Positron emission tomography in molecular imaging

IEEE Engineering in Medicine and Biology Magazine

Volumn 23, Issue 4, 2004, Pages 28-37

  Pomper, Martin G ^a,b,c,e   Hammoud, Dima A ^d  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b J H Small Anim Imaging Rsrc P   (United States)

^c In Vivo Cell/Molec Imaging Ctr   (United States)

^d AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 NITRO 1H IMIDAZOL 1 YL) N (2,2,3,3,3 PENTAFLUOROPROPYL)ACETAMIDE F 18; ANNEXIN; ANNEXIN V F 18; ANNEXIN V I 124; DIACETYL BIS(N4 METHYLTHIOSEMICARBAZONE) CU 60; FLUORODEOXYGLUCOSE F 18; IMATINIB; METHIONINE C 11; RADIOISOTOPE; TRACER; UNCLASSIFIED DRUG;

CLINICAL RESEARCH; COMPUTER ASSISTED TOMOGRAPHY; HUMAN; IMAGING; INSTRUMENTATION; ISOTOPE LABELING; MOLECULAR IMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

EID: 7044232001     PISSN: 07395175     EISSN: None     Source Type: Journal    
DOI: 10.1109/MEMB.2004.1337947     Document Type: Review

References (111)

1. A.P. Jeavons, R.A. Chandler, and C.A.R. Dettmar, "A 3D HIDAC-PET camera with sub-millimetre resolution for imaging small animals, " Nucl. Sci. Trans., vol. 46, pp. 468-473, 1999.
2. M. Mandelkern and J. Raines, "Positron emission tomography in cancer research and treatment," Technol. Cancer Res. Treat., vol. 1, pp. 423-439, 2002.
3. F. Fahey, "Instrumentation in positron emission tomography," Neuroimag. Clin. N. Amer., vol. 13, pp. 659-669, 2003.
4. G. Tarantola, F. Zito, and P. Gerundini, "PET instrumentation and reconstruction algorithms in whole-body applications," J. Nucl. Med., vol. 44, pp. 756-769, 2003.
5. M. Pomper, "Functional and metabolic imaging," in Cancer: Principles and Practice of Oncology, H.S. DeVita, V and S.A. Rosenberg, Eds. Philadelphia, PA: Lippincott Williams & Wilkins, 2000, pp. 679-689.
6. B. Thrall, "Single-photon emission computed tomography and positron emission tomography," in Nuclear Medicine: The Requisites. St. Louis, MO: Mosby, 2001, pp. 33-47.
7. K.R. Zasadny and R.L. Wahl, "Standardized uptake values of normal tissues at PET with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose: Variations with body weight and a method for correction," Radiology, vol. 189, pp. 847-850, 1993.
8. H. Schoder, S.M. Larson, and H.W. Yeung, "PET/CT in oncology: Integration into clinical management of lymphoma, melanoma, and gastrointestinal malignancies," J. Nucl. Med., vol. 45, pp. 72S-81S, 2004.
9. D.W. Townsend, T. Beyer, and T.M. Blodgett, "PET/CT scanners: A hardware approach to image fusion," Semin. Nucl. Med., vol. 33, pp. 193-204, 2003.
10. R.L. Wahl, "Why nearly all PET of abdominal and pelvic cancers will be performed as PET/CT," J. Nucl. Med., vol. 45, pp. 82S-95S, 2004.
11. R.E. Gibson, H.D. Burns, and W.C. Eckelman, "The potential uses of radiopharmaceuticals in the pharmaceutical industry," in Nuclear Imaging in Drug Discovery, Development, and Approval, H.D. Burns, R. Gibson, R. Dannals, and P. Siegl, Eds. Boston, MA: Birkhauser, 1993, pp. 321-331.
12. F. Dehdashti, P.W. Grigsby, M.A. Mintun, J.S. Lewis, B.A. Siegel, and M.J. Welch, "Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: Relationship to therapeutic response-A preliminary report," Int. J. Radiat. Oncol. Biol. Phys., vol. 55, pp. 1233-1238, 2003.
13. A. Jacobs, J. Voges, R. Reszka, M. Lercher, A. Gossmann, L. Kracht, C. Kaestle, R. Wagner, K. Wienhard, and W.D. Heiss, "Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas," Lancet, vol. 358, pp. 727-729, 2001.
14. N.S. Mason and C.A. Mathis, "Positron emission tomography radiochemistry," Neuroimag. Clin. N. Amer., vol. 13, pp. 671-687, 2003.
15. W.C. Eckelman, R.C. Reba, R.E. Gibson, W.J. Rzeszotarski, F. Vieras, J.K. Mazaitis, and B. Francis, "Receptor-binding radiotracers: A class of potential radiopharmaceuticals," J. Nucl. Med., vol. 20, pp. 350-357, 1979.
16. J.A. Katzenellenbogen, D.F. Heiman, and K.E. Carlson, "In vitro and in vivo steroid receptor assays in the design of estrogen radiopharmaceuticals, " W.C. Eckelman, Ed. Boca Raton, FL: CRC, 1982, pp. 93-126.
17. S.R. Cherry, "Fundamentals of positron emission tomography and applications in preclinical drug development," J. Clin. Pharmacol., vol. 41, pp. 482-491, 2001.
18. W.C. Eckelman, J.A. Frank, and M. Brechbiel, "Theory and practice of imaging saturable binding sites," Invest Radiol., vol. 37, pp. 101-106, 2002.
19. W.C. Eckelman, "Mechanism of target specific uptake using examples of muscarinic receptor binding radiotracers," in Radiochemistry and Applications, M.J. Welch and C. Redvanly, Eds. West Sussex, U.K.: Wiley, 2002.
20. G.J. Hunter, L.M. Hamberg, N.M. Alpert, N.C. Choi, and A.J. Fischman, "Simplified measurement of deoxyglucose utilization rate," J. Nucl. Med., vol. 37, pp. 950-955, 1996.
21. N.C. Krak, J.J. van der Hoeven, O.S. Hoekstra, J.W. Twisk, E. van der Wall, and A.A. Lammertsma, "Measuring [(18)F]FDG uptake in breast cancer during chemotherapy: Comparison of analytical methods," Eur. J. Nucl. Med. Mol. Imag., vol. 30, pp. 674-681, 2003.
22. C.S. Patlak and R.G. Blasberg, "Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations," J. Cereb. Blood Flow Metab., vol. 5, pp. 584-590, 1985.
23. J. Logan, J.S. Fowler, N.D. Volkow, A.P. Wolf, S.L. Dewey, D.J. Schlyer, R.R. MacGregor, R. Hitzemann, B. Bendriem, S.J. Gatley, et al., "Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects," J. Cereb. Blood Flow Metab., vol. 10, pp. 740-747, 1990.
24. A.Y. Louie, M.M. Huber, E.T. Ahrens, U. Rothbacher, R. Moats, R.E. Jacobs, S.E. Fraser, and T.J. Meade, "In vivo visualization of gene expression using magnetic resonance imaging," Nat. Biotechnol., vol. 18, pp. 321-325, 2000.
25. R. Weissleder, A. Moore, U. Mahmood, R. Bhorade, H. Benveniste, E.A. Chiocca, and J.P. Basilion, "In vivo magnetic resonance imaging of transgene expression," Nat. Med., vol. 6, pp. 351-355, 2000.
26. S.S. Gambhir, H.R. Herschman, S.R. Cherry, J.R. Barrio, N. Satyamurthy, T. Toyokuni, M.E. Phelps, S.M. Larson, J. Balatoni, R. Finn, M. Sadelain, J. Tjuvajev, and R. Blasberg, "Imaging transgene expression with radionuclide imaging technologies," Neoplasia., vol. 2, pp. 118-138, 2000.
27. X. Sun, A.J. Annala, S.S. Yaghoubi, J.R. Barrio, K.N. Nguyen, T. Toyokuni, N. Satyamurthy, M. Namavari, M.E. Phelps, H.R. Herschman, and S.S. Gambhir, "Quantitative imaging of gene induction in living animals," Gene. Ther., vol. 8, pp. 1572-1579, 2001.
28. Y. Yu, A.J. Annala, J.R. Barrio, T. Toyokuni, N. Satyamurthy, M. Namavari, S.R. Cherry, M.E. Phelps, H.R. Herschman, and S.S. Gambhir, "Quantification of target gene expression by imaging reporter gene expression in living animals," Nat. Med., vol. 6, pp. 933-937, 2000.
29. V. Sharma, G.D. Luker, and D. Piwnica-Worms, "Molecular imaging of gene expression and protein function in vivo with PET and SPECT," J. Magn. Reson. Imag., vol. 16, pp. 336-351, 2002.
30. L.A. Green, C.S. Yap, K. Nguyen, J.R. Barrio, M. Namavari, N. Satyamurthy, M.E. Phelps, E.P. Sandgren, H.R. Herschman, and S.S. Gambhir, "Indirect monitoring of endogenous gene expression by positron emission tomography (PET) imaging of reporter gene expression in transgenic mice," Mol. Imaging Biol., vol. 4, pp. 71-81, 2002.
31. R.G. Blasberg and J.G. Tjuvajev, "Molecular-genetic imaging: Current and future perspectives," J. Clin. Invest., vol. 111, pp. 1620-1629, 2003.
32. J. Passchier, A. Gee, A. Willemsen, W. Vaalburg, and A. van Waarde, "Measuring drug-related receptor occupancy with positron emission tomography," Methods, vol. 27, p. 278, 2002.
33. S.P. Hume, R.N. Gunn, and T. Jones, "Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals," Eur. J. Nucl. Med., vol. 25, pp. 173-176, 1998.
34. L.A. Green, S.S. Gambhir, A. Srinivasan, P.K. Banerjee, C.K. Hoh, S.R. Cherry, S. Sharfstein, J.R. Barrio, H.R. Herschman, and M.E. Phelps, "Noninvasive methods for quantitating blood time-activity curves from mouse PET images obtained with fluorine-18-fluorodeoxyglucose," J. Nucl. Med., vol. 39, pp. 729-734, 1998.
35. A.F. Chatziioannou, "Molecular imaging of small animals with dedicated PET tomographs," Eur. J. Nucl. Med. Mol. Imag., vol. 29, pp. 98-114, 2002.
36. T. Sharp, J.Y. Kim, C.S. Dence, L.A. Jones, N.M. Mercer, J.A. Engelbach, P. Herrero, and M.J. Welch, "Quantification of cardiovascular metabolism in mice," presented at the Acad. Mol. Im., Los Angeles, CA, 2002.
37. J.Y. Kim, T. Sharp, P. Herrero, J.A. Engelbach, N.M. Mercer, L.A. Jones, and M.J. Welch, "Quantification of F-18 FDG myocardial glucose utilization in mice with microPET," presented at the Acad. Mol. Im., Los Angeles, CA, 2002.
38. D. Lapointe, J. Cadorette, S. Rodrigue, D. Rouleau, and R. Lecomte, "A microvolumetric blood counter/sampler for metabolic PET studies in small animals," IEEE Trans. Nucl. Sci., vol. 45, pp. 2195-2199, 1998.
39. H.M. Wu, S.C. Huang, V. Allada, P.J. Wolfenden, H.R. Schelbert, M.E. Phelps, and C.K. Hoh, "Derivation of input function from FDG-PET studies in small hearts," J. Nucl. Med., vol. 37, pp. 1717-1722, 1996.
40. 15O dynamic myocardial PET using independent component analysis," J. Nucl. Med., vol. 42, pp. 938-943, 2001.
41. J.S. Lee, D.D. Lee, S. Choi, K.S. Park, and D.S. Lee, "Non-negative matrix factorization of dynamic images in nuclear medicine," in Nucl. Sci. Symp. Conf. Rec., 2001.
42. H.M. Wu, D. Stout, K. Shoghi-Jodid, A. Chatziioannou, and S.C. Huang, "Derivation of input function from dynamic FDG microPET images of mice," presented at the Acad. Mol. Im., Los Angeles, CA, 2002.
43. S. Takikawa, V. Dhawan, P. Spetsieris, W. Robeson, T. Chaly, R. Dahl, D. Margouleff, and D. Eidelberg, "Noninvasive quantitative fluorodeoxyglucose PET studies with an estimated input function derived from a population-based arterial blood curve," Radiology, vol. 188, pp. 131-136, 1993.
44. T. Shiozaki, N. Sadato, M. Senda, K. Ishii, T. Tsuchida, Y. Yonekura, H. Fukuda, and J. Konishi, "Noninvasive estimation of FDG input function for quantification of cerebral metabolic rate of glucose: Optimization and multicenter evaluation," J. Nucl. Med., vol. 41, pp. 1612-1618, 2000.
45. S.P. Hume, R. Myers, P.M. Bloomfield, J. Opacka-Juffry, J.E. Cremer, R.G. Ahier, S.K. Luthra, D.J. Brooks, and A.A. Lammertsma, "Quantitation of carbon-11-labeled raclopride in rat striatum using positron emission tomography," Synapse, vol. 12, pp. 47-54, 1992.
46. A.A. Lammertsma and S.P. Hume, "Simplified reference tissue model for PET receptor studies," Neuroimage, vol. 4, pp. 153-158, 1996.
47. Y.C. Tai, A.F. Chatziioannou, Y. Yang, R.W. Silverman, K. Meadors, S. Siegel, D.F. Newport, J.R. Stickel, and S.R. Cherry, "MicroPET II: Design, development and initial performance of an improved microPET scanner for small-animal imaging," Phys. Med. Biol., vol. 48, pp. 1519-1537, 2003.
48. C. Tai, A. Chatziioannou, S. Siegel, J. Young, D. Newport, R.N. Goble, R.E. Nutt, and S.R. Cherry, "Performance evaluation of the microPET P4: A PET system dedicated to animal imaging," Phys. Med. Biol., vol. 46, pp. 1845-1862, 2001.
49. S.P. Hume and R. Myers, "Dedicated small animal scanners: A new tool for drug development?," Curr. Pharm. Des., vol. 8, pp. 1497-1511, 2002.
50. J.S. Lewis, S. Achilefu, J.R. Garbow, R. Laforest, and M.J. Welch, "Small animal imaging current technology and perspectives for oncological imaging," Eur. J. Cancer, vol. 38, p. 2173, 2002.
51. R. Myers, "The biological application of small animal PET imaging," Nucl. Med. Biol., vol. 28, pp. 585-593, 2001.
52. F.J. Beekman, D.P. McElroy, F. Berger, S.S. Gambhir, E.J. Hoffman, and S.R. Cherry, "Towards in vivo nuclear microscopy: Iodine-125 imaging in mice using micro-pinholes," Eur. J. Nucl. Med. Mol. Imaging, vol. 29, pp. 933-938, 2002.
53. P.D. Acton, M.P. Kung, C. Hou, K. Plossl, C. Keeney, and H.F. Kung, "Ultra-high resolution single photon emission tomography imaging of the mouse striatum," Eur. J. Nucl. Med. Mol. Imaging, vol. 29, p. 446, 2002.
54. R.J. Jaszczak, J. Li, H. Wang, Z.M.R., and R.E. Coleman, "Pinhole collimation for ultra high resolution small field of view SPECT," Phys. Med. Biol., vol. 39, pp. 425-437, 1994.
55. K. Ishizu, T. Mukai, Y. Yonekura, M. Pagani, T. Fujita, Y. Magata, S. Nishizawa, N. Tamaki, H. Shibasaki, and J. Konishi, "Ultra-high resolution SPECT system using four pinhole collimators for small animal studies," J. Nucl. Med., vol. 36, pp. 2282-2287, 1995.
56. D.A. Weber and M. Ivanovic, "Pinhole SPECT: Ultra-high resolution imaging for small animal studies," J. Nucl. Med., vol. 36, pp. 2287-2289, 1995.
57. L.R. Macdonald, B.E. Patt, J.S. Iwanczyk, T.B.M.W., Y. Wang, E.C. Frey, D.E. Wessell, P.D. Acton, and H.F. Kung, "Pinhole SPECT of mice using the LumaGEM gamma camera," IEEE Trans. Nucl. Sci., vol. 48, pp. 830-836, 2001.
58. D.P. McElroy, L.R. Macdonald, F.J. Beekman, Y. Wang, B.E. Patt, J.S. Iwanczyk, B.M.W. Tsui, and E.J. Hoffman, "Evaluation of A-SPECT: A desktop pinhole SPECT system for small animal imaging," in Nucl. Sci. Symp. Conf. Rec., vol. 3, 2002, pp. 1835-1839.
59. A. Alavi, J.W. Kung, and H. Zhuang, "Implications of PET based molecular imaging on the current and future practice of medicine," Semin. Nucl. Med., vol. 34, pp. 56-69, 2004.
60. P. Blake, B. Johnson, and J.W. VanMeter, "Positron emission tomography (PET) and single photon emission computed tomography (SPECT): Clinical applications," J. Neuroophthalmol., vol. 23, pp. 34-41, 2003.
61. G. Jerusalem, R. Hustinx, Y. Beguin, and G. Fillet, "PET scan imaging in oncology," Eur. J. Cancer., vol. 39, pp. 1525-1534, 2003.
62. A. Becherer, U. Jaeger, M. Szabo, and K. Kletter, "Prognostic value of FDG-PET in malignant lymphoma," Q. J. Nucl. Med., vol. 47, pp. 14-21, 2003.
63. S.P. Hong, J.S. Hahn, J.D. Lee, S.W. Bae, and M.J. Youn, "18F-fluorodeoxyglucose-positron emission tomography in the staging of malignant lymphoma compared with CT and 67Ga scan," Yonsei. Med. J., vol. 44, pp. 779-786, 2003.
64. O.A. Ogunbiyi, F.L. Flanagan, F. Dehdashti, B.A. Siegel, D.D. Trask, E.H. Birnbaum, J.W. Fleshman, T.E. Read, G.W. Philpott, and I.J. Kodner, "Detection of recurrent and metastatic colorectal cancer: Comparison of positron emission tomography and computed tomography," Ann. Surg. Oncol., vol. 4, pp. 613-620, 1997.
65. K.D. Stumpe, M. Urbinelli, H.C. Steinert, C. Glanzmann, A. Buck, and G.K. von Schulthess, "Whole-body positron emission tomography using fluorodeoxyglucose for staging of lymphoma: Effectiveness and comparison with computed tomography," Eur. J. Nucl. Med., vol. 25, pp. 721-728, 1998.
66. H.A. Nabi and J.M. Zubeldia, "Clinical applications of (18)F-FDG in oncology," J. Nucl. Med. Technol., vol. 30, pp. 3-9, quiz 10-1, 2002.
67. H.W. Prauer, W.A. Weber, W. Romer, T. Treumann, S.I. Ziegler, and M. Schwaiger, "Controlled prospective study of positron emission tomography using the glucose analogue [18f]fluorodeoxyglucose in the evaluation of pulmonary nodules," Br. J. Surg., vol. 85, pp. 1506-1511, 1998.
68. S.F. Barrington and M.J. O'Doherty, "Limitations of PET for imaging lymphoma," Eur. J. Nucl. Med. Mol. Imaging, vol. 30, suppl. 1, pp. S117-S127, 2003.
69. J.M. Goo, J.G. Im, K.H. Do, J.S. Yeo, J.B. Seo, H.Y. Kim, and J.K. Chung, "Pulmonary tuberculoma evaluated by means of FDG PET: Findings in 10 cases," Radiology, vol. 216, pp. 117-121, 2000.
70. F. De Winter, D. Vogelaers, F. Gemmel, and R.A. Dierckx, "Promising role of 18-F-fluoro-D-deoxyglucose positron emission tomography in clinical infectious diseases," Eur. J. Clin. Microbiol. Infect. Dis., vol. 21, pp. 247-257, 2002.
71. M. Tatsumi, C. Cohade, Y. Nakamoto, and R.L. Wahl, " Fluorodeoxyglucose uptake in the aortic wall at PET/CT: Possible finding for active atherosclerosis," Radiology, vol. 229, pp. 831-837, 2003.
72. P. Bartenstein, S. Asenbaum, A. Catafau, C. Halldin, L. Pilowski, A. Pupi, and K. Tatsch, "European Association of Nuclear Medicine procedure guidelines for brain imaging using [(18)F]FDG," Eur. J. Nucl. Med. Mol. Imaging, vol. 29, pp. BP43-BP48, 2002.
73. S. Minoshima, "Imaging Alzheimer's disease: Clinical applications," Neuroimag. Clin. N. Amer., vol. 13, pp. 769-780, 2003.
74. G. Berding, P. Odin, D.J. Brooks, G. Nikkhah, C. Matthies, T. Peschel, M. Shing, H. Kolbe, J. van Den Hoff, H. Fricke, R. Dengler, M. Samii, and W.H. Knapp, "Resting regional cerebral glucose metabolism in advanced Parkinson's disease studied in the off and on conditions with [(18)F]FDG-PET," Mov. Disord., vol. 16, pp. 1014-1022, 2001.
75. D.A. Rottenberg, J.J. Sidtis, S.C. Strother, K.A. Schaper, J.R. Anderson, M.J. Nelson, and R.W. Price, "Abnormal cerebral glucose metabolism in HIV-1 seropositive subjects with and without dementia," J. Nucl. Med., vol. 37, pp. 1133-1141, 1996.
76. R. Casse, C.C. Rowe, M. Newton, S.U. Berlangieri, and A.M. Scott, "Positron emission tomography and epilepsy," Mol. Imaging Biol., vol. 4, pp. 338-351, 2002.
77. H. Barthel, M.C. Cleij, D.R. Collingridge, O.C. Hutchinson, S. Osman, Q. He, S.K. Luthra, F. Brady, P.M. Price, and E.O. Aboagye, "3′-deoxy- 3′-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography," Cancer Res., vol. 63, pp. 3791-3798, 2003.
78. D.C. Cobben, P.L. Jager, P.H. Elsinga, B. Maas, A.J. Suurmeijer, and H.J. Hoekstra, "3′-18F-fluoro-3′-deoxy-L-thymidine: A new tracer for staging metastatic melanoma?," J. Nucl. Med., vol. 44, pp. 1927-1932, 2003.
79. D.L. Francis, A. Freeman, D. Visvikis, D.C. Costa, S.K. Luthra, M. Novelli, I. Taylor, and P.J. Ell, "In vivo imaging of cellular proliferation in colorectal cancer using positron emission tomography," Gut., vol. 52, pp. 1602-1606, 2003.
80. P.L. Jager, W. Vaalburg, J. Pruim, E.G.de Vries, K.J. Langen, and D.A. Piers, "Radiolabeled amino acids: Basic aspects and clinical applications in oncology," J. Nucl. Med., vol. 42, pp. 432-445, 2001.
81. T.Z. Wong, G.J. van der Westhuizen, and R.E. Coleman, "Positron emission tomography imaging of brain tumors," Neuroimaging Clin. N. Amer., vol. 12, pp. 615-626, 2002.
82. T. Inoue, K. Koyama, N. Oriuchi, S. Alyafei, Z. Yuan, H. Suzuki, K. Takeuchi, Y. Tomaru, K. Tomiyoshi, J. Aoki, and K. Endo, "Detection of malignant tumors: Whole-body PET with fluorine 18 alpha-methyl tyrosine versus FDG-Preliminary study," Radiology, vol. 220, pp. 54-62, 2001.
83. D. Pauleit, F. Floeth, H. Herzog, K. Hamacher, L. Tellmann, H.W. Muller, H.H. Coenen, and K.J. Langen, "Whole-body distribution and dosimetry of O-(2-[18F]fluoroethyl)-L-tyrosine," Eur. J. Nucl. Med. Mol. Imaging, vol. 30, pp. 519-524, 2003.
84. T.A. Bonasera, J.P. O'Neil, M. Xu, J.A. Dobkin, P.D. Cutler, L.L. Lich, Y.S. Choe, J.A. Katzenellenbogen, and M.J. Welch, "Preclinical evaluation of fluorine-18-labeled androgen receptor ligands in baboons, " J. Nucl. Med., vol. 37, pp. 1009-1015, 1996.
85. M.A. Mintun, M.J. Welch, B.A. Siegel, C.J. Mathias, J.W. Brodack, A.H. McGuire, and J.A. Katzenellenbogen, "Breast cancer: PET imaging of estrogen receptors," Radiology, vol. 169, pp. 45-48, 1988.
86. M.J. Reinhardt, A. Matthies, and H.J. Biersack, "PET-imaging in tumors of the reproductive trac," Q. J. Nucl. Med., vol. 46, pp. 105-112, 2002.
87. Y. Murakami, H. Takamatsu, J. Taki, M. Tatsumi, A. Noda, R. Ichise, J.F. Tait, and S. Nishimura, "18F-labelled annexin V: A PET tracer for apoptosis imaging," Eur. J. Nucl. Med. Mol. Imaging, vol. 30, 2003.
88. L.W. Kracht, M. Friese, K. Herholz, R. Schroeder, B. Bauer, A. Jacobs, and W.D. Heiss, "Methyl-[11C]- 1-methionine uptake as measured by positron emission tomography correlates to microvessel density in patients with glioma," Eur. J. Nucl. Med. Mol. Imaging, vol. 30, pp. 868-873, 2003.
89. W.R. Dolbier, Jr., A.R. Li, C.J. Koch, C.Y. Shiue, and A.V. Kachur, "[18F]-EF5, a marker for PET detection of hypoxia: Synthesis of precursor and a new fluorination procedure," Appl. Radiat. Isot., vol. 54, pp. 73-80, 2001.
90. D.M. Goldenberg, "Advancing role of radiolabeled antibodies in the therapy of cancer," Cancer Immunol. Immunother., vol. 52, pp. 281-296, 2003.
91. M. Zhang, Z. Zhang, K. Garmestani, J. Schultz, D.B. Axworthy, C.K. Goldman, M.W. Brechbiel, J.A. Carrasquillo, and T.A. Waldmann, "Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts," Proc. Nat. Acad. Sci. USA, vol. 100, pp. 1891-1895, 2003.
92. G. Sundaresan, P.J. Yazaki, J.E. Shively, R.D. Finn, S.M. Larson, A.A. Raubitschek, L.E. Williams, A.F. Chatziioannou, S.S. Gambhir, and A.M. Wu, "124I-labeled engineered anti-CEA minibodies and diabodies allow high-contrast, antigen-specific small-animal PET imaging of xenografts in athymic mice," J. Nucl. Med., vol. 44, pp. 1962-1969, 2003.
93. D.F. Wong and M.G. Pomper, "Predicting the success of a radiopharmaceutical for in vivo imaging of central nervous system neuroreceptor systems," Mol. Imaging Biol., vol. 5, pp. 350-362, 2003.
94. M. Laruelle, M. Slifstein, and Y. Huang, "Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography," Mol. Imaging Biol., vol. 5, pp. 363-375, 2003.
95. R.N. Waterhouse, "Determination of lipophilicity and its use as a predictor of blood-brain barrier penetration of molecular imaging agents," Mol. Imaging Biol., vol. 5, pp. 376-389, 2003.
96. E.D. Agdeppa, V. Kepe, J. Liu, G.W. Small, S.C. Huang, A. Petric, N. Satyamurthy, and J.R. Barrio, "2-dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): Novel diagnostic and therapeutic tools in Alzheimer's disease," Mol. Imaging Biol., vol. 5, pp. 404-417, 2003.
97. H.F. Kung, M.P. Kung, Z.P. Zhuang, C. Hou, C.W. Lee, R. Plossl, B. Zhuang, D.M. Skovronsky, V.M. Lee, and J.Q. Trojanowski, "Iodinated tracers for imaging amyloid plaques in the brain," Mol. Imaging Biol., vol. 5, pp. 418-426, 2003.
98. A.M. Paans, "The use of radiotracers in drug discovery and development," Drug. Discov. Today, vol. 8, p. 734, 2003.
99. C.A. Mathis, Y. Wang, D.P. Holt, G.F. Huang, M.L. Debnath, and W.E. Klunk, "Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents," J. Med. Chem., vol. 46, pp. 2740-2752, 2003.
100. B.J. Bacskai, G.A. Hickey, J. Skoch, S.T. Kajdasz, Y. Wang, G.F. Huang, C.A. Mathis, W.E. Klunk, and B.T. Hyman, "Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice," Proc. Nat. Acad. Sci. USA, vol. 100, pp. 12462-12467, 2003.
101. A. Saleem, J. Yap, S. Osman, F. Brady, B. Suttle, S.V. Lucas, T. Jones, P.M. Price, and E.O. Aboagye, "Modulation of fluorouracil tissue pharmacokinetics by eniluracil: In-vivo imaging of drug action," Lancet, vol. 355, pp. 2125-2131, 2000.
102. 11C]paclitaxel, " J. Label. Compd. Radiopharm., vol. 45, pp. 471-477, 2002.
103. K.A. Kurdziel, D.O. Kiesewetter, R.E. Carson, W.C. Eckelman, and P. Herscovitch, "Biodistribution, radiation dose estimates, and in vivo Pgp modulation studies of 18F-paclitaxel in nonhuman primates," J. Nucl. Med., vol. 44, pp. 1330-1339, 2003.
104. G.D. Demetri, M. von Mehren, C.D. Blanke, A.D. Van den Abbeele, B. Eisenberg, P.J. Roberts, M.C. Heinrich, D.A. Tuveson, S. Singer, M. Janicek, J.A. Fletcher, S.G. Silverman, S.L. Silberman, R. Capdeville, B. Kiese, B. Peng, S. Dimitrijevic, B.J. Druker, C. Corless, C.D. Fletcher, and H. Joensuu, "Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors," New. Eng. J. Med., vol. 347, pp. 472-480, 2002.
105. J.R. Woolfrey and G.S. Weston, "The use of computational methods in the discovery and design of kinase inhibitors," Curr. Pharm. Des., vol. 8, pp. 1527-1545, 2002.
106. M. Bergstrom, R. Awad, S. Estrada, J. Malman, L. Lu, G. Lendvai, E. Bergstrom-Pettermann, and B. Langstrom, "Autoradiography with positron emitting isotopes in positron emission tomography tracer discovery," Mol. Imaging Biol., vol. 5, pp. 390-396, 2003.
107. G.D. Luker, V. Sharma, C.M. Pica, J.L. Prior, W. Li, and D. Piwnica-Worms, "Molecular imaging of protein-protein interactions: Controlled expression of p53 and large T-antigen fusion proteins in vivo," Cancer Res., vol. 63, pp. 1780-1788, 2003.
108. G.D. Luker, V. Sharma, and D. Piwnica-Worms, "Visualizing protein-protein interactions in living animals," Methods, vol. 29, pp. 110-122, 2003.
109. G.C. Houston, S.P. Hume, E. Hirani, J.L. Goggi, and P.M. Grasby, "Temporal characterisation of amphetamine-induced dopamine release assessed with [11C]raclopride in anaesthetised rodents," Synapse, vol. 51, pp. 206-212, 2004.
110. P.D. Acton, C. Hou, M.P. Kung, K. Plossl, C.L. Keeney, and H.F. Kung, "Occupancy of dopamine D2 receptors in the mouse brain measured using ultra-high-resolution single-photon emission tomography and [123]IBF," Eur. J. Nucl. Med. Mol. Imaging, vol. 29, pp. 1507-1515, 2002.
111. J.A. Katzenellenbogen, "The pharmacology of steroid radiopharmaceuticals: Specific and non-specific binding and uptake selectivity," in Radiopharmaceuticals: Chemistry and Pharmacology, A.D. Nunn, Ed. New York: Dekker, 1992, pp. 297-331.