메뉴 건너뛰기




Volumn 16, Issue 6, 2004, Pages 732-737

Cellular mechanisms of T cell mediated drug hypersensitivity

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; CONTRAST MEDIUM; HAPTEN; LAMOTRIGINE; LIDOCAINE; MEPIVACAINE; PHENYLENEDIAMINE; SULFAMETHOXAZOLE; T LYMPHOCYTE RECEPTOR;

EID: 7044226467     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2004.09.016     Document Type: Review
Times cited : (57)

References (42)
  • 1
    • 0142087834 scopus 로고    scopus 로고
    • Delayed drug hypersensitivity reactions
    • W.J. Pichler Delayed drug hypersensitivity reactions Ann Intern Med 139 2003 683 693 A comprehensive review on how drugs interact with the immune system, leading to different forms of immune reactions. Based on the heterogeneous picture of drug-induced exanthema, a new subclassification of type IV reactions into IVa-IVd is proposed.
    • (2003) Ann Intern Med , vol.139 , pp. 683-693
    • Pichler, W.J.1
  • 2
    • 0028077408 scopus 로고
    • Severe adverse cutaneous reactions to drugs
    • J.C. Roujeau, and R.S. Stern Severe adverse cutaneous reactions to drugs N Engl J Med 331 1994 1272 1285
    • (1994) N Engl J Med , vol.331 , pp. 1272-1285
    • Roujeau, J.C.1    Stern, R.S.2
  • 4
    • 0031719374 scopus 로고    scopus 로고
    • Role of drug disposition in drug hypersensitivity: A chemical, molecular, and clinical perspective
    • B.K. Park, M. Pirmohamed, and N.R. Kitteringham Role of drug disposition in drug hypersensitivity: A chemical, molecular, and clinical perspective Chem Res Toxicol 11 1998 969 987
    • (1998) Chem Res Toxicol , vol.11 , pp. 969-987
    • Park, B.K.1    Pirmohamed, M.2    Kitteringham, N.R.3
  • 5
    • 0034529448 scopus 로고    scopus 로고
    • Immunological principles of adverse drug reactions: The initiation and propagation of immune responses elicited by drug treatment
    • D.J. Naisbitt, S.F. Gordon, M. Pirmohamed, and B.K. Park Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment Drug Saf 23 2000 483 507
    • (2000) Drug Saf , vol.23 , pp. 483-507
    • Naisbitt, D.J.1    Gordon, S.F.2    Pirmohamed, M.3    Park, B.K.4
  • 7
    • 0033774505 scopus 로고    scopus 로고
    • T cells isolated from positive epicutaneous test reactions to amoxicillin and ceftriaxone are drug specific and cytotoxic
    • N. Yawalkar, Y. Hari, K. Frutig, F. Egli, T. Wendland, L.R. Braathen, and W.J. Pichler T cells isolated from positive epicutaneous test reactions to amoxicillin and ceftriaxone are drug specific and cytotoxic J Invest Dermatol 115 2000 647 652
    • (2000) J Invest Dermatol , vol.115 , pp. 647-652
    • Yawalkar, N.1    Hari, Y.2    Frutig, K.3    Egli, F.4    Wendland, T.5    Braathen, L.R.6    Pichler, W.J.7
  • 8
    • 0344951264 scopus 로고    scopus 로고
    • Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones
    • D.J. Naisbitt, M. Britschgi, G. Wong, J. Farrell, J.P. Depta, D.W. Chadwick, W.J. Pichler, M. Pirmohamed, and B.K. Park Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones Mol Pharmacol 63 2003 732 741 A detailed analysis of the specific T cell immune response in patients with carbamazepine hypersensitivity. The clones analyzed in detail secreted high amounts of IFN-γ but low amounts of IL-5, which distinguishes them from clones isolated from patients with cutaneous symptoms. Interestingly, all clones expressed the skin-homing receptor cutaneous lymphocyte antigen (CLA) and secreted substantial amounts of IFN-γ. Moreover, the parent compound was recognized by the TCCs.
    • (2003) Mol Pharmacol , vol.63 , pp. 732-741
    • Naisbitt, D.J.1    Britschgi, M.2    Wong, G.3    Farrell, J.4    Depta, J.P.5    Chadwick, D.W.6    Pichler, W.J.7    Pirmohamed, M.8    Park, B.K.9
  • 9
    • 0038797941 scopus 로고    scopus 로고
    • Characterization of drug-specific T cells in lamotrigine hypersensitivity
    • D.J. Naisbitt, J. Farrell, G. Wong, J.P. Depta, C.C. Dodd, J.E. Hopkins, C.A. Gibney, D.W. Chadwick, W.J. Pichler, M. Pirmohamed, and B.K. Park Characterization of drug-specific T cells in lamotrigine hypersensitivity J Allergy Clin Immunol 111 2003 1393 1403 A detailed analysis of the specific T cell immune response in patients with systemic lamotrigine hypersensitivity with hepatic involvement. Interestingly, all clones expressed the skin-homing receptor cutaneous lymphocyte antigen (CLA) and secreted substantial amounts of IFN-γ, IL-5 and several chemokines. Moreover, the parent compound was recognized by the TCCs.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 1393-1403
    • Naisbitt, D.J.1    Farrell, J.2    Wong, G.3    Depta, J.P.4    Dodd, C.C.5    Hopkins, J.E.6    Gibney, C.A.7    Chadwick, D.W.8    Pichler, W.J.9    Pirmohamed, M.10    Park, B.K.11
  • 10
    • 0030918532 scopus 로고    scopus 로고
    • Penicilloyl peptides are recognized as T cell antigenic determinants in penicillin allergy
    • E. Padovan, T. Bauer, M.M. Tongio, H. Kalbacher, and H.U. Weltzien Penicilloyl peptides are recognized as T cell antigenic determinants in penicillin allergy Eur J Immunol 27 1997 1303 1307
    • (1997) Eur J Immunol , vol.27 , pp. 1303-1307
    • Padovan, E.1    Bauer, T.2    Tongio, M.M.3    Kalbacher, H.4    Weltzien, H.U.5
  • 11
    • 0031691280 scopus 로고    scopus 로고
    • Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells
    • A. Cavani, D. Mei, E. Guerra, S. Corinti, M. Giani, L. Pirrotta, P. Puddu, and G. Girolomoni Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells J Invest Dermatol 111 1998 621 628
    • (1998) J Invest Dermatol , vol.111 , pp. 621-628
    • Cavani, A.1    Mei, D.2    Guerra, E.3    Corinti, S.4    Giani, M.5    Pirrotta, L.6    Puddu, P.7    Girolomoni, G.8
  • 12
    • 0037515534 scopus 로고    scopus 로고
    • A new type of metal recognition by human T cells: Contact residues for peptide-independent bridging of T cell receptor and major histocompatibility complex by nickel
    • K. Gamerdinger, C. Moulon, D.R. Karp, J. Van Bergen, F. Koning, D. Wild, U. Pflugfelder, and H.U. Weltzien A new type of metal recognition by human T cells: contact residues for peptide-independent bridging of T cell receptor and major histocompatibility complex by nickel J Exp Med 197 2003 1345 1353 This is a very detailed and comprehensive structure/function analysis of a Ni-specific TCC, which identifies three Ni coordination sites, two on the TCR and one in the MHC. The direct linkage between TCR and MHC is similar to superantigen stimulation even though idiotypic residues are required for stimulation.
    • (2003) J Exp Med , vol.197 , pp. 1345-1353
    • Gamerdinger, K.1    Moulon, C.2    Karp, D.R.3    Van Bergen, J.4    Koning, F.5    Wild, D.6    Pflugfelder, U.7    Weltzien, H.U.8
  • 15
    • 0034605712 scopus 로고    scopus 로고
    • Idiosyncratic drug reactions: The reactive metabolite syndromes
    • S.R. Knowles, J. Uetrecht, and N.H. Shear Idiosyncratic drug reactions: the reactive metabolite syndromes Lancet 356 2000 1587 1591
    • (2000) Lancet , vol.356 , pp. 1587-1591
    • Knowles, S.R.1    Uetrecht, J.2    Shear, N.H.3
  • 16
    • 0036676978 scopus 로고    scopus 로고
    • Pharmacological interaction of drugs with antigen-specific immune receptors: The p-i concept
    • W.J. Pichler Pharmacological interaction of drugs with antigen-specific immune receptors: the p-i concept Curr Opin Allergy Clin Immunol 2 2002 301 305
    • (2002) Curr Opin Allergy Clin Immunol , vol.2 , pp. 301-305
    • Pichler, W.J.1
  • 17
    • 0030822702 scopus 로고    scopus 로고
    • Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones
    • B. Schnyder, D. Mauri-Hellweg, M. Zanni, F. Bettens, and W.J. Pichler Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones J Clin Invest 100 1997 136 141
    • (1997) J Clin Invest , vol.100 , pp. 136-141
    • Schnyder, B.1    Mauri-Hellweg, D.2    Zanni, M.3    Bettens, F.4    Pichler, W.J.5
  • 20
    • 0036279452 scopus 로고    scopus 로고
    • Delayed-type hypersensitivity reaction to paraphenylenediamine is mediated by 2 different pathways of antigen recognition by specific alphabeta human T-cell clones
    • S. Sieben, Y. Kawakubo, T. Al Masaoudi, H.F. Merk, and B. Blomeke Delayed-type hypersensitivity reaction to paraphenylenediamine is mediated by 2 different pathways of antigen recognition by specific alphabeta human T-cell clones J Allergy Clin Immunol 109 2002 1005 1011
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 1005-1011
    • Sieben, S.1    Kawakubo, Y.2    Al Masaoudi, T.3    Merk, H.F.4    Blomeke, B.5
  • 21
    • 0033660060 scopus 로고    scopus 로고
    • Delayed allergy-like reactions to X-ray contrast media: Mechanistic considerations
    • C. Christiansen, W.J. Pichler, and T. Skotland Delayed allergy-like reactions to X-ray contrast media: mechanistic considerations Eur Radiol 10 2000 1965 1975
    • (2000) Eur Radiol , vol.10 , pp. 1965-1975
    • Christiansen, C.1    Pichler, W.J.2    Skotland, T.3
  • 22
    • 0026552198 scopus 로고
    • Sulfamethoxazole is metabolized to the hydroxylamine in humans
    • A.E. Cribb, and S.P. Spielberg Sulfamethoxazole is metabolized to the hydroxylamine in humans Clin Pharmacol Ther 51 1992 522 526
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 522-526
    • Cribb, A.E.1    Spielberg, S.P.2
  • 27
    • 0033505138 scopus 로고    scopus 로고
    • Functional expression and analysis of a human HLA-DQ restricted, nickel-reactive T cell receptor in mouse hybridoma cells
    • J. Vollmer, H.U. Weltzien, A. Dormoy, F. Pistoor, and C. Moulon Functional expression and analysis of a human HLA-DQ restricted, nickel-reactive T cell receptor in mouse hybridoma cells J Invest Dermatol 113 1999 175 181
    • (1999) J Invest Dermatol , vol.113 , pp. 175-181
    • Vollmer, J.1    Weltzien, H.U.2    Dormoy, A.3    Pistoor, F.4    Moulon, C.5
  • 28
    • 1542616264 scopus 로고    scopus 로고
    • Drug interaction with T-cell receptors: T-cell receptor density determines degree of cross-reactivity
    • J.P. Depta, F. Altznauer, K. Gamerdinger, C. Burkhart, H.U. Weltzien, and W.J. Pichler Drug interaction with T-cell receptors: T-cell receptor density determines degree of cross-reactivity J Allergy Clin Immunol 113 2004 519 527 This is a comprehensive analysis of hybridoma cells transfected with SMX-specific TCR to investigate the influence of receptor density, specificity and cross-specificity on various cellular responses. A higher density led to a broader cross-reactivity, closely mimicking the phenotype of the original TCCs.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 519-527
    • Depta, J.P.1    Altznauer, F.2    Gamerdinger, K.3    Burkhart, C.4    Weltzien, H.U.5    Pichler, W.J.6
  • 29
    • 0035112838 scopus 로고    scopus 로고
    • Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells
    • C. Burkhart, S. von Greyerz, J.P. Depta, D.J. Naisbitt, M. Britschgi, K.B. Park, and W.J. Pichler Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole- metabolite-specific human CD4+ T-cells Br J Pharmacol 132 2001 623 630
    • (2001) Br J Pharmacol , vol.132 , pp. 623-630
    • Burkhart, C.1    Von Greyerz, S.2    Depta, J.P.3    Naisbitt, D.J.4    Britschgi, M.5    Park, K.B.6    Pichler, W.J.7
  • 30
    • 0031896946 scopus 로고    scopus 로고
    • Allele-unrestricted presentation of lidocaine by HLA-DR molecules to specific αβ+ T cell clones
    • M.P. Zanni, S. von Greyerz, B. Schnyder, T. Wendland, and W.J. Pichler Allele-unrestricted presentation of lidocaine by HLA-DR molecules to specific αβ+ T cell clones Int Immunol 10 1998 507 515
    • (1998) Int Immunol , vol.10 , pp. 507-515
    • Zanni, M.P.1    Von Greyerz, S.2    Schnyder, B.3    Wendland, T.4    Pichler, W.J.5
  • 31
    • 0036434911 scopus 로고    scopus 로고
    • Non-covalent presentation of sulfamethoxazole to human CD4+ T cells is independent of distinct human leucocyte antigen-bound peptides
    • C. Burkhart, M. Britschgi, I. Strasser, J.P. Depta, S. von Greyerz, V. Barnaba, and W.J. Pichler Non-covalent presentation of sulfamethoxazole to human CD4+ T cells is independent of distinct human leucocyte antigen-bound peptides Clin Exp Allergy 32 2002 1635 1643
    • (2002) Clin Exp Allergy , vol.32 , pp. 1635-1643
    • Burkhart, C.1    Britschgi, M.2    Strasser, I.3    Depta, J.P.4    Von Greyerz, S.5    Barnaba, V.6    Pichler, W.J.7
  • 32
    • 0032960782 scopus 로고    scopus 로고
    • Interaction of sulfonamide derivatives with the TCR of sulfamethoxazole-specific human αβ+ T cell clones
    • S. von Greyerz, M.P. Zanni, K. Frutig, B. Schnyder, C. Burkhart, and W.J. Pichler Interaction of sulfonamide derivatives with the TCR of sulfamethoxazole-specific human αβ+ T cell clones J Immunol 162 1999 595 602
    • (1999) J Immunol , vol.162 , pp. 595-602
    • Von Greyerz, S.1    Zanni, M.P.2    Frutig, K.3    Schnyder, B.4    Burkhart, C.5    Pichler, W.J.6
  • 34
    • 0035369825 scopus 로고    scopus 로고
    • Genetic susceptibility to adverse drug reactions
    • M. Pirmohamed, and B.K. Park Genetic susceptibility to adverse drug reactions Trends Pharmacol Sci 22 2001 298 305
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 298-305
    • Pirmohamed, M.1    Park, B.K.2
  • 35
    • 0141791128 scopus 로고    scopus 로고
    • Cytochrome P450 enzyme polymorphisms and adverse drug reactions
    • M. Pirmohamed, and B.K. Park Cytochrome P450 enzyme polymorphisms and adverse drug reactions Toxicology 192 2003 23 32
    • (2003) Toxicology , vol.192 , pp. 23-32
    • Pirmohamed, M.1    Park, B.K.2
  • 36
  • 37
    • 0035836342 scopus 로고    scopus 로고
    • TNFalpha promoter region gene polymorphisms in carbamazepine- hypersensitive patients
    • M. Pirmohamed, K. Lin, D. Chadwick, and B.K. Park TNFalpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients Neurology 56 2001 890 896
    • (2001) Neurology , vol.56 , pp. 890-896
    • Pirmohamed, M.1    Lin, K.2    Chadwick, D.3    Park, B.K.4
  • 39
    • 1842784823 scopus 로고    scopus 로고
    • Medical genetics: A marker for Stevens-Johnson syndrome
    • W.H. Chung, S.I. Hung, H.S. Hong, M.S. Hsih, L.C. Yang, H.C. Ho, J.Y. Wu, and Y.T. Chen Medical genetics: a marker for Stevens-Johnson syndrome Nature 428 2004 486 This is the second demonstration of an HLA association with a drug hypersensitivity reaction, and the strongest known association between an HLA allele and any disease to date.
    • (2004) Nature , vol.428 , pp. 486
    • Chung, W.H.1    Hung, S.I.2    Hong, H.S.3    Hsih, M.S.4    Yang, L.C.5    Ho, H.C.6    Wu, J.Y.7    Chen, Y.T.8
  • 40
    • 1542285424 scopus 로고    scopus 로고
    • A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals
    • O.B. Engler, I. Strasser, D.J. Naisbitt, A. Cerny, and W.J. Pichler A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals Toxicology 197 2004 47 56 This paper describes for the first time the induction of a primary T cell immune response against a chemically inert drug in healthy individuals who have not been exposed to the drug previously.
    • (2004) Toxicology , vol.197 , pp. 47-56
    • Engler, O.B.1    Strasser, I.2    Naisbitt, D.J.3    Cerny, A.4    Pichler, W.J.5
  • 41
    • 0034256051 scopus 로고    scopus 로고
    • Can peptides be mimicked?
    • N.R. Beeley Can peptides be mimicked? Drug Discov Today 5 2000 354 363
    • (2000) Drug Discov Today , vol.5 , pp. 354-363
    • Beeley, N.R.1
  • 42
    • 0029791171 scopus 로고    scopus 로고
    • Antibody deficiency associated with gold treatment: Natural history and management in 22 patients
    • N. Snowden, D.M. Dietch, L.S. Teh, R.C. Hilton, and M.R. Haeney Antibody deficiency associated with gold treatment: natural history and management in 22 patients Ann Rheum Dis 55 1996 616 621
    • (1996) Ann Rheum Dis , vol.55 , pp. 616-621
    • Snowden, N.1    Dietch, D.M.2    Teh, L.S.3    Hilton, R.C.4    Haeney, M.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.