Nitric oxides mediates a shift from early necrosis to late apoptosis in cytokine-treated β-cells that is associated with irreversible DNA damage

American Journal of Physiology - Endocrinology and Metabolism

Volumn 297, Issue 5, 2009, Pages

  Hughes, Katherine J ^a   Chambers, Kari T ^a   Meares, Gordon P ^b   Corbett, John A ^b  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Death; Insulin; Islet

Indexed keywords

CASPASE 3; DNA; INTERLEUKIN 1; NITRIC OXIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL DEGENERATION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RAT; TIME;

ANIMALS; APOPTOSIS; CASPASE 3; CELL DEATH; CELL SEPARATION; COMET ASSAY; CYTOKINES; DNA DAMAGE; DNA REPAIR; ENERGY METABOLISM; ENZYME ACTIVATION; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; INTERLEUKIN-1; MALE; NECROSIS; NITRIC OXIDE; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 70350451227     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00214.2009     Document Type: Article

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