyring S, Gordon KB, Poulin Y, et al. Long-term safety and efficacy of 50 mg of etanercept twice weekly in patients with psoriasis. Arch Dermatol. 2007;143:719-26.
    • (2007) Arch Dermatol. , vol.143 , pp. 719-726
    • Tyring, S.1    Gordon, K.B.2    Poulin, Y.3
  • 12
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol. 1989;7:145-173.
    • (1989) Annu Rev Immunol. , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 13
    • 0017599305 scopus 로고
    • The dermal inflammatory reaction in initial psoriatic lesions
    • Braun-Falco O, Schmoeckel C. The dermal inflammatory reaction in initial psoriatic lesions. Arch Dermatol Res. 1977;258:9-16.
    • (1977) Arch Dermatol Res. , vol.258 , pp. 9-16
    • Braun-Falco, O.1    Schmoeckel, C.2
  • 14
    • 0002303840 scopus 로고    scopus 로고
    • Pathogenic interactions of keratinocytes and T lymphocytes in psoriasis
    • In: Roenigk HH, Maibach HI, editors. New York: Marcel Dekker
    • Krueger JG. Pathogenic interactions of keratinocytes and T lymphocytes in psoriasis. In: Roenigk HH, Maibach HI, editors. Psoriasis. New York: Marcel Dekker; 1998. p. 315-327.
    • (1998) Psoriasis , pp. 315-327
    • Krueger, J.G.1
  • 15
    • 0029812593 scopus 로고    scopus 로고
    • Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
    • Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med. 1996;184(2)747-752.
    • (1996) J Exp Med. , vol.184 , Issue.2 , pp. 747-752
    • Cella, M.1    Scheidegger, D.2    Palmer-Lehmann, K.3    Lane, P.4    Lanzavecchia, A.5    Alber, G.6
  • 16
    • 0029937221 scopus 로고    scopus 로고
    • Accessory signaling by CD40 for T cell activation: Induction of Th1 and Th2 cytokines and synergy with interleukin-12 for interferon-gamma production
    • Peng X, Kasran A, Warmerdam PA, de Boer M, Ceuppens JL. Accessory signaling by CD40 for T cell activation: induction of Th1 and Th2 cytokines and synergy with interleukin-12 for interferon-gamma production. Eur J Immunol. 1996;26:1621-1627.
    • (1996) Eur J Immunol. , vol.26 , pp. 1621-1627
    • Peng, X.1    Kasran, A.2    Warmerdam, P.A.3    de Boer, M.4    Ceuppens, J.L.5
  • 17
    • 0032729645 scopus 로고    scopus 로고
    • The majority of epidermal T cells in psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factoralpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: A type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients
    • Austin LM, Ozawa M, Kikuchi T, Walters IB, Krueger JG. The majority of epidermal T cells in psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factoralpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. J Invest Dermatol. 1999;113:752-759.
    • (1999) J Invest Dermatol. , vol.113 , pp. 752-759
    • Austin, L.M.1    Ozawa, M.2    Kikuchi, T.3    Walters, I.B.4    Krueger, J.G.5
  • 19
    • 0033404492 scopus 로고    scopus 로고
    • Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions
    • Trepicchio WL, Ozawa M, Walters IB, et al. Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions. J Clin Invest. 1999;104:1527-1537.
    • (1999) J Clin Invest. , vol.104 , pp. 1527-1537
    • Trepicchio, W.L.1    Ozawa, M.2    Walters, I.B.3
  • 20
    • 0027197436 scopus 로고
    • Interleukin-12/T cell stimulating factor, a cytokine with multiple effects of T helper (Th1) but not on Th2 cells
    • Germann T, Gately MK, Schoenhaut DS, et al. Interleukin-12/T cell stimulating factor, a cytokine with multiple effects of T helper (Th1) but not on Th2 cells. Eur J Immunol. 1993;23:1762-1770.
    • (1993) Eur J Immunol. , vol.23 , pp. 1762-1770
    • Germann, T.1    Gately, M.K.2    Schoenhaut, D.S.3
  • 21
    • 36049052516 scopus 로고    scopus 로고
    • Interleukin-12, interleukin-23, and psoriasis: Current prospects
    • Torti DC, Feldman SR. Interleukin-12, interleukin-23, and psoriasis: current prospects. JAAD. 2007;57(6):1059-1068.
    • (2007) JAAD. , vol.57 , Issue.6 , pp. 1059-1068
    • Torti, D.C.1    Feldman, S.R.2
  • 22
    • 0032847323 scopus 로고    scopus 로고
    • The immunologic and genetic basis of psoriasis
    • Nickoloff BJ. The immunologic and genetic basis of psoriasis. Arch Dermatol. 1999;135:1104-1110.
    • (1999) Arch Dermatol. , vol.135 , pp. 1104-1110
    • Nickoloff, B.J.1
  • 23
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem. 2003;278: 1910-1914.
    • (2003) J Biol Chem. , vol.278 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3    de Sauvage, F.J.4    Gurney, A.L.5
  • 24
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park H, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nature Immunol. 2005;6: 1133-1141.
    • (2005) Nature Immunol. , vol.6 , pp. 1133-1141
    • Park, H.1
  • 25
    • 0025873502 scopus 로고
    • Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor)
    • Gately MK, Desai BB, Wolitzky AB, et al. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J Immunol. 1991;147(3):874-882.
    • (1991) J Immunol. , vol.147 , Issue.3 , pp. 874-882
    • Gately, M.K.1    Desai, B.B.2    Wolitzky, A.B.3
  • 26
    • 0033120525 scopus 로고    scopus 로고
    • Expression of murine IL-12 is regulated by translational control of the p35 subunit
    • Babik JM, Adams E, Tone Y, Fairchild PJ, Tone M, Waldmann H. Expression of murine IL-12 is regulated by translational control of the p35 subunit. J Immunol. 1999;162(7): 4069-4078.
    • (1999) J Immunol. , vol.162 , Issue.7 , pp. 4069-4078
    • Babik, J.M.1    Adams, E.2    Tone, Y.3    Fairchild, P.J.4    Tone, M.5    Waldmann, H.6
  • 28
    • 8944226108 scopus 로고    scopus 로고
    • Interferon-γ-inducing factor enhances T helper I cytokine production by stimulated human T cells: Synergism with interleukin-12 for interferon-γproduction
    • Micallef MJ, Ohtsuki T, Kohno K, et al. Interferon-γ-inducing factor enhances T helper I cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-γproduction. Eur J Immunol. 1996;26(7): 1647-1651.
    • (1996) Eur J Immunol. , vol.26 , Issue.7 , pp. 1647-1651
    • Micallef, M.J.1    Ohtsuki, T.2    Kohno, K.3
  • 29
    • 0032700570 scopus 로고    scopus 로고
    • Synergistic proliferation and activation of natural killer cells by interleukin-12 and interleukin-18
    • Lauwerys BR, Renauld JC, Houssiau FA. Synergistic proliferation and activation of natural killer cells by interleukin-12 and interleukin-18. Cytokine. 1999;11(11):822-830.
    • (1999) Cytokine. , vol.11 , Issue.11 , pp. 822-830
    • Lauwerys, B.R.1    Renauld, J.C.2    Houssiau, F.A.3
  • 30
    • 10644294508 scopus 로고    scopus 로고
    • Role of the IL-12/IL-23 system in the regulation of T-cell responses in central nervous system inflammatory demyelination
    • Gran B, Zhang GX, Rostami A. Role of the IL-12/IL-23 system in the regulation of T-cell responses in central nervous system inflammatory demyelination. Crit Rev Immunol. 2004;24:111-128.
    • (2004) Crit Rev Immunol. , vol.24 , pp. 111-128
    • Gran, B.1    Zhang, G.X.2    Rostami, A.3
  • 31
    • 0034763143 scopus 로고    scopus 로고
    • Regulation of interleukin-12 production in antigenproducing cells
    • Ma X, Trinchieri G. Regulation of interleukin-12 production in antigenproducing cells. Adv Immunol. 2001;79:55-92.
    • (2001) Adv Immunol. , vol.79 , pp. 55-92
    • Ma, X.1    Trinchieri, G.2
  • 32
    • 0030064148 scopus 로고    scopus 로고
    • The interleukin-12 p40 gene promoter is primed by interferon-γin monocytic cells
    • Ma X, et al. The interleukin-12 p40 gene promoter is primed by interferon-γin monocytic cells. J Exp Med. 1996;183(1):147-157.
    • (1996) J Exp Med. , vol.183 , Issue.1 , pp. 147-157
    • Ma, X.1
  • 33
    • 0034601012 scopus 로고    scopus 로고
    • Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
    • Chu CQ, Wittmer S, Dalton DK. Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. J Exp Med. 2000;192:123-128.
    • (2000) J Exp Med. , vol.192 , pp. 123-128
    • Chu, C.Q.1    Wittmer, S.2    Dalton, D.K.3
  • 34
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann B, Lesley R, Blom B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000;13:715-725.
    • (2000) Immunity. , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3
  • 37
    • 34548133583 scopus 로고    scopus 로고
    • Development, cytokine profile and function of human interleukin 17-producing helper T cells
    • Wilson NJ, Boniface K, Chan JR, et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol. 2007;8(9):950-957.
    • (2007) Nat Immunol. , vol.8 , Issue.9 , pp. 950-957
    • Wilson, N.J.1    Boniface, K.2    Chan, J.R.3
  • 38
    • 33751546237 scopus 로고    scopus 로고
    • IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis
    • Chan JR, Blumenschein W, Murphy E, et al. IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med. 2006;203:2577-2587.
    • (2006) J Exp Med. , vol.203 , pp. 2577-2587
    • Chan, J.R.1    Blumenschein, W.2    Murphy, E.3
  • 39
    • 0347285359 scopus 로고    scopus 로고
    • Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
    • Lee E, Trepicchio WL, Oestreicher JL, et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med. 2004;199:125-130.
    • (2004) J Exp Med. , vol.199 , pp. 125-130
    • Lee, E.1    Trepicchio, W.L.2    Oestreicher, J.L.3
  • 40
    • 0030445948 scopus 로고    scopus 로고
    • A functional interleukin 12 receptor complex is composed of two ββtype cytokine receptor subunits
    • Presky DH, Yang H, Minetti LJ, et al. A functional interleukin 12 receptor complex is composed of two ββtype cytokine receptor subunits. Proc Natl Acad Sci USA. 1996;93: 14002-14007.
    • (1996) Proc Natl Acad Sci USA. , vol.93 , pp. 14002-14007
    • Presky, D.H.1    Yang, H.2    Minetti, L.J.3
  • 41
    • 0035910037 scopus 로고    scopus 로고
    • T-bet is rapidly induced by interferon-γγin lymphoid and myeloid cells
    • Lighvani AA, Frucht DM, Jankovic D, et al. T-bet is rapidly induced by interferon-γγin lymphoid and myeloid cells. Proc Natl Acad Sci U S A. 2001;98(26): 15137-15142.
    • (2001) Proc Natl Acad Sci U S A. , vol.98 , Issue.26 , pp. 15137-15142
    • Lighvani, A.A.1    Frucht, D.M.2    Jankovic, D.3
  • 42
    • 0035997908 scopus 로고    scopus 로고
    • T-bet is a STAT1-induced regulator of IL-12 receptor expression in naïve CD4eeT cells
    • Afkarian M, Sedy JR, Yang J, et al. T-bet is a STAT1-induced regulator of IL-12 receptor expression in naïve CD4eeT cells. Nat Immunol. 2002;3(6):549-557.
    • (2002) Nat Immunol. , vol.3 , Issue.6 , pp. 549-557
    • Afkarian, M.1    Sedy, J.R.2    Yang, J.3
  • 43
    • 0032168336 scopus 로고    scopus 로고
    • IL-12 acts directly on DC to promote nuclear localization of NF-κββand primes DC for IL-12 production
    • Grohmann U, Frucht DM, Jankovic D, et al. IL-12 acts directly on DC to promote nuclear localization of NF-κββand primes DC for IL-12 production. Immunity. 1998;9:315-323.
    • (1998) Immunity. , vol.9 , pp. 315-323
    • Grohmann, U.1    Frucht, D.M.2    Jankovic, D.3
  • 44
    • 0036604306 scopus 로고    scopus 로고
    • A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R
    • Parham C, Chirica M, Timans J, et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J Immunol. 2002:168(11):5699-5708.
    • (2002) J Immunol. , vol.168 , Issue.11 , pp. 5699-5708
    • Parham, C.1    Chirica, M.2    Timans, J.3
  • 45
    • 34948840330 scopus 로고    scopus 로고
    • The IL23 axis plays a key role in the pathogenesis of IBD
    • McGovern D, Powrie F. The IL23 axis plays a key role in the pathogenesis of IBD. Gut. 2007;56(10):133-136.
    • (2007) Gut. , vol.56 , Issue.10 , pp. 133-136
    • McGovern, D.1    Powrie, F.2
  • 46
    • 0036604062 scopus 로고    scopus 로고
    • IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells
    • Belladonna ML, Renauld JC, Bianchi R, et al. IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J Immunol. 2002;168:5448-5454.
    • (2002) J Immunol. , vol.168 , pp. 5448-5454
    • Belladonna, M.L.1    Renauld, J.C.2    Bianchi, R.3
  • 47
    • 16044363695 scopus 로고    scopus 로고
    • IL-12-deficient mice are defective in IFN-γγproduction and type I cytokine responses
    • Magram J, Connaughton SE, Warrier RR, et al. IL-12-deficient mice are defective in IFN-γγproduction and type I cytokine responses. Immunity. 1996;4(5):471-481.
    • (1996) Immunity. , vol.4 , Issue.5 , pp. 471-481
    • Magram, J.1    Connaughton, S.E.2    Warrier, R.R.3
  • 48
    • 0031571205 scopus 로고    scopus 로고
    • Characterization of IL-12 receptorβ1 chain (IL-12Rβ1)-deficient mice: IL-12Rβ1 is an essential component of the functional mouse IL-12 receptor
    • Wu C, Ferrante J, Gately MK, Magram J. Characterization of IL-12 receptorβ1 chain (IL-12Rβ1)-deficient mice: IL-12Rβ1 is an essential component of the functional mouse IL-12 receptor. J Immunol. 1997;159(4):1658-1665.
    • (1997) J Immunol. , vol.159 , Issue.4 , pp. 1658-1665
    • Wu, C.1    Ferrante, J.2    Gately, M.K.3    Magram, J.4
  • 49
    • 0036149971 scopus 로고    scopus 로고
    • Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis
    • Camoglio L, Juffermans NP, Peppelenbosch M, et al. Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis. Eur J Immunol. 2002;32(1):261-269.
    • (2002) Eur J Immunol. , vol.32 , Issue.1 , pp. 261-269
    • Camoglio, L.1    Juffermans, N.P.2    Peppelenbosch, M.3
  • 50
    • 3242805827 scopus 로고    scopus 로고
    • IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12
    • Lieberman LA, Cardillo F, Owyang AM, et al. IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12. J Immunol. 2004;173(3):1887-1893.
    • (2004) J Immunol. , vol.173 , Issue.3 , pp. 1887-1893
    • Lieberman, L.A.1    Cardillo, F.2    Owyang, A.M.3
  • 51
    • 0036677420 scopus 로고    scopus 로고
    • Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
    • Becher B, Durell BG, Noelle RJ. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J Clin Invest. 2002;110:493-497.
    • (2002) J Clin Invest. , vol.110 , pp. 493-497
    • Becher, B.1    Durell, B.G.2    Noelle, R.J.3
  • 52
    • 0347285359 scopus 로고    scopus 로고
    • Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
    • Lee E, Trepicchio WL, Oestericher JL, et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med. 2004;199:125-130.
    • (2004) J Exp Med. , vol.199 , pp. 125-130
    • Lee, E.1    Trepicchio, W.L.2    Oestericher, J.L.3
  • 53
    • 0031691282 scopus 로고    scopus 로고
    • Interleukin-17 and interferon-γγsynergize in the enhancement of proinflammatory cytokine production by human keratinocytes
    • Teunissen MB, Koomen CW, de Waal Malefyt R, Wierenga EA, Bos JD. Interleukin-17 and interferon-γγsynergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J Invest Dermatol. 1998;111:645-649.
    • (1998) J Invest Dermatol. , vol.111 , pp. 645-649
    • Teunissen, M.B.1    Koomen, C.W.2    de Waal Malefyt, R.3    Wierenga, E.A.4    Bos, J.D.5
  • 54
    • 34247555353 scopus 로고    scopus 로고
    • Differentiation and function of Th17 T cells
    • Stockinger B, Veldhoen M. Differentiation and function of Th17 T cells. Curr Opin Immunol. 2007;19:281-286.
    • (2007) Curr Opin Immunol. , vol.19 , pp. 281-286
    • Stockinger, B.1    Veldhoen, M.2
  • 55
    • 27544469550 scopus 로고    scopus 로고
    • T(H)-17: A giant step from T(H)1 and T(H)2 [comment]
    • Wynn TA. T(H)-17: a giant step from T(H)1 and T(H)2 [comment]. Nat Immunol. 2005;6:1069-1070.
    • (2005) Nat Immunol. , vol.6 , pp. 1069-1070
    • Wynn, T.A.1
  • 56
    • 33749318470 scopus 로고    scopus 로고
    • Interleukin (IL)-22 and IL-17 are co-expressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    • Liang SC, Tan XY, Luxenberg DP, et al. Interleukin (IL)-22 and IL-17 are co-expressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med. 2006;203:2271-2279.
    • (2006) J Exp Med. , vol.203 , pp. 2271-2279
    • Liang, S.C.1    Tan, X.Y.2    Luxenberg, D.P.3
  • 57
    • 33646552450 scopus 로고    scopus 로고
    • IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: A potential role in psoriasis
    • Wolk K, Witte E, Wallace E, et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Imunnol. 2006;36:1309-1323.
    • (2006) Eur J Imunnol. , vol.36 , pp. 1309-1323
    • Wolk, K.1    Witte, E.2    Wallace, E.3
  • 58
    • 33750282677 scopus 로고    scopus 로고
    • The IL-23/Th(17) axis: Therapeutic targets for autoimmune inflammation
    • Kikly K, Liu L, Na S, Sedgwick JD. The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation. Curr Opin Immunol. 2006;18(6):670-675.
    • (2006) Curr Opin Immunol. , vol.18 , Issue.6 , pp. 670-675
    • Kikly, K.1    Liu, L.2    Na, S.3    Sedgwick, J.D.4
  • 59
  • 60
    • 33846906224 scopus 로고    scopus 로고
    • Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    • Zheng Y, Danilenko DM, Valdez P, et al. Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature. 2007;445:648-651.
    • (2007) Nature. , vol.445 , pp. 648-651
    • Zheng, Y.1    Danilenko, D.M.2    Valdez, P.3
  • 61
    • 28844465015 scopus 로고    scopus 로고
    • IL-23: Changing the verdict on IL-12 function in inflammation and autoimmunity
    • Kreymborg K, Böhlmann U, Becher B. IL-23: changing the verdict on IL-12 function in inflammation and autoimmunity. Expert Opin Ther Targets. 2005;9(6):1123-1136.
    • (2005) Expert Opin Ther Targets. , vol.9 , Issue.6 , pp. 1123-1136
    • Kreymborg, K.1    Böhlmann, U.2    Becher, B.3
  • 62
    • 0036884860 scopus 로고    scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody
    • Brok HP, van Meurs M, Blezer E, et al. Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody. J Immunol. 2002;169: 6554-6563.
    • (2002) J Immunol. , vol.169 , pp. 6554-6563
    • Brok, H.P.1    van Meurs, M.2    Blezer, E.3
  • 63
    • 77953355190 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and biological response profile of an IL-12p40 antagonist in MS: A phase I clinical trial
    • Kasper LH, Everitt D, Leist T, et al. Safety, pharmacokinetic, and biological response profile of an IL-12p40 antagonist in MS: A phase I clinical trial. Proc Congress Eur Committee Treatment Res Multiple Sclerosis. 2004;107.
    • (2004) Proc Congress Eur Committee Treatment Res Multiple Sclerosis , pp. 107
    • Kasper, L.H.1    Everitt, D.2    Leist, T.3
  • 64
    • 0028966091 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
    • Leonard JP, Waldburger KE, Goldman SJ. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J Exp Med. 1995;181(1):381-386.
    • (1995) J Exp Med. , vol.181 , Issue.1 , pp. 381-386
    • Leonard, J.P.1    Waldburger, K.E.2    Goldman, S.J.3
  • 65
    • 0031885819 scopus 로고    scopus 로고
    • Blockade of IL-12 during the induction of collageninduced arthritis (CIA) markedly attenuates the severity of the arthritis
    • Malfait AM, Butler DM, Presky DH, Maini RN, Brennan FM, Feldmann M. Blockade of IL-12 during the induction of collageninduced arthritis (CIA) markedly attenuates the severity of the arthritis. Clin Exp Immunol. 1998;111(2):377-383.
    • (1998) Clin Exp Immunol. , vol.111 , Issue.2 , pp. 377-383
    • Malfait, A.M.1    Butler, D.M.2    Presky, D.H.3    Maini, R.N.4    Brennan, F.M.5    Feldmann, M.6
  • 66
    • 0036884860 scopus 로고    scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody
    • Brok HP, van Meurs M, Blezer E, et al. Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody. J Immunol. 2002;169(11): 6554-6563.
    • (2002) J Immunol. , vol.169 , Issue.11 , pp. 6554-6563
    • Brok, H.P.1    van Meurs, M.2    Blezer, E.3
  • 67
    • 0033564323 scopus 로고    scopus 로고
    • IL-12, independently of IFN-γ, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder
    • Hong K, Chu A, Ludviksson BR, Berg EL, Ehrhardt RO. IL-12, independently of IFN-γ, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder. J Immunol. 1999;162:7480-7491.
    • (1999) J Immunol. , vol.162 , pp. 7480-7491
    • Hong, K.1    Chu, A.2    Ludviksson, B.R.3    Berg, E.L.4    Ehrhardt, R.O.5
  • 68
    • 48849087125 scopus 로고    scopus 로고
    • Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: A phase II, double-blind, placebo-controlled, randomized, dose-ranging study
    • Segal BM, Constantinescu CS, Raychaudhuri A, Kim L, Fidelus-Gort R, Kasper LH. Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomized, dose-ranging study. Lancet Neurol. 2008;7(9):796-804.
    • (2008) Lancet Neurol. , vol.7 , Issue.9 , pp. 796-804
    • Segal, B.M.1    Constantinescu, C.S.2    Raychaudhuri, A.3    Kim, L.4    Fidelus-Gort, R.5    Kasper, L.H.6
  • 69
    • 53049091561 scopus 로고    scopus 로고
    • A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate to severe Crohn's disease
    • Sandborn WJ, Feagan BG, Fedorak RN, et al. A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate to severe Crohn's disease. Gastroenterology. 2008;135(4):1130-1141.
    • (2008) Gastroenterology. , vol.135 , Issue.4 , pp. 1130-1141
    • Sandborn, W.J.1    Feagan, B.G.2    Fedorak, R.N.3
  • 70
    • 9744265704 scopus 로고    scopus 로고
    • A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis
    • Kauffman CL, Aria N, Toichi E, et al. A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis. J Invest Dermatol. 2004;123:1037-1044.
    • (2004) J Invest Dermatol. , vol.123 , pp. 1037-1044
    • Kauffman, C.L.1    Aria, N.2    Toichi, E.3
  • 71
    • 34249039292 scopus 로고    scopus 로고
    • A phase 1, doubleblind, placebo-controlled study evaluating single subcutaneous administration of a human interleukin-12/23 monoclonal antibody in subjects with plaque psoriasis
    • Gottlieb AB, Cooper KD, McCormick TS, et al. A phase 1, doubleblind, placebo-controlled study evaluating single subcutaneous administration of a human interleukin-12/23 monoclonal antibody in subjects with plaque psoriasis. Curr Med Res Opin. 2007;23:1081-1092.
    • (2007) Curr Med Res Opin. , vol.23 , pp. 1081-1092
    • Gottlieb, A.B.1    Cooper, K.D.2    McCormick, T.S.3
  • 72
    • 33749151636 scopus 로고    scopus 로고
    • An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL12/IL23 in psoriasis
    • Toichi E, Torres G, McCormick TS, et al. An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL12/IL23 in psoriasis. J Immunol. 2006;177(7):4917-4926.
    • (2006) J Immunol. , vol.177 , Issue.7 , pp. 4917-4926
    • Toichi, E.1    Torres, G.2    McCormick, T.S.3
  • 73
    • 77953332552 scopus 로고    scopus 로고
    • Quantitation of cutaneous cytokine mRNA levels following anti-IL-12 psoriasis therapy: Identification of a psoriasis subset
    • Toichi E, McCormick TS, Kaufmann CL, et al. Quantitation of cutaneous cytokine mRNA levels following anti-IL-12 psoriasis therapy: identification of a psoriasis subset. J Invest Dermatol. 2003;121:1249.
    • (2003) J Invest Dermatol. , vol.121 , pp. 1249
    • Toichi, E.1    McCormick, T.S.2    Kaufmann, C.L.3
  • 74
    • 33846889522 scopus 로고    scopus 로고
    • A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis
    • Krueger GC, Langley RG, Leonardi C, et al. A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med. 2007;356:580-592.
    • (2007) N Engl J Med. , vol.356 , pp. 580-592
    • Krueger, G.C.1    Langley, R.G.2    Leonardi, C.3
  • 75
    • 43449111187 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX1)
    • Leonardi C, Kimball AB, Papp KA, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX1). Lancet. 2008;371:1665-1674.
    • (2008) Lancet. , vol.371 , pp. 1665-1674
    • Leonardi, C.1    Kimball, A.B.2    Papp, K.A.3
  • 76
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX1)
    • Papp KA, Langley RG, Lebwohl M, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX1). Lancet. 2008;371:1675-1684.
    • (2008) Lancet. , vol.371 , pp. 1675-1684
    • Papp, K.A.1    Langley, R.G.2    Lebwohl, M.3
  • 78
    • 0036005890 scopus 로고    scopus 로고
    • Interleukin-12 in anti-tumor immunity and immunotherapy
    • Colombo MP, Trinchieri G. Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev. 2002;13:155-168.
    • (2002) Cytokine Growth Factor Rev. , vol.13 , pp. 155-168
    • Colombo, M.P.1    Trinchieri, G.2
  • 79
    • 33645972617 scopus 로고    scopus 로고
    • Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvant
    • Overwijk WW, de Visser KE, Tirion FH, et al. Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvant. J Immunol. 2006;176:5213-5222.
    • (2006) J Immunol. , vol.176 , pp. 5213-5222
    • Overwijk, W.W.1    de Visser, K.E.2    Tirion, F.H.3
  • 80
    • 59649083691 scopus 로고    scopus 로고
    • Interleukin-23: Immunological roles and clinical implications
    • doi:10.1016/j.biocel. 2008.04.027
    • Tan ZY, Bealgey KW, Fang Y, Gong YM, Bao S. Interleukin-23: immunological roles and clinical implications. Int J Biochem Cell Biol. 2008;doi:10.1016/j.biocel. 2008.04.027.
    • (2008) Int J Biochem Cell Biol.
    • Tan, Z.Y.1    Bealgey, K.W.2    Fang, Y.3    Gong, Y.M.4    Bao, S.5
  • 81
    • 1342324752 scopus 로고    scopus 로고
    • Compromised humoral and delayed-type hypersensitivity responses in IL-23 deficient mice
    • Ghiladri N, Klajavin N, Chen Q, Lucas S, Gurney AL, Sauvage FJ. Compromised humoral and delayed-type hypersensitivity responses in IL-23 deficient mice. J Immunol. 2004;172(5):2827-2833.
    • (2004) J Immunol. , vol.172 , Issue.5 , pp. 2827-2833
    • Ghiladri, N.1    Klajavin, N.2    Chen, Q.3    Lucas, S.4    Gurney, A.L.5    Sauvage, F.J.6
  • 82
    • 0032577295 scopus 로고    scopus 로고
    • Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients
    • de Jong R, Altare F, Haagen IA, et al. Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science. 1998;280(5368):1435-1438.
    • (1998) Science. , vol.280 , Issue.5368 , pp. 1435-1438
    • de Jong, R.1    Altare, F.2    Haagen, I.A.3
  • 83
    • 0036252393 scopus 로고    scopus 로고
    • Inherited disorders of IL-12 and IFN-γ-mediated immunity: A molecular genetics update
    • Doffinger R, Dupuis S, Picard C, et al. Inherited disorders of IL-12 and IFN-γ-mediated immunity: a molecular genetics update. Mol Immunol. 2002;38(12-13):903-909.
    • (2002) Mol Immunol. , vol.38 , Issue.12-13 , pp. 903-909
    • Doffinger, R.1    Dupuis, S.2    Picard, C.3
  • 84
    • 0344926414 scopus 로고    scopus 로고
    • Etanercept as monotherapy in patients with psoriasis
    • Leonardi CL, Powers JL, Matheson RT, et al. Etanercept as monotherapy in patients with psoriasis. N Engl J Med. 2003;349:2014-2022.
    • (2003) N Engl J Med. , vol.349 , pp. 2014-2022
    • Leonardi, C.L.1    Powers, J.L.2    Matheson, R.T.3
  • 85
    • 0038385972 scopus 로고    scopus 로고
    • An international, randomized, double-blind, placebocontrolled phase 3 trial of intramuscular alefacept in patients with chronic plaque psoriasis
    • Lebwohl M, Christophers E, Langley R, Ortonne JP, Roberts J, Griffiths CE. An international, randomized, double-blind, placebocontrolled phase 3 trial of intramuscular alefacept in patients with chronic plaque psoriasis. Arch Dermatol. 2003;139:719-727.
    • (2003) Arch Dermatol. , vol.139 , pp. 719-727
    • Lebwohl, M.1    Christophers, E.2    Langley, R.3    Ortonne, J.P.4    Roberts, J.5    Griffiths, C.E.6
  • 86
    • 0345107256 scopus 로고    scopus 로고
    • A novel targeted T-cell modulator, efalizumab, for plaque psoriasis
    • Lebwohl M, Tyring SK, Hamilton TK, et al. A novel targeted T-cell modulator, efalizumab, for plaque psoriasis. N Engl J Med. 2003;349:2004-2013.
    • (2003) N Engl J Med. , vol.349 , pp. 2004-2013
    • Lebwohl, M.1    Tyring, S.K.2    Hamilton, T.K.3
  • 87
    • 54349091558 scopus 로고    scopus 로고
    • Safety-related regulatory actions for biologicals approved in the United States and the European Union
    • Giezen TJ, Mantel-Teeuwisse AK, Straus SM, Schellekens H, Leufkens HG, Egberts A. Safety-related regulatory actions for biologicals approved in the United States and the European Union. JAMA. 2008;300(16): 1887-1896.
    • (2008) JAMA. , vol.300 , Issue.16 , pp. 1887-1896
    • Giezen, T.J.1    Mantel-Teeuwisse, A.K.2    Straus, S.M.3    Schellekens, H.4    Leufkens, H.G.5    Egberts, A.6


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