Crystal structure of γ-chymotrypsin in complex with 7-hydroxycoumarin

Journal of Molecular Biology

Volumn 314, Issue 3, 2001, Pages 519-525

  Ghani, Usman ^a,b   Ng, Kenneth K S ^b   Atta ur Rahman, ^a   Choudhary, M Iqbal ^a   Ullah, Nisar ^a   James, Michael N G ^b  

^a UNIVERSITY OF KARACHI   (Pakistan)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

7 hydroxycoumarin; Acylating agents; Coumarin chymotrypsin inhibitors; X ray crystallography

Indexed keywords

CHYMOTRYPSIN; UMBELLIFERONE;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STRUCTURE; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN INTERACTION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 0035976783     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5148     Document Type: Article

References (31)

1. Crystal structure of the thrombin: Hirudin complex: A novel mode of serine protease inhibition
2. Pharmacological activity of the C-terminal and N-terminal domains of secretory leukoprotease inhibitor in vitro
3. X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid β-protein precursor
4. Activities, localizations and roles of serine proteases in human brain tumor progression
5. Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: Design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin
6. Coumarinic derivatives as mechanism-based inhibitors of α-chymotrypsin and human leukocyte elastase
7. A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin Aα with substituted benzoxazinones, quinazolines and anthranilates
8. Suicide inactivation of chymotrypsin by benzoxazinones
9. Reaction of serine proteases with substituted 3-alkoxy-4-chloroisocoumarins and 3-alkoxy-7-amino-4-chloroisocoumarins: New reactive mechanism-based inhibitors
10. Mechanism-based isocoumarin inhibitors for trypsin and blood coagulation serine proteases: New anticoagulants
11. Preliminary studies on coumarin compounds in plants of the Umbelliferae family
12. Traitement statistique des erreurs dans la determination des structures cristallines
13. Improved Fourier coefficients for maps using phases from partial structures with errors
14. Photolysis and deacylation of inhibited chymotrypsin
15. X-ray diffraction analysis of the inactivation of chymotrypsin by 3-benzyl-6-chloro-2-pyrone
16. Mechanism of inactivation of chymotrypsin by 3-benzyl-6-chloro-2-pyrone
17. Substituted isocoumarins as inhibitors of complement serine proteases
18. Esters and amides of 6-(chloromethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of α-chymotrypsin: Significance of the "aromatic nature" of the novel ester-type coumarin for strong inhibitory activity
19. Synthetic inhibitors targeting serine and aspartic acid proteases
20. Aromatic-aromatic interaction: A mechanism of protein structure stabilization
21. Structure of 3,4-dichloroisocoumarin-inhibited factor D
22. Structure and activity of two photoreversible cinnamates bound to chymotrypsin
23. Observation of the light-triggered binding of pyrone to chymotrypsin by Laue X-ray crystallography
24. Chemical constituents of Daphne oleoides
25. Results of a large scale screen of microalgae for the production of protease inhibitors
26. Processing of X-ray diffraction data collected in oscillation mode
27. Is γ-chymotrypsin a tetrapeptide acyl-enzyme adduct of α-chymotrypsin?
28. Crystallography and NMR system: A new software suite for macromolecular structure determination
29. An extensively modified version of Molscript that includes greatly enhanced coloring capabilities
30. Raster3D-photorealistic molecular graphics