Kauren-19-oic acid induces DNA damage followed by apoptosis in human leukemia cells

Journal of Applied Toxicology

Volumn 29, Issue 7, 2009, Pages 560-568

  Cavalcanti, Bruno C ^a   Bezerra, Daniel P ^a   Magalhães, Hemerson I F ^a   Moraes, Manoel O ^a   Lima, Mary Anne S ^a   Silveira, Edilberto R ^a   Câmara, Cláudio A G ^b   Rao, Vietla S ^a   Pessoa, Cláudia ^a   Costa Lotufo, Letícia V ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b UNIVERSIDADE FEDERAL RURAL DE PERNAMBUCO   (Brazil)

Author keywords

Apoptosis; Cytotoxicity; DNA damage; Kaurenoic acid; Topoisomerase I inhibitor

Indexed keywords

14 HYDROXY KAURANE; ACRIDINE ORANGE; DNA TOPOISOMERASE; ETHIDIUM BROMIDE; KAUREN 19 OIC ACID; KAURENE DERIVATIVE; UNCLASSIFIED DRUG; XYLOPIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ERYTHROCYTE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; LEUKEMIA; LYMPHOCYTE; MOUSE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL;

ACRIDINE ORANGE; APOPTOSIS; BROMODEOXYURIDINE; CELL LINE, TUMOR; CELL PROLIFERATION; COMET ASSAY; DITERPENES; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ETHIDIUM; FLUORESCENT DYES; GLIOBLASTOMA; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; INTERCALATING AGENTS; K562 CELLS; LEUKEMIA; MELANOMA; MOLECULAR STRUCTURE; NECROSIS;

EID: 70350246100     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1439     Document Type: Article

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