Nonproteolytic induction of catalytic activity into the single-chain form of urokinase-type plasminogen activator by dipeptides

Biochemistry

Volumn 48, Issue 40, 2009, Pages 9606-9617

  Bøtkjær, Kenneth A ^a   Byszuk, Aleksandra A ^a,b   Andersen, Lisbeth M ^a   Christensen, Anni ^a   Andreasen, Peter A ^a   Blouse, Grant E ^a,c  

^a AARHUS UNIVERSITY   (Denmark)

^b JAGIELLONIAN UNIVERSITY   (Poland)

^c Catalyst Biosciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AMINO TERMINUS; ASPARTATE RESIDUE; CATALYTIC ACTIVITY; CATALYTIC SITES; CONFORMATIONAL CHANGE; DI-PEPTIDES; DIPEPTIDE; DIRECT OBSERVATION; FLUORESCENT PROBES; HYDROPHOBIC POCKETS; ORDERS OF MAGNITUDE; OXYANION HOLE; PROTEASE COMPLEX; PROTEOLYTIC ACTIVATION; PROTEOLYTIC CLEAVAGE; SALT BRIDGES; SERINE PROTEASE; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA); ZYMOGEN ACTIVATION;

AMINATION; AMINES; AMINO ACIDS; CHEMICAL ACTIVATION; ENZYMES; FLUORESCENCE;

ENZYME ACTIVITY;

DIPEPTIDE; ISOLEUCYLISOLEUCINE; ISOLEUCYLVALINE; PLASMINOGEN ACTIVATOR INHIBITOR 1; UNCLASSIFIED DRUG; UROKINASE;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INDUCTION; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ANALYSIS;

ANIMALS; CATALYSIS; CATTLE; CHROMOGENIC COMPOUNDS; DIPEPTIDES; ENZYME INDUCTION; ENZYME PRECURSORS; HUMANS; PEPTIDE HYDROLASES; SUBSTRATE SPECIFICITY; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 70350065910     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900510f     Document Type: Article

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