Analysis of lysine clipping of a humanized Lewis-Y specific IgG antibody and its relation to Fc-mediated effector function

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 852, Issue 1-2, 2007, Pages 250-256

  Antes, Bernhard ^a   Amon, Sabine ^b   Rizzi, Andreas ^b   Wiederkum, Susi ^a   Kainer, Manuela ^a   Szolar, Oliver ^a   Fido, Markus ^a   Kircheis, Ralf ^a   Nechansky, Andreas ^a  

^a Igeneon Immunotherapy of Cancer   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Charge heterogeneity; IEF; Lewis Y; Lysine clipping; mAb

Indexed keywords

BIOASSAY; ENZYMES; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ONCOLOGY;

CATION EXCHANGE; CHARGE HETEROGENEITY; ISOELECTRIC FOCUSING; LYSINE CLIPPING; SERUM;

MONOCLONAL ANTIBODIES;

CARBOXYPEPTIDASE B; IMMUNOGLOBULIN G ANTIBODY; LYSINE; MONOCLONAL ANTIBODY;

ARTICLE; CATION EXCHANGE; CELL HETEROGENEITY; CYTOTOXICITY; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOELECTRIC FOCUSING; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; QUALITY CONTROL;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN G; LEWIS BLOOD-GROUP SYSTEM; LYSINE; MOLECULAR SEQUENCE DATA; RECEPTORS, FC; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 34249707388     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.01.024     Document Type: Article

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