In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies

Farmaco

Volumn 60, Issue 11-12, 2005, Pages 874-883

  Sharma, Pradeep ^a   Varma, Manthena V S ^a   Chawla, Harmander P S ^a   Panchagnula, Ramesh ^a,b  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

Absorption enhancers; Bioavailability; Cefotaxime sodium; Cyclosporin A; In situ rat single pass intestinal perfusion

Indexed keywords

CEFOTAXIME; CYCLOSPORIN A; DECANOIC ACID; DEOXYCHOLATE SODIUM; DODECYL SULFATE SODIUM; DRUG ADDITIVE; GLYCOPROTEIN P; LACTATE DEHYDROGENASE; PIPERINE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG PENETRATION; ENZYME RELEASE; ENZYME SUBSTRATE; INTESTINE MUCOSA; INTESTINE MUCOSA PERMEABILITY; LIPID SOLUBILITY; MALE; NONHUMAN; PROTEIN DOMAIN; PROTEIN TRANSPORT; RAT; TRANSMISSION ELECTRON MICROSCOPY;

ALKALOIDS; ANIMALS; BENZODIOXOLES; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; BIOPHARMACEUTICS; CEFOTAXIME; CYCLOSPORINE; DECANOIC ACIDS; DEOXYCHOLIC ACID; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; L-LACTATE DEHYDROGENASE; MALE; P-GLYCOPROTEIN; PERFUSION; PERMEABILITY; PIPERIDINES; POLYUNSATURATED ALKAMIDES; RATS; RATS, SPRAGUE-DAWLEY; SURFACE-ACTIVE AGENTS;

EID: 27744605985     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.farmac.2005.08.007     Document Type: Article

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