메뉴 건너뛰기




Volumn 132, Issue 7, 2007, Pages 2383-2394

LIGHT Signals Directly to Intestinal Epithelia to Cause Barrier Dysfunction via Cytoskeletal and Endocytic Mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

CAVEOLIN 1; GAMMA INTERFERON; LYMPHOTOXIN BETA; MYOSIN II; MYOSIN LIGHT CHAIN KINASE; OCCLUDIN; PROTEIN DERIVATIVE; PROTEIN LIGHT; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

EID: 34250190636     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.02.052     Document Type: Article
Times cited : (166)

References (70)
  • 2
    • 0035576394 scopus 로고    scopus 로고
    • Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction
    • Shaikh R.B., Santee S., Granger S.W., Butrovich K., Cheung T., Kronenberg M., Cheroutre H., and Ware C.F. Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction. J Immunol 167 (2001) 6330-6337
    • (2001) J Immunol , vol.167 , pp. 6330-6337
    • Shaikh, R.B.1    Santee, S.2    Granger, S.W.3    Butrovich, K.4    Cheung, T.5    Kronenberg, M.6    Cheroutre, H.7    Ware, C.F.8
  • 3
    • 20444413440 scopus 로고    scopus 로고
    • The critical role of LIGHT in promoting intestinal inflammation and Crohn's disease
    • Wang J., Anders R.A., Wang Y., Turner J.R., Abraham C., Pfeffer K., and Fu Y.X. The critical role of LIGHT in promoting intestinal inflammation and Crohn's disease. J Immunol 174 (2005) 8173-8182
    • (2005) J Immunol , vol.174 , pp. 8173-8182
    • Wang, J.1    Anders, R.A.2    Wang, Y.3    Turner, J.R.4    Abraham, C.5    Pfeffer, K.6    Fu, Y.X.7
  • 4
    • 0035500607 scopus 로고    scopus 로고
    • Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis
    • Granger S.W., Butrovich K.D., Houshmand P., Edwards W.R., and Ware C.F. Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis. J Immunol 167 (2001) 5122-5128
    • (2001) J Immunol , vol.167 , pp. 5122-5128
    • Granger, S.W.1    Butrovich, K.D.2    Houshmand, P.3    Edwards, W.R.4    Ware, C.F.5
  • 6
    • 2942755965 scopus 로고    scopus 로고
    • LIGHT expression by mucosal T cells may regulate IFN-gamma expression in the intestine
    • Cohavy O., Zhou J., Granger S.W., Ware C.F., and Targan S.R. LIGHT expression by mucosal T cells may regulate IFN-gamma expression in the intestine. J Immunol 173 (2004) 251-258
    • (2004) J Immunol , vol.173 , pp. 251-258
    • Cohavy, O.1    Zhou, J.2    Granger, S.W.3    Ware, C.F.4    Targan, S.R.5
  • 7
    • 16244410786 scopus 로고    scopus 로고
    • Tumor necrosis factor family members and inflammatory bowel disease
    • Wang J., and Fu Y.X. Tumor necrosis factor family members and inflammatory bowel disease. Immunol Rev 204 (2005) 144-155
    • (2005) Immunol Rev , vol.204 , pp. 144-155
    • Wang, J.1    Fu, Y.X.2
  • 9
    • 0026630075 scopus 로고
    • The intestinal permeability barrier. A hypothesis as to its regulation and involvement in Crohn's disease
    • Hollander D. The intestinal permeability barrier. A hypothesis as to its regulation and involvement in Crohn's disease. Scand J Gastroenterol 27 (1992) 721-726
    • (1992) Scand J Gastroenterol , vol.27 , pp. 721-726
    • Hollander, D.1
  • 10
    • 0028878346 scopus 로고
    • CD45RO expression on circulating CD19+ B cells in Crohn's disease correlates with intestinal permeability
    • Yacyshyn B.R., and Meddings J.B. CD45RO expression on circulating CD19+ B cells in Crohn's disease correlates with intestinal permeability. Gastroenterology 108 (1995) 132-137
    • (1995) Gastroenterology , vol.108 , pp. 132-137
    • Yacyshyn, B.R.1    Meddings, J.B.2
  • 11
    • 0027217379 scopus 로고
    • Intestinal permeability and the prediction of relapse in Crohn's disease
    • Wyatt J., Vogelsang H., Hubl W., Waldhoer T., and Lochs H. Intestinal permeability and the prediction of relapse in Crohn's disease. Lancet 341 (1993) 1437-1439
    • (1993) Lancet , vol.341 , pp. 1437-1439
    • Wyatt, J.1    Vogelsang, H.2    Hubl, W.3    Waldhoer, T.4    Lochs, H.5
  • 12
    • 0027161142 scopus 로고
    • Permeability in Crohn's disease: altered barrier functions in healthy relatives?
    • Hollander D. Permeability in Crohn's disease: altered barrier functions in healthy relatives?. Gastroenterology 104 (1993) 1848-1851
    • (1993) Gastroenterology , vol.104 , pp. 1848-1851
    • Hollander, D.1
  • 14
    • 21844465744 scopus 로고    scopus 로고
    • Hyperresponsiveness of the mucosal barrier in Crohn's disease is not tumor necrosis factor-dependent
    • Suenaert P., Bulteel V., Vermeire S., Noman M., Van Assche G., and Rutgeerts P. Hyperresponsiveness of the mucosal barrier in Crohn's disease is not tumor necrosis factor-dependent. Inflamm Bowel Dis 11 (2005) 667-673
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 667-673
    • Suenaert, P.1    Bulteel, V.2    Vermeire, S.3    Noman, M.4    Van Assche, G.5    Rutgeerts, P.6
  • 15
    • 0036677473 scopus 로고    scopus 로고
    • Crohn's disease, TNF-alpha, and the leaky gut. The chicken or the egg?
    • Hollander D. Crohn's disease, TNF-alpha, and the leaky gut. The chicken or the egg?. Am J Gastroenterol 97 (2002) 1867-1868
    • (2002) Am J Gastroenterol , vol.97 , pp. 1867-1868
    • Hollander, D.1
  • 18
  • 19
    • 0345447585 scopus 로고    scopus 로고
    • Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms
    • Bruewer M., Luegering A., Kucharzik T., Parkos C.A., Madara J.L., Hopkins A.M., and Nusrat A. Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol 171 (2003) 6164-6172
    • (2003) J Immunol , vol.171 , pp. 6164-6172
    • Bruewer, M.1    Luegering, A.2    Kucharzik, T.3    Parkos, C.A.4    Madara, J.L.5    Hopkins, A.M.6    Nusrat, A.7
  • 20
    • 33749428028 scopus 로고    scopus 로고
    • Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo
    • Clayburgh D.R., Musch M.W., Leitges M., Fu Y.X., and Turner J.R. Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest 116 (2006) 2682-2694
    • (2006) J Clin Invest , vol.116 , pp. 2682-2694
    • Clayburgh, D.R.1    Musch, M.W.2    Leitges, M.3    Fu, Y.X.4    Turner, J.R.5
  • 21
    • 0033672942 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells
    • Nusrat A., Turner J.R., and Madara J.L. Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am J Physiol Gastrointest Liver Physiol 279 (2000) G851-G857
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.279
    • Nusrat, A.1    Turner, J.R.2    Madara, J.L.3
  • 22
    • 26244442836 scopus 로고    scopus 로고
    • Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: Myosin II-dependent vacuolarization of the apical plasma membrane
    • Utech M., Ivanov A.I., Samarin S.N., Bruewer M., Turner J.R., Mrsny R.J., Parkos C.A., and Nusrat A. Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: Myosin II-dependent vacuolarization of the apical plasma membrane. Mol Biol Cell 16 (2005) 5040-5052
    • (2005) Mol Biol Cell , vol.16 , pp. 5040-5052
    • Utech, M.1    Ivanov, A.I.2    Samarin, S.N.3    Bruewer, M.4    Turner, J.R.5    Mrsny, R.J.6    Parkos, C.A.7    Nusrat, A.8
  • 23
    • 0025218790 scopus 로고
    • Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability
    • Mullin J.M., and Snock K.V. Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability. Cancer Res 50 (1990) 2172-2176
    • (1990) Cancer Res , vol.50 , pp. 2172-2176
    • Mullin, J.M.1    Snock, K.V.2
  • 24
    • 0031898947 scopus 로고    scopus 로고
    • Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumor necrosis factor alpha
    • Taylor C.T., Dzus A.L., and Colgan S.P. Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumor necrosis factor alpha. Gastroenterology 114 (1998) 657-668
    • (1998) Gastroenterology , vol.114 , pp. 657-668
    • Taylor, C.T.1    Dzus, A.L.2    Colgan, S.P.3
  • 25
    • 0034465577 scopus 로고    scopus 로고
    • Modulation of barrier function during Fas-mediated apoptosis in human intestinal epithelial cells
    • Abreu M.T., Palladino A.A., Arnold E.T., Kwon R.S., and McRoberts J.A. Modulation of barrier function during Fas-mediated apoptosis in human intestinal epithelial cells. Gastroenterology 119 (2000) 1524-1536
    • (2000) Gastroenterology , vol.119 , pp. 1524-1536
    • Abreu, M.T.1    Palladino, A.A.2    Arnold, E.T.3    Kwon, R.S.4    McRoberts, J.A.5
  • 26
    • 0033818743 scopus 로고    scopus 로고
    • Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis
    • Gitter A.H., Bendfeldt K., Schulzke J.D., and Fromm M. Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis. FASEB J 14 (2000) 1749-1753
    • (2000) FASEB J , vol.14 , pp. 1749-1753
    • Gitter, A.H.1    Bendfeldt, K.2    Schulzke, J.D.3    Fromm, M.4
  • 27
    • 0035210487 scopus 로고    scopus 로고
    • Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging
    • Gitter A.H., Wullstein F., Fromm M., and Schulzke J.D. Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging. Gastroenterology 121 (2001) 1320-1328
    • (2001) Gastroenterology , vol.121 , pp. 1320-1328
    • Gitter, A.H.1    Wullstein, F.2    Fromm, M.3    Schulzke, J.D.4
  • 28
    • 30944443377 scopus 로고    scopus 로고
    • Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease
    • Blair S.A., Kane S.V., Clayburgh D.R., and Turner J.R. Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. Lab Invest 86 (2006) 191-201
    • (2006) Lab Invest , vol.86 , pp. 191-201
    • Blair, S.A.1    Kane, S.V.2    Clayburgh, D.R.3    Turner, J.R.4
  • 29
    • 13844308129 scopus 로고    scopus 로고
    • Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression
    • Ma T.Y., Boivin M.A., Ye D., Pedram A., and Said H.M. Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol 288 (2005) G422-G430
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Ma, T.Y.1    Boivin, M.A.2    Ye, D.3    Pedram, A.4    Said, H.M.5
  • 30
    • 13244298599 scopus 로고    scopus 로고
    • Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression
    • Wang F., Graham W.V., Wang Y., Witkowski E.D., Schwarz B.T., and Turner J.R. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am J Pathol 166 (2005) 409-419
    • (2005) Am J Pathol , vol.166 , pp. 409-419
    • Wang, F.1    Graham, W.V.2    Wang, Y.3    Witkowski, E.D.4    Schwarz, B.T.5    Turner, J.R.6
  • 31
    • 33749466490 scopus 로고    scopus 로고
    • IFN-gamma-induced TNFR2 upregulation is required for TNF-dependent intestinal epithelial barrier dysfunction
    • Wang F., Schwarz B.T., Graham W.V., Wang Y., Su L., Clayburgh D.R., Abraham C., and Turner J.R. IFN-gamma-induced TNFR2 upregulation is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology 131 (2006) 1153-1163
    • (2006) Gastroenterology , vol.131 , pp. 1153-1163
    • Wang, F.1    Schwarz, B.T.2    Graham, W.V.3    Wang, Y.4    Su, L.5    Clayburgh, D.R.6    Abraham, C.7    Turner, J.R.8
  • 32
    • 0036305854 scopus 로고    scopus 로고
    • A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease
    • Zolotarevsky Y., Hecht G., Koutsouris A., Gonzalez D.E., Quan C., Tom J., Mrsny R.J., and Turner J.R. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 123 (2002) 163-172
    • (2002) Gastroenterology , vol.123 , pp. 163-172
    • Zolotarevsky, Y.1    Hecht, G.2    Koutsouris, A.3    Gonzalez, D.E.4    Quan, C.5    Tom, J.6    Mrsny, R.J.7    Turner, J.R.8
  • 34
    • 0012731458 scopus 로고    scopus 로고
    • LIGHT sensitizes IFNgamma-mediated apoptosis of MDA-MB-231 breast cancer cells leading to down-regulation of anti-apoptosis Bcl-2 family members
    • Zhang M., Guo R., Zhai Y., and Yang D. LIGHT sensitizes IFNgamma-mediated apoptosis of MDA-MB-231 breast cancer cells leading to down-regulation of anti-apoptosis Bcl-2 family members. Cancer Lett 195 (2003) 201-210
    • (2003) Cancer Lett , vol.195 , pp. 201-210
    • Zhang, M.1    Guo, R.2    Zhai, Y.3    Yang, D.4
  • 35
    • 0030669302 scopus 로고    scopus 로고
    • Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation
    • Turner J.R., Rill B.K., Carlson S.L., Carnes D., Kerner R., Mrsny R.J., and Madara J.L. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. Am J Physiol 273 (1997) C1378-C1385
    • (1997) Am J Physiol , vol.273
    • Turner, J.R.1    Rill, B.K.2    Carlson, S.L.3    Carnes, D.4    Kerner, R.5    Mrsny, R.J.6    Madara, J.L.7
  • 36
    • 0026755585 scopus 로고
    • Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal cell line, Caco-2
    • Peterson M.D., and Mooseker M.S. Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal cell line, Caco-2. J Cell Sci 102 (1992) 581-600
    • (1992) J Cell Sci , vol.102 , pp. 581-600
    • Peterson, M.D.1    Mooseker, M.S.2
  • 38
    • 33748747620 scopus 로고    scopus 로고
    • Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter
    • Graham W.V., Wang F., Clayburgh D.R., Cheng J.X., Yoon B., Wang Y., Lin A., and Turner J.R. Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter. J Biol Chem 281 (2006) 26205-26215
    • (2006) J Biol Chem , vol.281 , pp. 26205-26215
    • Graham, W.V.1    Wang, F.2    Clayburgh, D.R.3    Cheng, J.X.4    Yoon, B.5    Wang, Y.6    Lin, A.7    Turner, J.R.8
  • 40
    • 0032127301 scopus 로고    scopus 로고
    • The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues
    • Futterer A., Mink K., Luz A., Kosco-Vilbois M.H., and Pfeffer K. The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9 (1998) 59-70
    • (1998) Immunity , vol.9 , pp. 59-70
    • Futterer, A.1    Mink, K.2    Luz, A.3    Kosco-Vilbois, M.H.4    Pfeffer, K.5
  • 41
    • 0034122209 scopus 로고    scopus 로고
    • Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma
    • Mankertz J., Tavalali S., Schmitz H., Mankertz A., Riecken E.O., Fromm M., and Schulzke J.D. Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma. J Cell Sci 113 (2000) 2085-2090
    • (2000) J Cell Sci , vol.113 , pp. 2085-2090
    • Mankertz, J.1    Tavalali, S.2    Schmitz, H.3    Mankertz, A.4    Riecken, E.O.5    Fromm, M.6    Schulzke, J.D.7
  • 45
    • 20444481707 scopus 로고    scopus 로고
    • Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process
    • Bruewer M., Utech M., Ivanov A.I., Hopkins A.M., Parkos C.A., and Nusrat A. Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. FASEB J 19 (2005) 923-933
    • (2005) FASEB J , vol.19 , pp. 923-933
    • Bruewer, M.1    Utech, M.2    Ivanov, A.I.3    Hopkins, A.M.4    Parkos, C.A.5    Nusrat, A.6
  • 46
    • 0347360336 scopus 로고    scopus 로고
    • Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment
    • Ivanov A.I., Nusrat A., and Parkos C.A. Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment. Mol Biol Cell 15 (2004) 176-188
    • (2004) Mol Biol Cell , vol.15 , pp. 176-188
    • Ivanov, A.I.1    Nusrat, A.2    Parkos, C.A.3
  • 47
    • 24344457031 scopus 로고    scopus 로고
    • Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis
    • Shen L., and Turner J.R. Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis. Mol Biol Cell 16 (2005) 3919-3936
    • (2005) Mol Biol Cell , vol.16 , pp. 3919-3936
    • Shen, L.1    Turner, J.R.2
  • 48
    • 0024836461 scopus 로고
    • Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells
    • West M.A., Bretscher M.S., and Watts C. Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells. J Cell Biol 109 (1989) 2731-2739
    • (1989) J Cell Biol , vol.109 , pp. 2731-2739
    • West, M.A.1    Bretscher, M.S.2    Watts, C.3
  • 49
    • 0027520440 scopus 로고
    • Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation
    • Wang L.H., Rothberg K.G., and Anderson R.G. Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation. J Cell Biol 123 (1993) 1107-1117
    • (1993) J Cell Biol , vol.123 , pp. 1107-1117
    • Wang, L.H.1    Rothberg, K.G.2    Anderson, R.G.3
  • 50
    • 0018864611 scopus 로고
    • Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones
    • Davies P.J., Davies D.R., Levitzki A., Maxfield F.R., Milhaud P., Willingham M.C., and Pastan I.H. Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones. Nature 283 (1980) 162-167
    • (1980) Nature , vol.283 , pp. 162-167
    • Davies, P.J.1    Davies, D.R.2    Levitzki, A.3    Maxfield, F.R.4    Milhaud, P.5    Willingham, M.C.6    Pastan, I.H.7
  • 52
    • 0034465898 scopus 로고    scopus 로고
    • Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk
    • Irvine E.J., and Marshall J.K. Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk. Gastroenterology 119 (2000) 1740-1744
    • (2000) Gastroenterology , vol.119 , pp. 1740-1744
    • Irvine, E.J.1    Marshall, J.K.2
  • 53
    • 0033228442 scopus 로고    scopus 로고
    • Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora
    • Madsen K.L., Malfair D., Gray D., Doyle J.S., Jewell L.D., and Fedorak R.N. Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora. Inflamm Bowel Dis 5 (1999) 262-270
    • (1999) Inflamm Bowel Dis , vol.5 , pp. 262-270
    • Madsen, K.L.1    Malfair, D.2    Gray, D.3    Doyle, J.S.4    Jewell, L.D.5    Fedorak, R.N.6
  • 55
    • 0028519015 scopus 로고
    • Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
    • Powrie F., Leach M.W., Mauze S., Menon S., Caddle L.B., and Coffman R.L. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1 (1994) 553-562
    • (1994) Immunity , vol.1 , pp. 553-562
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Menon, S.4    Caddle, L.B.5    Coffman, R.L.6
  • 56
    • 33845995125 scopus 로고    scopus 로고
    • Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
    • Zeissig S., Burgel N., Gunzel D., Richter J., Mankertz J., Wahnschaffe U., Kroesen A.J., Zeitz M., Fromm M., and Schulzke J.D. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56 (2007) 61-72
    • (2007) Gut , vol.56 , pp. 61-72
    • Zeissig, S.1    Burgel, N.2    Gunzel, D.3    Richter, J.4    Mankertz, J.5    Wahnschaffe, U.6    Kroesen, A.J.7    Zeitz, M.8    Fromm, M.9    Schulzke, J.D.10
  • 57
    • 33845965299 scopus 로고    scopus 로고
    • Inflammatory bowel disease: is it really just another break in the wall?
    • Weber C.R., and Turner J.R. Inflammatory bowel disease: is it really just another break in the wall?. Gut 56 (2007) 6-8
    • (2007) Gut , vol.56 , pp. 6-8
    • Weber, C.R.1    Turner, J.R.2
  • 58
    • 0037442918 scopus 로고    scopus 로고
    • Constitutive activation of Rho proteins by CNF-1 influences tight junction structure and epithelial barrier function
    • Hopkins A.M., Walsh S.V., Verkade P., Boquet P., and Nusrat A. Constitutive activation of Rho proteins by CNF-1 influences tight junction structure and epithelial barrier function. J Cell Sci 116 (2003) 725-742
    • (2003) J Cell Sci , vol.116 , pp. 725-742
    • Hopkins, A.M.1    Walsh, S.V.2    Verkade, P.3    Boquet, P.4    Nusrat, A.5
  • 59
    • 0030043414 scopus 로고    scopus 로고
    • Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures
    • Furuse M., Fujimoto K., Sato N., Hirase T., and Tsukita S. Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures. J Cell Sci 109 (1996) 429-435
    • (1996) J Cell Sci , vol.109 , pp. 429-435
    • Furuse, M.1    Fujimoto, K.2    Sato, N.3    Hirase, T.4    Tsukita, S.5
  • 61
    • 0030748172 scopus 로고    scopus 로고
    • COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos
    • Chen Y., Merzdorf C., Paul D.L., and Goodenough D.A. COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos. J Cell Biol 138 (1997) 891-899
    • (1997) J Cell Biol , vol.138 , pp. 891-899
    • Chen, Y.1    Merzdorf, C.2    Paul, D.L.3    Goodenough, D.A.4
  • 62
    • 0031047483 scopus 로고    scopus 로고
    • A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier
    • Wong V., and Gumbiner B.M. A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier. J Cell Biol 136 (1997) 399-409
    • (1997) J Cell Biol , vol.136 , pp. 399-409
    • Wong, V.1    Gumbiner, B.M.2
  • 63
    • 0034102426 scopus 로고    scopus 로고
    • Occludin modulates transepithelial migration of neutrophils
    • Huber D., Balda M.S., and Matter K. Occludin modulates transepithelial migration of neutrophils. J Biol Chem 275 (2000) 5773-5778
    • (2000) J Biol Chem , vol.275 , pp. 5773-5778
    • Huber, D.1    Balda, M.S.2    Matter, K.3
  • 64
    • 0034695923 scopus 로고    scopus 로고
    • Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin
    • Li D., and Mrsny R.J. Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin. J Cell Biol 148 (2000) 791-800
    • (2000) J Cell Biol , vol.148 , pp. 791-800
    • Li, D.1    Mrsny, R.J.2
  • 65
    • 25844492029 scopus 로고    scopus 로고
    • Down-regulation of survival signaling through MAPK and Akt in occludin-deficient mouse hepatocytes in vitro
    • Murata M., Kojima T., Yamamoto T., Go M., Takano K., Osanai M., Chiba H., and Sawada N. Down-regulation of survival signaling through MAPK and Akt in occludin-deficient mouse hepatocytes in vitro. Exp Cell Res 310 (2005) 140-151
    • (2005) Exp Cell Res , vol.310 , pp. 140-151
    • Murata, M.1    Kojima, T.2    Yamamoto, T.3    Go, M.4    Takano, K.5    Osanai, M.6    Chiba, H.7    Sawada, N.8
  • 66
    • 0030983484 scopus 로고    scopus 로고
    • Occludin confers adhesiveness when expressed in fibroblasts
    • Van Itallie C.M., and Anderson J.M. Occludin confers adhesiveness when expressed in fibroblasts. J Cell Sci 110 (1997) 1113-1121
    • (1997) J Cell Sci , vol.110 , pp. 1113-1121
    • Van Itallie, C.M.1    Anderson, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.