Drug interaction with T-cell receptors: T-cell receptor density determines degree of cross-reactivity

Journal of Allergy and Clinical Immunology

Volumn 113, Issue 3, 2004, Pages 519-527

  Depta, Jan Paul Heribert ^a   Altznauer, Frank ^a   Gamerdinger, Katharina ^b   Burkhart, Christoph ^a   Weltzien, Hans Ulrich ^b   Pichler, Werner Joseph ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

Cross reactivity; Drug hypersensitivity; Drug reactive T cells; Sulfonamides; T cell receptor

Indexed keywords

ANTIINFECTIVE AGENT; CELECOXIB; FUROSEMIDE; GLIBENCLAMIDE; GLUTARALDEHYDE; INTERLEUKIN 2; SULFADIAZINE; SULFADIMETHOXINE; SULFADIMIDINE; SULFADOXINE; SULFAMERAZINE; SULFAMETHIZOLE; SULFAMETHOXAZOLE; SULFAMETHOXYPYRIDAZINE; SULFAMETOXYDIAZINE; SULFAMOXOLE; SULFAPYRIDINE; SULFASOMIDINE; SULFATHIAZOLE; SULFONAMIDE; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTING CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CROSS REACTION; DRUG HYPERSENSITIVITY; DRUG STRUCTURE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYBRIDOMA; MAJOR HISTOCOMPATIBILITY COMPLEX; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DENSITY; T LYMPHOCYTE;

EID: 1542616264     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2003.11.030     Document Type: Article

References (33)

1. Landsteiner K, Jacobs J. Studies on the sensitization of animals with sim-ple chemical compounds. J Exp Med 1935;61:643-56.
2. Schneider CH, de Weck AL. Chemical aspects of penicillin allergy: the direct penicilloylation of epsilon-amino groups by penicillin at pH 7.4. Helv Chim Acta 1966;49:1695-706.
3. Schnyder B, Mauri-Hellweg D, Zanni M, Bettens F, Pichler WJ, Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones. J Clin Invest 1997;100:136-41.
4. Zanni MP, von Greyerz S, Schnyder B, Brander KA, Frutig K, Hari Y, et al. HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes. J Clin Invest 1998;102:1591-8.
5. von Greyerz S, Zanni MP, Frutig K, Schnyder B, Burkhart C, Pichler WJ. Interaction of sulfonamide derivatives with the TCR of sulfamethoxazole- specific human αβ+ T cell clones. J Immunol 1999;162:595-602.
6. Zanni MP, von Greyerz S, Schnyder B, Wendland T, Pichler WJ. Allele-unrestricted presentation of lidocaine by HLA-DR molecules to specific αβ+ T cell clones. Int Immunol 1998;10:507-15.
7. Burkhart C, Britschgi M, Strasser I, Depta JP, von Greyerz S, Barnaba V, et al. Non-covalent presentation of sulfamethoxazole to human CD4+ T cells is independent of distinct human leucocyte antigen-bound peptides. Clin Exp Allergy 2002;32:1635-43.
8. Pichler WJ. Pharmacological interaction of drugs with antigen-specific immune receptors: the p-I concept. Curr Opin Allergy Clin Immunol 2002;2:301-5.
9. Grabstein K, Eisenman J, Mochizuki D, Shanebeck K, Conlon P, Hopp T, et al. Purification to homogeneity of B cell stimulating factor: a molecule that stimulates proliferation of multiple lymphokine-dependent cell lines. J Exp Med 1986;163:1405-14.
10. Leo O, Foo M, Sachs DH, Samelson LE, Bluestone JA. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc Natl Acad Sci U S A 1987;84:1374-8.
11. Wei S, Charmley P, Robinson MA, Concannon P. The extent of the human germline T-cell receptor V beta gene segment repertoire. Immunogenetics 1994;40:27-36.
12. Schnyder B, Burkhart C, Schnyder-Frutig K, von Greyerz S, Naisbitt DJ, Pirmohamed M, et al. Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals. J Immunol 2000;164:6647-54.
13. Zanni MP, Mauri-Hellweg D, Brander C, Wendland T, Schnyder B, Frei E, et al. Characterization of lidocaine-specific T cells. J Immunol 1997;158:1139-48.
14. Blank U, Boitel B, Mege D, Ermonval M, Acuto O. Analysis of tetanus toxin peptide/DR recognition by human T cell receptors reconstituted into a murine T cell hybridoma. Eur J Immunol 1993;23:3057-65.
15. Letourneur F, Malissen B. Derivation of a T cell hybridoma variant deprived of functional T cell receptor alpha and beta chain transcripts reveals a nonfunctional alpha-mRNA of BW5147 origin. Eur J Immunol 1989;19:2269-74.
16. Glaichenhaus N, Shastri N, Littman DR, Turner JM, Requirement for association of p561ck with CD4 in antigen-specific signal transduction in T cells. Cell 1991;64:511-20.
17. Altznauer F, von Gunten S, Späth P, Simon HU. Concurrent presence of agonistic and antagonistic anti-CD95 autoantibodies in intravenous immunoglobulin (IVIg) preparations. J Allergy Clin Immunol 2003;112:1185-90.
18. Genevee C, Diu A, Nierat J, Caignard A, Dietrich PY, Ferradini L, et al. An experimentally validated panel of subfamily-specific oligonucleotide primers (V alpha 1-w29/V beta 1-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction. Eur J Immunol 1992;22:1261-9.
19. Casorati G, Traunecker A, Karjalainen K. The T cell receptor alpha beta V-J shuffling shows lack of autonomy between the combining site and the constant domain of the receptor chains. Eur J Immunol 1993;23:586-9.
20. Vollmer J, Weltzien HU, Dormoy A, Pistoor F, Moulon C. Functional expression and analysis of a human HLA-DQ restricted, nickel-reactive T cell receptor in mouse hybridoma cells. J Invest Dermatol 1999;113:175-81.
21. Lefranc MP. The T cell receptor facts book. London: Academic Press; 2001.
22. Vollmer J, Weltzien HU, Moulon C. TCR reactivity in human nickel allergy indicates contacts with complementarity-determining region 3 but excludes superantigen-like recognition. J Immunol 1999;163:2723-31.
23. Gamerdinger K, Moulon C, Karp DR, Van Bergen J, Koning F, Wild D, et al. A new type of metal recognition by human T cells: contact residues for peptide-independent bridging of T cell receptor and major histocompatibility complex by nickel. J Exp Med 2003;197:1345-53.
24. Whitehurst CE, Geppert TD. MEK1 and the extracellular signal-regulated kinases are required for the stimulation of 1L-2 gene transcription in T cells. J Immunol 1996;156:1020-9.
25. von Greyerz S, Bultemann G, Schnyder K, Burkhart C, Lotti B, Hari Y, et al. Degeneracy and additional alloreactivity of drag-specific human alpha beta(+) T cell clones. Int Immunol 2001;13:877-85.
26. von Greyerz S, Burkhart C, Pichler WJ. Molecular basis of drug recognition by specific T-cell receptors. Int Arch Allergy Immunol 1999;119:173-80.
27. Britschgi M, Steiner UC, Schmid S, Depta JP, Senti G, Bircher A, et al. T-cell involvement in drug-induced acute generalized exanthematous pustulosis. J Clin Invest 2001;107:1433-41.
28. Zanni MP, von Greyerz S, Hari Y, Schnyder B, Pichler WJ, Recognition of local anesthetics by alphabeta+ T cells. J Invest Dermatol 1999;112:197-204.
29. Kim DT, Rothbard JB, Bloom DD, Fathman CG. Quantitative analysis of T cell activation: role of TCR/ligand density and TCR affinity. J Immunol 1996;156:2737-42.
30. Viola A, Lanzavecchia A. T cell activation determined by T cell receptor number and tunable thresholds. Science 1996;273:p104-6.
31. Depta JP, Pichler WJ. Cross-reactivity with drugs at the T cell level. Curr Opin Allergy Clin Immunol 2003;3:261-7.
32. Zhao Z, Baldo BA, Rimmer J. Beta-lactam allergenic determinants: fine structural recognition of a cross-reacting determinant on benzylpenicillin and cephalothin. Clin Exp Allergy 2002;32:1644-50.
33. Fernandez M, Warbrick EV, Blanca M, Coleman JW. Activation and hapten inhibition of mast cells sensitized with monoclonal IgE anti-penicillin antibodies: evidence for two-site recognition of the penicillin derived determinant. Eur J Immunol 1995;25:2486-91.