메뉴 건너뛰기




Volumn 11, Issue 5, 2009, Pages 485-492

Clinical trials for glioblastoma multiforme using adenoviral vectors

Author keywords

Adenoviral vector; Cerepro; Gene therapy; Glioma; HSV tk; Sitimagene ceradenovec

Indexed keywords

ADENOVIRUS VECTOR; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CEREPRO; CONDITIONALLY REPLICATING HERPES SIMPLEX VIRUS 1 G207; GANCICLOVIR; GENDICINE; H 101; HERPESVIRUS VECTOR; IRINOTECAN; ONCORINE; PLASMID DNA; RETROVIRUS VECTOR; SITIMAGENE CERADENOVEC; TEMOZOLOMIDE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

EID: 70349900808     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (17)

References (99)
  • 1
    • 58149471244 scopus 로고    scopus 로고
    • Epidemiology of brain tumors
    • Ohgaki H: Epidemiology of brain tumors. Methods Mol Biol (2009) 472:323-342.
    • (2009) Methods Mol Biol , vol.472 , pp. 323-342
    • Ohgaki, H.1
  • 2
    • 34250877865 scopus 로고    scopus 로고
    • Genetic pathways to primary and secondary glioblastoma
    • Ohgaki H, Kleihues P: Genetic pathways to primary and secondary glioblastoma. Am J Pathol (2007) 170(5):1445-1453.
    • (2007) Am J Pathol , vol.170 , Issue.5 , pp. 1445-1453
    • Ohgaki, H.1    Kleihues, P.2
  • 4
    • 2442642550 scopus 로고    scopus 로고
    • Brain tumours: Classification and genes
    • Collins VP: Brain tumours: Classification and genes. J Neurol Neurosurg Psychiatry (2004) 75(Suppl 2):ii2-11.
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , Issue.SUPPL. 2
    • Collins, V.P.1
  • 6
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • Latest results of a randomized phase III clinical trial evaluating the effects of radiation therapy with concomitant and adjuvant temozolomide
    • Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, Hau P et al: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol (2009) 10(5):459-466. •• Latest results of a randomized phase III clinical trial evaluating the effects of radiation therapy with concomitant and adjuvant temozolomide.
    • (2009) Lancet Oncol , vol.10 , Issue.5 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3    Van Den Bent, M.J.4    Taphoorn, M.J.5    Janzer, R.C.6    Ludwin, S.K.7    Allgeier, A.8    Fisher, B.9    Belanger, K.10    Hau, P.11
  • 10
    • 34548427504 scopus 로고    scopus 로고
    • Active targeting of brain tumors using nanocarriers
    • DOI 10.1016/j.biomaterials.2007.06.011, PII S0142961207004656
    • Beduneau A, Saulnier P, Benoit JP: Active targeting of brain tumors using nanocarriers. Biomaterials (2007) 28(33):4947-4967. (Pubitemid 47362345)
    • (2007) Biomaterials , vol.28 , Issue.33 , pp. 4947-4967
    • Beduneau, A.1    Saulnier, P.2    Benoit, J.-P.3
  • 11
    • 38349135709 scopus 로고    scopus 로고
    • Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization
    • Claes A, Wesseling P, Jeuken J, Maass C, Heerschap A, Leenders WP: Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization. Mol Cancer Ther (2008) 7(1):71-78.
    • (2008) Mol Cancer Ther , vol.7 , Issue.1 , pp. 71-78
    • Claes, A.1    Wesseling, P.2    Jeuken, J.3    Maass, C.4    Heerschap, A.5    Leenders, W.P.6
  • 13
    • 0037968240 scopus 로고    scopus 로고
    • Gene transfer as a tool to induce therapeutic vascular growth
    • Comprehensive review on gene therapy and the use of gene therapy to induce therapeutic vascular growth using different growth factors
    • Ylä-Herttuala S, Alitalo K: Gene transfer as a tool to induce therapeutic vascular growth. Nat Med (2003) 9(6):694-701. • Comprehensive review on gene therapy and the use of gene therapy to induce therapeutic vascular growth using different growth factors.
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 694-701
    • Ylä-Herttuala, S.1    Alitalo, K.2
  • 14
    • 0024988334 scopus 로고
    • Gene transfer into humans - Immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction
    • Rosenberg SA, Aebersold P, Cornetta K, Kasid A, Morgan RA, Moen R, Karson EM, Lotze MT, Yang JC, Topalian SL: Gene transfer into humans - Immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med (1990) 323(9):570-578.
    • (1990) N Engl J Med , vol.323 , Issue.9 , pp. 570-578
    • Rosenberg, S.A.1    Aebersold, P.2    Cornetta, K.3    Kasid, A.4    Morgan, R.A.5    Moen, R.6    Karson, E.M.7    Lotze, M.T.8    Yang, J.C.9    Topalian, S.L.10
  • 15
    • 0034159940 scopus 로고    scopus 로고
    • Gene therapy: The first decade
    • Mountain A: Gene therapy: The first decade. Trends Biotechnol (2000) 18(3):119-128.
    • (2000) Trends Biotechnol , vol.18 , Issue.3 , pp. 119-128
    • Mountain, A.1
  • 16
    • 59449108477 scopus 로고    scopus 로고
    • Gene therapy fulfilling its promise
    • Kohn DB, Candotti F: Gene therapy fulfilling its promise. N Engl J Med (2009) 360(5):518-521.
    • (2009) N Engl J Med , vol.360 , Issue.5 , pp. 518-521
    • Kohn, D.B.1    Candotti, F.2
  • 17
    • 70349923364 scopus 로고    scopus 로고
    • John Wiley & Sons Inc, Chichester, UK
    • Gene therapy clinical trials worldwide: John Wiley & Sons Inc, Chichester, UK (2009). www.wiley.co.uk/genetherapy/clinical/
    • (2009) Gene Therapy Clinical Trials Worldwide
  • 18
    • 70349707110 scopus 로고    scopus 로고
    • Gene therapy: The first approved gene-based medicines, molecular mechanisms and clinical indications
    • Räty JK, Pikkarainen JT, Wirth T, Ylä-Herttuala S: Gene therapy: The first approved gene-based medicines, molecular mechanisms and clinical indications. Curr Mol Pharmacol (2008) 1(1):13-23.
    • (2008) Curr Mol Pharmacol , vol.1 , Issue.1 , pp. 13-23
    • Räty, J.K.1    Pikkarainen, J.T.2    Wirth, T.3    Ylä-Herttuala, S.4
  • 19
    • 25144436834 scopus 로고    scopus 로고
    • Gene therapy for malignant glioma: Current clinical status
    • DOI 10.1016/j.ymthe.2005.07.357, PII S1525001605010798
    • Pulkkanen KJ, Ylä-Herttuala S: Gene therapy for malignant glioma: Current clinical status. Mol Ther (2005) 12(4):585-598. (Pubitemid 41350140)
    • (2005) Molecular Therapy , vol.12 , Issue.4 , pp. 585-598
    • Pulkkanen, K.J.1    Yla-Herttuala, S.2
  • 20
    • 7044235842 scopus 로고    scopus 로고
    • AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: A randomised, controlled study
    • DOI 10.1016/j.ymthe.2004.08.002, PII S1525001604013723
    • Immonen A, Vapalahti M, Tyynela K, Hurskainen H, Sandmair A, Vanninen R, Langford G, Murray N, Ylä-Herttuala S: AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: A randomised, controlled study. Mol Ther (2004) 10(5):967-972. (Pubitemid 39419922)
    • (2004) Molecular Therapy , vol.10 , Issue.5 , pp. 967-972
    • Immonen, A.1    Vapalahti, M.2    Tyynela, K.3    Hurskainen, H.4    Sandmair, A.5    Vanninen, R.6    Langford, G.7    Murray, N.8    Yla-Herttuala, S.9
  • 21
    • 33747173765 scopus 로고    scopus 로고
    • Gene therapy for glioblastoma
    • Aghi M, Chiocca EA: Gene therapy for glioblastoma. Neurosurg Focus (2006) 20(4):E18.
    • (2006) Neurosurg Focus , vol.20 , Issue.4
    • Aghi, M.1    Chiocca, E.A.2
  • 22
    • 32844466513 scopus 로고    scopus 로고
    • Genetic strategies for brain tumor therapy
    • DOI 10.1038/sj.cgt.7700886, PII 7700886
    • Lawler SE, Peruzzi PP, Chiocca EA: Genetic strategies for brain tumor therapy. Cancer Gene Ther (2006) 13(3):225-233. (Pubitemid 43255759)
    • (2006) Cancer Gene Therapy , vol.13 , Issue.3 , pp. 225-233
    • Lawler, S.E.1    Peruzzi, P.P.2    Chiocca, E.A.3
  • 25
    • 67649277701 scopus 로고    scopus 로고
    • Gene- And viral-based therapies for brain tumors
    • Comprehensive review on gene therapy approaches and vectors used for treatment of brain tumors
    • Asadi-Moghaddam K, Chiocca EA: Gene- and viral-based therapies for brain tumors. Neurotherapeutics (2009) 6(3):547-557. • Comprehensive review on gene therapy approaches and vectors used for treatment of brain tumors.
    • (2009) Neurotherapeutics , vol.6 , Issue.3 , pp. 547-557
    • Asadi-Moghaddam, K.1    Chiocca, E.A.2
  • 26
    • 0027548077 scopus 로고
    • Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir
    • Oldfield EH, Ram Z, Culver KW, Blaese RM, DeVroom HL, Anderson WF: Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther (1993) 4(1):39-69. (Pubitemid 223002217)
    • (1993) Human Gene Therapy , vol.4 , Issue.1 , pp. 39-69
    • Oldfield, E.H.1    Ram, Z.2    Culver, K.W.3    Blaese, R.M.4    Devroom, H.L.5    Anderson, W.F.6
  • 30
    • 0030994260 scopus 로고    scopus 로고
    • Adenovirus type 5 fiber knob binds to MHC class I α2 domain at the surface of human epithelial and B lymphoblastoid cells
    • DOI 10.1093/emboj/16.9.2294
    • Hong SS, Karayan L, Tournier J, Curiel DT, Boulanger PA: Adenovirus type 5 fiber knob binds to MHC class I α2 domain at the surface of human epithelial and B lymphoblastoid cells. EMBO J (1997) 16(9):2294-2306. (Pubitemid 27258631)
    • (1997) EMBO Journal , vol.16 , Issue.9 , pp. 2294-2306
    • Hong, S.S.1    Karayan, L.2    Tournier, J.3    Curiel, D.T.4    Boulanger, P.A.5
  • 31
    • 0034654569 scopus 로고    scopus 로고
    • Heparan sulfate glycosaminoglycans are involved in adenovirus type 5 and 2-host cell interactions
    • DOI 10.1006/viro.1999.0171
    • Dechecchi MC, Tamanini A, Bonizzato A, Cabrini G: Heparan sulfate glycosaminoglycans are involved in adenovirus type 5 and 2-host cell interactions. Virology (2000) 268(2):382-390. (Pubitemid 30159987)
    • (2000) Virology , vol.268 , Issue.2 , pp. 382-390
    • Dechecchi, M.C.1    Tamanini, A.2    Bonizzato, A.3    Cabrini, G.4
  • 32
    • 0034890820 scopus 로고    scopus 로고
    • Heparan sulfate glycosaminoglycans are receptors sufficient to mediate the initial binding of adenovirus types 2 and 5
    • DOI 10.1128/JVI.75.18.8772-8780.2001
    • Dechecchi MC, Melotti P, Bonizzato A, Santacatterina M, Chilosi M, Cabrini G: Heparan sulfate glycosaminoglycans are receptors sufficient to mediate the initial binding of adenovirus types 2 and 5. J Virol (2001) 75(18):8772-8780. (Pubitemid 32768981)
    • (2001) Journal of Virology , vol.75 , Issue.18 , pp. 8772-8780
    • Dechecchi, M.C.1    Melotti, P.2    Bonizzato, A.3    Santacatterina, M.4    Chilosi, M.5    Cabrini, G.6
  • 33
    • 0035140753 scopus 로고    scopus 로고
    • Vascular cell adhesion molecule-1 augments adenovirus-mediated gene transfer
    • Chu Y, Heistad D, Cybulsky MI, Davidson BL: Vascular cell adhesion molecule-1 augments adenovirus-mediated gene transfer. Arterioscler Thromb Vasc Biol (2001) 21(2):238-242.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , Issue.2 , pp. 238-242
    • Chu, Y.1    Heistad, D.2    Cybulsky, M.I.3    Davidson, B.L.4
  • 34
    • 0037119944 scopus 로고    scopus 로고
    • Adenovirus triggers macropinocytosis and endosomal leakage together with its clathrin-mediated uptake
    • DOI 10.1083/jcb.200112067
    • Meier O, Boucke K, Hammer SV, Keller S, Stidwill RP, Hemmi S, Greber UF: Adenovirus triggers macropinocytosis and endosomal leakage together with its clathrin-mediated uptake. J Cell Biol (2002) 158(6):1119-1131. (Pubitemid 35052694)
    • (2002) Journal of Cell Biology , vol.158 , Issue.6 , pp. 1119-1131
    • Meier, O.1    Boucke, K.2    Hammer, S.V.3    Keller, S.4    Stidwill, R.P.5    Hemmi, S.6    Greber, U.F.7
  • 35
    • 25144499159 scopus 로고    scopus 로고
    • Adenovirus receptors
    • Zhang Y, Bergelson JM: Adenovirus receptors. J Virol (2005) 79(19):12125-12131.
    • (2005) J Virol , vol.79 , Issue.19 , pp. 12125-12131
    • Zhang, Y.1    Bergelson, J.M.2
  • 40
    • 0033533669 scopus 로고    scopus 로고
    • Virus treatment questioned after gene therapy death
    • Lehrman S: Virus treatment questioned after gene therapy death. Nature (1999) 401(6753):517-518.
    • (1999) Nature , vol.401 , Issue.6753 , pp. 517-518
    • Lehrman, S.1
  • 42
    • 0033759405 scopus 로고    scopus 로고
    • Production of first generation adenovirus vectors: A review
    • Danthinne X, Imperiale MJ: Production of first generation adenovirus vectors: A review. Gene Ther (2000) 7(20):1707-1714. (Pubitemid 30821568)
    • (2000) Gene Therapy , vol.7 , Issue.20 , pp. 1707-1714
    • Danthinne, X.1    Imperiale, M.J.2
  • 43
    • 0027260609 scopus 로고
    • Packaging capacity and stability of human adenovirus type 5 vectors
    • Bett AJ, Prevec L, Graham FL: Packaging capacity and stability of human adenovirus type 5 vectors. J Virol (1993) 67(10):5911-5921. (Pubitemid 23277501)
    • (1993) Journal of Virology , vol.67 , Issue.10 , pp. 5911-5921
    • Bett, A.J.1    Prevec, L.2    Graham, F.L.3
  • 44
    • 0028559768 scopus 로고
    • An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3
    • Bett AJ, Haddara W, Prevec L, Graham FL: An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc Natl Acad Sci USA (1994) 91(19):8802-8806.
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.19 , pp. 8802-8806
    • Bett, A.J.1    Haddara, W.2    Prevec, L.3    Graham, F.L.4
  • 45
    • 22244459917 scopus 로고    scopus 로고
    • Gene therapy: Twenty-first century medicine
    • Verma IM, Weitzman MD: Gene therapy: Twenty-first century medicine. Annu Rev Biochem (2005) 74:711-738.
    • (2005) Annu Rev Biochem , vol.74 , pp. 711-738
    • Verma, I.M.1    Weitzman, M.D.2
  • 46
    • 0019295352 scopus 로고
    • The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene
    • McKnight SL: The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene. Nucleic Acids Res (1980) 8(24):5949-5964. (Pubitemid 11100297)
    • (1980) Nucleic Acids Research , vol.8 , Issue.24 , pp. 5949-5964
    • McKnight, S.L.1
  • 47
    • 0022485359 scopus 로고
    • Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy
    • Important paper suggesting the use of HSV-tk for cancer therapy
    • Moolten FL: Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy. Cancer Res (1986) 46(10):5276-5281. •• Important paper suggesting the use of HSV-tk for cancer therapy.
    • (1986) Cancer Res , vol.46 , Issue.10 , pp. 5276-5281
    • Moolten, F.L.1
  • 48
    • 0025241769 scopus 로고
    • Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors
    • Moolten FL, Wells JM: Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. J Natl Cancer Inst (1990) 82(4):297-300.
    • (1990) J Natl Cancer Inst , vol.82 , Issue.4 , pp. 297-300
    • Moolten, F.L.1    Wells, J.M.2
  • 49
    • 0026772206 scopus 로고
    • In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
    • Culver KW, Ram Z, Wallbridge S, Ishii H, Oldfield EH, Blaese RM: In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science (1992) 256(5063):1550-1552.
    • (1992) Science , vol.256 , Issue.5063 , pp. 1550-1552
    • Culver, K.W.1    Ram, Z.2    Wallbridge, S.3    Ishii, H.4    Oldfield, E.H.5    Blaese, R.M.6
  • 50
    • 0027531548 scopus 로고
    • In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats
    • Ram Z, Culver KW, Walbridge S, Blaese RM, Oldfield EH: In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res (1993) 53(1):83-88. (Pubitemid 23019380)
    • (1993) Cancer Research , vol.53 , Issue.1 , pp. 83-88
    • Ram, Z.1    Culver, K.W.2    Walbridge, S.3    Blaese, R.M.4    Oldfield, E.H.5
  • 52
    • 0034186366 scopus 로고    scopus 로고
    • Prodrug activation enzymes in cancer gene therapy
    • Aghi M, Hochb erg F, Breakefield XO: Prodrug activation enzymes in cancer gene therapy. J Gene Med (2000) 2(3):148-164.
    • (2000) J Gene Med , vol.2 , Issue.3 , pp. 148-164
    • Aghi, M.1    Hochb Erg, F.2    Breakefield, X.O.3
  • 53
    • 0030668915 scopus 로고    scopus 로고
    • A 'distant' bystander effect of suicide gene therapy: Regression of nontransduced tumors together with a distant transduced tumor
    • Kianmanesh AR, Perrin H, Panis Y, Fabre M, Nagy HJ, Houssin D, Klatzmann D: A 'distant' bystander effect of suicide gene therapy: Regression of nontransduced tumors together with a distant transduced tumor. Hum Gene Ther (1997) 8(15):1807-1814.
    • (1997) Hum Gene Ther , vol.8 , Issue.15 , pp. 1807-1814
    • Kianmanesh, A.R.1    Perrin, H.2    Panis, Y.3    Fabre, M.4    Nagy, H.J.5    Houssin, D.6    Klatzmann, D.7
  • 54
    • 0030917683 scopus 로고    scopus 로고
    • Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression
    • DOI 10.1002/(SICI)1097-0215(19970410)71:2<267::AID-IJC23>3.0.CO;2-D
    • Vile RG, Castleden S, Marshall J, Camplejohn R, Upton C, Chong H: Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression. Int J Cancer (1997) 71(2):267-274. (Pubitemid 27253001)
    • (1997) International Journal of Cancer , vol.71 , Issue.2 , pp. 267-274
    • Vile, R.G.1    Castleden, S.2    Marshall, J.3    Camplejohn, R.4    Uptov, C.5    Chong, H.6
  • 55
    • 27644570382 scopus 로고    scopus 로고
    • Synthesis, physicochemical properties and antiviral activities of ester prodrugs of ganciclovir
    • DOI 10.1016/j.ijpharm.2005.08.024, PII S0378517305006034
    • Patel K, Trivedi S, Luo S, Zhu X, Pal D, Kern ER, Mitra AK: 55. Synthesis, physicochemical properties and antiviral activities of ester prodrugs of ganciclovir. Int J Pharm (2005) 305(1-2):75-89. (Pubitemid 41562219)
    • (2005) International Journal of Pharmaceutics , vol.305 , Issue.1-2 , pp. 75-89
    • Patel, K.1    Trivedi, S.2    Luo, S.3    Zhu, X.4    Pal, D.5    Kern, E.R.6    Mitra, A.K.7
  • 59
    • 0029161615 scopus 로고
    • The 'bystander effect': Association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice
    • Important paper demonstrating the bystander effect in vitro
    • Colombo BM, Benedetti S, Ottolenghi S, Mora M, Pollo B, Poli G, Finocchiaro G: The 'bystander effect': Association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice. Hum Gene Ther (1995) 6(6):763-772. • Important paper demonstrating the bystander effect in vitro.
    • (1995) Hum Gene Ther , vol.6 , Issue.6 , pp. 763-772
    • Colombo, B.M.1    Benedetti, S.2    Ottolenghi, S.3    Mora, M.4    Pollo, B.5    Poli, G.6    Finocchiaro, G.7
  • 60
    • 0029997766 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells
    • Hamel W, Magnelli L, Chiarugi VP, Israel MA: Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer Res (1996) 56(12):2697-2702. (Pubitemid 26175720)
    • (1996) Cancer Research , vol.56 , Issue.12 , pp. 2697-2702
    • Hamel, W.1    Magnelli, L.2    Chiarugi, V.P.3    Israel, M.A.4
  • 61
    • 0032741719 scopus 로고    scopus 로고
    • Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials
    • DOI 10.1038/15207
    • Dewey RA, Morrissey G, Cowsill CM, Stone D, Bolognani F, Dodd NJ, Southgate TD, Klatzmann D, Lassmann H, Castro MG, Lowenstein PR: Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials. Nat Med (1999) 5(11):1256-1263. (Pubitemid 29535602)
    • (1999) Nature Medicine , vol.5 , Issue.11 , pp. 1256-1263
    • Dewey, R.A.1    Morrissey, G.2    Cowsill, C.M.3    Stone, D.4    Bolognani, F.5    Dodd, N.J.F.6    Southgate, T.D.7    Klatzmann, D.8    Lassmann, H.9    Castro, M.G.10    Lowenstein, P.R.11
  • 62
    • 0037192631 scopus 로고    scopus 로고
    • Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: Critical role of DNA breaks, Bcl-2 decline and caspase-9 activation
    • DOI 10.1038/sj.onc.1205280
    • Tomicic MT, Thust R, Kaina B: Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: Critical role of DNA breaks, Bcl-2 decline and caspase-9 activation. Oncogene (2002) 21(14):2141-2153. (Pubitemid 34311368)
    • (2002) Oncogene , vol.21 , Issue.14 , pp. 2141-2153
    • Tomicic, M.T.1    Thust, R.2    Kaina, B.3
  • 63
    • 0029884088 scopus 로고    scopus 로고
    • Cytogenetic genotoxicity of antiherpes virostatics in Chinese hamster V79-E cells. I. Purine nucleoside analogues
    • DOI 10.1016/0166-3542(96)00961-8
    • Thust R, Schacke M, Wutzler P: Cytogenetic genotoxicity of antiherpes virostatics in Chinese hamster V79-E cells. I. Purine nucleoside analogues. Antiviral Res (1996) 31(1-2):105-113. (Pubitemid 26184463)
    • (1996) Antiviral Research , vol.31 , Issue.1-2 , pp. 105-113
    • Thust, R.1    Schacke, M.2    Wutzler, P.3
  • 64
    • 0032148384 scopus 로고    scopus 로고
    • 64. Irreversible G2-M arrest and cytoskeletal reorganization induced by cytotoxic nucleoside analogues
    • Halloran PJ, Fenton RG: 64. Irreversible G2-M arrest and cytoskeletal reorganization induced by cytotoxic nucleoside analogues. Cancer Res (1998) 58(17):3855-3865.
    • (1998) Cancer Res , vol.58 , Issue.17 , pp. 3855-3865
    • Halloran, P.J.1    Fenton, R.G.2
  • 67
    • 0034128036 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: Effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions
    • Sandmair AM, Turunen M, Tyynela K, Loimas S, Vainio P, Vanninen R, Vapalahti M, Bjerkvig R, Janne J, Ylä-Herttuala S: Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: Effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions. Cancer Gene Ther (2000) 7(3):413-421. (Pubitemid 30210408)
    • (2000) Cancer Gene Therapy , vol.7 , Issue.3 , pp. 413-421
    • Sandmair, A.-M.1    Turunen, M.2    Tyynela, K.3    Loimas, S.4    Vainio, P.5    Vanninen, R.6    Vapalahti, M.7    Bjerkvig, R.8    Janne, J.9    Yla-Herttuala, S.10
  • 71
  • 73
    • 0347926503 scopus 로고    scopus 로고
    • Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene
    • DOI 10.1016/S0014-4827(02)00052-6
    • Asklund T, Appelskog IB, Ammerpohl O, Langmoen IA, Dilber MS, Aints A, Ekstrom TJ, Almqvist PM: Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene. Exp Cell Res (2003) 284(2):185-195. (Pubitemid 36329174)
    • (2003) Experimental Cell Research , vol.284 , Issue.2 , pp. 185-195
    • Asklund, T.1    Appelskog, I.B.2    Ammerpohl, O.3    Langmoen, I.A.4    Dilber, M.S.5    Aints, A.6    Ekstrom, T.J.7    Almqvist, P.M.8
  • 74
    • 0032213438 scopus 로고    scopus 로고
    • Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions
    • Touraine RL, Vahanian N, Ramsey WJ, Blaese RM: Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions. Hum Gene Ther (1998) 9(16):2385-2391. (Pubitemid 28523987)
    • (1998) Human Gene Therapy , vol.9 , Issue.16 , pp. 2385-2391
    • Touraine, R.L.1    Vahanian, N.2    Ramsey, W.J.3    Blaese, R.M.4
  • 78
    • 0032711633 scopus 로고    scopus 로고
    • A cell type-specific and gap junction-independent mechanism for the herpes simplex virus-1 thymidine kinase gene/ganciclovir-mediated bystander effect
    • Princen F, Robe P, Lechanteur C, Mesnil M, Rigo JM, Gielen J, Merville MP, Bours V: A cell type-specific and gap junction-independent mechanism for the herpes simplex virus-1 thymidine kinase gene/ganciclovir-mediated bystander effect. Clin Cancer Res (1999) 5(11):3639-3644.
    • (1999) Clin Cancer Res , vol.5 , Issue.11 , pp. 3639-3644
    • Princen, F.1    Robe, P.2    Lechanteur, C.3    Mesnil, M.4    Rigo, J.M.5    Gielen, J.6    Merville, M.P.7    Bours, V.8
  • 80
    • 85047698025 scopus 로고    scopus 로고
    • Purified herpes simplex virus thymidine kinase retroviral particles: III. Characterization of bystander killing mechanisms in transfected tumor cells
    • DOI 10.1038/sj/cgt/7700401
    • Burrows FJ, Gore M, Smiley WR, Kanemitsu MY, Jolly DJ, Read SB, Nicholas T, Kruse CA: Purified herpes simplex virus thymidine kinase retroviral particles: III. Characterization of bystander killing mechanisms in transfected tumor cells. Cancer Gene Ther (2002) 9(1):87-95. (Pubitemid 34052857)
    • (2002) Cancer Gene Therapy , vol.9 , Issue.1 , pp. 87-95
    • Burrows, F.J.1    Gore, M.2    Smiley, W.R.3    Kanemitsu, M.Y.4    Jolly, D.J.5    Read, S.B.6    Nicholas, T.7    Kruse, C.A.8
  • 81
    • 0033980574 scopus 로고    scopus 로고
    • Purified herpes simplex thymidine kinase retroviral particles. II. Influence of clinical parameters and bystander killing mechanisms
    • Kruse CA, Lamb C, Hogan S, Smiley WR, Kleinschmidt-Demasters BK, Burrows FJ: Purified herpes simplex thymidine kinase retroviral particles. II. Influence of clinical parameters and bystander killing mechanisms. Cancer Gene Ther (2000) 7(1):118-127. (Pubitemid 30080995)
    • (2000) Cancer Gene Therapy , vol.7 , Issue.1 , pp. 118-127
    • Kruse, C.A.1    Lamb, C.2    Hogan, S.3    Smiley, W.R.4    Kleinschmidt-DeMasters, B.K.5    Burrows, F.J.6
  • 82
    • 0028071271 scopus 로고
    • The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats
    • Ram Z, Walbridge S, Shawker T, Culver KW, Blaese RM, Oldfield EH: The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats. J Neurosurg (1994) 81(2):256-260. (Pubitemid 24238006)
    • (1994) Journal of Neurosurgery , vol.81 , Issue.2 , pp. 256-260
    • Ram, Z.1    Walbridge, S.2    Shawker, T.3    Culver, K.W.4    Blaese, R.M.5    Oldfield, E.H.6
  • 83
    • 0034329438 scopus 로고    scopus 로고
    • Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses
    • The first controlled clinical trial demonstrating a significant survival advantage using HSV-tk gene therapy
    • Sandmair AM, Loimas S, Puranen P, Immonen A, Kossila M, Puranen M, Hurskainen H, Tyynela K, Turunen M, Vanninen R, Lehtolainen P et al: Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses. Hum Gene Ther (2000) 11(16):2197-2205. •• The first controlled clinical trial demonstrating a significant survival advantage using HSV-tk gene therapy.
    • (2000) Hum Gene Ther , vol.11 , Issue.16 , pp. 2197-2205
    • Sandmair, A.M.1    Loimas, S.2    Puranen, P.3    Immonen, A.4    Kossila, M.5    Puranen, M.6    Hurskainen, H.7    Tyynela, K.8    Turunen, M.9    Vanninen, R.10    Lehtolainen, P.11
  • 85
    • 0034694011 scopus 로고    scopus 로고
    • A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme
    • Important paper describing a phase III clinical trial, which demonstrated a lack of efficacy using VPCs in the treatment of MGs
    • Rainov NG: A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum Gene Ther (2000) 11(17):2389-2401. • Important paper describing a phase III clinical trial, which demonstrated a lack of efficacy using VPCs in the treatment of MGs.
    • (2000) Hum Gene Ther , vol.11 , Issue.17 , pp. 2389-2401
    • Rainov, N.G.1
  • 86
    • 17344365922 scopus 로고    scopus 로고
    • Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: Results of a phase I clinical trial in malignant mesothelioma
    • Sterman DH, Treat J, Litzky LA, Amin KM, Coonrod L, Molnar-Kimber K, Recio A, Knox L, Wilson JM, Albelda SM, Kaiser LR: Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: Results of a phase I clinical trial in malignant mesothelioma. Hum Gene Ther (1998) 9(7):1083-1092.
    • (1998) Hum Gene Ther , vol.9 , Issue.7 , pp. 1083-1092
    • Sterman, D.H.1    Treat, J.2    Litzky, L.A.3    Amin, K.M.4    Coonrod, L.5    Molnar-Kimber, K.6    Recio, A.7    Knox, L.8    Wilson, J.M.9    Albelda, S.M.10    Kaiser, L.R.11
  • 89
    • 0033588816 scopus 로고    scopus 로고
    • A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group
    • Shand N, Weber F, Mariani L, Bernstein M, Gianella-Borradori A, Long Z, Sorensen AG, Barbier N: A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group. Hum Gene Ther (1999) 10(14):2325-2335.
    • (1999) Hum Gene Ther , vol.10 , Issue.14 , pp. 2325-2335
    • Shand, N.1    Weber, F.2    Mariani, L.3    Bernstein, M.4    Gianella-Borradori, A.5    Long, Z.6    Sorensen, A.G.7    Barbier, N.8
  • 90
    • 0037812853 scopus 로고    scopus 로고
    • Treatment of relapsed malignant glioma with an adenoviral vector containing the herpes simplex thymidine kinase gene followed by ganciclovir
    • DOI 10.1016/S1525-0016(03)00100-X
    • Smitt PS, Driesse M, Wolbers J, Kros M, Avezaat C: Treatment of relapsed malignant glioma with an adenoviral vector containing the herpes simplex thymidine kinase gene followed by ganciclovir. Mol Ther (2003) 7(6):851-858. (Pubitemid 36790262)
    • (2003) Molecular Therapy , vol.7 , Issue.6 , pp. 851-858
    • Smitt, P.S.1    Driesse, M.2    Wolbers, J.3    Kros, M.4    Avezaat, C.5
  • 91
    • 2442767029 scopus 로고    scopus 로고
    • A phase I/II study of herpes simplex virus type 1 thymidine kinase 'Suicide' gene therapy for recurrent glioblastoma
    • DOI 10.1089/10430349850019436
    • Klatzmann D, Valery CA, Bensimon G, Marro B, Boyer O, Mokhtari K, Diquet B, Salzmann JL, Philippon J: A phase I/II study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma. Hum Gene Ther (1998) 9(17):2595-2604. (Pubitemid 29004632)
    • (1998) Human Gene Therapy , vol.9 , Issue.17 , pp. 2595-2604
    • Klatzmann, D.1    Valery, C.A.2    Bensimon, G.3    Marro, B.4    Boyer, O.5    Mokhtari, K.6    Diquet, B.7    Salzmann, J.-L.8    Philippon, J.9
  • 95
    • 67349112757 scopus 로고    scopus 로고
    • Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer
    • Important paper demonstrating the safety of gene therapy using Ad vectors
    • Hedman M, Muona K, Hedman A, Kivela A, Syvanne M, Eranen J, Rantala A, Stjernvall J, Nieminen MS, Hartikainen J, Ylä-Herttuala S: Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer. Gene Ther (2009) 16(5):629-634. •• Important paper demonstrating the safety of gene therapy using Ad vectors.
    • (2009) Gene Ther , vol.16 , Issue.5 , pp. 629-634
    • Hedman, M.1    Muona, K.2    Hedman, A.3    Kivela, A.4    Syvanne, M.5    Eranen, J.6    Rantala, A.7    Stjernvall, J.8    Nieminen, M.S.9    Hartikainen, J.10    Ylä-Herttuala, S.11
  • 96
    • 0346243603 scopus 로고    scopus 로고
    • Adenovirus/herpes simplex-thymidine kinase/ganciclovir complex: Preliminary results of a phase I trial in patients with recurrent malignant gliomas
    • DOI 10.1023/B:NEON.0000003657.95085.56
    • Germano IM, Fable J, Gultekin SH, Silvers A: Adenovirus/herpes simplex-thymidine kinase/ganciclovir complex: Preliminary results of a phase I trial in patients with recurrent malignant gliomas. J Neurooncol (2003) 65(3):279-289. (Pubitemid 37526820)
    • (2003) Journal of Neuro-Oncology , vol.65 , Issue.3 , pp. 279-289
    • Germano, I.M.1    Fable, J.2    Gultekin, S.H.3    Silvers, A.4
  • 97
    • 0032818594 scopus 로고    scopus 로고
    • Low efficacy of gene therapy for rat BT4C malignant glioma using intra-tumoural transduction with Thymidine kinase retrovirus packaging cell injections and ganciclovir treatment
    • DOI 10.1007/s007010050389
    • Sandmair AM, Loimas S, Poptani H, Vainio P, Vanninen R, Turunen M, Tyynela K, Vapalahti M, Yla-Herttuala S: Low efficacy of gene therapy for rat BT4C malignant glioma using intra-tumoural transduction with thymidine kinase retrovirus packaging cell injections and ganciclovir treatment. Acta Neurochir (Wien) (1999) 141(8):867-872; discussion 872-873. (Pubitemid 29408429)
    • (1999) Acta Neurochirurgica , vol.141 , Issue.8 , pp. 867-873
    • Sandmair, A.-M.1    Loimas, S.2    Poptani, H.3    Vainio, P.4    Vanninen, R.5    Turunen, M.6    Tyynela, K.7    Vapalahti, M.8    Yla-Herttuala, S.9    Westphal, M.10    De Tribolet, N.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.