Mutation of the Highly Conserved Tryptophan in the Serpin Breach Region Alters the Inhibitory Mechanism of Plasminogen Activator Inhibitor-1

Biochemistry

Volumn 42, Issue 42, 2003, Pages 12260-12272

  Blouse, Grant E ^a,b   Perron, Michel J ^a   Kvassman, Jan Olov ^c   Yunus, Saadia ^a   Thompson, Jannah H ^a   Betts, Russell L ^a   Lutter, Leonard C ^a   Shore, Joseph D ^a,b  

^a HENRY FORD HEALTH SCIENCES CENTER   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LINNAEUS UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYME INHIBITION; HYDROLYSIS; REACTION KINETICS;

KINETIC BARRIERS;

BIOCHEMISTRY;

PHENYLALANINE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEINASE; SERINE PROTEINASE INHIBITOR; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ARTICLE; BETA SHEET; CHEMICAL REACTION KINETICS; DEACYLATION; ENZYME INHIBITION; HYDROLYSIS; MOLECULAR INTERACTION; MUTATION; NONHUMAN; PRIORITY JOURNAL;

BASE SEQUENCE; CIRCULAR DICHROISM; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECOMBINANT PROTEINS; SERPINS; TRYPTOPHAN;

INSERTION SEQUENCES;

EID: 0142095053     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034737n     Document Type: Article

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