The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq-type G proteins. Regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling

Journal of Biological Chemistry

Volumn 276, Issue 4, 2001, Pages 2474-2479

  Rümenapp, Ulrich ^a   Asmus, Melanie ^a   Schablowski, Helge ^a   Woznicki, Markus ^a   Han, Li ^a   Jakobs, Karl H ^a   Fahimi Vahid, Mercedeh ^b   Michalek, Christina ^b   Wieland, Thomas ^b   Schmidt, Martina ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL ACTIVATION; ENZYME KINETICS; PROTEINS;

PERTUSSIS; TOXIN RESISTANT;

BIOCHEMISTRY;

G(Q) PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN 12; GUANINE NUCLEOTIDE BINDING PROTEIN 13; MUSCARINIC M3 RECEPTOR; PERTUSSIS TOXIN; PHOSPHOLIPASE C; PHOSPHOLIPASE D; RGS PROTEIN; UNCLASSIFIED DRUG; BORDETELLA VIRULENCE FACTOR; CARBACHOL; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC AGENT; MUSCARINIC RECEPTOR;

ARTICLE; CELL LINE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; DRUG RESISTANCE; METABOLISM;

CARBACHOL; DRUG RESISTANCE; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MUSCARINIC AGONISTS; PERTUSSIS TOXIN; PHOSPHOLIPASE C; PHOSPHOLIPASE D; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; RGS PROTEINS; SIGNAL TRANSDUCTION; VIRULENCE FACTORS, BORDETELLA;

EID: 0242570882     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M004957200     Document Type: Article

References (47)

1. Exton, J. H. (1997) Physiol. Rev. 77, 303-320
2. Singer, W. D., Brown, H. A., and Sternweis, P. C. (1997) Annu. Rev. Biochem. 66, 475-509
3. Exton, J. H. (1999) Biochim. Biophys. Acta 1439, 121-133
4. Jones, D., Morgan, C., and Cockcroft, S. (1999) Biochim. Biophys. Acta 1439, 229-244
5. Liscovitch, M., Czarny, M., Fiucci, G., and Tang X. (2000) Biochem. J. 345, 401-415
6. Neer, E. J. (1995) Cell 80, 249-257
7. Gudermann, T., Kalkbrenner, F., and Schultz, G. (1996) Annu. Rev. Pharmacol. Toxicol. 36, 429-459
8. Rhee, S. G., and Bae, Y. S. (1997) J. Biol. Chem. 272, 15045-15048
9. Fensome, A., Whatmore, J., Morgan, C. P., Jones, D., and Cockcroft, S. (1998) J. Biol. Chem. 273, 13157-13164
10. Plonk, S. G., Park, S.-K., and Exton, J. H. (1998) J. Biol. Chem. 273, 4823-4826
11. Dhanasekaran, N., and Dermott, J. M. (1996) Cell. Signal. 8, 235-245
12. Fields, T. A., and Casey, P. J. (1997) Biochem. J. 321, 561-571
13. Sandmann, J., Peralta, E. G., and Wurtman, R. J. (1991) J. Biol. Chem. 266, 6031-6034
14. Offermanns, S., Wieland, T., Homann, D., Sandmann, J., Bombien, E., Spicher, K., Schultz, G., and Jakobs, K. H. (1994) Mol. Pharmacol. 45, 890-898
15. Schmidt, M., Hüwe, S. M., Fasselt, B., Homann, D., Rümenapp, U., Sandmann, J., and Jakobs, K. H. (1994) Eur. J. Biochem. 225, 667-675
16. Rümenapp, U., Schmidt, M., Wahn, F., Tapp, E., Granass, A., and Jakobs, K. H. (1997) Eur. J. Biochem. 248, 407-414
17. Berman, D. M., and Gilman, A. G. (1998) J. Biol. Chem. 273, 1269-1272
18. Wieland, T., and Chen, C.-K. (1999) Naunyn-Schmiedeberg's Arch. Pharmacol. 360, 14-26
19. De Vries, L., and Farquhar, M. G. (1999) Trends Cell Biol. 9, 138-144
20. Berman, D. M., Wilkie, T. M., and Gilman, A. G. (1996) Cell 86, 445-452
21. Berman, D. M., Kozasa, T., and Gilman, A. G. (1996) J. Biol. Chem. 271, 27209-27212
22. Popov, S., Yu, K., Kozasa, T., and Wilkie, T. M. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 7216-7220
23. Tesmer, J. J. G., Berman, D. M., Gilman, A. G., and Sprang, S. R. (1997) Cell 89, 251-261
24. Srinivasa, S. P., Watson, N., Overton, M. C., and Blumer, K. J. (1998) J. Biol. Chem. 273, 1529-1533
25. Kozasa, T., Jiang, X. J., Hart, M. J., Sternweis, P. M., Singer, W. D., Gilman, A. G., Bollag, G., and Sternweis, P. C. (1998) Science 280, 2109-2111
26. Strathmann, M. P., and Simon, M. I. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 9113-9117
27. Strathmann, M. P., and Simon, M. I. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 5582-5586
28. He, T.-C., Zhou, S., Da Costa, L. T., Yu, J., Kinzler, K. W., and Vogelstein, B. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 2509-2514
29. Gsell, S., Eschenhagen, T., Kaspareit, G., Nose, M., Scholz, H., Behrends, O., and Wieland, T. (2000) FASEB J. 14, 17-26
30. Wieland, T., Nürnberg, B., Ulibarri, I., Kaldenberg-Stasch, S., Schultz, G., and Jakobs, K. H. (1993) J. Biol. Chem. 268, 18111-18118
31. Yan, Y., Chi, P. P., and Bourne, H. R. (1997) J. Biol. Chem. 272, 11924-11921
32. Huang, C., Hepler, J. R., Gilman, A. G., and Mumby, S. M. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 6159-6163
33. Xu, X., Zeng, W., Popov, S., Berman, D. M., Davignon, I., Yu, K., Yowe, D., Offermanns, S., Muallem, S., and Wilkie, T. M. (1999) J. Biol. Chem. 274, 3549-3556
34. Ushio-Fukai, M., Alexander, R. W., Akers, M., Lyons, P. R., Lassègue, B., and Griendling, K. K. (1999) Mol. Pharmacol. 55, 142-149
35. Ushio-Fukai, M., Griendling, K. K., Akers, M., Lyons, P. R., and Alexander, R. W. (1998) J. Biol. Chem. 273, 19772-19777
36. Buhl, A. M., Johnson, M. L., Dhanasekaran, N., and Johnson, G. L. (1995) J. Biol. Chem. 270, 24631-24634
37. Katoh, H., Aoki, J., Yamaguchi, Y., Kitano, Y., Ichikawa, A., and Negishi, M. (1998) J. Biol. Chem. 273, 28700-28707
38. Hooley, R., Yu, C.-Y., Symons, M., and Barber, D. L. (1996) J. Biol. Chem. 271, 6152-6158
39. Fromm, C., Coso, O. A., Montaner, S., Xu, N., and Gutkind, J. S. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 10098-10103
40. Mao, J., Yuan, H., Xie, W., and Wu, D. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 12973-12976
41. Sah, V. P., Hoshijima, M., Chien, K. R., and Brown, J. H. (1996) J. Biol. Chem. 271, 31185-31190
42. Kjøller, L., and Hall, A. (1999) Exp. Cell Res. 253, 166-179
43. Mao, J., Yuan, H., Xie, W., Simon, M. I., and Wu, D. (1998) J. Biol. Chem. 273, 27118-27123
44. Schmidt, M., Rümenapp, U., Bienek, C., Keller, J., von Eichel-Streiber, C., and Jakobs, K. H. (1996) J. Biol. Chem. 271, 2422-2426
45. Schmidt, M., Voß, M., Oude Weernink, P. A., Wetzel, J., Amano, M., Kaibuchi, K., and Jakobs, K. H. (1999) J. Biol. Chem. 274, 14648-14654
46. Rümenapp, U., Geiszt, M., Wahn, F., Schmidt, M., and Jakobs, K. H. (1995) Eur. J. Biochem. 234, 240-244
47. Schürmann, A., Schmidt, M., Asmus, M., Bayer, S., Fliegert, F., Koling, S., Maßmann, S., Schilf, C., Subauste, M. C., Voß, M., Jakobs, K. H., and Joost, H.-G. (1999) J. Biol. Chem. 274, 9744-9751