Method to differentiate Asn deamidation that occurred prior to and during sample preparation of a monoclonal antibody

Analytical Chemistry

Volumn 80, Issue 24, 2008, Pages 9491-9498

  Gaza Bulseco, Georgeen ^a   Li, Biqin ^a   Bulseco, Ashley ^a   Liu, Hongcheng ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL ARTIFACTS; DEAMIDATION; ENZYME DIGESTIONS; MICRO HETEROGENEITIES; PEAK CLUSTERS; RETENTION TIMES; SAMPLE PREPARATIONS; WEIGHT DIFFERENCES;

AMINES; CHROMATOGRAPHIC ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROCARBONS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; MONOCLONAL ANTIBODIES; PEPTIDES; PROTEINS;

ANTIBODIES;

AMIDES; ANALYTIC SAMPLE PREPARATION METHODS; ANTIBODIES, MONOCLONAL; ASPARAGINE; CHROMATOGRAPHY, LIQUID; MASS SPECTROMETRY; OXYGEN ISOTOPES; RECOMBINANT PROTEINS;

EID: 58149129880     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac801617u     Document Type: Article

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