Structural model for phenylalkylamine binding to L-type calcium channels

Journal of Biological Chemistry

Volumn 284, Issue 41, 2009, Pages 28332-28342

  Cheng, Ricky C K ^a   Tikhonov, Denis B ^a,b   Zhorov, Boris S ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM GROUPS; AROMATIC RINGS; CALCIUM CHANNELS; CHANNEL INTERACTIONS; COMMON FEATURES; DIHYDROPYRIDINES; ELECTRONEGATIVE ATOMS; ENERGY MINIMIZATION; FLEXIBLE CHAINS; METHOXY GROUP; MONTE CARLO; NITRILE GROUPS; PHENYLALKYLAMINE; SELECTIVITY FILTER; STRUCTURAL ASPECTS; STRUCTURAL MODELS; STRUCTURE ACTIVITY RELATIONSHIPS; VERAPAMIL;

AMMONIUM COMPOUNDS; CALCIUM ALLOYS; CYANIDES; MODEL STRUCTURES; MUTAGENS;

CALCIUM;

CALCIUM CHANNEL L TYPE; DEVAPAMIL; GALLOPAMIL; PHENYLALKYLAMINE; VERAPAMIL;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; GENE MUTATION; HYDROGEN BOND; MATHEMATICAL MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BINDING SITES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; COMPUTER SIMULATION; DIHYDROPYRIDINES; GALLOPAMIL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MONTE CARLO METHOD; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; VERAPAMIL;

RUMEX;

EID: 70350500062     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.027326     Document Type: Article

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