Suppressive effects of leflunomide on leptin-induced TIMP-1 production involves on hepatic stellate cell proliferation and apoptosis

European Journal of Pharmacology

Volumn 580, Issue 1-2, 2008, Pages 63-69

  Li, Jun ^a   Si, H F ^a   Lü, Xiongwen ^a   Guo, Anping ^a   Jiang, Hui ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Hepatic stellate cell; Leflunomide; Leptin; Proliferation

Indexed keywords

JANUS KINASE; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STAT PROTEIN; TERIFLUNOMIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; FIBROGENESIS; IN VITRO STUDY; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; STELLATE CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANILINE COMPOUNDS; ANIMALS; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; HYDROXYBUTYRATES; IMMUNOSUPPRESSIVE AGENTS; ISOXAZOLES; JANUS KINASES; LEPTIN; LIVER; MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 37649016036     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.10.061     Document Type: Article

References (25)

1. Andrew N.C., and Faller D.V. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic. Acids. Res. 19 (1991) 2499
2. Arthur M.J.P. Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis. Am. J. Physiol.: Gastrointest. Liver. Physiol. 279 (2000) 245-249
3. Arthur M.J.P., Iredale J.P., and Mann D.A. Tissue inhibitors of metalloproteinases: role in liver fibrosis and alcoholic liver disease. Alcohol., Clin. Exp. Res. 23 (1999) 940-943
4. 2-dependant MAPK pathways. J. Biol. Chem. 279 (2004) 4292-4304
5. Cherwinski H.M., Cohn R.G., Cheung P., Webster D.J., Xu Y.Z., Caulfield J.P., Young J.M., Nakano G., and Ransom J.T. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. J. Pharmacol. Exp. Ther. 275 (1995) 1043-1049
6. Davis J.P., Cain G.A., Pitts W.J., Magolda R.L., and Copeland R.A. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dehydrogenase. Biochemistry 35 (1996) 1270-1273
7. Elder R.T., Xu X., Williams J.W., Gong H., Finnegan A., and Chong A.S. The immunosuppressive metabolite of leflunomide, A771726, affects murine T cells through two biochemical mechanisms. J. Immunol. 159 (1997) 22-27
8. Friedman S.L., and Roll F.J. Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with stractan. Anal. Biochem. 161 (1987) 207-218
9. Geerts A., Lazou J.M., De Bleser P., and Wisse E. Tissue distribution, quantitation and proliferation kinetics of fat-storing cells in carbon tetrachloride-injured rat liver. Hepatology 13 (1991) 1193-1202
10. Harvey J., McKay N.G., Walker K.S., Van der Kaay J., Downes C.P., and Ashford M.L.J. Essential role of phosphoinositide 3-kinase in leptin-induced KATP channel activation in the rat CRI-G1 insulinoma cell line. J. Biol. Chem. 275 (2000) 4660-4669
11. Honda H., Ikejima K., Hirose M., Yoshikawa M., Lang T., Enomoto N., Kitamura T., Takei Y., and Sato N. Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver. Hepatology 36 (2002) 12-21
12. Iredale J.P., Benyon R.C., Arthur M.J., Ferris W.F., Alcolado R., Winwood P.J., Clark N., and Murphy G. Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis. Hepatology 24 (1996) 176-184
13. Kawada N., Ikeda K., Seki S., and Kuroki T. Expression of cyclins D1, D2 and E correlates with proliferation of rat stellate cells in culture. J. Hepatol. 30 (1999) 1057-1064
14. Kim Y.B., Uotani S., Pierroz D.D., Flier J.S., and Khan B.B. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology 141 (2000) 2328-2339
15. Manna S.K., and Aggarwal B.B. Immunosuppressive leflunomide metabolite (A771726) blocks TNF-dependent nuclear factor-k{cyrillic}B activation and gene expression. J. Immunol. 162 (1999) 2095-2102
16. Matter T., Kochhar K., Bartlett R., Bremer E.G., and Finnegan A. Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide. FEBS. Lett. 334 (1993) 161-164
17. Rebbaa A., Hurh J., Yamamoto H., Donna S., Kersey, and Bremer E.G. Ganglioside GM3 inhibition of EGF receptor mediated signal transduction. Glycobiology 6 (1996) 399-406
18. Saxena N.K., Ikeda K., Rockey D.C., Friedman S.L., and Anania F.A. Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology 35 (2002) 762-771
19. Saxena N.K., Titus M.A., Ding X., Floyd J., Srinivasan S., Sitaraman S.V., and Frank A. Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (ERK) and Akt phosphorylation. FASEB. J. 18 (2004) 1612-1614
20. Schmitt-Graff A., Kruger S., Bochard F., Gabbiani G., and Denk H. Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers. Am. J. Pathol. 138 (1991) 1233-1242
21. Takahashi Y., Okimura Y., Mizuno I., Iida K., Takahashi T., Kaji H., Abe H., and Chihara K. Leptin induces mitogen activated protein kinase-dependent proliferation of C3H10T1/2 cells. J. Biol. Chem. 272 (1997) 12897-12900
22. Wagner B.J., Hayes T.E., Hoban C.J., and Cochran B.H. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO. J. 9 (1990) 4477-4484
23. White D.W., Kuropatwinski K.K., Devos R., Baumann H., and Tartaglia L.A. Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. J. Biol. Chem. 272 (1997) 4065-4071
24. Xu X., Williams J.W., Bremer E.G., Finnegan A., and Chong A.S.F. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J. Biol. Chem. 270 (1995) 12398-12403
25. Xu X., Williams J.W., Gong H., Finnegan A., and Chong A.S. Two activities of immunosuppressive metabolite of leflunomide, A771726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation. Biochem. Pharmacol. 52 (1996) 527-534