Fragment-based discovery of BACE1 inhibitors using functional assays

Biochemistry

Volumn 48, Issue 45, 2009, Pages 10743-10751

  Godemann, Robert ^a   Madden, James ^b   Krämer, Joachim ^a   Smith, Myron ^b   Fritz, Ulrike ^a   Hesterkamp, Thomas ^a   Barker, John ^b   Höppner, Sabine ^c   Hallett, David ^b   Cesura, Andrea ^a   Ebneth, Andreas ^a   Kemp, John ^a  

^a EVOTEC AG   (Germany)

^b EVOTEC UK LTD   (United Kingdom)

^c PROTEROS BIOSTRUCTURES GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FUNCTIONAL ASSAYS; LOW-MOLECULAR WEIGHT; NONPEPTIDIC INHIBITORS; SCREENING APPROACHES; SECRETASES;

SURFACE PLASMON RESONANCE;

X RAY CRYSTALLOGRAPHY;

BETA SECRETASE INHIBITOR;

ARTICLE; BINDING AFFINITY; CHEMICAL ANALYSIS; CONFORMATION; CRYSTAL STRUCTURE; HIGH THROUGHPUT SCREENING; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN DETERMINATION; X RAY CRYSTALLOGRAPHY;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEASE INHIBITORS;

EID: 70449586603     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901061a     Document Type: Article

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