Modification of epithelial tight junction integrity to enhance transmucosal absorption

Critical Reviews in Therapeutic Drug Carrier Systems

Volumn 22, Issue 4, 2005, Pages 331-418

  Mrsny, Randall J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Biopharmaceuticals; Drug delivery; Drug transport; Epithelial cell; Paracellular permeability; Tight junction

Indexed keywords

CELL ADHESION MOLECULE; CLAUDIN; CYTOSKELETON PROTEIN; MEMBRANE PROTEIN; OCCLUDIN; PROTEIN ZO1; PROTEIN ZO2; PROTEIN ZO3; SERINE; THREONINE; TYROSINE; UNCLASSIFIED DRUG;

CELL FUNCTION; CELL INTERACTION; CELL MEMBRANE; CELL MIGRATION; CELL TRANSPORT; DOWN REGULATION; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG UPTAKE; EPITHELIUM CELL; NONHUMAN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN TRANSPORT; REVIEW; TIGHT JUNCTION;

AMINO ACID SEQUENCE; ANIMALS; DRUG CARRIERS; EPITHELIUM; HUMANS; MOLECULAR SEQUENCE DATA; MUCOUS MEMBRANE; TIGHT JUNCTIONS;

EID: 27644461045     PISSN: 07434863     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevTherDrugCarrierSyst.v22.i4.10     Document Type: Review

References (422)

1. Farquhar MG, Palade GE.Junctional complexes in various epithelia. J Cell Biol 1963; 17:375-412.
2. Madara JL, Stafford J, Barenberg D, Carlson S. Functional coupling of tight junctions and micronlaments in T84 monolayers. Am J Physiol 1988; 254(3 Pt 1):G416-423.
3. Goodenough DA. Plugging the leaks. Proc Natl Acad Sci USA 1999; 96:319-321.
4. Tice LW, Carter RL, Cahill MC.Tracer and freeze fracture observations on developing tight junctions in fetal rat thyroid. Tissue Cell 1977; 9(3):395-417.
5. Kachar B, Reese TS. Evidence for the lipidic nature of tight junction strands. Nature 1982; 296(5856):464-466.
6. Pinto da Silva P, Kachar B. On tight-junction structure. Cell 1982; 28(3):441-450.
7. Huber D, Balda MS, Matter K. Occludin modulates transepithelial migration of neutrophils. J Biol Chem 2000; 275(8):5773-5778.
8. Claude P, Goodenough DA. Fracture faces of zonulae occludentes from "tight" and "leaky" epithelia. J Cell Biol 1973; 58(2):390-400.
9. Madara JL. Increases in guinea pig small intestinal transepithelial resistance induced by osmotic loads are accompanied by rapid alterations in absorptive-cell tight-junction structure. J Cell Biol 1983; 97(1):125-136.
10. Tang VW, Goodenough DA. Paracellular ion channel at the tight junction. Biophys J2003;84(3):1660-1673.
11. Meyer HW. [Current findings for the interpretation of "tight junctions" as lipid structures]. Acta Histochem Suppl 1984; 30:291-300.
12. Stevenson BR, Siliciano MS, Mooseker MS, Goodenough DA. Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol 1986; 103:755-766.
13. Balda MS, Matter K. Tight junctions. J Cell Sci 1998; 111(Pt 5):541-547.
14. Madara JL. Regulation of the movement of solutes across tight junctions. Annu Rev Physiol 1998; 60:143-159.
15. Stevenson BR, Keon BH. The tight junction: morphology to molecules. Annu Rev Cell Dev Biol 1998; 14:89-109.
16. Balda MS, Whitney JA, Flores C, Gonzalez S, Cereijido M, Matter K. Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J Cell Biol 1996; 134(4): 1031-1049.
17. Gerstein M, Lan N, Jansen R. Proteomics. Integrating interactomes. Science 2002; 295(5553):284-287.
18. Lencer WI, Cheung G, Strohmeier GR, Currie MG, Ouellette AJ, Selsted ME, et al. Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3. Proc Natl Acad Sci USA 1997; 94(16):8585-8589.
19. Zhou CX, Zhang YL, Xiao L, Zheng M, Leung KM, Chan MY, et al. An epididymis-specific beta-defensin is important for the initiation of sperm maturation. Nat CeU Biol 2004; 6(5) :458-464.
20. Dumas JJ, Kumar R, Seehra J, Somers WS, Mosyak L. Crystal structure of the GpI-balpha-thrombin complex essential for platelet aggregation. Science 2003; 301(5630): 222-226.
21. Kong M, Fox CJ, Mu J, Solt L, Xu A, Cinalli RM, et al. The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis. Science 2004; 306(5696):695-698.
22. Barbany M, Gutierrez-de-Teran H, Sanz F, Villa-Freixa J. Towards a MIP-based alignment and docking in computer-aided drug design. Proteins 2004; 56(3): 585-594.
23. Itoh M, Sasaki H, Furuse M, Ozaki H, Kita T,Tsukita S. Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions. J Cell Biol 2001; 154(3):491-497.
24. Balda MS, Matter K. Transmembrane proteins of tight junctions. Semin Cell Dev Biol 2000; 11(4):281-289.
25. D'Atri F, Citi S. Molecular complexity of vertebrate tight junctions (review). Mol Membr Biol 2002; 19(2):103-112.
26. Matter K, Balda MS. Functional analysis of tight junctions. Methods 2003; 30(3): 228-234.
27. Mitic LL, Van Itallie CM, Anderson JM. Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: lessons from mutant animals and proteins. Am J Physiol Gastrointest Liver Physiol 2000; 279(2):G250-254.
28. Zahraoui A, Louvard D, Galli T. Tight junction, a platform for trafficking and signaling protein complexes. J Cell Biol 2000; 151(5):F31-36.
29. Knust E, Bossinger O. Composition and formation of intercellular junctions in epithelial cells. Science 2002; 298(5600):1955-1959.
30. Kramer H. The ups and downs of life in an epithelium. J Cell Biol 2000; 151(4): F15-18.
31. Furuse M, Fujimoto K, Sato N, Hirase T, Tsukita S. Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures. J Cell Sci 1996; 109 (Pt 2):429-435.
32. Takakuwa R, Kokai Y, Kojima T, Akatsuka T, Tobioka H, Sawada N, et al. Uncoupling of gate and fence functions of MDCK cells by the actin-depolymerizing reagent mycalolide B. Exp Cell Res 2000; 257(2):238-244.
33. Van Itallie C, Rahner C, Anderson JM. Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J Clin Invest 2001; 107(10):1319-1327.
34. Madara JL. Tight junction dynamics: is paracellular transport regulated? Cell 1988; 53(4):497-498.
35. Nusrat A, Parkos CA, Verkade P, Foley CS, Liang TW, Innis-Whitehouse W, et al. Tight junctions are membrane microdomains. J Cell Sci 2000; 113(Pt 10):1771-1781.
36. Brown DA, London E. Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J Biol Chem 2000; 275(23):17221-17224.
37. Simons K, Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 2000; 1(1):31-39.
38. Blom N, Gammeltoft S, Brunak S. Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J Mol Biol 1999; 294(5):1351-1362.
39. Kreegipuu A, Blom N, Brunak S. PhosphoBase, a database of phosphorylation sites: release 2.0. Nucleic Acids Res 1999; 27(1):237-239.
40. Smith CM, Shindyalov IN, Veretnik S, Gribskov M, Taylor SS, L.F. TE, et al. The protein kinase resource. Trends Biol Sci 1997; 22(11):444-446.
41. Yaffe MB, Leparc GG, Lai J, Obata T, Volinia S, Cantley LC. A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat Biotechnol 2001; 19(4):348-353.
42. Yaffe MB, Rittinger K, Volinia S, Caron PR, Aitken A, Leffers H, et al. The structural basis for 14-3-3:phosphopeptide binding specificity. Cell 1997; 91(7): 961-971.
43. Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 1998; 141(7):1539-1550.
44. Furuse M, Sasaki H, Fujimoto K, Tsukita S. A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J Cell Biol 1998; 143(2):391-401.
45. Tsukita S, Furuse M, Itoh M. Multifunctional strands in tight junctions. Trends Cell Biol 1999; 9(7):268-273.
46. Tsukita S, Furuse M, Itoh M. Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol 2001; 2(4):285-293.
47. Morita K, Furuse M, Fujimoto K, Tsukita S. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci USA 1999; 96:511-516.
48. Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol 1999; 147(6):1351-1363.
49. Tsukita S, Furuse M. Overcoming barriers in the study of tight junction functions: from occludin to claudin. Genes Cells 1998; 3:569-573.
50. Ruffer C, Gerke V. The C-terminal cytoplasmic tail of claudins 1 and 5 but not its PDZ-binding motif is required for apical localization at epithelial and endothelial tight junctions. Eur J Cell Biol 2004; 83(4):135-144.
51. Ishizaki T, Chiba H, Kojima T, Fujibe M, Soma T, Miyajima H, et al. Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways. Exp Cell Res 2003; 290(2):275-288.
52. Fujibe M, Chiba H, Kojima T, Soma T, Wada T, Yamashita T, et al. Thr(203) of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions. Exp Cell Res 2004; 295(1):36-47.
53. Tsukita S, Furuse M, Itoh M. Molecular dissection of tight junctions. Cell Struct Funct 1996; 21:381-385.
54. Tamagawa H, Takahashi I, Furuse M, Yoshitake-Kitano Y, Tsukita S, Ito T, et al. Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: preferential localization of claudin-4 at the apex of the dome region. Lab Invest 2003; 83(7):1045-1053.
55. 2+ resorption. Science 1999; 285(5424):103-106.
56. Wilcox ER, Burton QL, Naz S, Riazuddin S, Smith TN, Ploplis B, et al. Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29. Cell 2001; 104(1):165-172.
57. Morita K, Sasaki H, Fujimoto K, Furuse M, Tsukita S. Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J Cell Biol 1999; 145(3): 579-588.
58. Clark MA, Hirst BH. Expression of junction-associated proteins differentiates mouse intestinal M cells from enterocytes. Histochem Cell Biol 2002; 118(2):137-147.
59. Rahner C, Mitic LL, Anderson JM. Heterogeneity in expression and subcellular localization of claudins 2,3,4, and 5 in the rat liver, pancreas, and gut. Gastroenterology 2001; 120(2):411-422.
60. Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, et al. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol 2002; 156(6):1099-1111.
61. Hadj-Rabia S, Baala L, Vabres P, Hamel-Teillac D, Jacquemin E, Fabre M, et al. Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease. Gastroenterology 2004; 127(5):1386-1390.
62. Tsukita S, Furuse M. Claudin-based barrier in simple and stratified cellular sheets. Curr Opin Cell Biol 2002; 14(5):531-536.
63. Amasheh S, Meiri N, Gitter AH, Schoneberg T, Mankertz J, Schulzke JD, et al. Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J Cell Sci 2002; 115(Pt 24):4969-4976.
64. Colegio OR, Van Itallie C, Rahner C, Anderson JM. Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. Am J Physiol Cell Physiol 2003; 284:C1346-1354.
65. Colegio OR, Van Itallie CM, McCrea HJ, Rahner C, Anderson JM. Claudins create charge-selective channels in the paracellular pathway between epithelial cells. Am J Physiol Cell Physiol 2002; 283(1):C142-147.
66. Tsukita S, Furuse M. Pores in the wall: claudins constitute tight junction strands containing aqueous pores. J Cell Biol 2000; 149(1):13-16.
67. Furuse M, Sasaki H, Tsukita S. Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol 1999; 147(4):891-903.
68. Madara JL, Dharmsathaphorn K. Occluding junction structure-function relationships in a cultured epithelial monolayer. J Cell Biol 1985; 101(6):2124-2133.
69. Nishiyama R, Sakaguchi T, Kinugasa T, Gu X, MacDermott RP, Podolsky DK, et al. Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions. J Biol Chem 2001; 276(38):35571-35580.
70. Kinugasa T, Sakaguchi T, Gu X, Reinecker HC. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 2000; 118(6):1001-1011.
71. Gregory M, Dufresne J, Hermo L, Cyr D. Claudin-1 is not restricted to tight junctions in the rat epididymis. Endocrinology 2001; 142(2):854-863.
72. Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S, et al. Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 1993; 123(6): 1777-1788.
73. Ando-Akatsuka Y, Saitou M, Hirase T, Kishi M, Sakakibara A, Itoh M, et al. Interspecies diversity of the occludin sequence: cDNA of human, mouse, dog, and rat-kangaroo homologues. J Cell Biol 1996; 133(1):43-47.
74. Sanchez-Pulido L, Martin-Belmonte F, Valencia A, Alonso MA. MARVEL: a conserved domain involved in membrane apposition events. Trends Biochem Sci 2002; 27(12):599-601.
75. Senes A, Ubarretxena-Belandia I, Engelman DM. The Calpha-H.O hydrogen bond: a determinant of stability and specificity in transmembrane helix interactions. Proc Natl Acad Sci USA 2001; 98(16):9056-9061.
76. Muller SL, Portwich M, Schmidt A, Utepbergenov DI, Huber O, Blasig IE, et al. The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1. J Biol Chem 2005; 280(5):3747-3756.
77. Schmidt A, Utepbergenov DI, Mueller SL, Beyermann M, Schneider-Mergener J, Krause G, et al. Occludin binds to the SH3-hinge-GuK unit of zonula occludens protein 1: potential mechanism of tight junction regulation. Cell Mol Life Sci 2004; 61(11):1354-1365.
78. Saitou M, Ando-Akatsuka Y, Itoh M, Furuse M, Inazawa J, Fujimoto K, et al. Mammalian occludin in epithelial cells: its expression and subcellular distribution. Eur J Cell Biol 1997; 73:222-231.
79. Moroi S, Saitou M, Fujimoto K, Sakakibara A, Furuse M, Yoshida O, et al. Occludin is concentrated at tight junctions of mouse/rat but not human/guinea pig Sertoli cells in testes. Am J Physiol 1998; 274(6 Pt 1):C1708-1717.
80. Saitou M, Fujimoto K, Doi Y, Fujimoto T, Furuse M, Takano H, et al. Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J Cell Biol 1998; 141(2):397-408.
81. Saitou M, Furuse M, Sasaki H, Schiulzake JD, Fromm M, Takano H, et al. Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell 2000; 11:4131-4142.
82. Muresan Z, Paul DL, Goodenough DA. Occludin 1B, a variant of the tight junction protein occludin. Mol Biol Cell 2000; 11(2):627-634.
83. Traweger A, Fang D, Liu YC, Stelzhammer W, Krizbai IA, Fresser F, et al. The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch. J Biol Chem 2002; 277(12):10201-10208.
84. Mitic LL, Anderson JM. Molecular architecture of tight junctions. Annu Rev Physiol 1998; 60:121-142.
85. Matter K, Balda MS. Signalling to and from tight junctions. Nat Rev Mol Cell Biol 2003; 4(3):225-236.
86. Sakakibara A, Furuse M, Saitou M, Ando-Akatsuka Y, Tsukita S. Possible involvement of phosphorylation of occludin in tight junction formation. J Cell Biol 1997; 137(6): 1393-1401.
87. Wong V. Phosphorylation of occludin correlates with occludin localization and function at the tight junction. Am J Physiol 1997; Cell Physiol 42:C1859-1867.
88. Antonetti DA, Barber AJ, Hollinger LA, Wolpert EB, Gardner TW. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J Biol Chem 1999; 274(33):23463-23467.
89. Hirase T, Kawashima S, Wong EY, Ueyama T, Rikitake Y, Tsukita S, et al. Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanisms. J Biol Chem 2001; 276(13):10423-10431.
90. Ohtake K, Maeno T, Ueda H, Ogihara M, Natsume H, Morimoto Y. Poly-L-arginine enhances paracellular permeability via serine/rhreonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium. Pharm Res 2003; 20(11):1838-1845.
91. Kale G, Naren AP, Sheth P, Rao RK. Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1, ZO-2, and ZO-3. Biochem Biophys Res Commun 2003; 302(2):324-329.
92. Lacaz-Vieira F, Jaeger MM. Protein kinase inhibitors and the dynamics of tight junction opening and closing in A6 cell monolayers. J Membr Biol 2001; 184(2):185-196.
93. Nusrat A, Chen JA, Foley CS, Liang TW, Tom J, Cromwell M, et al. The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction. J Biol Chem 2000; 275(38):29816-29822.
94. Durocher D, Henckel J, Fersht AR, Jackson SP. The FHA domain is a modular phosphopeptide recognition motif. Mol Cell 1999; 4(3):387-394.
95. Hofmann K, Bucher P. The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors. Trends Biochem Sci 1995; 20(9):347-349.
96. Shilatifard A, Lane WS, Jackson KW, Conaway RC, Conaway JW. An RNA polymerase II elongation factor encoded by the human ELL gene. Science 1996; 271(5257): 1873-1876.
97. Zambrano N, Buxbaum JD, Minopoli G, Fiore F, De Candia P, De Renzis S, et al. Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins. J Biol Chem 1997; 272(10):6399-6405.
98. Nagai M, Meerloo T, Takeda T, Farquhar MG. The adaptor protein ARH escorts megalin to and through endosomes. Mol Biol Cell 2003; 14(12):4984-4996.
99. Cordenonsi M, Mazzon E, De Rigo L, Baraldo S, Meggio F, Citi S. Occludin dephosphorylation in early development of Xenopus laevis. J Cell Sci 1997; 110(Pt 24): 3131-3139.
100. Cordenonsi M, Turco F, D'Atri F, Hammar E, Martinucci G, Meggio F, et al. Xenopus laevis occludin. Identification of in vitro phosphorylation sites by protein kinase CK2 and association with cingulin. Eur J Biochem 1999; 264(2):374-384.
101. Smales C, Ellis M, Baumber R, Hussain N, Desmond H, Staddon JM. Occludin phosphorylation: identification of an occludin kinase in brain and cell extracts as CK2. FEBS Lett 2003; 545(2-3):161-166.
102. Andreeva AY, Krause E, Muller EC, Blasig IE, Utepbergenov DI. Protein kinase C regulates the phosphorylation and cellular localization of occludin. J Biol Chem 2001; 276(42):38480-38486.
103. Ghassemifar MR, Sheth B, Papenbrock T, Leese HJ, Houghton FD, Fleming TP. Occludin TM4(-): an isoform of the tight junction protein present in primates lacking the fourth transmembrane domain. J Cell Sci 2002; 115(Pt 15): 3171-3180.
104. Ren R, Mayer BJ, Cicchetti P, Baltimore D. Identification of a ten-amino acid proline-rich SH3 binding site. Science 1993; 259(5098):1157-1161.
105. Aoki N, Ito K, Ito M. Isolation and characterization of mouse high-glycine/tyrosine proteins. J Biol Chem 1997; 272(48):30512-30518.
106. Mita K, Ichimura S, James TC. Highly repetitive structure and its organization of the silk fibroin gene. J Mol Evol 1994; 38(6):583-592.
107. Nusrat A, Brown GT, Tom J, Drake A, Bui TT, Quan C, et al. Multiple protein interactions involving proposed extracellular loop domains of the tight junction protein occludin. Mol Biol Cell 2005; 16(4):1725-1734.
108. Balda MS, Anderson JM, Matter K. The SH3 domain of the tight junction protein ZO-1 binds to a serine protein kinase that phosphorylates a region C-terminal to this domain. FEBS Lett 1996; 399(3):326-332.
109. McCarthy KM, Skare IB, Stankewich MC, Furuse M, Tsukita S, Rogers RA, et al. Occludin is a functional component of the tight junction. J Cell Sci 1996; 109(Pt 9): 2287-2298.
110. Van Itallie CM, Anderson JM. Occludin confers adhesiveness when expressed in fibroblasts. J Cell Sci 1997; 110:1113-1121.
111. Medina R, Rahner C, Mitic LL, Anderson JM, Van Itallie CM. Occludin localization at the tight junction requires the second extracellular loop. J Membr Biol 2000; 178: 235-247.
112. Wong V, Gumbiner BM. A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier. J Cell Biol 1997; 136(2): 339-409.
113. Victor I, Bader T, Paiha K, Huber LA. Perturbation of the tight junction permeability barrier by occludin loop peptides activates beta-catenin/TCF/LEF- mediated transcription. EMBO Rep 2001; 2(4):306-312.
114. Tavelin S, Hashimoto K, Malkinson J, Lazorova L, Toth I, Artursson P. A new principle for tight junction modulation based on occludin peptides. Mol Pharmacol 2003; 64(6):1530-1540.
115. Lacaz-Vieira F, Jaeger MM, Farshori P, Kachar B. Small synthetic peptides homologous to segments of the first external loop of occludin impair tight junction resealing. J Membr Biol 1999; 168(3):289-297.
116. Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, et al. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell 1998; 93(5):863-873.
117. Jeansonne B, Lu Q, Goodenough DA, Chen YH. Claudin-8 interacts with multi-PDZ domain protein 1 (MUPP1) and reduces paracellular conductance in epithelial cells. Cell Mol Biol (Noisy-le-grand) 2003; 49(1):13-21.
118. Bazzoni G, Martinez-Estrada OM, Orsenigo F, Cordenonsi M, Citi S, Dejana E. Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin. J Biol Chem 2000; 275(27):20520-20526.
119. Raschperger E, Engstrom U, Pettersson RF, Fuxe J. CLMP, a novel member of the CTX family and a new component of epithelial tight junctions. J Biol Chem 2004; 279(1):796-804.
120. Nishimura M, Kakizaki M, Ono Y, Morimoto K, Takeuchi M, Inoue Y, et al. JEAP, a novel component of tight junctions in exocrine cells. J Biol Chem 2002; 277(7): 5583-5587.
121. Fanning AS, Jameson BJ, Jesaitis LA, Anderson JM. The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J Biol Chem 1998; 273(45):29745-29753.
122. Lapierre LA, Tuma PL, Navarre J, Goldenring JR, Anderson JM. VAP-33 localizes to both an intracellular vesicle population and with occludin at the tight junction. J Cell Sci 1999; 112(Pt 21):3723-3732.
123. Bazzoni G. The JAM family of junctional adhesion molecules. Curr Opin Cell Biol 2003; 15(5):525-530.
124. Ebnet K, Suzuki A, Ohno S, Vestweber D. Junctional adhesion molecules (JAMs): more molecules with dual functions? J Cell Sci 2004; 117(Pt 1):19-29.
125. Kostrewa D, Brockhaus M, D'Arcy A, Dale GE, Nelboeck P, Schmid G, et al. X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motif. Embo J 2001; 20(16):4391-4398.
126. Prota AE, Campbell JA, Schelling P, Forrest JC, Watson MJ, Peters TR, et al. Crystal structure of human junctional adhesion molecule 1: implications for reovirus binding. Proc Natl Acad Sci USA 2003; 100(9):5366-5371.
127. Liang TW, DeMarco RA, Mrsny RJ, Gurney A, Gray A, Hooley J, et al. Characterization of huJAM: evidence for involvement in cell-cell contact and tight junction regulation. Am J Physiol Cell Physiol 2000; 279(6):C1733-1743.
128. Liu Y, Nusrat A, Schnell FJ, Reaves TA, Walsh S, Pochet M, et al. Human junction adhesion molecule regulates tight junction resealing in epithelia. J Cell Sci 2000; 113 (Pt 13):2363-2374.
129. Zen K, Babbin BA, Liu Y, Whelan JB, Nusrat A, Parkos CA. JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration. Mol Biol Cell 2004; 15(8):3926-3937.
130. Martìn-Padura I, Lostaglio S, Schneemannn M, Williams L, Romano M, Fruscella P, et al. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol 1998; 142(1):117-127.
131. Mandell KJ, Babbin BA, Nusrat A, Parkos CA. Junctional adhesion molecule-1 (JAM1) regulates epithelial cell morphology through effects on beta 1 integrins and Rap1 activity. J Biol Chem 2005; 280(12):11665-11674.
132. Ostermann G, Weber KS, Zernecke A, Schroder A, Weber C. JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes. Nat Immunol 2002; 3(2):151-158.
133. Cunningham SA, Rodriguez JM, Arrate MP, Tran TM, Brock TA. JAM2 interacts with alpha4beta1. Facilitation by JAM3. J Biol Chem 2002; 277(31):27589-27592.
134. Santoso S, Sachs UJ, Kroll H, Linder M, Ruf A, Preissner KT, et al. The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1. J Exp Med 2002; 196(5):679-691.
135. Gliki G, Ebnet K, Aurrand-Lions M, Imhof BA, Adams RH. Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C. Nature 2004; 431(7006):320-324.
136. Hirabayashi S, Tajima M, Yao I, Nishimura W, Mori H, Hata Y. JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1. Mol Cell Biol 2003; 23(12):4267-4282.
137. Mori H, Hirabayashi S, Shirasawa M, Sugimura H, Hata Y. JAM4 enhances hepatocyte growth factor-mediated branching and scattering of Madin-Darby canine kidney cells. Genes Cells 2004; 9(9):811-819.
138. Nasdala I, Wolburg-Buchholz K, Wolburg H, Kuhn A, Ebnet K, Brachtendorf G, et al. A transmembrane tight junction protein selectively expressed on endothelial cells and platelets. J Biol Chem 2002; 277(18):16294-16303.
139. Tajima M, Hirabayashi S, Yao I, Shirasawa M, Osuga J, Ishibashi S, et al. Roles of immunoglobulin-like loops of junctional cell adhesion molecule 4; involvement in the subcellular localization and the cell adhesion. Genes Cells 2003; 8(9):759-768.
140. Kawabe H, Nakanishi H, Asada M, Fukuhara A, Morimoto K, Takeuchi M, et al. Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells. J Biol Chem 2001; 276(51):48350-48355.
141. Honda T, Shimizu K, Fukuhara A, Irie K, Takai Y. Regulation by nectin of the velocity of the formation of adherens junctions and tight junctions. Biochem Biophys Res Commun 2003; 306(1):104-109.
142. Yamada A, Irie K, Fukuhara A, Ooshio T, Takai Y. Requirement of the actin cytoskeleton for the association of nectins with other cell adhesion molecules at adherens and tight junctions in MDCK cells. Genes Cells 2004; 9(9):843-855.
143. Yamada A, Irie K, Deguchi-Tawarada M, Ohtsuka T, Takai Y. Nectin-dependent localization of synaptic scaffolding molecule (S-SCAM) at the puncta adherentia junctions formed between the mossy fibre terminals and the dendrites of pyramidal cells in the CA3 area of the mouse hippocampus. Genes Cells 2003; 8(12):985-994.
144. Dueber JE, Yeh BJ, Chak K, Lim WA. Reprogramming control of an allosteric signaling switch through modular recombination. Science 2003; 301(5641):1904-1908.
145. Gonzalez-Mariscal L, Betanzos A, Avila-Flores A. MAGUK proteins: structure and role in the tight junction. Semin Cell Dev Biol 2000; 11(4):315-324.
146. Willott E, Balda MS, Heintzelman M, Jameson B, Anderson JM. Localization and differential expression of two isoforms of the tight junction protein ZO-1. Am J Physiol 1992; 262(5 Pt 1):C1119-1124.
147. Tsukomoto T, Nigam SK. Tight junction proteins form large complexes and associate with the cytoskeleton in an ATP depletion model for reversible junction assembly. J Biol Chem 1997; 272:16133-16139.
148. Beatch M, Jesaitis LA, Gallin WJ, Goodenough DA, Stevenson BR. The tight junction protein ZO-2 contains three PDZ (PSD-95/Discs-Large/ZO-1) domains and an alternatively spliced region. J Biol Chem 1996; 271(42):25723-25726.
149. Gumbiner B, Lowenkopf T, Apatira D. Identification of 160-kDa polypeptide that binds to the tight junction protein ZO-1. Proc Natl Acad Sci USA 1991; 88:3460-3464.
150. Jesaitis LA, Goodenough DA. Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the drosophila discs-large tumor suppressor protein. J Cell Biol 1994; 124:949-961.
151. Haskins J, Gu L, Wittchen ES, Hibbard J, Stevenson BR. ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin. J Cell Biol 1998; 141(1):199-208.
152. Furuse M, Itoh M, Hirase T, Nagafuchi A, Yonemura S, Tsukita S, et al. Direct association of occludin with ZO-1 and its possible involvement in the localization at tight junctions. J Cell Biol 1994; 127(6):1617-1626.
153. Wittchen ES, Haskins J, Stevenson BR. Protein interactions at the tight junction. J Biol Chem 1999; 274(49):35179-35185.
154. Cordenonsi M, D'Atri F, Hammar E, Parry DA, Kendrick-Jones J, Shore D, et al. Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin. J Cell Biol 1999; 147(7):1569-1582.
155. Yamamoto T, Harada N, Kano K, Taya S, Canaani E, Matsuura Y, et al. The ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells. J Cell Biol 1997; 139(3):785-795.
156. Comerford KM, Lawrence DW, Synnestvedt K, Levi BP, Colgan SP. Role of vasodilator-stimulated phosphoprotein in PKA-induced changes in endothelial junctional permeability. FASEB J 2002; 16(6):583-585.
157. Umeda K, Matsui T, Nakayama M, Furuse K, Sasaki H, Furuse M, et al. Establishment and characterization of cultured epithelial cells lacking expression of ZO-1. J Biol Chem 2004; 274(43):44785-44794.
158. Itoh M, Morita K, Tsukita S. Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin. J Biol Chem 1999; 274(9):5981-5986.
159. Wittchen ES, Haskins J, Stevenson BR. Exogenous expression of the amino-terminal half of the tight junction protein ZO-3 perturbs junctional complex assembly. J Cell Biol 2000; 151(4):825-836.
160. Balda MS, Matter K. The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression. EMBO J 2000; 19(9):2024-2033.
161. Balda MS, Garrett MD, Matter K. The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density. J Cell Biol 2003; 160(3): 423-432.
162. Ryeom SW, Paul D, Goodenough DA. Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology. Mol Biol Cell 2000; 11(5): 1687-1696.
163. Citi S, Sabanay H, Jakes R, Geiger B, Kendrick-Jones J. Cingulin, a new peripheral component of tight junctions. Nature 1988; 333:272-276.
164. Keon BH, Schafer S, Kuhn C, Grund C, Franke WW. Symplekin, a novel type of tight junction plaque protein. J Cell Biol 1996; 134(4):1003-1018.
165. Zhong Y, Saitoh T, Minase T, Sawada N, Enomoto Y, Mori M. Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin, and ZO-2. J Cell Biol 1993; 120:477-483.
166. Stuart RO, Nigam SM. Regulated assembly of tight junctions by protein kinase C. Proc Natl Acad Sci USA 1995; 92(13):6072-6076.
167. Fleming TP, Hay M, Javed Q, Citi S. Localisation of tight junction protein cingulin is temporally and spatially regulated during early mouse development. Development 1993; 117(3):1135-1144.
168. Guillemot L, Hammar E, Kaister C, Ritz J, Caille D, Jond L, et al. Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression. J Cell Sci 2004; 117(Pt 22):5245-5256.
169. D'Atri F, Nadalutti F, Citi S. Evidence for a functional interaction between cingulin and ZO-1 in cultured cells. J Biol Chem 2002; 277(31):27757-27764.
170. D'Atri F, Citi S. Cingulin interacts with F-actin in vitro. FEBS Lett 2001; 507(1): 21-24.
171. Ohnishi H, Nakahara T, Furuse K, Sasaki H, Tsukita S, Furuse M. JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin. J Biol Chem 2004; 279(44):46014-46022.
172. Skehel PA, Martin KC, Kandel ER, Bartsch D. A VAMP-binding protein from Aplysia required for neurotransmitter release. Science 1995; 269(5230):1580-1583.
173. Macara IG. Par proteins: partners in polarization. Curr Biol 2004; 14(4):R160-162.
174. Zhong Y, Enomoto K, Tobioka H, Konishi Y, Satoh M, Mori M. Sequential decrease in tight junctions as revealed by 7H6 tight junction-associated protein during rat hepatocarcinogenesis. Jpn J Cancer Res 1994; 85(4):351-356.
175. Lupas A. Coiled coils: new structures and new functions. Trends Biochem Sci 1996; 21:375-382.
176. Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S. Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. J Biol Chem 2002; 277(1):455-461.
177. Madara JL. Intestinal absorptive cell tight junctions are linked to cytoskeleton. Am J Physiol 1987; 253:C171-175.
178. Siccardi D, Turner JR, Mrsny RJ. Regulation of intestinal epithelial function: a link between opportunities for macromolecular drug delivery and inflammatory bowel disease. Adv Drug Deliv Rev 2005; 57(2):219-235.
179. Clayburgh DR, Rosen S, Witkowski ED, Wang F, Blair S, Dudek S, et al. A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. J Biol Chem 2004; 279(53): 55506-55513.
180. Itoh M, Nagafuchi A, Moroi S, Tsukita S. Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to a catenin and actin filaments. J Cell Biol 1997; 138(1):181-192.
181. Turner JR, Angle JM, Black ED, Joyal JL, Sacks DB, Madara JL. PKC-dependent regulation of transepithelial resistance: roles of MLC and MLC kinase. Am J Physiol 1999; 277(3 Pt 1):C554-562.
182. Nusrat A, Turner JR, Parkos CA, von Eichel-Streiber C, Anderson JM, Carnes DK, et al. Rho uncoupling by Clostridium difficile toxins A and B displaces tight junction associated proteins from the membrane of polarized epithelial cells. Mol Biol Cell 1996; 7(Suppl.):607a.
183. Atisook K, Carlson S, Madara JL. Effects of phlorizin and sodium on glucose-elicited alterations of cell junctions in intestinal epithelia. Am J Physiol 1990; 258(1 Pt 1): C77-85.
184. Turner JR. Show me the pathway! Regulation of paracellular permeability by Na(+)-glucose cotransport. Adv Drug Deliv Rev 2000; 41(3):265-281.
185. Turner JR. "Putting the squeeze" on the tight junction: understanding cytoskeletal regulation. Semin Cell Dev Biol 2000; 11(4):301-308.
186. Nusrat A, Parkos CA, Bacarra AE, Godowski PJ, Delp-Ancher C, Rosen EM, et al. Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium. J Clin Invest 1994; 93(5):2056-2065.
187. Caccamo AE, Scaltriti M, Caporali A, D'Arca D, Scorcioni F, Astancolle S, et al. Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin. Biochem J 2004; 382(Pt 1):157-168.
188. Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994; 124(4):619-626.
189. McFall A, Ulku A, Lambert QJ, Kusa A, Rogers-Graham K, Der CJ. Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol Cell Biol 2001; 21(16):5488-5499.
190. Huber D, Balda MS, Matter K. Transepithelial migration of neutrophils. Invasion Metastasis 1998; 18(2):70-80.
191. Pfeffer S, Aivazian D. Targeting Rab GTPases to distinct membrane compartments. Nat Rev Mol Cell Biol 2004; 5(11):886-896.
192. Weber E, Berta G, Tousson A, St John P, Green MW, Gopalokrishnan U, et al. Expression and polarized targeting of a rab3 isoform in epithelial cells. J Cell Biol 1994; 125(3):583-594.
193. Zahraoui A, Joberty G, Arpin M, Fontaine JJ, Hellio R, Tavitian A, et al. A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells. J Cell Biol 1994; 124(1-2):101-115.
194. van der Wouden JM, Maier O, van ISC, Hoekstra D. Membrane dynamics and the regulation of epithelial cell polarity. Int Rev Cytol 2003; 226:127-164.
195. Yamamoto Y, Nishimura N, Morimoto S, Kitamura H, Manabe S, Kanayama HO, et al. Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane. Biochem Biophys Res Commun 2003; 308(2):270-275.
196. Marzesco AM, Dunia I, Pandjaitan R, Recouvreur M, Dauzonne D, Benedetti EL, et al. The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells. Mol Biol Cell 2002; 13(6):1819-1831.
197. Kohler K, Louvard D, Zahraoui A. Rab13 regulates PKA signaling during tight junction assembly. J Cell Biol 2004; 165(2):175-180.
198. 1) tight junction permeability and cell division. Exp Cell Res 1993; 207:398-406.
199. Van Itallie CM, Balda MS, Anderson JM. Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells. J Cell Sci 1995; 108(Pt 4):1735-1742.
200. Nusrat A, Parkos CA, Bacarra AE, Godowski PJ, Delp-Archer C, Rosen EM, et al. Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium. J Clin Invest 1994; 93(5):2056-2065.
201. Harhaj NS, Barber AJ, Antonetti DA. Platelet-derived growth factor mediates tight junction redistribution and increases permeability in MDCK cells. J Cell Physiol 2002; 193(3):349-364.
202. Grande M, Franzen A, Karlsson JO, Ericson LE, Heldin NE, Nilsson M. Transforming growth factor-beta and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytes. J Cell Sci 2002; 115(Pt 22):4227-4236.
203. Massague J. G1 cell-cycle control and cancer. Nature 2004; 432(7015):298-306.
204. Li D, Mrsny RJ. Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin. J Cell Biol 2000; 148(4):791-800.
205. Schlessinger J. Common and distinct elements in cellular signaling via EGF and FGF receptors. Science 2004; 306(5701):1506-1507.
206. Downward J. PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 2004; 15(2):177-182.
207. Keely PJ, Westwick JK, Whitehead IP, Der CJ, Parise LV. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 1997; 390(6660):632-636.
208. Sheth P, Basuroy S, Li C, Naren AP, Rao RK. Role of phosphatidylinositol 3-kinase in oxidative stress-induced disruption of tight junctions. J Biol Chem 2003; 278(49):49239-49245.
209. Okkenhaug K, Vanhaesebroeck B. New responsibilities for the PI3K regulatory subunit p85 alpha. Sci STKE 2001; 2001(65):PE1.
210. Deane JA, Trifilo MJ, Yballe CM, Choi S, Lane TE, Fruman DA. Enhanced T cell proliferation in mice lacking the p85beta subunit of phosphoinositide 3-kinase. J Immunol 2004; 172(11):6615-6625.
211. Duronio V, Scheid MP, Ettinger S. Downstream signalling events regulated by phosphatidylinositol 3-kinase activity. Cell Signal 1998; 10(4):233-239.
212. Parker PJ, Murray-Rust J. PKC at a glance. J Cell Sci 2004; 117(Pt 2):131-132.
213. Clarke H, Soler AP, Mullin JM. Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets. J Cell Sci 2000; 113(Pt 18):3187-3196.
214. Mullin JM. Epithelial barriers, compartmentation, and cancer. Sci STKE 2004; 2004(216):pe2.
215. Marano CW, Garulacan LA, Ginanni N, Mullin JM. Phorbol ester treatment increases paracellular permeability across IEC-18 gastrointestinal epithelium in vitro. Dig Dis Sci 2001; 46(7):1490-1499.
216. Lahn M, Paterson BM, Sundell K, Ma D. The role of protein kinase C-alpha (PKC-alpha) in malignancies of the gastrointestinal tract. Eur J Cancer 2004; 40(1):10-20.
217. Pula G, Crosby D, Baker J, Poole AW. Functional interaction of PKCalpha with the tyrosine kinases Syk and Src in human platelets. J Biol Chem 2005; 280(8):7194-7205.
218. Takeda H, Tsukita S. Effects of tyrosine phosphorylation on tight junctions in temperature-sensitive v-src-transfected MDCK cells. Cell Struct Funct 1995; 20:387-393.
219. Basuroy S, Sheth P, Kuppuswamy D, Balasubramanian S, Ray RM, Rao RK. Expression of kinase-inactive c-Src delays oxidative stress-induced disassembly and accelerates calcium-mediated reassembly of tight junctions in the Caco-2 cell monolayer. J Biol Chem 2003; 278(14):11916-11924.
220. Kortmansky J, Schwartz GK. Bryostatin-1: a novel PKC inhibitor in clinical development. Cancer Invest 2003; 21(6):924-936.
221. Yoo J, Nichols A, Mammen J, Calvo I, Song JC, Worrell RT, et al. Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins. Am J Physiol Cell Physiol 2003; 285(2):C300-309.
222. Cario E, Gerken G, Podolsky DK. Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology 2004; 127(1):224-238.
223. Suzuki A, Yamanaka T, Hirose T, Manabe N, Mizuno K, Shimizu M, et al. Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J Cell Biol 2001; 152(6):1183-1196.
224. Suzuki A, Ishiyama C, Hashiba K, Shimizu M, Ebnet K, Ohno S. aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization. J Cell Sci 2002; 115(Pt 18):3565-3573.
225. Suzuki A, Hirata M, Kamimura K, Maniwa R, Yamanaka T, Mizuno K, et al. aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. Curr Biol 2004; 14(16):1425-1435.
226. Toker A, Newton AC. Cellular signaling: pivoting around PDK-1. Cell 2000; 103(2):185-188.
227. Ebnet K, Suzuki A, Horikoshi Y, Hirose T, Meyer Zu Brickwedde MK, Ohno S, et al. The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM). EMBO J 2001; 20(14):3738-3748.
228. Chen ML, Pothoulakis C, LaMont JT. Protein kinase C signaling regulates ZO-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin A. J Biol Chem 2002; 277(6):4247-4254.
229. Nunbhakdi-Craig V, Machleidt T, Ogris E, Bellotto D, White CL, 3rd, Sontag E. Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex. J Cell Biol 2002; 158(5):967-978.
230. Heriche JK, Lebrin F, Rabilloud T, Leroy D, Chambaz EM, Goldberg Y. Regulation of protein phosphatase 2A by direct interaction with casein kinase 2alpha. Science 1997; 276(5314):952-925.
231. Perrella FW, Chen SF, Behrens DL, Kaltenbach RF 3rd, Seitz SP. Phospholipase C inhibitors: a new class of cytotoxic agents. J Med Chem 1994; 37(14):2232-2237.
232. Ward PD, Klein RR, Troutman MD, Desai S, Thakker DR. Phospholipase C-gamma modulates epithelial tight junction permeability through hyperphosphorylation of tight junction proteins. J Biol Chem 2002; 277(38):35760-35765.
233. Staddon JM, Herrenknecht K, Smales C, Rubin LL. Evidence that tyrosine phosphorylation may increase tight junctional permeability. J Cell Sci 1995; 108:609-619.
234. Meyer TN, Schwesinger C, Ye J, Denker BM, Nigam SK. Reassembly of the tight junction after oxidative stress depends on tyrosine kinase activity. J Biol Chem 2001; 276(25):22048-22055.
235. Tsukamoto T, Nigam SK. Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins. Am J Physiol 1999; 276(5 Pt 2):F737-750.
236. Chen YH, Lu Q, Goodenough DA, Jeansonne B. Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells. Mol Biol Cell 2002; 13(4):1227-1237.
237. Chen Y, Lu Q, Schneeberger EE, Goodenough DA. Restoration of tight junction structure and barrier function by downregulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells. Mol Biol Cell 2000; 11(3):849-862.
238. White MF, Shoelson SE, Keutmann H, Kahn CR. A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. J Biol Chem 1988; 263(6):2969-2980.
239. Adamsky K, Schilling J, Garwood J, Faissner A, Peles E. Glial tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to tenascin C. Oncogene 2001; 20(5):609-618.
240. Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q, et al. Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. J Biol Chem 2000; 275(28):21477-21485.
241. Adamsky K, Arnold K, Sabanay H, Peles E. Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins. J Cell Sci 2003; 116(Pt 7):1279-1289.
242. Wachtel M, Frei K, Ehler E, Fontana A, Winterhalter K, Gloor SM. Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibition. J Cell Sci 1999; 112(Pt 23):4347-4356.
243. Ye J, Tsukamoto T, Sun A, Nigam SK. A role for intracellular calcium in tight junction reassembly after ATP depletion-repletion. Am J Physiol 1999; 277(4 Pt 2):F524-532.
244. Denker BM, Saha C, Khawaja S, Nigam SK. Involvement of a heterotrimeric G protein alpha subunit in tight junction biogenesis. J Biol Chem 1996; 271(42):25750-25753.
245. Luton F, Klein S, Chauvin JP, Le Bivic A, Bourgoin S, Franco M, et al. EFA6, exchange factor for ARF6, regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement. Mol Biol Cell 2004; 15(3):1134-1145.
246. Nusrat A, Giry M, Turner JR, Colgan SP, Parkos CA, Carnes D, et al. Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia. Proc Natl Acad Sci USA 1995; 92(23):10629-10633.
247. Takaishi K, Sasaki T, Kotani H, Nishioka H, Takai Y. Regulation of cell-cell adhesion by Rac and Rho small G proteins in MDCK cells. J Cell Biol 1997; 139(4):1047-1059.
248. Jou T-S, Nelson WJ. Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. J Cell Biol 1998; 142(1):85-100.
249. Jou T-S, Schneeberger EE, Nelson WJ. Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases. J Cell Biol 1998; 142(1):101-115.
250. Gao L, Joberty G, Macara IG. Assembly of epithelial tight junctions is negatively regulated by Par6. Curr Biol 2002; 12(3):221-225.
251. Hopkins AM, Walsh SV, Verkade P, Boquet P, Nusrat A. Constitutive activation of Rho proteins by CNF-1 influences tight junction structure and epithelial barrier function. J Cell Sci 2003; 116(Pt 4):725-742.
252. Scudamore CL, Jepson MA, Hirst BH, Miller HR. The rat mucosal mast cell chymase, RMCP-II, alters epithelial cell monolayer permeability in association with altered distribution of the tight junction proteins ZO-1 and occludin. Eur J Cell Biol 1998; 75(4):321-330.
253. Moolenaar WH. Lysophosphatidic acid, a multifunctional phospholipid messenger. J Biol Chem 1995; 270(22):12949-12952.
254. Sahai E, Ishizaki T, Narumiya S, Treisman R. Transformation mediated by RhoA requires activity of ROCK kinases. Curr Biol 1999; 9(3):136-145.
255. Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH. Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology. J Cell Biol 1997; 137(7):1603-1613.
256. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 1997; 389(6654):990-994.
257. Schoenwaelder SM, Burridge K. Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho. A novel role for the calpain inhibitor calpeptin in the inhibition of protein-tyrosine phosphatases. J Biol Chem 1999; 274(20):14359-14367.
258. Gopalakrishnan S, Hallett MA, Atkinson SJ, Marrs JA. Differential regulation of junctional complex assembly in renal epithelial cell lines. Am J Physiol Cell Physiol 2003; 285(1):C102-111.
259. Bruewer M, Hopkins AM, Hobert ME, Nusrat A, Madara JL. RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin. Am J Physiol Cell Physiol 2004; 287(2):C327-335.
260. Gopalakrishnan S, Raman N, Atkinson SJ, Marrs JA. Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion. Am J Physiol 1998; 275(3 Pt 1):C798-809.
261. Hopkins AM, Li D, Mrsny RJ, Walsh SV, Nusrat A. Modulation of tight junction function by G protein-coupled events. Adv Drug Deliv Rev 2000; 41(3):329-340.
262. Benais-Pont G, Punn A, Flores-Maldonado C, Eckert J, Raposo G, Fleming TP, et al. Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability. J Cell Biol 2003; 160(5):729-740.
263. Wang Q, Wang X, Hernandez A, Kim S, Evers BM. Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation. Gastroenterology 2001; 120(6):1381-1392.
264. Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, et al. Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. Biochem J 2002; 361(Pt 3):525-536.
265. DiNitto JP, Cronin TC, Lambright DG. Membrane recognition and targeting by lipid-binding domains. Sci STKE 2003; 2003(213):re16.
266. Misra S, Hurley JH. Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p. Cell 1999; 97(5):657-666.
267. Piper RC, Cooper AA, Yang H, Stevens TH. VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae. J Cell Biol 1995; 131(3):603-617.
268. Nalefski EA, Sultzman LA, Martin DM, Kriz RW, Towler PS, Knopf JL, et al. Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain. J Biol Chem 1994; 269(27):18239-18249.
269. Gibbons DL, Vaney MC, Roussel A, Vigouroux A, Reilly B, Lepault J, et al. Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus. Nature 2004; 427(6972):320-325.
270. Blaschuck OW, Oshima T, Gour BJ, Symonds JM, Park JH, Kevil CG, et al. Identification of an occludin cell adhesion recognition sequence. Inflammation 2002; 26(4):193-198.
271. Ivanov AI, Nusrat A, Parkos CA. Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment. Mol Biol Cell 2004; 15(1):176-188.
272. Ivanov AI, McCall IC, Parkos CA, Nusrat A. Role for actin filament turnover and a myosin II motor in cytoskeleton-driven disassembly of the epithelial apical junctional complex. Mol Biol Cell 2004; 15(6):2639-2651.
273. Matsuda M, Kubo A, Furuse M, Tsukita S. A peculiar internalization of claudins, tight junction-specific adhesion molecules, during the intercellular movement of epithelial cells. J Cell Sci 2004; 117(Pt 7):1247-1257.
274. Jordan K, Chodock R, Hand AR, Laird DW. The origin of annular junctions: a mechanism of gap junction internalization. J Cell Sci 2001; 114(Pt 4):763-773.
275. Farshori P, Kachar B. Redistribution and phosphorylation of occludin during opening and resealing of tight junctions in cultured epithelial cells. J Membr Biol 1999; 170(2):147-156.
276. Balda MS, Gonzalez-Mariscal L, Matter K, Cereijido M, Anderson JM. Assembly of the tight junction: the role of diacylglycerol. J Cell Biol 1993; 123(2):293-302.
277. Tomson FL, Koutsouris A, Viswanathan VK, Turner JR, Savkovic SD, Hecht G. Differing roles of protein kinase C-zeta in disruption of tight junction barrier by enteropathogenic and enterohemorrhagic Escherichia coli. Gastroenterology 2004; 127(3):859-869.
278. Madara JL, Pappenheimer JR. Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J Membr Biol 1987; 100(2):149-164.
279. Pappenheimer JR. Physiological regulation of transepithelial impedance in the intestinal mucosa of rats and hamsters. J Membr Biol 1987; 100(2):137-148.
280. Pappenheimer JR, Reiss KZ. Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat. J Membr Biol 1987; 100(2):123-136.
281. Clayburgh DR, Shen L, Turner JR. A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest 2004; 84(3):282-291.
282. Nusrat A, Turner JR, Madara JL. Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am J Physiol Gastrointest Liver Physiol 2000; 279(5):G851-857.
283. Pappenheimer JR. Role of pre-epithelial "unstirred" layers in absorption of nutrients from the human jejunum. J Membr Biol 2001; 179(3):185-204.
284. Alexander JS, Elrod JW, Park JH. Roles of leukocyte and immune cell junctional proteins. Microcirculation 2001; 8(3):169-179.
285. Rescigno M, Rotta G, Valzasina B, Ricciardi-Castagnoli P. Dendritic cells shuttle microbes across gut epithelial monolayers. Immunobiology 2001; 204(5):572-581.
286. Mrsny RJ, Gewirtz AT, Siccardi D, Savidge T, Hurley BP, Madara JL, et al. Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proc Natl Acad Sci USA 2004; 101(19):7421-7426.
287. Nusrat A, Parkos CA, Liang TW, Carnes DK, Madara JL. Neutrophil migration across model intestinal epithelia: monolayer disruption and subsequent events in epithelial repair. Gastroenterology 1997; 113(5):1489-1500.
288. Parkos CA, Colgan SP, Delp C, Arnaout MA, Madara JL. Neutrophil migration across a cultured epithelial monolayer elicits a biphasic resistance response representing sequential effects on transcellular and paracellular pathways. J Cell Biol 1992; 117(4):757-764.
289. Rescigno M, Urbano M, Valzasina B, Francolini M, Rotta G, Bonasio R, et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2001; 2(4):361-367.
290. Lechner J, Krall M, Netzer A, Radmayr C, Ryan MP, Pfaller W. Effects of interferon alpha-2b on barrier function and junctional complexes of renal proximal tubular LLC-PK1 cells. Kidney Int 1999; 55(6):2178-2191.
291. Zolotarevsky Y, Hecht G, Koutsouris A, Gonzalez DE, Quan C, Tom J, et al. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 2002; 123(1):163-172.
292. Mankertz J, Tavalali S, Schmitz H, Mankertz A, Riecken EO, Fromm M, et al. Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma. J Cell Sci 2000; 113(Pt 11):2085-2090.
293. Sanders SE, Madara JL, McGuirk DK, German DS, Colgan SP. Assessment of inflammatory events in epithelial permeability: a rapid screening method using fluorescein dextrans. Epithelial Cell Biol 1995; 4(1):25-34.
294. Tedelind S, Ericson LE, Karlsson JO, Nilsson M. Interferon-gamma downregulates claudin-1 and impairs the epithelial barrier function in primary cultured human thyrocytes. Eur J Endocrinol 2003; 149(3):215-221.
295. Walsh SV, Hopkins AM, Nusrat A. Modulation of tight junction structure and function by cytokines. Adv Drug Deliv Rev 2000; 41(3):303-313.
296. Peralta Soler A, Mullin JM, Knudsen KA, Marano CW. Tissue remodeling during tumor necrosis factor-induced apoptosis in LLC-PK1 renal epithelial cells. Am J Physiol 1996; 270(5 Pt 2):F869-879.
297. Poritz LS, Garver KI, Tilberg AF, Koltun WA. Tumor necrosis factor alpha disrupts tight junction assembly. J Surg Res 2004; 116(1):14-18.
298. Papini E, Satin B, Norais N, de Bernard M, Telford JL, Rappuoli R, et al. Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin. J Clin Invest 1998; 102(4):813-820.
299. Okada T, Narai A, Matsunaga S, Fusetani N, Shimizu M. Assessment of the marine toxins by monitoring the integrity of human intestinal Caco-2 cell monolayers. Toxicol In Vitro 2000; 14(3):219-226.
300. Tripuraneni J, Koutsouris A, Pestic L, De Lanerolle P, Hecht G. The toxin of diarrheic shellfish poisoning, okadaic acid, increases intestinal epithelial paracellular permeability. Gastroenterology 1997; 112(1):100-108.
301. McClane BA. Clostridium perfringens enterotoxin and intestinal tight junctions. Trends Microbiol 2000; 8(4):145-146.
302. Sonoda N, Furuse M, Sasaki H, Yonemura S, Katahira J, Horiguchi Y, et al. Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: evidence for direct involvement of claudins in tight junction barrier. J Cell Biol 1999; 147(1):195-204.
303. Wu Z, Nybom P, Magnusson KE. Distinct effects of Vibrio cholerae haemagglutinin/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1. Cell Microbiol 2000; 2(1):11-17.
304. Barton ES, Forrest JC, Connolly JL, Chappell JD, Liu Y, Schnell FJ, et al. Junction adhesion molecule is a receptor for reovirus. Cell 2001; 104(3):441-451.
305. Cohen CJ, Shieh JT, Pickles RJ, Okegawa T, Hsieh JT, Bergelson JM. The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. Proc Natl Acad Sci USA 2001; 98(26):15191-15196.
306. Manes S, del Real G, Martinez AC. Pathogens: raft hijackers. Nat Rev Immunol 2003; 3(7):557-568.
307. Lynch RD, Tkachuk-Ross LJ, McCormack JM, McCarthy KM, Rogers RA, Schneeberger EE. Basolateral but not apical application of protease results in a rapid rise of transepithelial electrical resistance and formation of aberrant tight junction strands in MDCK cells. Eur J Cell Biol 1995; 66(3):257-267.
308. McDermott JR, Bartram RE, Knight PA, Miller HR, Garrod DR, Grencis RK. Mast cells disrupt epithelial barrier function during enteric nematode infection. Proc Natl Acad Sci USA 2003; 100(13):7761-7766.
309. Scudamore CL, Thornton EM, McMillan L, Newlands GF, Miller HR. Release of the mucosal mast cell granule chymase, rat mast cell protease-II, during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum. J Exp Med 1995; 182(6):1871-1881.
310. Wan H, Winton HL, Soeller C, Tovey ER, Gruenert DC, Thompson PJ, et al. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest 1999; 104(1):123-133.
311. Wan H, Winton HL, Soeller C, Taylor GW, Gruenert DC, Thompson PJ, et al. The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus. Clin Exp Allergy 2001; 31(2):279-294.
312. Fasano A, Baudry B, Pumplin DW, Wasserman SS, Tall BD, Ketley JM, et al. Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions. Proc Natl Acad Sci USA 1991; 88(12):5242-5246.
313. Di Pierro M, Lu R, Uzzau S, Wang W, Margaretten K, Pazzani C, et al. Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain. J Biol Chem 2001; 276(22):19160-19165.
314. Salama NN, Fasano A, Thakar M, Eddington ND. The effect of delta G on the transport and oral absorption of macromolecules. J Pharm Sci 2004; 93(5):1310-1319.
315. Fasano A, Florentini C, Donelli G, Uzzau S, Kaper JB, Margaretten K, et al. Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro. J Clin Invest 1995; 96(2):710-720.
316. Fasano A, Uzzau S, Fiore C, Margaretten K. The enterotoxic effect of zonula occludens toxin on rabbit small intestine involves the paracellular pathway. Gastroenterology 1997; 112(3):839-846.
317. Fasano A, Nataro JP. Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins. Adv Drug Deliv Rev 2004; 56(6):795-807.
318. Dickman KG, Hempson SJ, Anderson J, Lippe S, Zhao L, Burakoff R, et al. Rotavirus alters paracellular permeability and energy metabolism in Caco-2 cells. Am J Physiol Gastrointest Liver Physiol 2000; 279(4):G757-766.
319. Obert G, Peiffer I, Servin AL. Rotavirus-induced structural and functional alterations in tight junctions of polarized intestinal Caco-2 cell monolayers. J Virol 2000; 74(10): 4645-4651.
320. Tafazoli F, Zeng CQ, Estes MK, Magnusson KE, Svensson L. NSP4 enterotoxin of rotavirus induces paracellular leakage in polarized epithelial cells. J Virol 2001; 75(3): 1540-1546.
321. Sakaguchi T, Kohler H, Gu X, McCormick BA, Reinecker HC. Shigella flexneri regulates tight junction-associated proteins in human intestinal epithelial cells. Cell Microbiol 2002; 4(6):367-381.
322. Simonovic I, Rosenberg J, Koutsouris A, Hecht G. Enteropathogenic Escherichia coli dephosphorylates and dissociates occludin from intestinal epithelial tight junctions. Cell Microbiol 2000; 2(4):305-315.
323. Berkes J, Viswanathan VK, Savkovic SD, Hecht G. Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut 2003; 52(3):439-451.
324. Savkovic SD, Koutsouris A, Hecht G. PKC zeta participates in activation of inflammatory response induced by enteropathogenic E. coli. Am J Physiol Cell Physiol 2003; 285(3):C512-521.
325. Savkovic SD, Villanueva J, Turner JR, Matkowskyj KA, Hecht G. Mouse model of enteropathogenic Escherichia coli infection. Infect Immun 2005; 73(2):1161-1170.
326. Leroy A, Lauwaet T, De Bruyne G, Cornelissen M, Marcel M. Entamoeba histolytica disturbs the tight junction complex in human enteric T84 cell layers. FASEB J 2000; 14(9):1139-1146.
327. Rogers PAW, Murphy CR, Leeton J, Hosie MJ, Beaton L. Turner's syndrome patients lack tight junctions between uterine epithelial cells. Human Reprod 1992; 7(6): 883-885.
328. Oderda G, Cinti S, Cangiotti AM, Forni M, Ansaldi N. Increased tight junction with in two children with Ménétrier's disease. J Pediatr Gastroenterol Nutr 1990; 11: 123-127.
329. Godfrey RWA, Severs NJ, Jeffery PK. Structural alterations of airway epithelial tight junctions in cystic fibrosis: comparison of transplant and postmortem tissue. Am J Respir Cell Mol Biol 1993; 9:148-156.
330. Pape HC, Dwenger A, Regel G, Auf'm'Kolck M, Gollub F, Wisner D, et al. Increased gut permeability after multiple trauma. Br J Surg 1994; 81(6):850-852.
331. Adenis A, Colombel JF, Lecouffe P, Wallaert B, Hecquet B, Marchandise X, et al. Increased pulmonary and intestinal permeability in Crohn's disease. Gut 1992; 33(5): 678-682.
332. Murakami H, Akbar SM, Matsui H, Horiike N, Onji M. Macrophage migration inhibitory factor activates antigen-presenting dendritic cells and induces inflammatory cytokines in ulcerative colitis. Clin Exp Immunol 2002; 128(3): 504-510.
333. McLaughlin J, Padfield PJ, Burt JP, O'Neill CA. Ochratoxin A increases permeability through tight junctions by removal of specific claudin isoforms. Am J Physiol Cell Physiol 2004; 287(5):C1412-1417.
334. Burgel N, Bojarski C, Mankertz J, Zeitz M, Fromm M, Schulzke JD. Mechanisms of diarrhea in collagenous colitis. Gastroenterology 2002; 123(2):433-443.
335. Yoshida Y, Morita K, Mizoguchi A, Ide C, Miyachi Y. Altered expression of occludin and tight junction formation in psoriasis. Arch Dermatol Res 2001; 293(5): 239-244.
336. Huber JD, Witt KA, Horn S, Egleton RD, Mark KS, Davis TP. Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression. Am J Physiol Heart Circ Physiol 2001; 280(3):H1241-1248.
337. Nunbhakdi-Craig V, Craig L, Machleidt T, Sontag E. Simian virus 40 small tumor antigen induces deregulation of the actin cytoskeleton and tight junctions in kidney epithelial cells. J Virol 2003; 77(5):2807-2818.
338. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 1995; 270(46):27489-27494.
339. Wang Z, Mandell KJ, Parkos CA, Mrsny RJ, Nusrat A. The second loop of occludin is required for suppression of Raf1-induced tumor growth. Oncogene 2005. Apr 4 Epub ahead of print.
340. Tan X, Tamori Y, Egami H, Ishikawa S, Kurizaki T, Takai E, et al. Analysis of invasion-metastasis mechanism in pancreatic cancer: involvement of tight junction transmembrane protein occludin and MEK/ERK signal transduction pathway in cancer cell dissociation. Oncol Rep 2004; 11(5):993-998.
341. Tobioka H, Isomura H, Kokai Y, Tokunaga Y, Yamaguchi J, Sawada N. Occludin expression decreases with the progression of human endometrial carcinoma. Hum Pathol 2004; 35(2):159-164.
342. Tobioka H,Tokunaga Y, Isomura H, Kokai Y, Yamaguchi J, Sawada N. Expression of occludin, a tight-junction-associated protein, in human lung carcinomas. Virchows Arch 2004; 445(5):472-476.
343. Tokunaga Y, Tobioka H, Isomura H, Kokai Y, Sawada N. Expression of occludin in human rectal carcinoid tumours as a possible marker for glandular differentiation. Histopathology 2004; 44(3):247-250.
344. Macek R, Swisshelm K, Kubbies M. Expression and function of tight junction associated molecules in human breast tumor cells is not affected by the Ras-MEK1 pathway. Cell Mol Biol (Noisy-le-grand) 2003; 49(1):1-11.
345. Qin M, Escuadro B, Dohadwala M, Sharma S, Batra RK. A novel role for the coxsackie adenovirus receptor in mediating tumor formation by lung cancer cells. Cancer Res 2004; 64(18):6377-6380.
346. Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004; 432(7015):324-331.
347. Hirsch M, Noske W. The tight junction: structure and function. Micron 1993; 24(3): 325-352.
348. Pappenheimer JR. Intestinal absorption of hexoses and amino acids: from apical cytosol to villus capillaries. J Membr Biol 2001; 184(3):233-239.
349. Pappenheimer JR, Dahl CE, Karnovsky ML, Maggio JE. Intestinal absorption and excretion of octapeptides composed of D amino acids. Proc Natl Acad Sci USA 1994; 91(5):1942-1945.
350. Pappenheimer JR, Karnovsky ML, Maggio JE. Absorption and excretion of undegradable peptides: role of lipid solubility and net charge. J Pharm Exp Ther 1997; 280(1): 292-300.
351. Pappenheimer JR. Paracellular intestinal absorption of glucose, creatinine, and mannitol in normal animals: relation to body size. Am J Physiol 1990; 259(2 Pt 1): G290-299.
352. +-glucose cotransport. Dig Dis Sci 2000; 45(11):2122-2126.
353. Coyne CB, Vanhook MK, Gambling TM, Carson JL, Boucher RC, Johnson LG. Regulation of airway tight junctions by proinflammatory cytokines. Mol Biol Cell 2002; 13(9):3218-3234.
354. Madara JL, Stafford J. Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest 1989; 83(2):724-727.
355. Mullin JM, Snock KV. Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability. Cancer Res 1990; 50(7):2172-2176.
356. Schmitz H, Barmeyer C, Fromm M, Runkel N, Foss HD, Bentzel CJ, et al. Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterology 1999; 116(2):301-309.
357. Bruewer M, Luegering A, Kucharzik T, Parkos CA, Madara JL, Hopkins AM, et al. Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol 2003; 171(11):6164-6172.
358. Mazzon E, Puzzolo D, Caputi AP, Cuzzocrea S. Role of IL-10 in hepatocyte tight junction alteration in mouse model of experimental colitis. Mol Med 2002; 8(7):353-366.
359. Tsukamoto T, Nigam SK. Cell-cell dissociation upon epithelial cell scattering requires a step mediated by the proteasome. J Biol Chem 1999; 274(35):24579-24584.
360. Hollande F, Blanc EM, Bali JP, Whitehead RH, Pelegrin A, Baldwin GS, et al. HGF regulates tight junctions in new nontumorigenic gastric epithelial cell line. Am J Physiol Gastrointest Liver Physiol 2001; 280(5):G910-921.
361. Zhang L, Bewick M, Lafrenie RM. EGFR and ErbB2 differentially regulate Raf-1 translocation and activation. Lab Invest 2002; 82(1):71-78.
362. Bolos V, Peinado H, Perez-Moreno MA, Fraga MF, Esteller M, Cano A. The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci 2003; 116(Pt 3): 499-511.
363. Schedin PJ, Eckel-Mahan KL, McDaniel SM, Prescott JD, Brodsky KS,Tender JJ, et al. ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells. Oncogene 2004; 23(9):1766-1779.
364. Matsuno A, Itoh J, Takekoshi S, Itoh Y, Ohsugi Y, Katayama H, et al. Dynamics of subcellular organelles, growth hormone, Rab3B, SNAP-25, and syntaxin in rat pituitary cells caused by growth hormone releasing hormone and somatostatin. Microsc Res Tech 2003; 62(3):232-239.
365. Cheng KW, Lahad JP, Kuo WL, Lapuk A, Yamada K, Auersperg N, et al.The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat Med 2004; 10(11):1251-1256.
366. Rao RK, Baker RD, Baker SS, Gupta A, Holycross M. Oxidant-induced disruption of intestinal epithelial barrier function: role of protein tyrosine phosphorylation. Am J Physiol 1997; 273(4 Pt 1):G812-823.
367. Rao RK, Basuroy S, Rao VU, Karnaky KJ Jr, Gupta A. Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress. Biochem J 2002; 368(Pt 2):471-481.
368. Lohmann C, Krischke M, Wegener J, Galla HJ. Tyrosine phosphatase inhibition induces loss of blood-brain barrier integrity by matrix metalloproteinase-dependent and -independent pathways. Brain Res 2004; 995(2):184-196.
369. Noble ME, Endicott JA, Johnson LN. Protein kinase inhibitors: insights into drug design from structure. Science 2004; 303(5665):1800-1805.
370. Barker AJ, Gibson KH, Grundy W, Godfrey AA, Barlow JJ, Healy MP, et al. Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer. Bioorg Med Chem Lett 2001; 11(14):1911-1914.
371. Hidalgo M, Siu LL, Nemunaitis J, Rizzo J, Hammond LA, Takimoto C, et al. Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol 2001; 19(13):3267-3279.
372. Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996; 2(5):561-566.
373. Palmer HG, Gonzalez-Sancho JM, Espada J, Berciano MT, Puig I, Baulida J, et al. Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J Cell Biol 2001; 154(2): 369-387.
374. Chen YT, Stewart DB, Nelson WJ. Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells. J Cell Biol 1999; 144(4):687-699.
375. Le TL, Yap AS, Stow JL. Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamics. J Cell Biol 1999; 146(1):219-232.
376. Chitaev NA,Troyanovsky SM. Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation. J Cell Biol 1998; 142(3):837-846.
377. Braga VM, Del Maschio A, Machesky L, Dejana E. Regulation of cadherin function by Rho and Rac: modulation by junction maturation and cellular context. Mol Biol Cell 1999; 10(1):9-22.
378. del Pozo MA, Alderson NB, Kiosses WB, Chiang HH, Anderson RG, Schwartz MA. Integrins regulate Rac targeting by internalization of membrane domains. Science 2004; 303(5659):839-842.
379. Palazzo AF, Eng CH, Schlaepfer DD, Marcantonio EE, Gundersen GG. Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling. Science 2004; 303(5659):836-839.
380. Gomez S, del Mont Llosas M, Verdu J, Roura S, Lloreta J, Fabre M, et al. Independent regulation of adherens and tight junctions by tyrosine phosphorylation in Caco-2 cells. Biochim Biophys Acta 1999; 1452(2):121-132.
381. Morgado-Diaz JA, de Souza W. Evidence that increased tyrosine phosphorylation causes disassembly of adherens junctions but does not perturb paracellular permeability in Caco-2 cells. Tissue Cell 2001; 33(5):500-513.
382. Atkinson KJ, Rao RK. Role of protein tyrosine phosphorylation in acetaldehyde-induced disruption of epithelial tight junctions. Am J Physiol Gastrointest Liver Physiol 2001; 280(6):G1280-1288.
383. Nava P, Lopez S, Arias CF, Islas S, Gonzalez-Mariscal L. The rotavirus surface protein VP8 modulates the gate and fence function of tight junctions in epithelial cells. J Cell Sci 2004; 117(Pt 23):5509-5519.
384. Fujita K, Katahira J, Horiguchi Y, Sonoda N, Furuse M, Tsukita S. Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein. FEBS Lett 2000; 476(3):258-261.
385. Chakrabarti G, Zhou X, McClane BA. Death pathways activated in Caco-2 cells by Clostridium perfringens enterotoxin. Infect Immun 2003; 71(8):4260-4270.
386. Kominsky SL, Vali M, Korz D, Gabig TG, Weitzman SA, Argani P, et al. Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4. Am J Pathol 2004; 164(5): 1627-1633.
387. Cywes C, Wessels MR. Group A Streptococcus tissue invasion by CD44-mediated cell signalling. Nature 2001; 414(6864):648-652.
388. Clarke H, Marano CW, Peralta Soler A, Mullin JM. Modification of tight junction function by protein kinase C isoforms. Adv Drug Deliv Rev 2000; 41(3):283-301.
389. Soler AP, Miller RD, Laughlin KV, Carp NZ, Klurfeld DM, Mullin JM. Increased tight junctional permeability is associated with the development of colon cancer. Carcinogenesis 1999; 20(8):1425-1431.
390. Martin TA, Jiang WG. Tight junctions and their role in cancer metastasis. Histol Histopathol 2001; 16(4):1183-1195.
391. Quinonez G, Simon GT Cellular junctions in a spectrum of human malignant tumors. Ultrastruct Pathol 1988; 12:389-405.
392. Robinson C, Baker SF, Garrod DR. Peptidase allergens, occludin and claudins. Do their interactions facilitate the development of hypersensitivity reactions at mucosal surfaces? Clin Exp Allergy 2001; 31(2):186-192.
393. Sawada N, Murata M, Kikuchi K, Osanai M, Tobioka H, Kojima T, et al. Tight junctions and human diseases. Med Electron Microsc 2003; 36(3):147-156.
394. Hoevel T, Macek R, Mundigl O, Swisshelm K, Kubbies M. Expression and targeting of the tight junction protein CLDN1 in CLDN1-negative human breast tumor cells. J Cell Physiol 2002; 191(1):60-68.
395. Hoevel T, Macek R, Swisshelm K, Kubbies M. Reexpression of the TJ protein CLDN1 induces apoptosis in breast tumor spheroids. Int J Cancer 2004; 108(3):374-383.
396. Menaker RJ, Sharaf AA, Jones NL. Helicobacter pylori infection and gastric cancer: host, bug, environment, or all three? Curr Gastroenterol Rep 2004; 6(6):429-435.
397. Clevers H. At the crossroads of inflammation and cancer. Cell 2004; 118(6):671-674.
398. Heathcote EJ. Prevention of hepatitis C virus-related hepatocellular carcinoma. Gastroenterology 2004; 127(5 Suppl 1):S294-302.
399. Lok AS. Prevention of hepatitis B virus-related hepatocellular carcinoma. Gastroenterology 2004; 127(5 Suppl 1):S303-309.
400. Leiser J, Molitoris BA. Disease processes in epithelia: the role of the actin cytoskeleton and altered surface membrane polarity. Biochim Biophys Acta 1993; 1225(1):1-13.
401. Antonetti DA, Barber AJ, Khin S, Lieth E, Tarbell JM, Gardner TW. Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group. Diabetes 1998; 47(12):1953-1959.
402. Barber AJ, Antonetti DA. Mapping the blood vessels with paracellular permeability in the retinas of diabetic rats. Invest Ophthalmol Vis Sci 2003; 44(12):5410-5416.
403. Chehade JM, Haas MJ, Mooradian AD. Diabetes-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1) expression. Neurochem Res 2002; 27(3): 249-252.
404. Dallasta LM, Pisarov LA, Esplen JE, Werley JV, Moses AV, Nelson JA, et al. Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis. Am J Pathol 1999; 155(6):1915-1927.
405. Schmitt M, Klonowski-Stumpe H, Eckert M, Luthen R, Haussinger D. Disruption of paracellular sealing is an early event in acute caerulein-pancreatitis. Pancreas 2004; 28(2):181-190.
406. Kwon EE, Prineas JW Blood-brain barrier abnormalities in longstanding multiple sclerosis lesions. An immunohistochemical study. J Neuropathol Exp Neurol 1994; 53(6):625-636.
407. Minagar A, Ostanin D, Long AC, Jennings M, Kelley RE, Sasaki M, et al. Serum from patients with multiple sclerosis downregulates occludin and VE-cadherin expression in cultured endothelial cells. Mult Scler 2003; 9(3):235-238.
408. Plumb J, McQuaid S, Mirakhur M, Kirk J. Abnormal endothelial tight junctions in active lesions and normal-appearing white matter in multiple sclerosis. Brain Pathol 2002; 12(2):154-169.
409. Suzuki K, Kokai Y, Sawada N, Takakuwa R, Kuwahara K, Isogai E, et al. SS1 Helicobacter pylori disrupts the paracellular barrier of the gastric mucosa and leads to neutrophilic gastritis in mice. Virchows Arch 2002; 440(3):318-324.
410. Yuhan R, Koutsouris A, Savkovic SD, Hecht G. Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability. Gastroenterology 1997; 113(6):1873-1882.
411. Warny M, Keates AC, Keates S, Castagliuolo I, Zacks JK, Aboudola S, et al. p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis. J Clin Invest 2000; 105(8):1147-1156.
412. Kucharzik T, Walsh SV, Chen J, Parkos CA, Nusrat A. Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junction proteins. Am J Pathol 2001; 159(6):2001-2009.
413. Gassler N, Rohr C, Schneider A, Kartenbeck J, Bach A, Obermuller N, et al. Inflammatory bowel disease is associated with changes of enterocytic junctions. Am J Physiol Gastrointest Liver Physiol 2001; 281(1):G216-228.
414. Fasano A, Not T, Wang W, Uzzau S, Berti I, Tommasini A, et al. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet 2000; 355(9214):1518-1519.
415. Dudek SM, Garcia JG. Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 2001; 91(4):1487-1500.
416. Lane NJ, Chandler HJ. Definitive evidence for the existence of tight junctions in invertebrates. J Cell Biol 1980; 86(3):765-774.
417. Giepmans BNG, Moolenaar WH. The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludins-1 protein. Curr Biol 1998; 8:931-934.
418. Amati L, Caradonna L, Leandro G, Magrone T, Minenna M, Faleo G, et al. Immune abnormalities and endotoxemia in patients with ulcerative colitis and in their first degree relatives: attempts at neutralizing endotoxin-mediated effects. Curr Pharm Des 2003; 9(24):1937-1945.
419. Manthous CA, Hall JB, Samsel RW. Endotoxin in human disease. Part 1: Biochemistry, assay, and possible role in diverse disease states. Chest 1993; 104(5):1572-1581.
420. Walker RI. The contribution of intestinal endotoxin to mortality in hosts with compromised resistance: a review. Exp Hematol 1978; 6(2):172-184.
421. Kimura H, Sawada N, Tobioka H, Isomura H, Kokai Y, Hirata K, et al. Bacterial lipopolysaccharide reduced intestinal barrier function and altered localization of 7H6 antigen in IEC-6 rat intestinal crypt cells. J Cell Physiol 1997; 171(3):284-290.
422. Dawson DC. Na and Cl transport across the isolated turtle colon: parallel pathways for transmural ion movement. J Membr Biol 1977; 37(3-4):213-233.