Peroxynitrite mediates muscle insulin resistance in mice via nitration of IRβ/IRS-1 and Akt

Toxicology and Applied Pharmacology

Volumn 241, Issue 1, 2009, Pages 101-110

  Zhou, Jun ^a   Huang, Kaixun ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Diabetes mellitus; Insulin receptor; Insulin receptor substrate 1; Insulin resistance; Peroxynitrite; Tyrosine nitration

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR BETA; INSULIN RECEPTOR SUBSTRATE 1; LINSIDOMINE; PEROXYNITRITE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; ENZYME ASSAY; IMMUNOPRECIPITATION; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID DIET; MALE; MOUSE; NITRATION; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; WESTERN BLOTTING;

ANIMALS; DIETARY FATS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MOLSIDOMINE; MUSCLE, SKELETAL; NITRIC OXIDE SYNTHASE TYPE II; PEROXYNITROUS ACID; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

MUS;

EID: 70350007177     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.08.005     Document Type: Article

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