In vitro and in vivo evaluation of effects of sodium caprate on enteral peptide absorption and on mucosal morphology

International Journal of Pharmaceutics

Volumn 191, Issue 1, 1999, Pages 15-24

  Chao, Anthony C ^a,b   Nguyen, Joseph Vu ^a   Broughall, Mary ^a   Griffin, Angelica ^a   Fix, Joseph A ^a,c   Daddona, Peter E ^a  

^a ALZA CORPORATION   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Absorption enhancing agent; Caco 2; Intestinal transport; Model peptide; Mucosal morphology; Sodium caprate

Indexed keywords

BIOLOGICAL MARKER; DECANOIC ACID; DECANOIC ACID DERIVATIVE; PEPTIDE;

ANIMAL; ARTICLE; BIOAVAILABILITY; CELL STRAIN CACO 2; DRUG EFFECT; ELECTROPHYSIOLOGY; EPITHELIUM; HISTOLOGY; HUMAN; INTESTINE ABSORPTION; INTESTINE MUCOSA; MALE; PHYSIOLOGY; RAT; RECTUM; SPRAGUE DAWLEY RAT;

ANIMALS; BIOLOGICAL AVAILABILITY; BIOLOGICAL MARKERS; CACO-2 CELLS; DECANOIC ACIDS; ELECTROPHYSIOLOGY; EPITHELIUM; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MALE; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECTUM;

EID: 0033604485     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00213-6     Document Type: Article

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