Methamphetamine causes depletion of glutathione and an increase in oxidized glutathione in the rat striatum and prefrontal cortex

Neurotoxicity Research

Volumn 3, Issue 3, 2001, Pages 277-280

  Açikgöz, Osman ^a   Gönenç, Sevil ^a   Gezer, Semra ^a   Kayatekin, Berkant Muammer ^a   Uysal, Nazan ^a   şemin, Ilgi ^a   Güre, Ataman ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

Author keywords

Glutathione; Methamphetamine; Oxidative stress; Prefrontal cortex; Striatum

Indexed keywords

GLUTATHIONE; METHAMPHETAMINE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; MALE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT;

EID: 0034793126     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033266     Document Type: Article

References (12)

1. Methamphetamine causes lipid peroxidation and an increase in superoxide dismutase activity in the rat striatum
2. Neurodegenerative disorders in humans: The role of glutathione in oxidative stress-mediated neuronal death
3. Striatal dopamine release in vivo following neurotoxic doses of methamphetamine and effect of the neuroprotective drugs, chlormethiazole and dizocilpine
4. Methamphetamine neurotoxicity involves vacualization of endocytic organelles and dopamine-dependent intracellular oxidative stress
5. Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones
6. Methamphetamine-induced neurotoxicity is associated with the formation of cysteinyl-dopamine
7. A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion
8. Rat striatal levels of the antioxidant glutathione are decreased following binge administration of methamphetamine
9. Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake
10. Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation
11. Methamphetamine-induced neurotoxicity: Roles for glutamate and dopamine efflux
12. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Application to mammalian blood and other tissues