메뉴 건너뛰기




Volumn 17, Issue 4, 2009, Pages 298-310

Muscarinic receptors in psychiatric disorders -Can we mimic 'health'?

Author keywords

Bipolar disorder; Depression; Muscarinic receptors; Schizophrenia; Signaling pathways

Indexed keywords

1,6 DIMETHYL 4 (6 NITROBENZO[D][1,3] DIOXOL 5 YL) 2 OXO 1,2,3,4 TETRAHYTETRAHYDROPYRIMIDINE 5 CARBOXYLATE; 2 (4 ETHOXYPHENYLAMINO) N' ((2 HYDROXYNAPHTHALEN 1 YL)METHYLENE)ACETOHYDRAZIDE; 3 AMINO 5 CHLORO 6 METHOXY 4 METHYLTHITHIENO(2,3 B)PYRIDINE 2 CARBOXYLIC ACID CYCLOPROPYLAMIDE; 3 AMINO N (4 METHOXYBENZYL) 4,6 DIMETHYLTHIENO [2,3 B] PYRIDINE CARBOXAMIDE; 3 AMINO N (BENZO[D][1,3]DIOXOL 5 YLMETHYL) 4,6 DIMETHYLTHIENO[2,3 B]PYRIDINE CARBOXAMIDE; 3 AMINO N [(4 CHLOROPHENYL)METHYL] 4,6 DIMETHYLTHIENO[2,3 B]PYRIDINE 2 CARBOXAMIDE; 4 (4 [3 (4 BUTYLPIPERIDIN 1 YL) PROPYL] 7 FLUORO 4H BENZO[1,4]OXAZIN 3 ONE; AC 260584; ACETYLCHOLINE; ACP 104; LY 2033298; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; NEUROLEPTIC AGENT; NEUROMUSCULAR BLOCKING AGENT; NORCLOZAPINE; OXOTREMORINE; PHYSOSTIGMINE; PLACEBO; SCOPOLAMINE; UNCLASSIFIED DRUG; VU 0029767; VU 0090157; VU 0152099; VU 0152100; VU 100010; XANOMELINE;

EID: 70350780200     PISSN: 1424862X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000231896     Document Type: Review
Times cited : (23)

References (113)
  • 1
    • 0033033206 scopus 로고    scopus 로고
    • The cholinergic 'pitfall': Acetylcholine, a universal cell molecule in biological systems, including humans
    • Wessler I, Kirkpatrick C, Racké K: The cholinergic 'pitfall': Acetylcholine, a universal cell molecule in biological systems, including humans. Clin Exp Pharmacol Physiol 1999; 26: 198-205.
    • (1999) Clin Exp Pharmacol Physiol , vol.26 , pp. 198-205
    • Wessler, I.1    Kirkpatrick, C.2    Racké, K.3
  • 2
    • 0015153848 scopus 로고
    • The cholinergic synapse and the site of memory
    • Deutsch JA: The cholinergic synapse and the site of memory. Science 1971; 174: 788-794.
    • (1971) Science , vol.174 , pp. 788-794
    • Deutsch, J.A.1
  • 3
    • 0344441293 scopus 로고    scopus 로고
    • The cholinergic innervation of the human cerebral cortex
    • Descarries L, Krnjevic K, Steriade M (eds), Amsterdam, Elsevier
    • Mesulam M-M: The cholinergic innervation of the human cerebral cortex; in Descarries L, Krnjevic K, Steriade M (eds): Progress in Brain Research Acetylcholine in the Cerebral Cortex. Amsterdam, Elsevier, 2004, pp 67-78.
    • (2004) Progress in Brain Research Acetylcholine in the Cerebral Cortex , pp. 67-78
    • Mesulam, M.-M.1
  • 4
    • 0033018477 scopus 로고    scopus 로고
    • Acetylcholine in mind: A neurotransmitter correlate of consciousness?
    • Perry E, Walker M, Grace J, Perry R: Acetylcholine in mind: A neurotransmitter correlate of consciousness? Trends Neurosci 1999; 22: 273-280.
    • (1999) Trends Neurosci , vol.22 , pp. 273-280
    • Perry, E.1    Walker, M.2    Grace, J.3    Perry, R.4
  • 5
    • 0001536516 scopus 로고
    • The action of certain esters and ethers of choline and their relation to muscarine
    • Dale HH: The action of certain esters and ethers of choline and their relation to muscarine. J Pharmacol Exp Ther 1914; 6: 147-190.
    • (1914) J Pharmacol Exp Ther , vol.6 , pp. 147-190
    • Dale, H.H.1
  • 6
    • 54049101939 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptors: From the genetic analysis to neurological diseases
    • Steinlein OK, Bertrand D: Neuronal nicotinic acetylcholine receptors: from the genetic analysis to neurological diseases. Biochem Pharmacol 2008; 76: 1175-1183.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1175-1183
    • Steinlein, O.K.1    Bertrand, D.2
  • 7
  • 8
    • 3042798261 scopus 로고    scopus 로고
    • Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: Molecular modeling and mutagenesis approaches to receptor structure and function
    • Kristiansen K: Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: Molecular modeling and mutagenesis approaches to receptor structure and function. Pharmacol Ther 2004; 103: 21-80.
    • (2004) Pharmacol Ther , vol.103 , pp. 21-80
    • Kristiansen, K.1
  • 9
    • 0029789994 scopus 로고    scopus 로고
    • Molecular biology of muscarinic acetylcholine receptors
    • Wess J: Molecular biology of muscarinic acetylcholine receptors. Crit Rev Neurobiol 1996; 10: 69-99.
    • (1996) Crit Rev Neurobiol , vol.10 , pp. 69-99
    • Wess, J.1
  • 10
    • 0031774720 scopus 로고    scopus 로고
    • International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors
    • Caulfield MP, Birdsall NJ: International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 1998; 50: 279-290.
    • (1998) Pharmacol Rev , vol.50 , pp. 279-290
    • Caulfield, M.P.1    Birdsall, N.J.2
  • 11
    • 55849094786 scopus 로고    scopus 로고
    • Muscarinic receptors: Do they have a role in the pathology of schizophrenia?
    • Scarr E, Dean B: Muscarinic receptors: Do they have a role in the pathology of schizophrenia? J Neurochem 2008; 107: 1188-1195.
    • (2008) J Neurochem , vol.107 , pp. 1188-1195
    • Scarr, E.1    Dean, B.2
  • 12
    • 38349193123 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors as CNS drug targets
    • Langmead CJ, Watson J, Reavill C: Muscarinic acetylcholine receptors as CNS drug targets. Pharmacol Ther 2008; 117: 232-243.
    • (2008) Pharmacol Ther , vol.117 , pp. 232-243
    • Langmead, C.J.1    Watson, J.2    Reavill, C.3
  • 14
    • 0033978239 scopus 로고    scopus 로고
    • Hippocampal astrocytes exhibit Ca 2+ -elevating muscarinic cholinergic and histaminergic receptors in situ
    • Shelton MK, McCarthy KD: Hippocampal astrocytes exhibit Ca 2+ -elevating muscarinic cholinergic and histaminergic receptors in situ. J Neurochem 2000; 74: 555-563.
    • (2000) J Neurochem , vol.74 , pp. 555-563
    • Shelton, M.K.1    McCarthy, K.D.2
  • 16
    • 0035879062 scopus 로고    scopus 로고
    • Hyperactivity and intact hippocampusdependent learning in mice lacking the M1 muscarinic acetylcholine receptor
    • Miyakawa T, Yamada M, Duttaroy A, Wess J: Hyperactivity and intact hippocampusdependent learning in mice lacking the M1 muscarinic acetylcholine receptor. J Neurosci 2001; 21: 5239-5250.
    • (2001) J Neurosci , vol.21 , pp. 5239-5250
    • Miyakawa, T.1    Yamada, M.2    Duttaroy, A.3    Wess, J.4
  • 17
    • 30644461032 scopus 로고    scopus 로고
    • Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus
    • Shinoe T, Matsui M, Taketo MM, Manabe T: Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus. J Neurosci 2005; 25: 11194-11200.
    • (2005) J Neurosci , vol.25 , pp. 11194-11200
    • Shinoe, T.1    Matsui, M.2    Taketo, M.M.3    Manabe, T.4
  • 19
    • 0035910050 scopus 로고    scopus 로고
    • Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice
    • Gerber DJ, Sotnikova TD, Gainetdinov RR, Huang SY, Caron MG, Tonegawa S: Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice. Proc Natl Acad Sci USA 2001; 98: 15312-15317.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 15312-15317
    • Gerber, D.J.1    Sotnikova, T.D.2    Gainetdinov, R.R.3    Huang, S.Y.4    Caron, M.G.5    Tonegawa, S.6
  • 20
    • 0035957582 scopus 로고    scopus 로고
    • Neostriatal muscarinic receptor subtypes involved in the generation of tremulous jaw movements in rodents implications for cholinergic involvement in parkinsonism
    • Salamone JD, Correa M, Carlson BB, Wisniecki A, Mayorga AJ, Nisenbaum E, Nisenbaum L, Felder C: Neostriatal muscarinic receptor subtypes involved in the generation of tremulous jaw movements in rodents implications for cholinergic involvement in parkinsonism. Life Sci 2001; 68: 2579-2584.
    • (2001) Life Sci , vol.68 , pp. 2579-2584
    • Salamone, J.D.1    Correa, M.2    Carlson, B.B.3    Wisniecki, A.4    Mayorga, A.J.5    Nisenbaum, E.6    Nisenbaum, L.7    Felder, C.8
  • 22
    • 9444239189 scopus 로고    scopus 로고
    • M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: Relevance to the pathophysiology and treatment of related CNS pathologies
    • Tzavara ET, Bymaster FP, Davis RJ, Wade MR, Perry KW, Wess J, McKinzie DL, Felder C, Nomikos GG: M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: Relevance to the pathophysiology and treatment of related CNS pathologies. FASEB J 2004; 18: 1410-1412.
    • (2004) FASEB J , vol.18 , pp. 1410-1412
    • Tzavara, E.T.1    Bymaster, F.P.2    Davis, R.J.3    Wade, M.R.4    Perry, K.W.5    Wess, J.6    McKinzie, D.L.7    Felder, C.8    Nomikos, G.G.9
  • 23
    • 0042575347 scopus 로고    scopus 로고
    • Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice
    • Tzavara ET, Bymaster FP, Felder CC, Wade M, Gomeza J, Wess J, McKinzie DL, Nomikos GG: Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice. Mol Psychiatry 2003; 8: 673-679.
    • (2003) Mol Psychiatry , vol.8 , pp. 673-679
    • Tzavara, E.T.1    Bymaster, F.P.2    Felder, C.C.3    Wade, M.4    Gomeza, J.5    Wess, J.6    McKinzie, D.L.7    Nomikos, G.G.8
  • 25
    • 0037143440 scopus 로고    scopus 로고
    • Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia
    • Basile AS, Fedorova I, Zapata A, Liu X, Shippenberg T, Duttaroy A, Yamada M, Wess J: Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia. Proc Natl Acad Sci USA 2002; 99: 11452-11457.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11452-11457
    • Basile, A.S.1    Fedorova, I.2    Zapata, A.3    Liu, X.4    Shippenberg, T.5    Duttaroy, A.6    Yamada, M.7    Wess, J.8
  • 26
    • 0001048556 scopus 로고
    • Atropine coma: A somatic therapy in psychiatry
    • Forrer GR, Miller JJ: Atropine coma: A somatic therapy in psychiatry. Am J Psychiatry 1958; 115: 455-458.
    • (1958) Am J Psychiatry , vol.115 , pp. 455-458
    • Forrer, G.R.1    Miller, J.J.2
  • 28
    • 0024321406 scopus 로고
    • Cholinergic hyperactivity and negative schizophrenic symptoms. A model of cholinergic/dopaminergic interactions in schizophrenia
    • Tandon R, Greden JF: Cholinergic hyperactivity and negative schizophrenic symptoms. A model of cholinergic/dopaminergic interactions in schizophrenia. Arch Gen Psychiatry 1989; 46: 745-753.
    • (1989) Arch Gen Psychiatry , vol.46 , pp. 745-753
    • Tandon, R.1    Greden, J.F.2
  • 30
    • 78651013959 scopus 로고
    • The effects of diisopropylfluorophosphonate in schizophrenia and manic depressive psychosis
    • Rowntree DW, Nevin S, Wilson A: The effects of diisopropylfluorophosphonate in schizophrenia and manic depressive psychosis. J Neurol Neurosurg Psychiatry 1950; 13: 47-62.
    • (1950) J Neurol Neurosurg Psychiatry , vol.13 , pp. 47-62
    • Rowntree, D.W.1    Nevin, S.2    Wilson, A.3
  • 31
    • 50549171499 scopus 로고
    • Psychiatric sequelae of chronic exposure to organophosphorus insecticides
    • Gershon S, Shaw FH: Psychiatric sequelae of chronic exposure to organophosphorus insecticides. Lancet 1961;i:1371-1374.
    • (1961) Lancet , vol.1 , pp. 1371-1374
    • Gershon, S.1    Shaw, F.H.2
  • 33
  • 34
    • 33749333018 scopus 로고    scopus 로고
    • Antidepressant efficacy of the antimuscarinic drug scopolamine: A randomized, placebo-controlled clinical trial
    • Furey ML, Drevets WC: Antidepressant efficacy of the antimuscarinic drug scopolamine: A randomized, placebo-controlled clinical trial. Arch Gen Psychiatry 2006; 63: 1121-1129.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 1121-1129
    • Furey, M.L.1    Drevets, W.C.2
  • 35
    • 0026579901 scopus 로고
    • Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells
    • Bolden C, Cusack B, Richelson E: Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells. J Pharmacol Exp Ther 1992; 260: 576-580.
    • (1992) J Pharmacol Exp Ther , vol.260 , pp. 576-580
    • Bolden, C.1    Cusack, B.2    Richelson, E.3
  • 38
    • 0021060772 scopus 로고
    • Increased muscarinic cholinergic receptors in prefrontal cortices of medicated schizophrenics
    • Watanabe S, Nishikawa T, Takashima M, Toru M: Increased muscarinic cholinergic receptors in prefrontal cortices of medicated schizophrenics. Life Sci 1983; 33: 2187-2196.
    • (1983) Life Sci , vol.33 , pp. 2187-2196
    • Watanabe, S.1    Nishikawa, T.2    Takashima, M.3    Toru, M.4
  • 39
    • 0033553589 scopus 로고    scopus 로고
    • Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland
    • Moriya H, Takagi Y, Nakanishi T, Hayashi M, Tani T, Hirotsu I: Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland. Life Sci 1999; 64: 2351-2358.
    • (1999) Life Sci , vol.64 , pp. 2351-2358
    • Moriya, H.1    Takagi, Y.2    Nakanishi, T.3    Hayashi, M.4    Tani, T.5    Hirotsu, I.6
  • 40
    • 0032924127 scopus 로고    scopus 로고
    • The neuropathology of schizophrenia. A critical review of the data and their interpretation
    • Harrison PJ: The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 1999; 122: 593-624.
    • (1999) Brain , vol.122 , pp. 593-624
    • Harrison, P.J.1
  • 41
    • 56049096939 scopus 로고    scopus 로고
    • Levels of [(3)H]pirenzepine binding in Brodmann's area 6 from subjects with schizophrenia is not associated with changes in the transcription factor SP1 or BACE1
    • Dean B, Soulby A, Evin G, Scarr E: Levels of [(3)H]pirenzepine binding in Brodmann's area 6 from subjects with schizophrenia is not associated with changes in the transcription factor SP1 or BACE1; Schiz Res 2008; 106: 229-236
    • (2008) Schiz Res , vol.106 , pp. 229-236
    • Dean, B.1    Soulby, A.2    Evin, G.3    Scarr, E.4
  • 42
    • 0034975130 scopus 로고    scopus 로고
    • Low muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: A study of Brodmann's areas 8, 9, 10, and 46 and the effects of neuroleptic drug treatment
    • Crook JM, Tomaskovic-Crook E, Copolov DL, Dean B: Low muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: A study of Brodmann's areas 8, 9, 10, and 46 and the effects of neuroleptic drug treatment. Am J Psychiatry 2001; 158: 918-925.
    • (2001) Am J Psychiatry , vol.158 , pp. 918-925
    • Crook, J.M.1    Tomaskovic-Crook, E.2    Copolov, D.L.3    Dean, B.4
  • 43
    • 0036932174 scopus 로고    scopus 로고
    • Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia
    • Dean B, McLeod M, Keriakous D, McKenzie J, Scarr E: Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia. Mol Psychiatry 2002; 7: 1083-1091.
    • (2002) Mol Psychiatry , vol.7 , pp. 1083-1091
    • Dean, B.1    McLeod, M.2    Keriakous, D.3    McKenzie, J.4    Scarr, E.5
  • 44
    • 1642415654 scopus 로고    scopus 로고
    • Investigation of m1/m4 muscarinic receptors in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression disorder
    • Zavitsanou K, Katsifis A, Mattner F, Xu-Feng H: Investigation of m1/m4 muscarinic receptors in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression disorder. Neuropsychopharmacology 2004; 29: 619-625.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 619-625
    • Zavitsanou, K.1    Katsifis, A.2    Mattner, F.3    Xu-Feng, H.4
  • 45
    • 27444444269 scopus 로고    scopus 로고
    • Decreased density of muscarinic receptors in the superior temporal gyrus in schizophrenia
    • Deng C, Huang XF: Decreased density of muscarinic receptors in the superior temporal gyrus in schizophrenia. J Neurosci Res 2005; 81: 883-890.
    • (2005) J Neurosci Res , vol.81 , pp. 883-890
    • Deng, C.1    Huang, X.F.2
  • 46
    • 34247643222 scopus 로고    scopus 로고
    • Altered hippocampal muscarinic M4, but not M1, receptor expression from subjects with schizophrenia
    • Scarr E, Sundram S, Keriakous D, Dean B: Altered hippocampal muscarinic M4, but not M1, receptor expression from subjects with schizophrenia. Biol Psychiatry 2007; 61: 1161-1170.
    • (2007) Biol Psychiatry , vol.61 , pp. 1161-1170
    • Scarr, E.1    Sundram, S.2    Keriakous, D.3    Dean, B.4
  • 47
    • 0034282537 scopus 로고    scopus 로고
    • Decreased muscarinic receptor binding in subjects with schizophrenia: A study of the human hippocampal formation
    • Crook JM, Tomaskovic-Crook E, Copolov DL, Dean B: Decreased muscarinic receptor binding in subjects with schizophrenia: A study of the human hippocampal formation. Biol Psychiatry 2000; 48: 381-388.
    • (2000) Biol Psychiatry , vol.48 , pp. 381-388
    • Crook, J.M.1    Tomaskovic-Crook, E.2    Copolov, D.L.3    Dean, B.4
  • 48
    • 2942665783 scopus 로고    scopus 로고
    • A comparison of M1 and M4 muscarinic receptors in the thalamus from control subjects and subjects with schizophrenia
    • Dean B, Gray L, Keriakous D, Scarr E: A comparison of M1 and M4 muscarinic receptors in the thalamus from control subjects and subjects with schizophrenia. Thalamus Relat Syst 2004; 2: 287-295.
    • (2004) Thalamus Relat Syst , vol.2 , pp. 287-295
    • Dean, B.1    Gray, L.2    Keriakous, D.3    Scarr, E.4
  • 49
    • 0030091175 scopus 로고    scopus 로고
    • The density of muscarinic M1 receptors is decreased in the caudate-putamen of subjects with schizophrenia
    • Dean B, Crook JM, Opeskin K, Hill C, Keks N, Copolov DL: The density of muscarinic M1 receptors is decreased in the caudate-putamen of subjects with schizophrenia. Mol Psychiatry 1996; 1: 54-58.
    • (1996) Mol Psychiatry , vol.1 , pp. 54-58
    • Dean, B.1    Crook, J.M.2    Opeskin, K.3    Hill, C.4    Keks, N.5    Copolov, D.L.6
  • 50
    • 0033515114 scopus 로고    scopus 로고
    • The binding of [ 3 H] AF-DX 384 is reduced in the caudate-putamen of subjects with schizophrenia
    • Crook JM, Dean B, Pavey G, Copolov D: The binding of [ 3 H]AF-DX 384 is reduced in the caudate-putamen of subjects with schizophrenia. Life Sci 1999; 64: 1761-1771.
    • (1999) Life Sci , vol.64 , pp. 1761-1771
    • Crook, J.M.1    Dean, B.2    Pavey, G.3    Copolov, D.4
  • 51
    • 33845683345 scopus 로고    scopus 로고
    • Alterations of muscarinic and GABA receptor binding in the posterior cingulate cortex in schizophrenia
    • Newell KA, Zavitsanou K, Jew SK, Huang XF: Alterations of muscarinic and GABA receptor binding in the posterior cingulate cortex in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31: 225-233.
    • (2007) Prog Neuropsychopharmacol Biol Psychiatry , vol.31 , pp. 225-233
    • Newell, K.A.1    Zavitsanou, K.2    Jew, S.K.3    Huang, X.F.4
  • 52
    • 17044413243 scopus 로고    scopus 로고
    • M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders
    • Zavitsanou K, Katsifis A, Yu Y, Huang XF: M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders. Brain Res Bull 2005; 65: 397-403.
    • (2005) Brain Res Bull , vol.65 , pp. 397-403
    • Zavitsanou, K.1    Katsifis, A.2    Yu, Y.3    Huang, X.F.4
  • 54
    • 0028924664 scopus 로고
    • Differential regulation of molecular subtypes of muscarinic receptors in Alzheimer's disease
    • Flynn DD, Ferrari-DiLeo G, Mash DC, Levey AI: Differential regulation of molecular subtypes of muscarinic receptors in Alzheimer's disease. J Neurochem 1995; 64: 1888-1891.
    • (1995) J Neurochem , vol.64 , pp. 1888-1891
    • Flynn, D.D.1    Ferrari-Dileo, G.2    Mash, D.C.3    Levey, A.I.4
  • 56
    • 31744438772 scopus 로고    scopus 로고
    • No change in cortical muscarinic M2, M3 receptors or [(35)S]GTPgammaS binding in schizophrenia
    • Scarr E, Keriakous D, Crossland N, Dean B: No change in cortical muscarinic M2, M3 receptors or [(35)S]GTPgammaS binding in schizophrenia. Life Sci 2006; 78: 1231-1237.
    • (2006) Life Sci , vol.78 , pp. 1231-1237
    • Scarr, E.1    Keriakous, D.2    Crossland, N.3    Dean, B.4
  • 57
    • 70350446516 scopus 로고    scopus 로고
    • Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia
    • [Epub ahead of print]; DOI: 10.1038/mp.2008.28
    • Scarr E, Cowie TF, Kanellakis S, Sundram S, Pantelis C, Dean B: Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia. Mol Psychiatry 2008 [Epub ahead of print]; DOI: 10.1038/ mp.2008.28.
    • (2008) Mol Psychiatry
    • Scarr, E.1    Cowie, T.F.2    Kanellakis, S.3    Sundram, S.4    Pantelis, C.5    Dean, B.6
  • 58
    • 60849113110 scopus 로고    scopus 로고
    • Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice
    • Jositsch G, Papadakis T, Haberberger RV, Wolff M, Wess J, Kummer W: Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice. Naunyn Schmiedebergs Arch Pharmacol 2009; 379: 389-395.
    • (2009) Naunyn Schmiedebergs Arch Pharmacol , vol.379 , pp. 389-395
    • Jositsch, G.1    Papadakis, T.2    Haberberger, R.V.3    Wolff, M.4    Wess, J.5    Kummer, W.6
  • 59
    • 0027177289 scopus 로고
    • Association of m1 and m2 muscarinic receptor proteins with asymmetric synapses in the primate cerebral cortex: Morphological evidence for cholinergic modulation of excitatory neurotransmission
    • Mrzljak L, Levey AI, Goldman-Rakic PS: Association of m1 and m2 muscarinic receptor proteins with asymmetric synapses in the primate cerebral cortex: Morphological evidence for cholinergic modulation of excitatory neurotransmission. Proc Natl Acad Sci USA 1993; 90: 5194-5198.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5194-5198
    • Mrzljak, L.1    Levey, A.I.2    Goldman-Rakic, P.S.3
  • 60
    • 23744450102 scopus 로고    scopus 로고
    • Acetylcholine modulates cortical synaptic transmission via different muscarinic receptors, as studied with receptor knockout mice
    • Kuczewski N, Aztiria E, Gautam D, Wess J, Domenici L: Acetylcholine modulates cortical synaptic transmission via different muscarinic receptors, as studied with receptor knockout mice. J Physiol 2005; 566: 907-919.
    • (2005) J Physiol , vol.566 , pp. 907-919
    • Kuczewski, N.1    Aztiria, E.2    Gautam, D.3    Wess, J.4    Domenici, L.5
  • 61
    • 0032530817 scopus 로고    scopus 로고
    • Activation of the genetically defined m1 muscarinic receptor potentiates Nmethyl-D -aspartate (NMDA) receptor currents in hippocampal pyramidal cells
    • Marino MJ, Rouse ST, Levey AI, Potter LT, Conn PJ: Activation of the genetically defined m1 muscarinic receptor potentiates Nmethyl-D -aspartate (NMDA) receptor currents in hippocampal pyramidal cells. Proc Natl Acad Sci USA 1998; 95: 11465-11470.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11465-11470
    • Marino, M.J.1    Rouse, S.T.2    Levey, A.I.3    Potter, L.T.4    Conn, P.J.5
  • 63
    • 28444483146 scopus 로고    scopus 로고
    • Event-related gamma activity in schizophrenia patients during a visual backward-masking task
    • Wynn JK, Light GA, Breitmeyer B, Nuechterlein KH, Green MF: Event-related gamma activity in schizophrenia patients during a visual backward-masking task. Am J Psychiatry 2005; 162: 2330-2336.
    • (2005) Am J Psychiatry , vol.162 , pp. 2330-2336
    • Wynn, J.K.1    Light, G.A.2    Breitmeyer, B.3    Nuechterlein, K.H.4    Green, M.F.5
  • 64
    • 0037075227 scopus 로고    scopus 로고
    • Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents
    • Fisahn A, Yamada M, Duttaroy A, Gan JW, Deng CX, McBain CJ, Wess J: Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents. Neuron 2002; 33: 615-624.
    • (2002) Neuron , vol.33 , pp. 615-624
    • Fisahn, A.1    Yamada, M.2    Duttaroy, A.3    Gan, J.W.4    Deng, C.X.5    McBain, C.J.6    Wess, J.7
  • 65
    • 34548797583 scopus 로고    scopus 로고
    • AC260584 (4-[3-(4-butylpiperidin-1-yl) -Propyl]-7-f luoro-4H-benzo[1,4] oxazin-3-one), a selective muscarinic M1 receptor agonist, increases acetylcholine and dopamine release in rat medial prefrontal cortex and hippocampus
    • Li Z, Bonhaus DW, Huang M, Prus AJ, Dai J, Meltzer HY: AC260584 (4-[3-(4-butylpiperidin-1-yl) -propyl]-7-f luoro-4H-benzo[ 1,4]oxazin-3-one), a selective muscarinic M1 receptor agonist, increases acetylcholine and dopamine release in rat medial prefrontal cortex and hippocampus. Eur J Pharmacol 2007; 572: 129-137.
    • (2007) Eur J Pharmacol , vol.572 , pp. 129-137
    • Li, Z.1    Bonhaus, D.W.2    Huang, M.3    Prus, A.J.4    Dai, J.5    Meltzer, H.Y.6
  • 66
    • 0022638886 scopus 로고
    • Basal forebrain neurons projecting to the rat frontoparietal cortex: Electrophysiological and pharmacological properties
    • Lamour Y, Dutar P, Rascol O, Jobert A: Basal forebrain neurons projecting to the rat frontoparietal cortex: Electrophysiological and pharmacological properties. Brain Res 1986; 362: 122-131.
    • (1986) Brain Res , vol.362 , pp. 122-131
    • Lamour, Y.1    Dutar, P.2    Rascol, O.3    Jobert, A.4
  • 67
    • 0030855903 scopus 로고    scopus 로고
    • S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors. I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2Aadrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity
    • Millan MJ, Newman-Tancredi A, Rivet JM, Brocco M, Lacroix P, Audinot V, Cistarelli L, Gobert A: S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors. I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2Aadrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity. J Pharmacol Exp Ther 1997; 282: 132-147.
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 132-147
    • Millan, M.J.1    Newman-Tancredi, A.2    Rivet, J.M.3    Brocco, M.4    Lacroix, P.5    Audinot, V.6    Cistarelli, L.7    Gobert, A.8
  • 69
    • 67349144696 scopus 로고    scopus 로고
    • Decreased muscarinic receptor binding in the frontal cortex of bipolar disorder and major depressive disorder subjects
    • Gibbons AS, Scarr E, McLean CA, Sundram S, Dean B: Decreased muscarinic receptor binding in the frontal cortex of bipolar disorder and major depressive disorder subjects. J Affect Disord 2009; 116: 184-191.
    • (2009) J Affect Disord , vol.116 , pp. 184-191
    • Gibbons, A.S.1    Scarr, E.2    McLean, C.A.3    Sundram, S.4    Dean, B.5
  • 71
    • 0036522982 scopus 로고    scopus 로고
    • Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice
    • Zhang W, Basile AS, Gomeza J, Volpicelli LA, Levey AI, Wess J: Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice. J Neurosci 2002; 22: 1709-1717.
    • (2002) J Neurosci , vol.22 , pp. 1709-1717
    • Zhang, W.1    Basile, A.S.2    Gomeza, J.3    Volpicelli, L.A.4    Levey, A.I.5    Wess, J.6
  • 72
    • 0031881557 scopus 로고    scopus 로고
    • Localization of the m2 muscarinic acetylcholine receptor protein and mRNA in cortical neurons of the normal and cholinergically deafferented rhesus monkey
    • Mrzljak L, Levey AI, Belcher S, Goldman-Rakic PS: Localization of the m2 muscarinic acetylcholine receptor protein and mRNA in cortical neurons of the normal and cholinergically deafferented rhesus monkey. J Comp Neurol 1998; 390: 112-132.
    • (1998) J Comp Neurol , vol.390 , pp. 112-132
    • Mrzljak, L.1    Levey, A.I.2    Belcher, S.3    Goldman-Rakic, P.S.4
  • 73
    • 32544439510 scopus 로고    scopus 로고
    • Simultaneous release of glutamate and acetylcholine from single magnocellular 'cholinergic' basal forebrain neurons
    • Allen TGJ, Abogadie FC, Brown DA: Simultaneous release of glutamate and acetylcholine from single magnocellular 'cholinergic' basal forebrain neurons. J Neurosci 2006; 26: 1588-1595.
    • (2006) J Neurosci , vol.26 , pp. 1588-1595
    • Allen, T.G.J.1    Abogadie, F.C.2    Brown, D.A.3
  • 74
    • 41549107533 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors in macaque V1 are most frequently expressed by parvalbumin-immunoreactive neurons
    • Disney AA, Aoki C: Muscarinic acetylcholine receptors in macaque V1 are most frequently expressed by parvalbumin-immunoreactive neurons. J Comp Neurol 2008; 507: 1748-1762.
    • (2008) J Comp Neurol , vol.507 , pp. 1748-1762
    • Disney, A.A.1    Aoki, C.2
  • 75
    • 34547758470 scopus 로고    scopus 로고
    • Muscarinic M2 and M1 receptors reduce GABA release by Ca 2+ channel modulation through activation of PI3K/Ca 2+ -independent and PLC/Ca 2+ -dependent PKC
    • Salgado H, Bellay T, Nichols JA, Bose M, Martinolich L, Perrotti L, Atzori M: Muscarinic M2 and M1 receptors reduce GABA release by Ca 2+ channel modulation through activation of PI3K/Ca 2+ -independent and PLC/Ca 2+ -dependent PKC. J Neurophysiol 2007; 98: 952-965.
    • (2007) J Neurophysiol , vol.98 , pp. 952-965
    • Salgado, H.1    Bellay, T.2    Nichols, J.A.3    Bose, M.4    Martinolich, L.5    Perrotti, L.6    Atzori, M.7
  • 76
    • 34247171857 scopus 로고    scopus 로고
    • Muscarinic control of long-range GABAergic inhibition within the rhinal cortices
    • Apergis-Schoute J, Pinto A, Pare D: Muscarinic control of long-range GABAergic inhibition within the rhinal cortices. J Neurosci 2007; 27: 4061-4071.
    • (2007) J Neurosci , vol.27 , pp. 4061-4071
    • Apergis-Schoute, J.1    Pinto, A.2    Pare, D.3
  • 77
    • 53049096358 scopus 로고    scopus 로고
    • Effect of muscarinic receptor agonists xanomeline and sabcomeline on acetylcholine and dopamine efflux in the rat brain; Comparison with effects of 4-[3-(4-butylpiperidin-1-yl)-propyl]-7-f luoro-4Hbenzo[1,4]oxazin-3-one (AC260584) and Ndesmethylclozapine
    • Li Z, Snigdha S, Roseman AS, Dai J, Meltzer HY: Effect of muscarinic receptor agonists xanomeline and sabcomeline on acetylcholine and dopamine efflux in the rat brain; comparison with effects of 4-[3-(4-butylpiperidin-1-yl) -propyl]-7-f luoro-4Hbenzo[ 1,4]oxazin-3-one (AC260584) and Ndesmethylclozapine. Eur J Pharmacol 2008; 596: 89-97.
    • (2008) Eur J Pharmacol , vol.596 , pp. 89-97
    • Li, Z.1    Snigdha, S.2    Roseman, A.S.3    Dai, J.4    Meltzer, H.Y.5
  • 78
    • 32644476485 scopus 로고    scopus 로고
    • Muscarinic suppression in stratum radiatum of CA1 shows dependence on presynaptic M1 receptors and is not dependent on effects at GABA(B) receptors
    • Kremin T, Gerber D, Giocomo LM, Huang SY, Tonegawa S, Hasselmo ME: Muscarinic suppression in stratum radiatum of CA1 shows dependence on presynaptic M1 receptors and is not dependent on effects at GABA(B) receptors. Neurobiol Learn Mem 2006; 85: 153-163.
    • (2006) Neurobiol Learn Mem , vol.85 , pp. 153-163
    • Kremin, T.1    Gerber, D.2    Giocomo, L.M.3    Huang, S.Y.4    Tonegawa, S.5    Hasselmo, M.E.6
  • 80
    • 0030898520 scopus 로고    scopus 로고
    • Behavioural evaluation of cholinergic drugs
    • Iversen SD: Behavioural evaluation of cholinergic drugs. Life Sci 1997; 60: 1145-1152.
    • (1997) Life Sci , vol.60 , pp. 1145-1152
    • Iversen, S.D.1
  • 81
    • 0024247522 scopus 로고
    • The current status of the dopamine hypothesis of schizophrenia
    • Carlsson A: The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1988; 1: 179-186.
    • (1988) Neuropsychopharmacology , vol.1 , pp. 179-186
    • Carlsson, A.1
  • 82
    • 7544244277 scopus 로고    scopus 로고
    • Longitudinal studies of cognition and functional outcome in schizophrenia: Implications for MATRICS
    • Green MF, Kern RS, Heaton RK: Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophr Res 2004; 72: 41-51.
    • (2004) Schizophr Res , vol.72 , pp. 41-51
    • Green, M.F.1    Kern, R.S.2    Heaton, R.K.3
  • 84
    • 4644271084 scopus 로고    scopus 로고
    • Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia
    • Roth BL, Sheffler DJ, Kroeze WK: Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia. Nat Rev Drug Discov 2004; 3: 353-359.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 353-359
    • Roth, B.L.1    Sheffler, D.J.2    Kroeze, W.K.3
  • 85
    • 0037691865 scopus 로고    scopus 로고
    • Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity
    • Bymaster FP, Carter PA, Yamada M, Gomeza J, Wess J, Hamilton SE, Nathanson NM, McKinzie DL, Felder CC: Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. Eur J Neurosci 2003; 17: 1403-1410.
    • (2003) Eur J Neurosci , vol.17 , pp. 1403-1410
    • Bymaster, F.P.1    Carter, P.A.2    Yamada, M.3    Gomeza, J.4    Wess, J.5    Hamilton, S.E.6    Nathanson, N.M.7    McKinzie, D.L.8    Felder, C.C.9
  • 86
    • 0032704025 scopus 로고    scopus 로고
    • Effects of clozapine on psychiatric symptoms, cognition, and functional outcome in schizophrenia
    • Manschreck TC, Redmond DA, Candela SF, Maher BA: Effects of clozapine on psychiatric symptoms, cognition, and functional outcome in schizophrenia. J Neuropsychiatry Clin Neurosci 1999; 11: 481-489.
    • (1999) J Neuropsychiatry Clin Neurosci , vol.11 , pp. 481-489
    • Manschreck, T.C.1    Redmond, D.A.2    Candela, S.F.3    Maher, B.A.4
  • 92
    • 58249122324 scopus 로고    scopus 로고
    • Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M(4) receptor knockout mice and attenuated in muscarinic M(1) receptor knockout mice
    • Woolley ML, Carter HJ, Gartlon JE, Watson JM, Dawson LA: Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M(4) receptor knockout mice and attenuated in muscarinic M(1) receptor knockout mice. Eur J Pharmacol 2008; 603: 147-149.
    • (2008) Eur J Pharmacol , vol.603 , pp. 147-149
    • Woolley, M.L.1    Carter, H.J.2    Gartlon, J.E.3    Watson, J.M.4    Dawson, L.A.5
  • 93
    • 0017105216 scopus 로고
    • The inhibitory effect of gallamine on muscarinic receptors
    • Clark AL, Mitchelson F: The inhibitory effect of gallamine on muscarinic receptors. Br J Pharmacol 1976; 58: 323-331.
    • (1976) Br J Pharmacol , vol.58 , pp. 323-331
    • Clark, A.L.1    Mitchelson, F.2
  • 94
    • 0029055030 scopus 로고
    • Allosteric modulation of muscarinic acetylcholine receptors
    • Tucek S, Proska J: Allosteric modulation of muscarinic acetylcholine receptors. Trends Pharmacol Sci 1995; 16: 205-212.
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 205-212
    • Tucek, S.1    Proska, J.2
  • 97
    • 30044435787 scopus 로고    scopus 로고
    • Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M1 receptor: Direct pharmacological evidence that AC-42 is an allosteric agonist
    • Langmead CJ, Fry VAH, Forbes IT, Branch CL, Christopoulos A, Wood MD, Herdon HJ: Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M1 receptor: Direct pharmacological evidence that AC-42 is an allosteric agonist. Mol Pharmacol 2006; 69: 236-246.
    • (2006) Mol Pharmacol , vol.69 , pp. 236-246
    • Langmead, C.J.1    Fry, V.A.H.2    Forbes, I.T.3    Branch, C.L.4    Christopoulos, A.5    Wood, M.D.6    Herdon, H.J.7
  • 98
    • 61349093537 scopus 로고    scopus 로고
    • Subtypeselective allosteric modulators of muscarinic receptors for the treatment of CNS disorders
    • Conn PJ, Jones CK, Lindsley CW: Subtypeselective allosteric modulators of muscarinic receptors for the treatment of CNS disorders. Trends Pharmacol Sci 2009; 30: 148-155.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 148-155
    • Conn, P.J.1    Jones, C.K.2    Lindsley, C.W.3
  • 99
    • 44649157592 scopus 로고    scopus 로고
    • Antipsychotic-like behavioral effects and cognitive enhancement by a potent and selective muscarinic M-sub-1 receptor agonist, AC-260584
    • Vanover KE, Veinbergs I, Davis RE: Antipsychotic-like behavioral effects and cognitive enhancement by a potent and selective muscarinic M-sub-1 receptor agonist, AC-260584. Behav Neurosci 2008; 122: 570-575.
    • (2008) Behav Neurosci , vol.122 , pp. 570-575
    • Vanover, K.E.1    Veinbergs, I.2    Davis, R.E.3
  • 105
    • 33751072945 scopus 로고    scopus 로고
    • Structural requirements of transmembrane domain 3 for activation by the M1 muscarinic receptor agonists AC-42, AC-260584, clozapine, and N-desmethylclozapine: Evidence for three distinct modes of receptor activation
    • Spalding TA, Ma JN, Ott TR, Friberg M, Bajpai A, Bradley SR, Davis RE, Brann MR, Burstein ES: Structural requirements of transmembrane domain 3 for activation by the M1 muscarinic receptor agonists AC-42, AC-260584, clozapine, and N-desmethylclozapine: Evidence for three distinct modes of receptor activation. Mol Pharmacol 2006; 70: 1974-1983.
    • (2006) Mol Pharmacol , vol.70 , pp. 1974-1983
    • Spalding, T.A.1    Ma, J.N.2    Ott, T.R.3    Friberg, M.4    Bajpai, A.5    Bradley, S.R.6    Davis, R.E.7    Brann, M.R.8    Burstein, E.S.9
  • 106
    • 59449090754 scopus 로고    scopus 로고
    • Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors
    • Lebon G, Langmead CJ, Tehan BG, Hulme EC: Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors. Mol Pharmacol 2009; 75: 331-341.
    • (2009) Mol Pharmacol , vol.75 , pp. 331-341
    • Lebon, G.1    Langmead, C.J.2    Tehan, B.G.3    Hulme, E.C.4
  • 107
    • 0037406701 scopus 로고    scopus 로고
    • Regulation of muscarinic acetylcholine receptor signaling
    • van Koppen CJ, Kaiser B: Regulation of muscarinic acetylcholine receptor signaling. Pharmacol Ther 2003; 98: 197-220.
    • (2003) Pharmacol Ther , vol.98 , pp. 197-220
    • Van Koppen, C.J.1    Kaiser, B.2
  • 108
    • 0242570882 scopus 로고    scopus 로고
    • The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq-type G proteins: Regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling
    • Rumenapp U, Asmus M, Schablowski H, Woznicki M, Han L, Jakobs KH, Fahimi-Vahid M, Michalek C, Wieland T, Schmidt M: The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq-type G proteins: Regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling. J Biol Chem 2001; 276: 2474-2479.
    • (2001) J Biol Chem , vol.276 , pp. 2474-2479
    • Rumenapp, U.1    Asmus, M.2    Schablowski, H.3    Woznicki, M.4    Han, L.5    Jakobs, K.H.6    Fahimi-Vahid, M.7    Michalek, C.8    Wieland, T.9    Schmidt, M.10
  • 109
    • 0035120732 scopus 로고    scopus 로고
    • G(q/11) and G(i/o) activation profiles in CHO cells expressing human muscarinic acetylcholine receptors: Dependence on agonist as well as receptor-subtype
    • Akam EC, Challiss RA, Nahorski SR: G(q/11) and G(i/o) activation profiles in CHO cells expressing human muscarinic acetylcholine receptors: Dependence on agonist as well as receptor-subtype. Br J Pharmacol 2001; 132: 950-958.
    • (2001) Br J Pharmacol , vol.132 , pp. 950-958
    • Akam, E.C.1    Challiss, R.A.2    Nahorski, S.R.3
  • 110
    • 0031815337 scopus 로고    scopus 로고
    • Effector pathwaydependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus
    • Berg KA, Maayani S, Goldfarb J, Scaramellini C, Leff P, Clarke WP: Effector pathwaydependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus. Mol Pharmacol 1998; 54: 94-104.
    • (1998) Mol Pharmacol , vol.54 , pp. 94-104
    • Berg, K.A.1    Maayani, S.2    Goldfarb, J.3    Scaramellini, C.4    Leff, P.5    Clarke, W.P.6
  • 111
    • 0032434460 scopus 로고    scopus 로고
    • Pleiotropic behavior of 5-HT2A and 5-HT2C receptor agonists
    • Berg KA, Maayani S, Goldfarb J, Clarke WP: Pleiotropic behavior of 5-HT2A and 5-HT2C receptor agonists. Ann NY Acad Sci 1998; 861: 104-110.
    • (1998) Ann NY Acad Sci , vol.861 , pp. 104-110
    • Berg, K.A.1    Maayani, S.2    Goldfarb, J.3    Clarke, W.P.4
  • 112
    • 54349106685 scopus 로고    scopus 로고
    • G Protein Coupling and signaling pathway activation by M1 muscarinic acetylcholine receptor orthosteric and allosteric agonists
    • Thomas RL, Mistry R, Langmead CJ, Wood MD, Challiss RJ: G Protein Coupling and signaling pathway activation by M1 muscarinic acetylcholine receptor orthosteric and allosteric agonists. J Pharmacol Exp Ther 2008; 327: 365-374.
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 365-374
    • Thomas, R.L.1    Mistry, R.2    Langmead, C.J.3    Wood, M.D.4    Challiss, R.J.5
  • 113
    • 1842333847 scopus 로고    scopus 로고
    • Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors
    • Jakubik J, Bacakova L, El Fakahany EE, Tucek S: Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol 1997; 52: 172-179.
    • (1997) Mol Pharmacol , vol.52 , pp. 172-179
    • Jakubik, J.1    Bacakova, L.2    El Fakahany, E.E.3    Tucek, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.