Small animal imaging: Current technology and perspectives for oncological imaging

European Journal of Cancer

Volumn 38, Issue 16, 2002, Pages 2173-2188

  Lewis, Jason S ^a,c   Achilefu, S ^a,c   Garbow, J R ^b,c   Laforest, R ^a,c   Welch, M J ^b,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Washington University in St Louis   (United States)

Author keywords

MRI; Optical; PET; Small animal imaging; Transgenic

Indexed keywords

COPPER 64; FLUORINE 18; INDOCYANINE GREEN; IODINE 125; MEDRONATE TECHNETIUM TC 99M; RADIOPHARMACEUTICAL AGENT; SOMATOSTATIN;

BIOMEDICINE; EXPERIMENTAL ANIMAL; GENE EXPRESSION; HUMAN; IMAGING SYSTEM; MOLECULAR PROBE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; ONCOLOGY; PHOTODYNAMIC THERAPY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; ULTRASOUND;

EID: 0036840676     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(02)00394-5     Document Type: Article

References (189)

1. Budinger T.F., Beneron D.A., Koretsky A.P. Imaging transgenic animals. Annu. Rev. Biomed. Eng. 1:1999;611-648.
2. Weissleder R. Scaling down imaging. molecular mapping of cancer in mice Nature Rev. 2:2002;1-8.
3. Borah B., Gross G.J., Dufresne T.E.et al. Three-dimensional microimaging (MRmicroI and microCT), finite element modeling and rapid prototyping provide unique insights into bone architecture in osteoporosis. Anat. Rec. 265:2001;101-110.
4. Rietbergen van B., Majumdar S., Pistoia W.et al. Assessment of cancellous bone mechanical properties from micro-FE models based on micro-CT, pQCT and MR images. Technol. Health Care. 6:1998;413-420.
5. Ruegsegger P., Koller B., Muller R. A microtomographic system for the non-destructive evaluation of bone architecture. Calcif. Tissue Int. 58:1996;24-29.
6. Kennel S.J., Davis I.A., Branning J., Pan H., Kabalka G.W., Paulus M.J. High resolution computed tomography and MRI for monitoring lung tumor growth in mice undergoing radioimmuntherapy. correlation with histology Med. Phys. 27:2000;1101-1107.
7. Paulus M.J., Gleason S.S., Sari-Sarrat H.et al. High-resolution X-ray CT screening of mutant mouse models. Proc. SPIE. 3921:2000;270-279.
8. Paulus M.J., Gleason S.S., Kennel S.J., Hunsicker P.R., Johnson D.K. High resolution X-ray computed tomography. an emerging tool for small animal cancer research Neoplasia. 21:2000;62-70.
9. Paulus M.J., Gleason S.S., Easterly M.E., Foltz C.J. A review of high-resolution X-ray computed tomography and other imaging modalities for small animal research. Lab. Animal. 30:2001;36-45.
10. Weber D.A., Ivanovic M., Franceschi D.et al. Pinhole SPECT. a new approach to in vivo high resolution SPECT imaging in small animal laboratory animals J. Nucl. Med. 35:1994;342-348.
11. Weber D.A., Ivanovic M. Ultra-high-resolution imaging of small animals. implications for preclinical and research studies J. Nucl. Cardiol. 6:1999;332-344.
12. Weisenberger A.G., Bradley E., Majewski S., Saha M. Development of a novel radiation imaging detector system for in vivo gene imaging in small animal studies. Conf. Rec. 1996 Med. Imag. Conf, 1996;1201-1205.
13. Wirrwar A., Schramm N., Vosberg H., Muller-Gartner H.W. High resolution SPECT in small animal research. Rev Neurosci. 12:2001;187-193.
14. Green M.V., Seidel J., Vaquero J.J., Jagoda E., Lee I., Eckelman W.C. High resolution PET, SPECT and projection imaging in small animals. Comput. Med. Imag Graph. 25:2001;79-86.
15. Ploux L., Mastrippolito R. In vivo radiolabel quantification in small-animal models. Nucl. Med. Biol. 28:1998;737-742.
16. Rooks V., Beecken W.-D., Iordanescu I., Taylor G.A. Sonographic evaluation of orthotopic bladder tumors in mice treated with TNP-470 an angiogenic inhibitor. Acad. Radiol. 8:2001;121-127.
17. Zagar B., Fornaris R., Ferrera K. Ultrasonic mapping of the microvasculature. siganl alignment Ultrasound Med. 24:1998;809-824.
18. Kish P.E., Blaivas M., Strawderman M., Muraszko K.M., Ross D.A., Ross B.D. G. M. Magnetic resonance imaging of ethyl-nitrosourea-induced rat gliomas. a model for experimental therapeutics of low-grade gliomas J. Neuro-Oncol. 53:2001;243-257.
19. Schabet M., Martos J., Buchholz R., Pietsch T. Animal model of human medulloblastoma. clinical, magnetic resonance imaging, and histopathological findings after intra-cisternal injection of MHH-MED-1 cells into nude rats Med. Pediatric. Oncol. 29:1997;92-97.
20. Martinez D.A., Kahwash S., O'Dorisio M.S., Lloyd T.V., McGhee R.B.J. Disseminated neuroblastoma in the nude rat. A xenograft model of human malignancy. Cancer. 77:1996;409-419.
21. Vertrees R.A., Deyo D.J., Quast M., Lightfoot K.M., Boor P.J., Zwischenberger J.B. Development of a human to murine orthotopic xenotransplanted lung cancer model. J. Invest. Surg. 13:2000;349-358.
22. Pulkkanen K.J., Parkkinen J.J., Kettunen M.I.et al. Characterization of a new animal model for human renal cell carcinoma. In Vivo. 14:2000;393-400.
23. Xiao Z., McCallum T.J., Brown K.M.et al. Characterization of a novel transplantable orthotopic rat bladder transitional cell tumour model. Br. J. Cancer. 81:1999;638-646.
24. Abdulkadir S.A., Qu Z., Garabedian E.et al. Impaired prostate tumorigenesis in Egr1-deficient mice. Nat Med. 7:2001;101-107.
25. He Z., Evelhoch J.L., Mohammad R.M.et al. Magnetic resonance imaging to measure therapeutic response using an orthotopic model of human pancreatic cancer. Pancreas. 21:2000;69-76.
26. Saini M., Bellinzona M., Weichhold W., Samii A. A new xenograft model of primary central nervous system lymphoma. J. Neuro-Oncol. 43:1999;153-160.
27. Chenevert T.L., Stegman L.D., Taylor J.M.et al. Diffusion magnetic resonance imaging. an early surrogate marker of therapeutic efficacy in brain tumors J. Natl. Cancer Inst. 92:2000;2029-2036.
28. Poptani H., Puumalainen A.-M., Grohn O.H.et al. Monitoring thymidine kinase and ganciclovir-induced changes in rat malignant glioma in vivo by nuclear magnetic resonance imaging. Cancer Gene Ther. 5:1998;101-109.
29. Jennings D., Hatton B.N., Guo J.et al. Early response of prostate carcinoma xenografts to docetaxel chemotherapy monitored with diffusion MRI. Neoplasia. 4:2002;255-262.
30. Beauregard D.A., Pedley R., Barbara H., Sally A., Brindle K.M. Differential sensitivity of two adenocarcinoma xenografts to the anti-vascular drugs combretastatin A4 phosphate and 5,6-dimethylxanthenone-4-acetic acid, assessed using MRI and MRS. NMR Biomed. 15:2002;99-105.
31. Khandaker M.H., Kadhim S.A., Ischim T.E., Howson-Jan K., Chin J., Sighal S.K. Prevention of bladder tumor formation in mice by a novel bone marrow-derived factor, reptimed. Anticancer Res. 20:2000;183-189.
32. Cordel S., Dupas B., Douillard J.Y., Meflah K. Interleukin-2/sodium butyrate treatment cures rats bearing liver tumors after acquired 5-fluorouracil resistance. Int. J. Cancer. 78:1998;735-739.
33. 4-methylthiosemicarbazone) for prevention of tumor growth at wound sites following laparoscopic surgery. monitoring therapy response with microPET and magnetic resonance imaging Cancer Res. 62:2002;445-449.
34. Su M.Y., Taylor J.A., Villarreal L.P., Nalcioglu O. Prediction of gene therapy-induced tumor size changes by the vascularity changes measured using dynamic contrast-enhanced MRI. Mag. Reson. Imag. 28:2000;311-317.
35. Stegman L.D., Rehemtulla A., Hamstra D.A.et al. Diffusion MRI detects early events in the response of a glioma model to the yeast cytosine deaminase gene therapy strategy. Gene Ther. 7:2000;1005-1010.
36. Fleige G., Nolte C., Synowitz M., Seeberger F., Kettenmann H., Zimmer C. Magnetic labeling of activated microglia in experimental gliomas. Neoplasia. 3:2001;489-499.
37. Fonchy E., Lahrech H., Francois-Joubert A.et al. A new gadolinium-based contrast agent for magnetic resonance imaging of brain tumors. kinetic study on a C6 rat glioma model J. Mag. Reson. Imag. 14:2000;97-105.
38. Prabhu S.S., Broaddus W.C., Oveissi C., Berr S.S., Gillies G.T. Determination of intracranial tumor volumes in a rodent brain using magnetic resonance imaging, Evans blue, and histology. a comparative study IEEE Trans. Biomed. Engin. 47:2000;259-265.
39. Helbich T.H., Roberts T.P., Gossmann A.et al. Quantitative gadopentetate-enhanced MRI of breast tumors. testing of different analytic methods Mag. Reson. Med. 44:2000;915-924.
40. Marinelli E.R., Neubeck R., Song B.et al. Synthesis, characterization, and imaging performance of a new class of macrocyclic hepatobiliary MR contrast agents. Invest. Radiol. 35:2000;8-24.
41. Konda S.D., Aref M., Wang S., Brechbiel M., Wiener E.C. Specific targeting of folate-dendrimer MRI contrast agents to the high affinity folate receptor expressed in ovarian tumor xenografts. Magma. 12:2001;104-113.
42. Wunderbaldinger P., Josephson L., Bremer C., Moore A., Weissleder R. Detection of lymph node metastases by contrast-enhanced MRI in an experimental model. Mag. Reson. Med. 47:2002;292-297.
43. Shahbazi-Gahrouei D., Williams M., Rizvi S., Allen B.J. In vivo studies of Gd-DTPA-monoclonal antibody and gd-porphyrins. potential magnetic resonance imaging contrast agents for melanoma J. Mag. Reson. Imag. 14:2001;169-174.
44. Maurer J., Strauss A., Ebert W., Bauer H., Felix R. Contrast-enhanced high resolution magnetic resonance imaging of pigmented malignant melanoma using Mn-TPPS4 and Gd-DTPA. experimental results Melanoma Res. 10:2000;40-46.
45. Kiessling F., Fink C., Hansen M.et al. Magnetic resonance imaging of nude mice with heterotransplanted high-grade squamous cell carcinomas. use of a low-loaded, covalently bound Gd-Hsa conjugate as contrast agent with high tumor affinity Invest. Radiol. 37:2002;193-198.
46. Pilatus, U., Aboagye, E., Artemov, D., Mori, N., Ackerstaff, E., Bhujwalla Z.M., Real-time measurements of cellular oxygen consumption, pH, and energy metabolism using nuclear magnetic resonance spectroscopy, Mag. Reson. Med., 45, 749-755.
47. Fan X., River J.N., Zamora M.et al. Differentiation of nonmetastatic and metastatic rodent prostate tumors with high spectral and spatial resolution MRI. Mag. Reson. Med. 45:2001;1046-1055.
48. Bhujwalla Z.M., Artemov D., Natarajan K., Ackerstaff E., Solaiyappan M. Vascular differences detected by MRI for metastatic versus nonmetastatic breast and prostate cancer xenografts. Neoplasia (New York). 3:2001;143-153.
49. Leach M.O. Application of magnetic resonance imaging to angiogenesis in breast cancer. Breast Cancer Res. 3:2001;22-27.
50. Tempel-Brami C., Neeman M. Non-invasive analysis of rat ovarian angiogenesis by MRI. Mol. Cell. Endocrin. 187:2002;19-22.
51. Verhoye M., van der Sanden B.P.J., Rijken P.F.J.W.et al. Assessment of the neovascular permeability in glioma xenografts by dynamic T(1) MRI with Gadomer-17. Mag. Reson. Med. 47:2002;305-313.
52. Maxwell R.J., Wilson J., Prise V.E.et al. Evaluation of the anti-vascular effects of combretastatin in rodent tumours by dynamic contrast enhanced MRI. NMR Biomed. 2002;89-98.
53. Wang Z., Su M.Y., Najafi A., Nalcioglu O. Effect of vasodilator hydralazine on tumor microvascular random flow and blood volume as measured by intravoxel incoherent motion (IVIM) weighted MRI in conjunction with Gd-DTPA-albumin enhanced MRI. Mag. Reson. Imag. 19:2001;1063-1072.
54. Bjornerud A., Johansson L.O., Ahlstrom H.K. Pre-clinical results with Clariscan (NC100150 Injection); experience from different disease models. Mag. Reson. Mater. Phys. Biol. Med. 12:2001;99-103.
55. Sato N., Kobayashi H., Hiraga A.et al. Pharmacokinetics and enhancement patterns of macromolecular MR contrast agents with various sizes of polyamidoamine dendrimer cores. Mag. Reson. Med. 46:2001;1169-1173.
56. Brasch R., Pham C., Shames D.et al. Assessing tumor angiogenesis using macromolecular MR imaging contrast media. J. Mag. Reson. Imag. 7:1997;68-74.
57. Amorino G.P., Lee H., Holburn G.E.et al. Enhancement of tumor oxygenation and radiation response by the allosteric effector of hemoglobin, RSR13. Radiat. Res. 156:2001;294-300.
58. Neeman M., Dafni H., Bukhari O., Braun R.D., Dewhirst M.W. In vivo BOLD contrast MRI mapping of subcutaneous vascular function and maturation. validation by intravital microscopy Mag. Res. Med. 45:2001;887-898.
59. Al-Hallaq H.A., Zamora M., Fish B.L., Farrell A., Moulder J.E., Karczmar G.S. MRI measurements correctly predict the relative effects of tumor oxygenating agents on hypoxic fraction in rodent BA1112 tumors. Int. J. Radiat. Oncol. Biol. Phys. 47:2000;481-488.
60. Robinson S.P., Howe F.A., Stubbs M., Griffiths J.R. Effects of nicotinamide and carbogen on tumour oxygenation, blood flow, energetics and blood glucose levels. Br. J. Cancer. 82:2000;2007-2014.
61. Chatziloannou A.F. Molecular imaging of small animals with dedicated PET tomographs. Eur. J. Nucl. Med. 29:2002;98-114.
62. Cherry S.R., Gambhir S.S. Use of positron emission tomography in animal research. J. Clin. Pharmacol. 41:2001;482-491.
63. Hume S.P., Jones T. Positron emission tomography (PET) methodology for small animals and its application in radiopharmaceutical preclinical investigation. Nucl. Med. Biol. 25:1998;729-732.
64. Myers R. The biological application of small animal PET imaging. Nucl. Med. Biol. 28:2001;585-593.
65. Myers R., Hume S., Bloomfield P., Jones T. Radio-imaging in small animals. J. Psychopharm. 13:1999;352-357.
66. Lapointe D., Bentourkia M., Cadorette J.et al. High-resolution cardiac PET in rats. J. Nucl. Med. 40:1999;185P.
67. Kudo T., Annala A.J., Cherry S.R., Phelps M.E., Schelbert H.R. Measurement of myocardial blood flow during occlusion/reperfusion in rats with dynamic microPET imaging. J. Nucl. Med. 40:1999;6P.
68. Kornblum H.I., Araujo D.M., Annala A.J., Tatsukawa K.J., Phelps M.E., Cherry S.R. In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET). Nat. Biotech. 18:2000;655-660.
69. Moore T.H., Osteen T.L., Chatziioannou T.F., Hovda D.A., Cherry T.R. Quantitative assessment of longitudinal metabolic changes in vivo after traumatic brain injury in the adult rat using FDG-microPET. J. Cereb. Blood Flow Metab. 20:2000;1492-1501.
70. Barrio J.R., Toyokuni T., Gambhir S.S.et al. In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET). Nucl. Med. Biol. 27:2000;157-162.
71. Qi J., Moore A., Annala A.et al. Deficits in striatal dopamine D(2) receptors and energy metabolism detected by in vivo microPET imaging in a rat model of Huntington's disease. IEEE Trans. Med. Imag. 19:2000;507-512.
72. Luthra S.K., Brown D.J., Opacka-Juffry J.et al. The potential of high-resolution positron emission tomography to monitor striatal dopaminergic function in rat models of disease. Nucl. Med. Biol. 23:1996;377-384.
73. Torres E.M., Hume S.P., Myers R.et al. In vivo saturation kinetics of two dopamine transporter probes measured using a small animal positron emission tomography scanner. Neuroscience. 79:1997;711-721.
74. Sargent P.A., Bench C.J., Rabiner E.A.et al. Positron emission tomography (PET) methodology for small animals and its application in radiopharmaceutical preclinical investigation. Neuroimage. 8:1998;426-440.
75. Kornblum H.I., Cherry S.R. The use of microPET for the development of neural repair therapeutics. studies in epilepsy and lesion models J. Clin. Pharmacol. (Suppl.). 41:2001;55S-63S.
76. Wipke B.T., Wang Z., Kim J., McCarthy T.J., Allen P.M. Dynamic visualization of a joint-specific autoimmune response through positron emission tomography. Nat Immunol. 3:2002;336-372.
77. Wang Z., Sharp T.L., Bora N.S.et al. Approaches toward the in vivo imaging of experimental accute autoimmune uvitis (EAAU). J. Label. Compd. Radiopharm. 44:2001;S372-S373.
78. Chatziioannou A.F., Cherry S.R., Shao Y.et al. Performance evaluation of microPET. a high-resolution lutetium oxyorthosilicate PET scanner for animal imaging J. Nucl. Med. 40:1999;1164-1175.
79. Cherry S.R., Shao Y., Silverman R.E.et al. MicroPET. a high resolution PET scanner for imaging small animals IEEE Trans Nucl. Sci. 44:1997;1161-1166.
80. Cherry S.R., Yiping S., Siegel S.et al. Optical fiber readout of scintillator arrays using a multi-channel PMT. a high resolution PET detector for animal imaging IEEE Trans. Nucl. Sci. 1996;43.
81. Saoudi A., Pepin C.M., Lecomte R. Study of light collection in multi-crystal detectors. IEEE Trans. Nucl. Sci. 47:2000;1634-1639.
82. Tai Y.C., Chatziioannou A., Siegel S.et al. Performacance evaluation of the microPET-P4. a PET system dedicated to animal imaging Phys. Med. Biol. 46:2001;1845-1862.
83. Jeavons A.P., Chandler R.A., Dettmar C.A.R. A 3D HIDAC-PET camera with sub-millimeter resolution for imaging small animals. IEEE Trans. Nucl. Sci. 46:1999;468-473.
84. Weber S., Bauer A., Herzog H.et al. Recent results of the TierPET scanner. IEEE Trans. Nucl. Sci. 47:2000;1665-1669.
85. Weber S., Herzog H., Cremer M.et al. Evaluation of the TierPET system. IEEE Trans. Nucl. Sci. 46:1999;1177-1183.
86. Del Guerra A., Di Domenico G., Scandola M., Zavattini G. YAP-PET. first results of a small animal Positron Emission Tomograph based on YAP:Ce finger crystal IEEE Trans. Nucl. Sci. 45:1998;3105-3108.
87. Del Guerra A, Damiani C, Di Domenico G, et al. First in vivo studies on rats with YAPPET scanner. In Conference Proceedings IEEE NSS-MIC. Seattle, WA, USA, 1999.
88. Siedel, J, Vaquero JJ, Green MV. Resolution uniformity and sensitivity of the NIH ATLAS small animal PET scanner: comparison to simulated LSO scanners without depth-of-interaction capability. In Conference Proceedings IEEE NSS-MIC. San Diego, CA, IEEE, 2001.
89. Siegel S., Vaquero J.J., Aloj L.et al. Initial results from a PET/planar small animal imaging system. IEEE Trans. Nucl. Sci. 46:1999;571-575.
90. Bruyndonckx P, Carnochan P, Yonggang W, et al. The VUB-PET system: performance evaluation and applications for radiotracer validation and anticancer drug development. In Conference Proceedings; High Resolution Imaging in Small Animals. Amsterdam, Netherlands, 1999.
91. Tavernier S., Bruyndonckx P., Shuping Z. A fully 3D small PET scanner. Phys. Med. Biol. 37:1992;635-643.
92. 2 scintillator and photosensitive wire chambers. In IEEE, ed. Conference Proceedings IEEE NSS-MIC, 1994.
93. Correia J.A., Burnham C.A., Kaufman D., Fishman A.J. Development of a small animal PET imaging device with resolution approaching 1mm. IEEE Trans. Nucl. Sci. 46:1999;631-635.
94. Rouze NC, Winkle W, Hutchins GD. IndyPET - a high resolution, high sensitivity dedicated research scanner. In IEEE NSS-MIC. Seattle, WA, 1999.
95. Rouze, NC, Stantz KM, Hutchins GD. Design of IndyPET-II, a high resolution, high-sensitivity dedicated research scanner. In IEEE Nucl Sci Symp Med Imaging. San Diego, CA, 2001.
96. Lecomte R., Cadorette J., Richard P., Rodrigue S., Rouleau D. Design and engineering aspects of a high resolution positron tomograph for small animal imaging. IEEE Trans. Nucl. Sci. 41:1994;1446-1452.
97. Pichler B., Boning G., Lorenz E.et al. Studies with a prototype high resolution PET scanner based on LSO-APD modules. IEEE Trans. Nucl. Sci. 45:1998;1298-1302.
98. Ziegler S.I., Pichler B.J., Boening G.et al. A prototype high-resolution animal positron tomograph with avalanche photodiode arrays and LSO crystals. Eur. J. Nucl. Med. 28:2001;136-143.
99. Rafecas M, Boning G, Pichler BJ, Lorenz E, Schwaiger M, Zeigler SI. Characterization and processing of inter-crystal scatter in a dual layer, high resolution LSO-APD-PET. In IEEE, ed. IEEE Nucl. Sci. Symp Med Imag Conf. San Diego, CA, 2001.
100. Cutler P.D., Cherry S., Hoffman E., Digby W.M., Phelps M.E. Design features and performance of a PET system for animal research. J. Nucl. Med. 33:1992;595-604.
101. Watanabe M., Uchida H., Okada H.et al. A high resolution PET for animal imaging. IEEE Trans. Med. Imag. 11:1992;577-580.
102. Watanabe M., Okada H., Shimizu K.et al. A high resolution animal PET scanner using compact PS-PMT detectors. IEEE Trans. Nucl. Sci. 44:1997;1277-1282.
103. Bloomfield P.M., Rajeswaran S., Spinks T.J.et al. The design and physical characteristics of a small animal positron emission tomograph. Phys. Med. Biol. 40:1995;1105-1206.
104. Bloomfield P.M., Myers R., Hume S.P., Spinks T.J., Lammertsma A.A., Jones T. Three-dimensional performance of a small-diameter positron emission tomograph. Phys. Med. Biol. 42:1997;389-400.
105. Chatziioannou A.F., Tai Y.C., Doshi N., Cherry S.R. Detector development for microPET II. a 1 μl resolution PET scanner for small animal imaging Phys. Med. Biol. 46:2001;2899-2910.
106. Shao Y., Silverman R.W., Cherry S.R., MacLaren D.C. PET imaging of transgene expression. Med. Phys. 27:2000;1535-1543.
107. Gambhir S.S., Herschman H.R., Cherry S.R.et al. Imaging transgene expression with radionuclide imaging technologies. Neoplasia. 2:2000;118-138.
108. Gambhir S.S., Barrio J.R., Hershman H.R., Phelps M.E. Imaging gene expression. principles and assays J. Nucl. Cardiol. 6:1999;219-233.
109. Gambhir S.S., Barrio J.R., Hershman H.R., Phelps M.E. Assays for noninvasive imaging of reporter gene expression. Nucl. Med. Biol. 26:1999;481-490.
110. Yaghoubi S.S., Wu L., Liang Q.et al. Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors. Gene Ther. 8:2001;1072-1080.
111. 18F]Fluoropenciclovir. an improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET J. Nucl. Med. 42:2001;96-105.
112. Gambhir S.S., Bauer E., Black M.E.et al. A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc. Natl. Acad. Sci. 97:2000;2785-2790.
113. Gambhir S.S., Barrio J.R., Phelps M.E.et al. Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc. Natl. Acad. Sci. USA. 96:1999;2333-2338.
114. Dehdashti F., Mortimer J.E., Siegel B.A.et al. Positron tomographic assessment of estrogen receptors in breast cancer. comparison with FDG-PET and in vitro receptor assays J. Nucl. Med. 36:1995;1766-1774.
115. 18F]-fluoro-17β-estradiol in breast cancer. correlation with estrogen receptor status and response to systemic therapy Clin. Cancer Res. 2:1996;933-939.
116. Oyama N., Jones L.A., Sharp T.L., Welch M.J. Androgenic control of glucose and acetate metabolism in rat prostate and prostate cancer tumour model. Nucl. Med. 42:2001;26P.
117. Volkert W.A., Hoffman T.J. Therapeutic radiopharmaceuticals. Chem. Rev. 99:1999;2269-2292.
118. Katzenellenbogen J.A., Coleman R.E., Hawkins R.A.et al. Tumor receptor imaging. proceedings of the National Cancer Institute Workshop, review of current work, and prospective for further investigations Clin. Cancer Res. 1:1995;921-932.
119. Cutler C.S., Lewis J.S., Anderson C.J. Utilization of metabolic, transport and receptor-mediated processes to deliver agents for cancer diagnosis. Adv. Drug. Dev. Rev. 37:1999;189-211.
120. Reichert D.A., Lewis J.S., Anderson C.J. Metal complexes as diagnostic tools. Coord. Chem. Rev. 184:1999;3-66.
121. Goldenberg D.M. Cancer Imaging and Therapy with Radiolabeled Antibodies. 1991;Plenum Press, New York.
122. Wu A.M., Yazaki P.J., Tsai S.et al. High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment. Proc. Natl. Acad. Sci. USA. 97:2000;8495-8500.
123. de Jong M., Breeman W.A.P., Bakker W.H.et al. Comparison of 111In-labeled somatostatin analogues for tumor scintigraphy and radionuclide therapy. Cancer Res. 58:1998;437-441.
124. 3]octreotide as carriers for somatostatin receptor-targeted scintigraphy and radionuclide therapy. Int. J. Cancer. 75:1998;406-411.
125. 64Cu-labeled somatostatin analogues in vitro and in a tumor-bearing rat model. evaluation of new derivatives for positron emission tomography imaging and targeted radiotherapy J. Med. Chem. 42:1999;1341-1347.
126. 1-octreotate: a somatostatin analog for labeling with metal and halogen radiolnuclides for cancer imaging and therapy. Bioconj Chem 2002, 13, 721-728.
127. 3-octreotide as a potential agent for positron emission tomography imaging and receptor mediated internal radiotherapy of somatostatin receptor positive tumors. Nucl. Med. Biol. 29:2002;147-157.
128. 4-methylthiosemicarbazone) for imaging cell trafficking in mice with positron-emission tomography. Proc. Natl. Acad. Sci. USA. 99:2002;3030-3035.
129. Sun X, Kim YJ, Bigott B, Kovacs Z, Sherry AD, Welch MJ, Anderson CJ. A potential bone-imaging agent: copper-64-labeled 1,4,7,10-tetraazacyclododecane-1,4,7-tri(methanephosphonic acid) J Nucl Med 2002, 43, 136P.
130. Shah N., Cerussi A., Eker C.et al. Noninvasive functional optical spectroscopy of human breast tissue. Proc. Natl. Acad. Sci. USA. 98:2001;4420-4425.
131. Hawrysz D.J., Sevick-Muraca E.M. Developments toward diagnostic breast cancer imaging using near-infrared optical measurements and fluorescent contrast agents. Neoplasia. 2:2000;388-417.
132. Schotland J.C. Continuous-wave diffusion imaging. J. Opt. Soc. Am. A - Optics Image Sci. Vision. 14:1997;275-279.
133. Lee J., Sevick-Muraca E. Fluorescence-enhanced absorption imaging using frequency-domain photon migration. tolerance to measurement error J. Biomed. Opt. 6:2001;58-67.
134. Cheong W.F., vanHouten J.P., Kermit E.L., Machold T.R., Stevenson D.K., Benaron D.A. Pilot comparison of light-based optical tomography versus ultrasound for real-time imaging of neonatal intraventricular hemorrhage. Pediatric Res. 39:1996;1189.
135. Rhine W.D., Benaron D.A., Darceuil H.E.et al. Simultaneous time of-flight adjusted (TOFA) near-infrared spectroscopy and magnetic resonance imaging of immature rabbit hypoxic-ischemic encephalopathy (HIE). Pediatric. Res. 39:1996;2264.
136. Wagnieres G.A., Star W.M., Wilson B.C. In vivo fluorescence spectroscopy and imaging for oncological applications. Photochem. Photobiol. 68:1998;603-632.
137. Ntziachristos V., Yodh A.G., Schnall M., Chance B. Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement. Proc. Natl. Acad. Sci. USA. 97:2000;2767-2772.
138. Cubeddu R., Pifferi A., Taroni P.et al. Fluorescence imaging during photodynamic therapy of experimental tumors in mice sensitized with disulfonated aluminum phthalocyanine. Photochem. Photobiol. 72:2000;690-695.
139. Achilefu S., Dorshow R.B., Bugaj J.E., Rajagopalan R. Novel receptor-targeted fluorescent contrast agents for in vivo tumor imaging. Invest. Radiol. 35:2000;479-485.
140. Bugaj J.E., Achilefu S., Dorshow R.B., Rajagopalan R. Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform. J. Biomed. Opt. 6:2001;122-133.
141. Bigio I.J., Mourant J.R. Ultraviolet and visible spectroscopies for tissue diagnostics. fluorescence spectroscopy and elastic-scattering spectroscopy Phys. Med. Biol. 42:1997;803-814.
142. Round A.J., Duller A.W.G., Fish P.J. Lesion classification using skin patterning. Skin Res. Tech. 6:2000;183-192.
143. Wallace V.P., Bamber J.C., Crawford D.C., Ott R.J., Mortimer P.S. Classification of reflectance spectra from pigmented skin lesions, a comparison of multivariate discriminant analysis and artificial neural networks. Phys. Med. Biol. 45:2000;2859-2871.
144. So P.T.C., Kim H., Kochevar I.E. Two-photon deep tissue ex vivo imaging of mouse dermal and subcutaneous structures. Optics Express. 3:1998;339-350.
145. Sterenborg H., Motamedi M., Wagner R.F., Duvic M., Thomsen S., Jacques S.L. In-vivo fluorescence spectroscopy and imaging of human skin tumors. Lasers Med. Sci. 9:1994;191-201.
146. Villringer A., Chance B. Non-invasive optical spectroscopy and imaging of human brain function. Trends Neurosci. 20:1997;435-442.
147. Seville M. A whole new way of looking at things. the use of Dark Reader technology to detect fluorophors Electrophoresis. 22:2001;814-828.
148. Tromberg B.J., Shah N., Lanning R.et al. Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy. Neoplasia. 2:2000;26-40.
149. Brancaleon L., Durkin A.J., Tu J.H., Menaker G., Fallon J.D., Kollias N. In vivo fluorescence spectroscopy of nonmelanoma skin cancer. Photochem. Photobiol. 73:2001;178-183.
150. Young A.R. Chromophores in human skin. Phys. Med. Biol. 42:1997;789-802.
151. Reynolds J.S., Troy T.L., Mayer R.H.et al. Imaging of spontaneous canine mammary tumors using fluorescent contrast agents. Photochem. Photobiol. 70:1999;87-94.
152. Nioka S., Yung Y., Shnall M.et al. Optical imaging of breast tumor by means of continuous waves. Adv. Exp. Med. Biol. 411:1997;227-232.
153. Sevick-Muraca E.M., Lopez G., Reynolds J.S., Troy T.L., Hutchinson C.L. Fluorescence and absorption contrast mechanisms for biomedical optical imaging using frequency-domain techniques. Photochem. Photobiol. 66:1997;55-64.
154. Licha K., Riefke B., Ntziachristos V., Becker A., Chance B., Semmler W. Hydrophilic cyanine dyes as contrast agents for near-infrared tumor imaging. synthesis, photophysical properties and spectroscopic in vivo characterization Photochem. Photobiol. 72:2000;392-398.
155. Ntziachristos V., Chance B. Probing physiology and molecular function using optical imaging. applications to breast cancer Breast Cancer Res. 3:2001;41-46.
156. Pelegrin A., Folli S., Buchegger F., Mach J.P., Wagnieres G., Vandenbergh H. Antibody fluorescein conjugates for photoimmunodiagnosis of human colon-carcinoma in nude-mice. Cancer. 67:1991;2529-2537.
157. Vogel C.A., Galmiche M.C., Westermann P.et al. Carcinoembryonic antigen expression, antibody localisation and immunophotodetection of human colon cancer liver metastases in nude mice. a model for radioimmunotherapy Int. J. Cancer. 67:1996;294-302.
158. Ballou B., Fisher G.W., Hakala T.R., Farkas D.L. Tumor detection and visualization using cyanine fluorochrome-labeled antibodies. Biotechnol. Prog. 13:1997;649-658.
159. Clauss M.A., Jain R.K. Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues. Cancer Res. 50:1990;3487-3492.
160. Folli S., Westermann P., Braichotte D.et al. Antibody-indocyanin conjugates for immunophotodetection of human squamous-cell carcinoma in nude-mice. Cancer Res. 54:1994;2643-2649.
161. Ballou B., Fisher G.W., Deng J.S., Hakala T.R., Srivastava M., Farkas D.L. Cyanine fluorochrome-labeled antibodies in vivo. assessment of tumor imaging using Cy3, Cy5, Cy5.5, and Cy7 Cancer Detect. Prev. 22:1998;251-257.
162. Ballou B., Fisher G.W., Waggoner A.S.et al. Tumor labeling in-vivo using cyanine-conjugated monoclonal-antibodies. Cancer Immunol. Immunother. 41:1995;257-263.
163. Becker A., Hessenius C., Licha K.et al. Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands. Nature Biotechnol. 19:2001;327-331.
164. Stolz B., Weckbecker G., Smith-Jones P.M., Albert R., Raulf F., Bruns C. The somatostatin receptor-targeted radiotherapeutic [Y-90-DOTA- DPhe(1),Tyr(3)]octreotide (Y-90-SMT 487) eradicates experimental rat pancreatic CA 20948 tumours. Eur. J. Nucl. Med. 25:1998;668-674.
165. Urizzi P., Allen C.M., Langlois R., Ouellet R., La Madeleine C., Van Lier J.E. Low-density lipoprotein-bound aluminum sulfophthalocyanine. targeting tumor cells for photodynamic therapy J. Porphyrins Phthalocyanines. 5:2001;154-160.
166. Callahan D.E., Forte T.M., Afzal S.M.J.et al. Boronated protoporphyrin (BOPP). localization in lysosomes of the human glioma cell line SF-767 with uptake modulated by lipoprotein levels Int. J. Radiat. Oncol. Biol. Phys. 45:1999;761-771.
167. Schmidt-Erfurth U., Diddens H., Birngruber R., Hasan T. Photodynamic targeting of human retinoblastoma cells using covalent low-density lipoprotein conjugates. Br. J. Cancer. 75:1997;54-61.
168. Maziere J.C., Morliere P., Biade S., Santus R. Photochemotherapy of tumors - biochemical basis, therapeutic application and prospects. Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales. 186:1992;88-106.
169. Hamblin M.R., Newman E.L. Photosensitized targeting in photodynamic therapy 2. Conjugates of hematoporphyrin with serum-lipoproteins. J. Photochem. Photobiol. B-Biol. 26:1994;147-157.
170. Allison B.A., Pritchard P.H., Levy J.G. Evidence for low-density-lipoprotein receptor-mediated uptake of benzoporphyrin derivative. Br. J. Cancer. 69:1994;833-839.
171. Desmidt P.C., Versluis A.J., Vanberkel T.J.C. Properties of incorporation, redistribution, and integrity of porphyrin low-density-lipoprotein complexes. Biochemistry. 32:1993;2916-2922.
172. Maziere J.C., Morliere P., Santus R. New trends in photobiology (invited teview) - the role of the low-density-lipoprotein receptor pathway in the delivery of lipophilic photosensitizers in the photodynamic therapy of tumors. J. Photochem. Photobiol. B-Biol. 8:1991;351-360.
173. Fischer F., Dickson E.F., Kennedy J.C., Pottier R.H. An affordable, portable fluorescence imaging device for skin lesion detection using a dual wavelength approach for image contrast enhancement and aminolaevulinic acid-induced protoporphyrin IX. Part II. In vivo testing. Lasers Med. Sci. 16:2001;207-212.
174. Hillemanns P., Weingandt H., Baumgartner R., Diebold J., Xiang W., Stepp H. Photodetection of cervical intraepithelial neoplasia using 5-aminolevulinic acid-induced porphyrin fluorescence. Cancer. 88:2000;2275-2282.
175. Hewett J., Nadeau V., Ferguson J.et al. The application of a compact multispectral imaging system with integrated excitation source to in vivo monitoring of fluorescence during topical photodynamic therapy of superficial skin cancers. Photochem. Photobiol. 73:2001;278-282.
176. Subbarayan M., Shetty S.J., Srivastava T.S., Noronha O.P.D., Samuel A.M., Mukhtar H. Water-soluble Tc-99m-labeled dendritic novel porphyrins tumor imaging and diagnosis. Biochem. Biophys. Res. Commun. 281:2001;32-36.
177. Hayase M., Woodbum K.W., Perlroth J.et al. Photoangioplasty with local motexafin lutetium delivery reduces macrophages in a rabbit post-balloon injury model. Cardiovasc Res. 49:2001;449-455.
178. Lam S., MacAulay C., leRiche J.C., Palcic B. Detection and localization of early lung cancer by fluorescence bronchoscopy. Cancer. 89:2000;2468-2473.
179. Sutton J.M., Fernandez N., Boyle R.W. Functionalized diphenylchlorins and bacteriochlorins. their synthesis and bioconjugation for targeted photodynamic therapy and tumour cell imaging J. Porphyrins. Phthalocyanines. 4:2000;655-658.
180. van den Akker J., de Bruijn H.S., van Henegouwen G., Star W.M., Sterenborg H. Protoporphyrin IX fluorescence kinetics and localization after topical application of ALA pentyl ester and ALA on hairless mouse skin with UVB-induced early skin cancer. Photochem. Photobiol. 72:2000;399-406.
181. Gurfinkel M., Thompson A.B., Ralston W.et al. Pharmacokinetics of ICG and HPPH-car for the detection of normal and tumor tissue using fluorescence, near-infrared reflectance imaging. a case study Photochem. Photobiol. 72:2000;94-102.
182. Weissleder R., Tung C.H., Mahmood U., Bogdanov A. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nature Biotech. 17:1999;375-378.
183. Bremer C., Tung C.H., Weissleder R. In vivo molecular target assessment of matrix metalloproteinase inhibition. Nature Med. 7:2001;743-748.
184. Hoffman R.M. Visualization of GFP-expressing tumors and metastasis in vivo. Biotechniques. 30:2001;1016-1022.
185. Yang M., Baranov E., Li X.M.et al. Whole-body and intravital optical imaging of angiogenesis in orthotopically implanted tumors. Proc. Natl. Acad. Sci. USA. 98:2001;2616-2621.
186. Mahmood U., Tung C.H., Bogdanov A., Weissleder R. Near-infrared optical imaging of protease activity for tumor detection. Radiology. 213:1999;866-870.
187. Moore A., Marecos E., Simonova M., Weissleder R., Bogdanov A. Novel gliosarcoma cell line expressing green fluorescent protein. a model for quantitative assessment of angiogenesis Microvascular Res. 56:1998;145-153.
188. Edinger M., Sweeney T.J., Tucker A.A., Adesuwa O.B., Negrin R.S., Contag C.H. Noninvasive assessment of tumor cell proliferation in animal models. Neoplasia. 1:1999;303-310.
189. Becker A., Riefke B., Ebert B.et al. Macromolecular contrast agents for optical imaging of tumors. comparison of indotricarbocyanine-labeled human serum albumin and transferrin Photochem. Photobiol. 72:2000;234-241.