The Gi-coupled P2Y12 receptor regulates diacylglycerol-mediated signaling in human platelets

Journal of Biological Chemistry

Volumn 283, Issue 43, 2008, Pages 28795-28805

  Guidetti, Gianni F ^a   Lova, Paolo ^a   Bernardi, Bruno ^a   Campus, Francesca ^a   Baldanzi, Gianluca ^b   Graziani, Andrea ^b   Balduini, Cesare ^a   Torti, Mauro ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CELL MEMBRANES; CHEMICAL REACTIONS; GLYCEROL; PHOSPHORYLATION; PLATELETS;

ACTIVATED PLATELETS; ADENYLYL CYCLASE; COUPLED RECEPTORS; DIACYLGLYCEROL; DIACYLGLYCEROL KINASES; INHIBITORY EFFECTS; PHOSPHATIDIC ACIDS; PHOSPHATIDYLINOSITOL; PHOSPHOLIPASE; PLATELET AGGREGATIONS; PROTEIN KINASES;

BLOOD SUBSTITUTES;

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADENOSINE DIPHOSPHATE; ADENYLATE CYCLASE; CALCIUM; DIACYLGLYCEROL KINASE; DIOCTANOIN; G I COUPLED PURINERGIC P2Y12 RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PLECKSTRIN; PROTEIN KINASE C; PURINERGIC P2Y12 RECEPTOR; RAP1 PROTEIN; UNCLASSIFIED DRUG; ANTITHROMBOCYTIC AGENT; DIACYLGLYCEROL; ENZYME INHIBITOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHOPROTEIN; PLASMA PROTEIN; PLATELET PROTEIN P47; PURINERGIC P2 RECEPTOR; THROMBOXANE A2;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; CHEMISTRY; METABOLISM; SIGNAL TRANSDUCTION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ADENOSINE DIPHOSPHATE; BLOOD PLATELETS; BLOOD PROTEINS; DIACYLGLYCEROL KINASE; DIGLYCERIDES; ENZYME INHIBITORS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; PHOSPHOPROTEINS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTEIN KINASE C; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION; THROMBOXANE A2;

EID: 57649198313     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801588200     Document Type: Article

References (39)

1. Woulfe, D. S. (2005) J. Thromb. Haemost. 3, 2193-2200
2. Offermanns, S., Toombs, C. F., Hu, Y. H., and Simon, M. I. (1997) Nature 389, 183-186
3. Rhee, S. G. (2001) Annu. Rev. Biochem. 70, 281-312
4. Dorsam, R. T., and Kunapuli, S. P. (2004) J. Clin. Investig. 113, 340-345
5. Jin, J., and Kunapuli, S. P. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 8070-8074
6. Eckly, A., Gendrault, J.-L., Hechler, B., Cazenave, J.-P., and Gachet, C. (2001) Thromb. Haemostasis 85, 694-701
7. Paul, B. Z., Jin, J., and Kunapuli, S. P. (1999) J. Biol. Chem. 274, 29108-29114
8. Yang, J., Wu, J., Kowalska, M. A., Dalvi, A., Prevost, N., O'Brien, P. J., Manning, D., Poncz, M., Lucki, I., Blendy, J. A., and Brass, L. F. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 9984-9989
9. Hollopeter, G., Jantzen, H. M., Vincent, D., Li, G., England, L., Ramakrishnan, V., Yang, R.-B., Nurden, P., Nurden, A., Julius, D., and Conley, P. B. (2001) Nature 409, 202-207
10. Foster, C. J., Prosser, D. M., Agans, J. M., Zhai, Y., Smith, M. D., Lachwicz, J. E., Zhang, F. L., Gustafson, E., Monsma, F. J., Wiekowski, M. T., Abbondanzo, S. J., Cook, D. N., Bayne, M. L., Lira, S. A., and Chintala, M. S. (2001) J. Clin. Investig. 107, 1591-1598
11. Gachet, C. (2008) Thromb. Haemostasis 99, 466-472
12. Daniel, J. L., Dangelmaier, C., Jin, J., Kim, Y. B., and Kunapuli, S. P. (1999) Thromb. Haemostasis 82, 1322-1326
13. Lova, P., Paganini, S., Sinigaglia, F., Balduini, C., and Torti, M. (2002) J. Biol. Chem. 277, 12009-12015
14. Hirsch, E., Bosco, O., Tropel, P., Laffargue, M., Calvez, R., Altruda, F., Wymann, M., and Montrucchio, G. (2001) FASEB J. 15, 2019-2021
15. Jackson, S. P., Schoenwaelder, S. M., Goncalves, I., Nesbitt, W. S., Yap, C. L., Wright, C. E., Kenche, V., Anderson, K. E., Dopheide, S. M., Yuan, Y., Sturgeon, S. A., Prabaharan, H., Thompson, P. E., Smith, G. D., Shepherd, P. R., Daniele, N., Kulkarni, S., Abbott, B., Saylik, D., Jones, C., Lu, L., Giuliano, S., Hughan, S. C., Angus, J. A., Robertson, A. D., and Salem, H. H. (2005) Nat. Med. 11, 507-514
16. Woulfe, D., Jiang, H., Mortensen, R., Yang, J., and Brass, L. F. (2002) J. Biol. Chem. 277, 23382-23390
17. Cosemans, J. M., Munnix, I. C., Wetzker, R., Heller, R., Jackson, S. P., and Heemskerk, J. W. (2006) Blood 108, 3045-3052
18. Lova, P., Paganini, S., Hirsch, E., Barberis, L., Wymann, M., Sinigaglia, F., Balduini, C., and Torti, M. (2003) J. Biol. Chem. 278, 131-138
19. Bertoni, A., Tadokoro, S., Eto, K., Pampori, N., Parise, L., White, G. C., and Shattil, S. J. (2002) J. Biol. Chem. 277, 25715-25721
20. Crittenden, J. R., Bergmeier, W., Zhang, Y., Piffath, C. L., Liang, Y., Wagner, D. A., Housman, D. E., and Graybiel, A. M. (2004) Nat. Med. 10, 982-986
21. Bernardi, B., Guidetti, G. F., Campus, F., Crittenden, J. R., Graybiel, A. M., Balduini, C., and Torti, M. (2006) Blood 107, 2728-2735
22. Dangelmaier, C., Jin, J., Smith, J. B., and Kunapuli, S. P. (2001) Thromb. Haemostasis 85, 341-348
23. Kauffenstein, G., Bergmeier, W., Eckly, A., Ohlmann, P., Leon, C., Cazenave, J. P., Nieswandt, B., and Gachet, C. (2001) FEBS Lett. 505, 281-290
24. Campus, F., Lova, P., Bertoni, A., Sinigaglia, F., Balduini, C., and Torti, M. (2005) J. Biol. Chem. 280, 24386-24395
25. Larson, M. K., Chen, H., Kahn, M. L., Taylor, A. M., Fabre, J.-E., Mortensen, R. M., Conley, P., and Parise, L. V. (2003) Blood 101, 1409-1415
26. Nieswandt, B., Bergmeier, W., Eckly, A., Schulte, V., Ohlmann, P., Cazenave, J.-P., Zirngibl, H., Offermanns, S., and Gachet, C. (2001) Blood 97, 3829-3835
27. Torti, M., Balduini, C., Ramaschi, G., and Sinigaglia, F. (1992) Cell Biochem. Funct. 10, 53-59
28. Lova, P., Campus, F., Lombardi, R., Cattaneo, M., Sinigaglia, F., Balduini, C., and Torti, M. (2004) J. Biol. Chem. 279, 25299-25306
29. Tyers, M., Rachubinski, R. A., Stewart, M. I., Varrichio, A. M., Shorr, R. G. L., Haslam, R. J., and Harley, C. B. (1988) Nature 333, 470-473
30. Vickers, J. D., Kinlough-Rathbone, R. L., Packham, M. A., and Mustard, J. F. (1990) Eur. J. Biochem. 193, 521-528
31. Sage, S. O., Yamoah, E. H., and Heemskerk, J. W. (2000) Cell Calcium 28, 119-126
32. Hardy, A. R., Jones, M. L., Mundell, S. J., and Poole, A. W. (2004) Blood 104, 1745-1752
33. Luo, B., Regier, D. S., Prescott, S. M., and Topham, M. K. (2004) Cell. Signal. 16, 983-989
34. Merida, I., Avina-Flores, A., and Merino, E. (2008) Biochem. J. 409, 1-18
35. Baldanzi, G., Cupriti, S., Chianale, F., Gnocchi, V. F., Rainero, E., Porporato, P. E., Filigheddu, N., van Blitterswijk, W. J., Parolini, O., Bussolino, F., Sinigaglia, F., and Graziani, A. (2008) Oncogene 27, 942-956
36. Bishop, W. R., and Bell, R. M. (1986) J. Biol. Chem. 261, 12513-12519
37. Packham, M. A., Livne, A. A., Ruben, D. H., and Rand, M. L. (1993) Biochem. J. 209, 849-856
38. Nunn, D. L., and Watson, S. P. (1987) Biochem. J. 243, 809-813
39. Yada, Y., Ozeki, T., Kanoh, H., and Nozawa, Y. (1990) J. Biol. Chem. 265, 19237-19243