Ultrafine chitosan nanoparticles as an efficient nucleic acid delivery system targeting neuronal cells ultrafine nanoparticles siRNA delivery system

Drug Development and Industrial Pharmacy

Volumn 35, Issue 6, 2009, Pages 719-726

  Malhotra, Meenakshi ^a   Kulamarva, Arun ^a   Sebak, Safaa ^a   Paul, Arghya ^a   Bhathena, Jasmine ^a   Mirzaei, Maryam ^a   Prakash, Satya ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Ultra small nanoparticles

Indexed keywords

CHITOSAN; NANOPARTICLE; NUCLEIC ACID; SMALL INTERFERING RNA; TRIPOLYPHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; BRAIN CELL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CROSS LINKING; DRUG DELIVERY SYSTEM; DRUG EFFICACY; GELATION; GENE TARGETING; GENETIC TRANSFECTION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PARTICLE SIZE; PH MEASUREMENT; SURFACE CHARGE; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; CELL LINE, TUMOR; CHITOSAN; CROSS-LINKING REAGENTS; GELS; GENE TRANSFER TECHNIQUES; HYDROGEN-ION CONCENTRATION; MICE; NANOPARTICLES; NEUROBLASTOMA; PARTICLE SIZE; POLYPHOSPHATES; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 70350589264     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040802526789     Document Type: Article

References (39)

1. Sanovich E, Bartus RT, Friden PM, et al. (1995). Pathway across blood-brain barrier opened by the bradykinin agonist, RMP-7. Brain Res, 705.
2. Molas M, Gomez-Valadés AG, Vidal-Alabró A, Miquel-Turu M, Bermudez J, Bartrons R, et al. (2003). Receptor mediated gene transfer vectors: Progress towards genetic pharmaceuticals. Curr Gene Ther, 3, 468-485
3. Peden CS, Burger C, Muzyczka N, Mandel RJ. (2004). Circulating anti wild type adeno associated virus type 2 (AAV2 antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5 mediated, gene transfer in the brain. J Virol, 78, 6344-6359
4. Lu PY, Xie F, Woodle MC. (2005). In vivo application of RNA interference: From functional genomics to therapeutics. Adv Genet, 54, 117-142
5. Liu WG, Yao K. (2002). Chitosan and its derivatives: A promising non-viral vector for gene transfection. J Controll Release, 83, 1-11.
6. Borchard G. (2001). Chitosans for gene delivery. Adv Drug Deliv Rev, 52, 145-150
7. Dodane V, Vilivalum VD. (1998). Pharmaceutical applications of chitosan. Pharm Sci Technol Today, 1, 246-253
8. Tomihata K, Ikada Y. (1997). In vitro and in vivo degradation of films of chitin and its deacetylation derivatives. Biomaterials, 18, 567-575
9. Onishi H, Machida Y. (1999). Biodegradation and distribution of water-soluble chitosan in mice. Biomaterials, 20, 175-182
10. Rao SB, Sharma CP. (1997). Use of chitosan as a biomterial: Studies on its safety and hemostatic potential. J Biomed Mater Res, 34, 21-28
11. Mao H-Q, Roy K, Walsch SM, et al. (1996). DNA-chitosan nanospheres for gene delivery. Proc Int Symp Control Rel Bioact Mater, 23, 401-402
12. Roy K, Mao H-Q, Leong KW. (1997). DNA-chitosan nanospheres: Transfection efficiency and cellular uptake. Proc Int Symp Control Rel Bioact Mater, 24, 673-674
13. Lee KY, Kwon IC, Kim YH, Jo WH, Jeong, SY. (1998). Preparation of chitosan self-aggregates as a gene delivery system. J Controll Release, 51, 213-220
14. Kiang T, Wen J, Lim HW, Leong KW. (2004). The effect of the degree of chitosan deacetylation on the efficiency of gene transfection. Biomaterials, 25, 5293-5301
15. Sato T, Ishii T, Okahata Y. (2001). In vitro gene delivery mediated by chitosan. Effect of pH, serum, and molecular mass of chitosan on the transfection efficiency. Biomaterials, 22, 2075-2080
16. Huang M, Fong CW, Khor E, Lim LY. (2005). Transfection efficiency of chitosan vectors: Effect of polymer molecular weight and degree of deacetylation. J Control Release, 106, 391-406.
17. Xu S, Dong M, Liu X, Howard KA, Kjems J, Besenbacher F. (2007). Direct force measurements between siRNA and chitosan molecules using force spectroscopy. Biophys J, 93, 952-959
18. Chellat F, Grandjean-laquerriere A, Naour R, Fernandes J, Yahia L, Guenounou M, et al. (2005). Metalloproteinase and cytokine production by THP-1 macrophages following exposure to chitosan-DNA nanoparticles. Biomaterials, 26, 961-970
19. Katas H, Alpar HO. (2006). Development and characterization of chitosan nanoparticles for siRNA delivery. J Control Release, 115, 216-225
20. Murata J, Ohya Y, Ouchi T. (1996). Possibility of application of quaternary chitosan having pendant galactose residues as gene delivery tool. Carbohydrate polymers, 29, 69-74.
21. Erbacher P, Zhou S, Bettinger T, Steffan AM, Remy JS. (1998). Chitosan based vector/DNA complexes for gene delivery: Biophysical characteristics and transfection ability. Pharm Res, 15, 1332-1339
22. Lee MK, Chun SK, Choi WJ, Kim JK, Choi SH, Kim A, et al. (2005). The use of chitosan as a condensing agent to enhance emulsion mediated gene transfer. Biomaterials, 26, 2147-2156
23. Howard KA, Rahbek UL, Liu X, Damgaard CK, Glud SZ, Andersen M, et al. (2006). RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system. Mol Ther, 14, 476-484
24. Illum L, Farraj NF, Davis SS. (1994). Chitosan as a novel nasal delivery system for peptide drugs. Pharm Res, 11, 1186-1189
25. Verhoef JC, Junginger HE, Thanou M. (2001). Chitosan and its derivatives as intestinal absorption enhancers. Adv Drug Deliver Rev, 50, S91-S101. (Pubitemid 32905357)
26. Liu X, Howard KA, Dong M, Anderson MO, Rahbek UL, Johnsen MG, et al. (2007). The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing. Biomaterials, 28, 1280-1288
27. Calvo P, Remunan-lopez C, Vila-Jato JL, Alonso MJ. (1997). Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers. J Appl Polym Sci, 63, 125-132
28. Shu XZ, Zhu KJ. (2000). A novel approach to prepare tripolyphosphate/ chitosan complex beads for controlled drug delivery. Int J Pharm, 201, 51-58
29. Rojanarata T, Opanasopit P, Techaarpornkul S, Ngawhirunpat T, Ruktanonchai U. (2008). Chitosan-Thiamine pyrophosphate as a novel carrier for siRNA delivery. Pharm Res, doi: 10.1007/ s11095-008-9648-9656
30. MacLaughlin FC, Mumper RJ, Wang J, Tagliaferri JM, Gill I, Hinchcliffe M, et al. (1998). Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery. J Control Release, 56, 259-272
31. Andersen M∅, Howard KA, Paludan SR, Besenbacher F, Kjems J. (2007). Delivery of siRNA from lyophilized polymeric surfaces. Biomaterials, 29, 506-512
32. Liu WG, Zhang X, Sun SJ, Sun GJ, Yao KD, Liang DC, et al. (2003). N-alkylated chitosan as a potential nonviral vector for gene delivery. Bioconjug Chem, 14, 782-789
33. Wolfert MA, Seymour LW. (1996). Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block copolymers. Human Gene Ther, 3, 269-273
34. Mao H-Q, Roy K, Troung-Le VL, Janes KA, Lin KY, Wang Y, August JT, Leong KW. (2001). Chitosan-DNA nanoparticles as gene carriers: Synthesis, characterization and transfection efficiency. J Control Release, 70, 399-421.
35. Boussif O, Lezoualch F, Zanta MA, Mergny MD, Scherman D, Demeneix B, et al. (1995). A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine. Proc Natl Acad Sci USA, 92, 7297-7301
36. Cho YW, Kim JD, Park K. (2003). Polycation gene delivery system: Escape from endosomes to cytosol. J Pharm Pharmacol, 55:721-734
37. Ishii T, Okahata Y, Sato T. (2001) Mechanism of cell transfection with plasmid/chitosan compleses. Biochim Biophys Acta, 1514, 51-64.
38. Fang N, Chan V, Mao H-Q, Leong KW. (2001) Interactions of phopholipid bilayer with Chitosan: effect of molecular weight and pH. Biomacromolecules, 2, 1161-1168
39. Dung TH, Lee S-R, Han S-D, Kim SJ, Ju YM, Kim MS, et al. (2007). Chitosan-TPP nanoparticle as a release system of antisense oligonucleotide in the oral environment. J Nanosci Nanotechnol, 7, 3695-3699