Streptokinase Triggers Conformational Activation of Plasminogen through Specific Interactions of the Amino-terminal Sequence and Stabilizes the Active Zymogen Conformation

Journal of Biological Chemistry

Volumn 276, Issue 28, 2001, Pages 26084-26089

  Boxrud, Paul D ^a   Verhamme, Ingrid M A ^a   Fay, William P ^c   Bock, Paul E ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CHEMICAL ACTIVATION; CONFORMATIONS; ENZYME KINETICS; FLUORESCENCE; POLYPEPTIDES;

CONFORMATIONAL CHANGES;

BIOCHEMISTRY;

ARGININE; ENZYME PRECURSOR; FLUORESCEIN; ISOLEUCINE; LYSINE; PLASMIN; PLASMINOGEN; STREPTOKINASE; VALINE;

ACTIVATED PROTEINASE DOMAIN; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING KINETICS; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME STABILITY; PLASMINOGEN CATALYTIC DOMAIN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; BINDING SITE; CHEMISTRY; ENZYME SPECIFICITY; HUMAN; PROTEIN BINDING; PROTEIN CONFORMATION;

INSERTION SEQUENCES;

BINDING SITES; ENZYME PRECURSORS; HUMANS; PLASMINOGEN; PROTEIN BINDING; PROTEIN CONFORMATION; STREPTOKINASE; SUBSTRATE SPECIFICITY;

EID: 0035854772     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101966200     Document Type: Article

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