Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2- methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M1 receptor: Direct pharmacological evidence that AC-42 is an allosteric agonist

Molecular Pharmacology

Volumn 69, Issue 1, 2006, Pages 236-246

  Langmead, Christopher J ^a   Fry, Victoria A H ^a   Forbes, Ian T ^a   Branch, Clive L ^a   Christopoulos, Arthur ^b   Wood, Martyn D ^a   Herdon, Hugh J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

4 N BUTYL 1 [4 (2 METHYLPHENYL) 4 OXO 1 BUTYL] PIPERIDINE; AC 42; ATROPINE; CARBACHOL; GALLAMINE; INOSITOL PHOSPHATE; METHYLSCOPOLAMINE; MUSCARINIC M1 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; PIPERIDINE DERIVATIVE; PIRENZEPINE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL MEMBRANE; CHO CELL; CONTROLLED STUDY; DISSOCIATION; MOLECULAR PROBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION;

ALLOSTERIC REGULATION; ANIMALS; CALCIUM; CHO CELLS; CRICETINAE; MOLECULAR PROBES; MUSCARINIC AGONISTS; N-METHYLSCOPOLAMINE; PIPERIDINES; RADIOLIGAND ASSAY; RECEPTOR, MUSCARINIC M1;

EID: 30044435787     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.017814     Document Type: Article

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