Improvement of norfloxacin oral bioavailability by EDTA and sodium caprate

International Journal of Pharmaceutics

Volumn 260, Issue 1, 2003, Pages 1-4

  Dos Santos, I ^a   Fawaz, F ^a   Lagueny, A M ^a   Bonini, F ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Absorption enhancer; Bioavailability; Dissolution; EDTA; Norfloxacin; Sodium caprate

Indexed keywords

DECANOATE SODIUM; EDETIC ACID; NORFLOXACIN; SOLUBILIZER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG SOLUBILITY; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0038344743     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(03)00257-6     Document Type: Article

References (11)

1. Alkaysi H.N., Abdel-Hay M.H., Sheikh Salem M., Gharaibeh A.M., Na'was T.E. Chemical and microbiological investigations of metal ion interaction with norfloxacin. Int. J. Pharm. 87:1992;73-77.
2. Aungst B.J. Intestinal permeation enhancers. J. Pharm. Sci. 89:2000;429-442.
3. Aungst B.J., Saitoh H., Burcham D.L., Huang S.M., Mousa S.A., Hussain M.A. Enhancement of intestinal absorption of peptides and non-peptides. J. Contr. Rel. 41:1996;19-31.
4. Fawaz F., Bonini F., Guyot M., Bildet J., Maury M., Lagueny A.M. Bioavailability of norfloxacin from PEG 6000 solid dispersion and cyclodextrin inclusion complexes in rabbits. Int. J. Pharm. 132:1996;271-275.
5. Guyot M., Fawaz F., Bildet J., Bonini F., Lagueny A.M. Physicochemical characterization and dissolution of norfloxacin/cylodextrin inclusion compounds and PEG solid dispersions. Int. J. Pharm. 123:1995;53-63.
6. 2 EDTA and sodium glycholate on intestinal absorption of insulin. Biol. Pharm. Bull. 16:1993;68-72.
7. Myers C.M., Blumer J.L. High-performance liquid chromatography of ciprofloxacin and its metabolites in serum, urine and sputum. J. Chromatogr. 422:1987;153-164.
8. Quan Y.S., Hattori K., Lundborg E., Fujita T., Murakami M., Muranishi S., Yamamoto A. Effectiveness and toxicity screening of various absorption enhancers using caco-2 cells monolayers. Biol. Pharm. Bull. 21:1998;615-620.
9. Robinson, J.R., Yang, X., 1999. Absorption enhancers. Encyclopedia of Pharmaceutical Technology, vol. 18. Dekker, New York.
10. Tomita M., Hayashi M., Awazu S. Absorption-enhancing mechanism of EDTA, caprate, and decanoylcarnitine in caco-2 cells. J. Pharm. Sci. 85:1996;608-611.
11. Wallis S.C., Charles B.G., Gahan L.R., Filippich L.J., Bredhauer M.G., Duckworth P.A. Interaction of norfloxacin with divalent and trivalent pharmaceutical cations. In vitro complexation and in vivo pharmacokinetic studies in the dog. J. Pharm. Sci. 85:1996;803-809.