Therapeutic dosing with anti-interleukin-13 monoclonal antibody inhibits asthma progression in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 313, Issue 1, 2005, Pages 8-15

  Yang, Gaoyun ^a   Li, Li ^a   Volk, Amy ^a   Emmell, Eva ^a   Petley, Ted ^a   Giles Komar, Jill ^a   Rafferty, Patricia ^a   Lakshminarayanan, Mani ^a   Griswold, Don E ^a   Bugelski, Peter J ^a   Das, Anuk M ^a  

^a CENTOCOR INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CNTO 134; CYTOKINE; GELATINASE B; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY INTERLEUKIN 13; OVALBUMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; BRONCHUS MUCUS; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FIBROSIS; HYPERPLASIA; IN VIVO STUDY; INFLAMMATION; MOUSE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINES; CYTOKINES; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; INFLAMMATION MEDIATORS; INTERLEUKIN-13; LUNG; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED BALB C; MUCUS; OVALBUMIN; PULMONARY FIBROSIS;

EID: 20144372895     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.076133     Document Type: Article

References (40)

1. Bandeira-Melo C, Woods LJ, Phoofolo M, and Weller PF (2002) Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion. J Exp Med 186:841-850.
2. Brightling CE, Symon FA, Holgate ST, Wardlaw AJ, Pavord ID, and Bradding P (2003) Interleukin-4 and -13 expression is co-localized to mast cells within the airway smooth muscle in asthma. Clin Exp Allergy 33:1711-1716.
3. Chibana K, Ishii Y, Asakura T, and Fukuda T (2003) Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin. J Immunol 170:4290-4295.
4. Dolhnikoff M, Mauad T, and Ludwig MS (1999) Extracellular matrix and oscillatory mechanics of rat lung parenchyma in bleomycin-induced fibrosis. Am J Respir Crit Care Med 160:1750-1757.
5. Doucet C, Brouty-Boye D, Pottin-Clemenceau C, Canonica GW, Jasmin C, and Azzarone B (1998) Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma. J Clin Investig 101:2129-2139.
6. Fireman P (2003) Understanding asthma pathophysiology. Allergy Asthma Proc 24:79-83.
7. Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, et al. (1998) Requirement for IL-13 independently of IL-4 in experimental asthma. Science (Wash DC) 282:2261-2263.
8. Hamelmann E, Schwarze J, Takeda K, Oshiba A, Larsen GL, Irvin CG, and Gelfand EW (1997) Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 156:766-775.
9. Horie S, Okubo Y, Hossain M, Sato E, Nomura H, Koyama S, Suzuki J, Isobe M, and Sekiguchi M (1997) Interleukin-13 but not interleukin-4 prolongs eosinophil survival and induces eosinophil chemotaxis. Intern Med 36:179-185.
10. Huang SK, Xiao HQ, Kleine-Tebbe J, Paciotti G, Marsh DG, Lichtenstein LM, and Liu MC (1995) IL-13 expression at the sites of allergen challenge in patients with asthma. J Immunol 155:2688-2694.
11. Ingram JL, Rice A, Geisenhoffer K, Madtes DK, and Bonner JC (2003) Interleukin-13 stimulates the proliferation of lung myofibroblasts via a signal transducer and activator of transcription-6-dependent mechanism: a possible mechanism for the development of airway fibrosis in asthma. Chest 123:4228-4248.
12. Jakubzick C, Choi ES, Kunkel SL, Joshi BH, Puri RK, and Hogaboam CM (2003) Impact of interleukin-13 responsiveness on the synthetic and proliferative properties of Th1- and Th2-type pulmonary granuloma fibroblasts. Am J Pathol 162: 1475-1486.
13. Kibe A, Inoue H, Fukuyama S, Machida K, Matsumoto K, Koto H, Ikegami T, Aizawa H, and Kara N (2003) Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness and goblet cell hyperplasia in mouse airways. Am J Respir Crit Care Med 167:50-56.
14. Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, and Erie DJ (2002) Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 8:885-889.
15. Lanone S, Zheng T, Zhu Z, Liu W, Lee CG, Ma B, Chen Q, Homer RJ, Wang J, Rabach LA, et al. (2002) Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Investig 110:463-474.
16. Laoukili J, Perret E, Willems T, Minty A, Parthoens E, Houcine O, Coste A, Jorissen M, Marano F, Caput D, et al. (2001) IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells. J Clin Investig 108:1817-1824.
17. Laporte JC, Moore PE, Baraldo S, Jouvin MH, Church TL, Schwartzman IN, Panettieri RA Jr, Kinet JP, and Shore SA (2001) Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells. Am J Respir Crit Care Med 164:141-148.
18. Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley JM, Gotwals P, Noble P, Chen Q, et al. (2001) Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med 194:809-821.
19. Leigh R, Ellis R, Wattie J, Donaldson DD, and Inman MD (2004) Is interleukin-13 critical in maintaining airway hyperresponsiveness in allergen-challenged mice? Am J Respir Crit Care Med 170:851-856.
20. Lentsch AB, Czermak BJ, Jordan JA, and Ward PA (1999) Regulation of acute lung inflammatory injury by endogenous IL-13. J Immunol 162:1071-1076.
21. Li L, Xia Y, Nguyen A, Lai YH, Feng L, Mosmann TR, and Lo D (1999) Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells. J Immunol 162:2477-2487.
22. Moore PE, Church TL, Chism DD, Panettieri RA Jr, and Shore SA (2002) IL-13 and IL-4 cause eotaxin release in human airway smooth muscle cells: a role for ERK. Am J Physiol Lung Cell Mol Physiol 282:L847-L853.
23. Richter A, Puddicombe SM, Lordan JL, Bucchieri F, Wilson SJ, Djukanovic R, Dent G, Holgate ST, and Davies DE (2001) The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am J Respir Cell Mol Biol 25:385-391.
24. Saito A, Okazaki H, Sugawara I, Yamamoto K, and Takizawa H (2003) Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro. Int Arch Allergy Immunol 132:168-176.
25. Shim JJ, Dabbagh K, Ueki IF, Dao-Pick T, Burgel PR, Takeyama K, Tam DC, and Nadel JA (2001) IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils. Am J Physiol Lung Cell Mol Physiol 280:L134-L140.
26. Singer M, Lefort J, and Vargaftig BB (2002) Granulocyte depletion and dexamethasone differentially modulate airways hyperreactivity, inflammation, mucus accumulation and secretion induced by rmIL-13 or antigen. Am J Respir Cell Mol Biol 26:74-84.
27. Taube C, Duez C, Cui ZH, Takeda K, Rha YH, Park JW, Balhorn A, Donaldson DD, Dakhama A, and Gelfand EW (2002) The role of IL-13 in established allergic airway disease. J Immunol 169:6482-6489.
28. Tliba O, Deshpande D, Chen H, Van Besien C, Kannan M, Panettieri RA Jr, and Amrani Y (2003) IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle. Br J Pharmacol 140:1159-1162.
29. Vargaftig BB and Singer M (2003a) Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. Am J Respir Cell Mol Biol 28:410-419.
30. Vargaftig BB and Singer M (2003b) Leukotrienes, IL-13 and chemokines cooperate to induce BHR and mucus in allergic mouse lungs. Am J Physiol Lung Cell Mol Physiol 284:L260-269.
31. Venkayya R, Lam M, Willkom M, Grunig G, Corry DB, and Erle DJ (2002) The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells. Am J Respir Cell Mol Biol 26:202-208.
32. Walter DM, McIntire JJ, Berry G, McKenzie AN, Donaldson DD, DeKruyff RH, and Umetsu DT (2001) Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J Immunol 167:4668-4675.
33. Watson ML, White AM, Campbell EM, Smith AW, Uddin J, Yoshimura T, and Westwick J (1999) Anti-inflammatory actions of interleukin-13: suppression of tumor necrosis factor-alpha and antigen-induced leukocyte accumulation in the guinea pig lung. Am J Respir Cell Mol Biol 20:1007-1012.
34. Wenzel SE, Balzar S, Cundall M, and Chu HW (2003) Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation and wound repair. J Allergy Clin Immunol 111:1345-1352.
35. Wills-Karp M (2000) The gene encoding interleukin-13: a susceptibility locus for asthma and related traits. Respir Res 1:19-23.
36. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, and Donaldson DD (1998) Interleukin-13: central mediator of allergic asthma. Science (Wash DC) 282:2258-2261.
37. Zhao A, McDermott J, Urban JF Jr, Cause W, Madden KB, Yeung KA, Morris SC, Finkelman FD, and Shea-Donohue T (2003) Dependence of IL-4, IL-13 and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves. J Immunol 171:948-954.
38. Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, Zhang Y, and Elias JA (1999) Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities and eotaxin production. J Clin Investis 103:779-788.
39. Zhu Z, Ma B, Homer RJ, Zheng T, and Elias JA (2001) Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. J Biol Chem 276:25222-25229.
40. Zuhdi Alimam M, Piazza FM, Selby DM, Letwin N, Huang L, and Rose MC (2000) Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am J Respir Cell Mol Biol 22:253-260.