Mechanism of activation and functional role of protein kinase Cη in human platelets

Journal of Biological Chemistry

Volumn 284, Issue 20, 2009, Pages 13413-13421

  Bynagari, Yamini S ^a   Nagy Jr , Bela ^a   Tuluc, Florin ^a   Bhavaraju, Kamala ^a   Kim, Soochong ^a   Vijayan, K Vinod ^b   Kunapuli, Satya P ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC SUBUNITS; CONCENTRATION-DEPENDENT; DEPHOSPHORYLATION; INTEGRIN; ISOFORM; KNOCK OUTS; MURINE PLATELETS; PLATELET AGGREGATION; PRE-TREATMENT; PROTEIN KINASE C; RECEPTOR ANTAGONISTS; SPECIFIC INHIBITORS; STIRRING CONDITIONS;

AMINES; BLOOD SUBSTITUTES; PEPTIDES; PHOSPHORYLATION;

PLATELETS;

2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; ADENOSINE DIPHOSPHATE; ALPHA2 INTEGRIN; ALPHA2BBETA3 INTEGRIN; GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 1C GAMMA; PROTEIN KINASE C ETA; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; THROMBOXANE; UNCLASSIFIED DRUG; ADENOSINE PHOSPHATE; CANGRELOR; CYCLOPEPTIDE; DRUG DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; ITGA2B PROTEIN, HUMAN; N(6) METHYL 2' DEOXYADENOSINE 3',5' DIPHOSPHATE; N(6)-METHYL-2'-DEOXYADENOSINE 3',5'-DIPHOSPHATE; PROTEIN KINASE C; PURINERGIC P2 RECEPTOR; YM 254890; YM-254890;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; KNOCKOUT GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE AGGREGATION; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; GENETICS; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; PHYSIOLOGY;

MURINAE; MUS;

ADENOSINE DIPHOSPHATE; ADENOSINE MONOPHOSPHATE; ANIMALS; BLOOD PLATELETS; ENZYME ACTIVATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; INTEGRIN ALPHA2; MICE; MICE, KNOCKOUT; PEPTIDES, CYCLIC; PHOSPHORYLATION; PLATELET AGGREGATION; PROTEIN KINASE C; PROTEIN PHOSPHATASE 1; RECEPTORS, PURINERGIC P2; THROMBOXANES;

EID: 67649392703     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808970200     Document Type: Article

References (55)

1. Shattil, S. J., Kashiwagi, H., and Pampori, N. (1998) Blood 91, 2645-2657
2. Brass, L. F. (1999) J. Clin. Investig. 104, 1663-1665
3. Brass, L. F., Hoxie, J. A., Kieber-Emmons, T., Manning, D. R., Poncz, M., and Woolkalis, M. (1993) Adv. Exp. Med. Biol. 344, 17-36
4. Dorsam, R. T., and Kunapuli, S. P. (2004) J. Clin. Investig. 113, 340-345
5. Daniel, J. L., Dangelmaier, C., Jin, J., Ashby, B., Smith, J. B., and Kunapuli, S. P. (1998) J. Biol. Chem. 273, 2024-2029
6. Jin, J., Daniel, J. L., and Kunapuli, S. P. (1998) J. Biol. Chem. 273, 2030-2034
7. Jin, J., and Kunapuli, S. P. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 8070-8074
8. Offermanns, S. (2000) Biol. Chem. 381, 389-396
9. Kunapuli, S. P. (2002) Scientific World J. 2, 424-433
10. Leon, C., Hechler, B., Freund, M., Eckly, A., Vial, C., Ohlmann, P., Dierich, A., LeMeur, M., Cazenave, J. P., and Gachet, C. (1999) J. Clin. Investig. 104, 1731-1737
11. Shattil, S. J., and Newman, P. J. (2004) Blood 104, 1606-1615
12. Quinton, T. M., Kim, S., Dangelmaier, C., Dorsam, R. T., Jin, J., Daniel, J. L., and Kunapuli, S. P. (2002) Biochem. J. 368, 535-543
13. Yang, X., Sun, L., Gabbeta, J., and Rao, A. K. (1997) Thromb. Res. 88, 317-328
14. Newton, A. C. (1997) Curr. Opin. Cell Biol. 9, 161-167
15. Murugappan, S., Tuluc, F., Dorsam, R. T., Shankar, H., and Kunapuli, S. P. (2004) J. Biol. Chem. 279, 2360-2367
16. Crosby, D., and Poole, A. W. (2003) J. Biol. Chem. 278, 24533-24541
17. Crosby, D., and Poole, A. W. (2002) J. Biol. Chem. 277, 9958-9965
18. Soriani, A., Moran, B., de Virgilio, M., Kawakami, T., Altman, A., Lowell, C., Eto, K., and Shattil, S. J. (2006) J. Thromb. Haemost. 4, 648-655
19. Nagy, B., Jr., Bhavaraju, K., Getz, T., Bynagari, Y. S., Kim, S., and Kunapuli, S. P. (2009) Blood 113, 2557-2567
20. Chari, R., Getz, T., Nagy, B., Jr., Bhavaraju, K., Mao, Y., Bynagari, Y. S., Murugappan, S., Nakayama, K., and Kunapuli, S. P. (2009) Arterioscler. Thromb. Vasc. Biol., in press
21. Newton, A. C. (2003) Biochem. J. 370, 361-371
22. Mochly-Rosen, D., Khaner, H., Lopez, J., and Smith, B. L. (1991) J. Biol. Chem. 266, 14866-14868
23. Ron, D., Chen, C. H., Caldwell, J., Jamieson, L., Orr, E., and Mochly-Rosen, D. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 839-843
24. Gushiken, F. C., Patel, V., Liu, Y., Pradhan, S., Bergeron, A. L., Peng, Y., and Vijayan, K. V. (2008) J. Biol. Chem. 283, 12862-12869
25. Vijayan, K. V., Liu, Y., Sun, W., Ito, M., and Bray, P. F. (2005) J. Biol. Chem. 280, 21756-21762
26. Vijayan, K. V., Liu, Y., Li, T. T., and Bray, P. F. (2004) J. Biol. Chem. 279, 33039-33042
27. Gushiken, F. C., Patel, V., Rumbaut, R., Varmuza, S., and Vijayan, K. V. (2007) Blood 110, 135a
28. Brandlin, I., Hubner, S., Eiseler, T., Martinez-Moya, M., Horschinek, A., Hausser, A., Link, G., Rupp, S., Storz, P., Pfizenmaier, K., and Johannes, F. J. (2002) J. Biol. Chem. 277, 6490-6496
29. Garcia, A., Shankar, H., Murugappan, S., Kim, S., and Kunapuli, S. P. (2007) Biochem. J. 404, 299-308
30. Shankar, H., Garcia, A., Prabhakar, J., Kim, S., and Kunapuli, S. P. (2006) J. Thromb. Haemost. 4, 638-647
31. Offermanns, S., Hashimoto, K., Watanabe, M., Sun, W., Kurihara, H., Thompson, R. F., Inoue, Y., Kano, M., and Simon, M. I. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 14089-14094
32. Varmuza, S., Jurisicova, A., Okano, K., Hudson, J., Boekelheide, K., and Shipp, E. B. (1999) Dev. Biol. 205, 98-110
33. Fabre, J. E., Nguyen, M., Latour, A., Keifer, J. A., Audoly, L. P., Coffman, T. M., and Koller, B. H. (1999) Nat. Med. 5, 1199-1202
34. Dorsam, R. T., Kim, S., Murugappan, S., Rachoor, S., Shankar, H., Jin, J., and Kunapuli, S. P. (2005) Blood 105, 2749-2756
35. Kim, S., Jin, J., and Kunapuli, S. P. (2004) J. Biol. Chem. 279, 4186-4195
36. Kim, S., Jin, J., and Kunapuli, S. P. (2006) Blood 107, 947-954
37. Dangelmaier, C., Jin, J., Daniel, J. L., Smith, J. B., and Kunapuli, S. P. (2000) Eur. J. Biochem. 267, 2283-2289
38. Uht, R. M., Amos, S., Martin, P. M., Riggan, A. E., and Hussaini, I. M. (2007) Oncogene 26, 2885-2893
39. Newton, A. C. (2001) Chem. Rev. 101, 2353-2364
40. Baurand, A., Raboisson, P., Freund, M., Leon, C., Cazenave, J. P., Bourguignon, J. J., and Gachet, C. (2001) Eur. J. Pharmacol. 412, 213-221
41. Taniguchi, M., Suzumura, K., Nagai, K., Kawasaki, T., Takasaki, J., Sekiguchi, M., Moritani, Y., Saito, T., Hayashi, K., Fujita, S., Tsukamoto, S., and Suzuki, K. (2004) Bioorg. Med. Chem. 12, 3125-3133
42. Kawasaki, T., Taniguchi, M., Moritani, Y., Hayashi, K., Saito, T., Takasaki, J., Nagai, K., Inagaki, O., and Shikama, H. (2003) Thromb. Haemost. 90, 406-413
43. Lum, H., Podolski, J. L., Gurnack, M. E., Schulz, I. T., Huang, F., and Holian, O. (2001) Am. J. Physiol. Lung Cell Mol. Physiol. 281, L546-L555
44. Liedtke, C. M., Wang, X., and Smallwood, N. D. (2005) J. Biol. Chem. 280, 25491-25498
45. Csukai, M., Chen, C. H., De Matteis, M. A., and Mochly-Rosen, D. (1997) J. Biol. Chem. 272, 29200-29206
46. Ron, D., Luo, J., and Mochly-Rosen, D. (1995) J. Biol. Chem. 270, 24180-24187
47. Inagaki, K., Hahn, H. S., Dorn, G. W., 2nd, and Mochly-Rosen, D. (2003) Circulation 108, 869-875
48. Mills, D. C. (1996) Thromb. Haemost. 76, 835-856
49. Schror, K. (1997) Semin Thromb. Hemost. 23, 349-356
50. Parker, P. J., Bosca, L., Dekker, L., Goode, N. T., Hajibagheri, N., and Hansra, G. (1995) Biochem. Soc. Trans. 23, 153-155
51. Goode, N. T., Hajibagheri, M. A., and Parker, P. J. (1995) J. Biol. Chem. 270, 2669-2673
52. Lee, H. W., Smith, L., Pettit, G. R., and Smith, J. B. (1997) Mol. Pharmacol. 51, 439-447
53. Dangelmaier, C. A., Quinter, P. G., Jin, J., Tsygankov, A. Y., Kunapuli, S. P., and Daniel, J. L. (2005) Blood 105, 3918-3924
54. Joseph, E. K., Bogen, O., Alessandri-Haber, N., and Levine, J. D. (2007) Pain 132, 67-73
55. Jin, J., Quinton, T. M., Zhang, J., Rittenhouse, S. E., and Kunapuli, S. P. (2002) Blood 99, 193-198