메뉴 건너뛰기




Volumn 28, Issue 6, 2004, Pages 224-232

Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling

Author keywords

Airway remodeling; Asthma; Cytokine; IL 13; Mucus

Indexed keywords

INTERLEUKIN 13 MONOCLONAL ANTIBODY; METHACHOLINE; MONOCLONAL ANTIBODY; OVALBUMIN; UNCLASSIFIED DRUG;

EID: 9644276704     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2004.08.007     Document Type: Article
Times cited : (173)

References (44)
  • 2
  • 3
    • 0037246364 scopus 로고    scopus 로고
    • Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling
    • S.T. Holgate, M. Peters-Golden, R.A. Panettieri, and W.R. Henderson Jr. Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling J Allergy Clin Immunol 111 suppl 1 2003 S18 S34 discussion S34-6
    • (2003) J Allergy Clin Immunol , vol.111 , Issue.1
    • Holgate, S.T.1    Peters-Golden, M.2    Panettieri, R.A.3    Henderson Jr., W.R.4
  • 4
    • 0345169967 scopus 로고    scopus 로고
    • Pathology of difficult asthma
    • S. Wenzel Pathology of difficult asthma Paediatr Respir Rev 4 4 2003 306 311
    • (2003) Paediatr Respir Rev , vol.4 , Issue.4 , pp. 306-311
    • Wenzel, S.1
  • 5
    • 0037775352 scopus 로고    scopus 로고
    • IL-13 effector functions
    • T.A. Wynn IL-13 effector functions Annu Rev Immunol 21 2003 425 456
    • (2003) Annu Rev Immunol , vol.21 , pp. 425-456
    • Wynn, T.A.1
  • 7
    • 0033856743 scopus 로고    scopus 로고
    • Increased interleukin-13 mRNA expression in bronchoalveolar lavage cells of atopic patients with mild asthma after repeated low-dose allergen provocations
    • J. Prieto, C. Lensmar, A. Roquet, I. van der Ploeg, D. Gigliotti, and A. Eklund Increased interleukin-13 mRNA expression in bronchoalveolar lavage cells of atopic patients with mild asthma after repeated low-dose allergen provocations Respir Med 94 8 2000 806 814
    • (2000) Respir Med , vol.94 , Issue.8 , pp. 806-814
    • Prieto, J.1    Lensmar, C.2    Roquet, A.3    Van Der Ploeg, I.4    Gigliotti, D.5    Eklund, A.6
  • 8
    • 0036772222 scopus 로고    scopus 로고
    • Genetics of IL-13 and functional relevance of IL-13 variants
    • D. Vercelli Genetics of IL-13 and functional relevance of IL-13 variants Curr Opin Allergy Clin Immunol 2 5 2002 389 393
    • (2002) Curr Opin Allergy Clin Immunol , vol.2 , Issue.5 , pp. 389-393
    • Vercelli, D.1
  • 9
    • 0034755167 scopus 로고    scopus 로고
    • Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin
    • M. Yang, S.P. Hogan, P.J. Henry, K.I. Matthaei, A.N. McKenzie, and I.G. Young Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin Am J Respir Cell Mol Biol 25 4 2001 522 530
    • (2001) Am J Respir Cell Mol Biol , vol.25 , Issue.4 , pp. 522-530
    • Yang, M.1    Hogan, S.P.2    Henry, P.J.3    Matthaei, K.I.4    McKenzie, A.N.5    Young, I.G.6
  • 10
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Z. Zhu, R.J. Homer, Z. Wang, Q. Chen, G.P. Geba, and J. Wang Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production J Clin Invest 103 6 1999 779 788
    • (1999) J Clin Invest , vol.103 , Issue.6 , pp. 779-788
    • Zhu, Z.1    Homer, R.J.2    Wang, Z.3    Chen, Q.4    Geba, G.P.5    Wang, J.6
  • 14
    • 0035206065 scopus 로고    scopus 로고
    • Understanding airway wall remodeling in asthma: A basis for improvements in therapy?
    • R.K. Kumar Understanding airway wall remodeling in asthma: a basis for improvements in therapy? Pharmacol Ther 91 2 2001 93 104
    • (2001) Pharmacol Ther , vol.91 , Issue.2 , pp. 93-104
    • Kumar, R.K.1
  • 15
    • 0033826756 scopus 로고    scopus 로고
    • Bronchial epithelium as a key regulator of airway allergen sensitization and remodeling in asthma
    • S.T. Holgate, P. Lackie, S. Wilson, W. Roche, and D. Davies Bronchial epithelium as a key regulator of airway allergen sensitization and remodeling in asthma Am J Respir Crit Care Med 162 3 Pt 2 2000 S113 S117
    • (2000) Am J Respir Crit Care Med , vol.162 , Issue.32
    • Holgate, S.T.1    Lackie, P.2    Wilson, S.3    Roche, W.4    Davies, D.5
  • 16
    • 0035888013 scopus 로고    scopus 로고
    • Critical role for IL-13 in the development of allergen-induced airway hyperreactivity
    • D.M. Walter, J.J. McIntire, G. Berry, A.N. McKenzie, D.D. Donaldson, and R.H. DeKruyff Critical role for IL-13 in the development of allergen-induced airway hyperreactivity J Immunol 167 8 2001 4668 4675
    • (2001) J Immunol , vol.167 , Issue.8 , pp. 4668-4675
    • Walter, D.M.1    McIntire, J.J.2    Berry, G.3    McKenzie, A.N.4    Donaldson, D.D.5    Dekruyff, R.H.6
  • 17
    • 0034235875 scopus 로고    scopus 로고
    • Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity
    • D.C. Webb, A.N. McKenzie, A.M. Koskinen, M. Yang, J. Mattes, and P.S. Foster Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity J Immunol 165 1 2000 108 113
    • (2000) J Immunol , vol.165 , Issue.1 , pp. 108-113
    • Webb, D.C.1    McKenzie, A.N.2    Koskinen, A.M.3    Yang, M.4    Mattes, J.5    Foster, P.S.6
  • 18
    • 0038579646 scopus 로고    scopus 로고
    • Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma
    • P.S. Foster, D.C. Webb, M. Yang, C. Herbert, and R.K. Kumar Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma Clin Exp Allergy 33 5 2003 688 695
    • (2003) Clin Exp Allergy , vol.33 , Issue.5 , pp. 688-695
    • Foster, P.S.1    Webb, D.C.2    Yang, M.3    Herbert, C.4    Kumar, R.K.5
  • 19
    • 0035402376 scopus 로고    scopus 로고
    • Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells
    • J.C. Laporte, P.E. Moore, S. Baraldo, M.H. Jouvin, T.L. Church, and I.N. Schwartzman Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells Am J Respir Crit Care Med 164 1 2001 141 148
    • (2001) Am J Respir Crit Care Med , vol.164 , Issue.1 , pp. 141-148
    • Laporte, J.C.1    Moore, P.E.2    Baraldo, S.3    Jouvin, M.H.4    Church, T.L.5    Schwartzman, I.N.6
  • 21
    • 1642545168 scopus 로고    scopus 로고
    • IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle
    • O. Tliba, D. Deshpande, H. Chen, C. Van Besien, M. Kannan, and R.A. Panettieri IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle Br J Pharmacol 140 7 2003 1159 1162
    • (2003) Br J Pharmacol , vol.140 , Issue.7 , pp. 1159-1162
    • Tliba, O.1    Deshpande, D.2    Chen, H.3    Van Besien, C.4    Kannan, M.5    Panettieri, R.A.6
  • 23
    • 0033104696 scopus 로고    scopus 로고
    • Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells
    • L. Li, Y. Xia, A. Nguyen, Y.H. Lai, L. Feng, and T.R. Mosmann Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells J Immunol 162 5 1999 2477 2487
    • (1999) J Immunol , vol.162 , Issue.5 , pp. 2477-2487
    • Li, L.1    Xia, Y.2    Nguyen, A.3    Lai, Y.H.4    Feng, L.5    Mosmann, T.R.6
  • 24
    • 0028176655 scopus 로고
    • Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells
    • G. Zurawski, and J.E. de Vries Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells Immunol Today 15 1 1994 19 26
    • (1994) Immunol Today , vol.15 , Issue.1 , pp. 19-26
    • Zurawski, G.1    De Vries, J.E.2
  • 25
    • 0031569104 scopus 로고    scopus 로고
    • IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: Correlation with down-modulation of TNF-alpha, IFN-gamma, and IL-12 production
    • T. Muchamuel, S. Menon, P. Pisacane, M.C. Howard, and D.A. Cockayne IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: correlation with down-modulation of TNF-alpha, IFN-gamma, and IL-12 production J Immunol 158 6 1997 2898 2903
    • (1997) J Immunol , vol.158 , Issue.6 , pp. 2898-2903
    • Muchamuel, T.1    Menon, S.2    Pisacane, P.3    Howard, M.C.4    Cockayne, D.A.5
  • 27
    • 0033126192 scopus 로고    scopus 로고
    • Anti-inflammatory actions of interleukin-13: Suppression of tumor necrosis factor-alpha and antigen-induced leukocyte accumulation in the guinea pig lung
    • M.L. Watson, A.M. White, E.M. Campbell, A.W. Smith, J. Uddin, and T. Yoshimura Anti-inflammatory actions of interleukin-13: suppression of tumor necrosis factor-alpha and antigen-induced leukocyte accumulation in the guinea pig lung Am J Respir Cell Mol Biol 20 5 1999 1007 1012
    • (1999) Am J Respir Cell Mol Biol , vol.20 , Issue.5 , pp. 1007-1012
    • Watson, M.L.1    White, A.M.2    Campbell, E.M.3    Smith, A.W.4    Uddin, J.5    Yoshimura, T.6
  • 29
    • 0035987319 scopus 로고    scopus 로고
    • Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma
    • R.K. Kumar, C. Herbert, M. Yang, A.M. Koskinen, A.N. McKenzie, and P.S. Foster Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma Clin Exp Allergy 32 7 2002 1104 1111
    • (2002) Clin Exp Allergy , vol.32 , Issue.7 , pp. 1104-1111
    • Kumar, R.K.1    Herbert, C.2    Yang, M.3    Koskinen, A.M.4    McKenzie, A.N.5    Foster, P.S.6
  • 30
    • 0035871623 scopus 로고    scopus 로고
    • Therapeutic effect of IL-13 immunoneutralization during chronic experimental fungal asthma
    • K. Blease, C. Jakubzick, J. Westwick, N. Lukacs, S.L. Kunkel, and C.M. Hogaboam Therapeutic effect of IL-13 immunoneutralization during chronic experimental fungal asthma J Immunol 166 8 2001 5219 5224
    • (2001) J Immunol , vol.166 , Issue.8 , pp. 5219-5224
    • Blease, K.1    Jakubzick, C.2    Westwick, J.3    Lukacs, N.4    Kunkel, S.L.5    Hogaboam, C.M.6
  • 32
    • 0036845165 scopus 로고    scopus 로고
    • Interleukin-13 induces goblet cell differentiation in primary cell culture from Guinea pig tracheal epithelium
    • M. Kondo, J. Tamaoki, K. Takeyama, J. Nakata, and A. Nagai Interleukin-13 induces goblet cell differentiation in primary cell culture from Guinea pig tracheal epithelium Am J Respir Cell Mol Biol 27 5 2002 536 541
    • (2002) Am J Respir Cell Mol Biol , vol.27 , Issue.5 , pp. 536-541
    • Kondo, M.1    Tamaoki, J.2    Takeyama, K.3    Nakata, J.4    Nagai, A.5
  • 33
    • 0033944865 scopus 로고    scopus 로고
    • Consequences of long-term inflammation. Airway remodeling
    • R.J. Homer, and J.A. Elias Consequences of long-term inflammation. Airway remodeling Clin Chest Med 21 2 2000 331 343 ix
    • (2000) Clin Chest Med , vol.21 , Issue.2 , pp. 331-343
    • Homer, R.J.1    Elias, J.A.2
  • 34
    • 0035903306 scopus 로고    scopus 로고
    • Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1)
    • C.G. Lee, R.J. Homer, Z. Zhu, S. Lanone, X. Wang, and V. Koteliansky Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1) J Exp Med 194 6 2001 809 821
    • (2001) J Exp Med , vol.194 , Issue.6 , pp. 809-821
    • Lee, C.G.1    Homer, R.J.2    Zhu, Z.3    Lanone, S.4    Wang, X.5    Koteliansky, V.6
  • 35
    • 0037108501 scopus 로고    scopus 로고
    • TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblasts
    • S.E. Wenzel, J.B. Trudeau, S. Barnes, X. Zhou, M. Cundall, and J.Y. Westcott TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblasts J Immunol 169 8 2002 4613 4619
    • (2002) J Immunol , vol.169 , Issue.8 , pp. 4613-4619
    • Wenzel, S.E.1    Trudeau, J.B.2    Barnes, S.3    Zhou, X.4    Cundall, M.5    Westcott, J.Y.6
  • 36
    • 0037335938 scopus 로고    scopus 로고
    • Interleukin-13 stimulates the proliferation of lung myofibroblasts via a signal transducer and activator of transcription-6-dependent mechanism: A possible mechanism for the development of airway fibrosis in asthma
    • J.L. Ingram, A. Rice, K. Geisenhoffer, D.K. Madtes, and J.C. Bonner Interleukin-13 stimulates the proliferation of lung myofibroblasts via a signal transducer and activator of transcription-6-dependent mechanism: a possible mechanism for the development of airway fibrosis in asthma Chest 123 3 Suppl 2003 422S 424S
    • (2003) Chest , vol.123 , Issue.3
    • Ingram, J.L.1    Rice, A.2    Geisenhoffer, K.3    Madtes, D.K.4    Bonner, J.C.5
  • 38
    • 0242405834 scopus 로고    scopus 로고
    • Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro
    • A. Saito, H. Okazaki, I. Sugawara, K. Yamamoto, and H. Takizawa Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro Int Arch Allergy Immunol 132 2 2003 168 176
    • (2003) Int Arch Allergy Immunol , vol.132 , Issue.2 , pp. 168-176
    • Saito, A.1    Okazaki, H.2    Sugawara, I.3    Yamamoto, K.4    Takizawa, H.5
  • 39
    • 0344393717 scopus 로고    scopus 로고
    • Clinical and immunological effects of low-dose IFN-alpha treatment in patients with corticosteroid-resistant asthma
    • H.U. Simon, H. Seelbach, R. Ehmann, and M. Schmitz Clinical and immunological effects of low-dose IFN-alpha treatment in patients with corticosteroid-resistant asthma Allergy 58 12 2003 1250 1255
    • (2003) Allergy , vol.58 , Issue.12 , pp. 1250-1255
    • Simon, H.U.1    Seelbach, H.2    Ehmann, R.3    Schmitz, M.4
  • 40
    • 0035029680 scopus 로고    scopus 로고
    • Decreased steroid responsiveness at night in nocturnal asthma. Is the macrophage responsible?
    • M. Kraft, Q. Hamid, G.P. Chrousos, R.J. Martin, and D.Y. Leung Decreased steroid responsiveness at night in nocturnal asthma. Is the macrophage responsible? Am J Respir Crit Care Med 163 5 2001 1219 1225
    • (2001) Am J Respir Crit Care Med , vol.163 , Issue.5 , pp. 1219-1225
    • Kraft, M.1    Hamid, Q.2    Chrousos, G.P.3    Martin, R.J.4    Leung, D.Y.5
  • 41
    • 0030587138 scopus 로고    scopus 로고
    • A novel action of IL-13: Induction of diminished monocyte glucocorticoid receptor-binding affinity
    • J.D. Spahn, S.J. Szefler, W. Surs, D.E. Doherty, S.R. Nimmagadda, and D.Y. Leung A novel action of IL-13: induction of diminished monocyte glucocorticoid receptor-binding affinity J Immunol 157 6 1996 2654 2659
    • (1996) J Immunol , vol.157 , Issue.6 , pp. 2654-2659
    • Spahn, J.D.1    Szefler, S.J.2    Surs, W.3    Doherty, D.E.4    Nimmagadda, S.R.5    Leung, D.Y.6
  • 42
    • 0035030820 scopus 로고    scopus 로고
    • IL-4, IL-13, and dexamethasone augment fibroblast proliferation in asthma
    • M. Kraft, C. Lewis, D. Pham, and H.W. Chu IL-4, IL-13, and dexamethasone augment fibroblast proliferation in asthma J Allergy Clin Immunol 107 4 2001 602 606
    • (2001) J Allergy Clin Immunol , vol.107 , Issue.4 , pp. 602-606
    • Kraft, M.1    Lewis, C.2    Pham, D.3    Chu, H.W.4
  • 43
    • 0037337767 scopus 로고    scopus 로고
    • Interleukin-4 and interleukin-13 augment the proliferative effect of dexamethasone on distal lung fibroblasts
    • C.C. Lewis, E.R. Sutherland, T.A. Moss, T.L. Metze, M.D. Rex, and M. Kraft Interleukin-4 and interleukin-13 augment the proliferative effect of dexamethasone on distal lung fibroblasts Chest 123 suppl 3 2003 356S
    • (2003) Chest , vol.123 , Issue.3
    • Lewis, C.C.1    Sutherland, E.R.2    Moss, T.A.3    Metze, T.L.4    Rex, M.D.5    Kraft, M.6
  • 44
    • 0037215576 scopus 로고    scopus 로고
    • Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways
    • A. Kibe, H. Inoue, S. Fukuyama, K. Machida, K. Matsumoto, and H. Koto Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways Am J Respir Crit Care Med 167 1 2003 50 56
    • (2003) Am J Respir Crit Care Med , vol.167 , Issue.1 , pp. 50-56
    • Kibe, A.1    Inoue, H.2    Fukuyama, S.3    MacHida, K.4    Matsumoto, K.5    Koto, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.