Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression

International Journal of Cancer

Volumn 71, Issue 2, 1997, Pages 267-274

  Vile, Richard G ^a,c   Castleden, Simon ^a   Marshall, John ^b   Camplejohn, Richard ^b   Uptov, Carol ^a   Chong, Heung ^a,c  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; THYMIDINE KINASE; VIRUS ENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL INFILTRATION; CONTROLLED STUDY; HERPES SIMPLEX VIRUS; IMMUNE RESPONSE; MALIGNANT NEOPLASTIC DISEASE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS EXPRESSION;

ANIMALS; ANTIVIRAL AGENTS; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DEATH; CYTOKINES; GANCICLOVIR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMMUNOHISTOCHEMISTRY; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTES, TUMOR-INFILTRATING; MACROPHAGES; MELANOMA; MICE; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; SIMPLEXVIRUS; TH1 CELLS; THYMIDINE KINASE; TIME FACTORS;

EID: 0030917683     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970410)71:2<267::AID-IJC23>3.0.CO;2-D     Document Type: Article

References (21)

1. ARENDS, M.J., MORRIS, R.G. and WYLLIE, A.M., Apoptosis. The role of endonuelcase. Amer. J. Pathol., 136, 593-608 (1990).
2. BARBA, D., HARDIN, J., SADELAIN, M. and GAGE, F.H., Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc. nat. Acad. Sci. (Wash.), 91, 4348-4352 (1994).
3. CARUSO, M., PANIS, Y., GAGANDEEP, S., HOUSSIN, D., SALZMANN, J.L. and KLATZMANN, D., Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc. nat. Acad. Sci. (Wash.), 90, 7024-7028 (1993).
4. CHONG, H. and VILE, R.G., New therapeutic approaches based on gene transfer techniques. Springer Semin. Immunopathol., 18, 149-170 (1996).
5. CONSALVO, M., MULLEN, C.A., MODESTI, A., MUSIANI, P., ALLIONE, A., CAVALLO, F., GIOVARELLI, M. and FORNI, G., 5-Fluorocytosine-induced eradication of murine adenocarcinomas engineered to express the cytosine deaminase suicide gene requires host immune competence and leaves an efficient memory. J. Immumol., 154, 5302-5312 (1995).
6. DRANOFF, G., JAFFEE, E., LAZENHY, A., GOLUMBEK, P., LEVITSKY, H., BROSE, K., JACKSON, V., HAMADA, H., PARDOLL, D. and MULLIGAN, R.C., Vaccination with irradiated tumor cells engineered to secrete murine granulocyte macrophage colony stimulating factor stimulates potent, specific, and long lasting anti-tumor immunity. Proc. nat. Acad, Sci. (Wash.), 90, 3539-3543 (1993).
7. FICK, J., BARKER II, F.G., DAZIN, P., WESTPHALE, E.M., BEYER, E.C. and ISRAEL, M.A., The extent of heterocelluar communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro. Proc. nat. Acad. Sci. (Wash.), 92, 11071-11075 (1995).
8. FISHER, D.E., Apoptosis in cancer therapy; crossing the threshold. Cell, 78, 539-542 (1994).
9. FREEMAN, S.M., ABBOUD, C.N., WHARTENBY, K.A., PACKMAN, C.H., KOEPLIN, D.S., MOOLTEN, F.L. and ABRAHAM, G.N., The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res., 53, 5274-5283 (1993).
10. GERARD, C.M., BRUYNS, C., DELAVAUX, A., BADUSON, N., DARGENT, J.-L., GOLDMAN, M. and VELU, T., Loss of tumorigenicity and increased immunogenicity induced by interleukin-10 gene transfer in B16 melanoma cells. Hum. Gene Therapy, 7, 11-22 (1996).
11. KANEKO, Y. and TSUKAMOTO, A., Gene therapy of hepatoma: bystander effects and non-apoptotic cell death induced by thymidine kinase and ganciclovir. Cancer Lett., 96, 105-110 (1995).
12. MAASS, G., SCHMIDT, W., BERGER, M., SCHILCHER, F., KOSZIK, F., SCHNEEBERGER, A., STINGL, G., BIRNSTIEL, M. and SCHWEIGHOFFER, T., Priming of tumor specific T cells in the draining lymph nodes after immunization with interleukin 2-secreting tumor cells: three consecutive stages may be required for successful tumor vaccination. Proc. nat. Acad. Sci. (Wash.), 92, 5540-5544 (1995).
13. MOOLTEN, F.L., Drug sensitivity ("suicide") genes for selective cancer chemotherapy. Cancer Gene Therapy, 1, 279-287 (1994).
14. ORMEROD, M.G., COLLINS, M.K.L., RODRIGUEZ-TARDUCHY, G. and ROBERTSON, D., Apoptosis in interleukin-3-dependent haemopoietic cells. J. immunol. Methods, 153, 57-65 (1992).
15. PLETTENBERG, A., BALLAUN, C., PAMMER, J., MILDNER, M., STRUNK, D., WENINGER, W. and TSCHACLER, E., Human melanocytes and melanoma cells constitutively express the Bcl-22 protooncogene in situ and in cell culture. Amer. J. Pathol., 146, 651-659 (1995).
16. RIDGE, J.P., FUCHS, E.J. and MATZINGER, P., Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science, 271, 1723-1726 (1996).
17. + T cells. Ann. Rev. Immunol., 12, 635-673 (1994).
18. VILE, R.G. and HART, I.R., Use of tissue-specific expression of the herpes simplex virus thymidine kinase gone to inhibit growth of established murine melanomas following direct intratumoral injection of DNA. Cancer Res., 53, 3860-3864 (1993).
19. VILE, R.G., MILLER, N., CHERNAJOVSKY, Y. and HART, I.R., A comparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes. Gene Therapy, 1, 307-316 (1994a).
20. VILE, R.G., NELSON, J.A., CASTLEDEN, S., CHONG, H. and HART, I.R., Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component. Cancer Res., 54, 6228-6234 (1994b).
21. WYLLIE, A.H., Apoptosis (The 1992 Frank Rose Memorial Lecture). Brit. J. Cancer, 67, 205-208 (1993).