Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport

Biochemistry

Volumn 48, Issue 38, 2009, Pages 9122-9131

  Hou, Yue Xian ^a   Li, Chang Zhong ^a   Palaniyandi, Kanagaraj ^a   Magtibay, Paul M ^a   Homolya, Laszlo ^b   Sarkadi, Balazs ^b   Chang, Xiu Bao ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ANTICANCER DRUG; ATP HYDROLYSIS; ATP-ASE ACTIVITY; ATP-BINDING CASSETTE; CATALYTIC BASE; CATALYTIC RESIDUE; FUSION PROTEINS; HETERODIMERS; HOMODIMERS; MEMBRANE VESICLES; NUCLEOTIDE-BINDING DOMAIN; PLASMA MEMBRANES; TRANS-MEMBRANE DOMAINS; TRANSPORT ACTIVITY;

ACTIVATION ANALYSIS; AMINES; AMINO ACIDS; BIOLOGICAL MEMBRANES; CELL MEMBRANES; CYTOLOGY; HYDROLYSIS; ORGANIC ACIDS; SOLUTE TRANSPORT;

MEMBRANES;

ABC TRANSPORTER; ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; GLUTAMINE; HYBRID PROTEIN; METHOTREXATE; UNCLASSIFIED DRUG; YFP ABCG2 FUSION PROTEIN; ABCG2 PROTEIN, HUMAN; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC ANTIMETABOLITE; BACTERIAL PROTEIN; PHOTOPROTEIN; PRIMER DNA; TUMOR PROTEIN; YELLOW FLUORESCENT PROTEIN, BACTERIA;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN BHK; CONTROLLED STUDY; DRUG TRANSPORT; GENE; GENE MUTATION; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; ACTIVE TRANSPORT; ANIMAL; CELL LINE; CHEMISTRY; DIMERIZATION; DRUG RESISTANCE; ENZYME ACTIVE SITE; GENETICS; HAMSTER; HUMAN; IN VITRO STUDY; KINETICS; METABOLISM; MULTIDRUG RESISTANCE; NUCLEOTIDE SEQUENCE; PROTEIN QUATERNARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; BASE SEQUENCE; BIOLOGICAL TRANSPORT, ACTIVE; CATALYTIC DOMAIN; CELL LINE; CRICETINAE; DIMERIZATION; DNA PRIMERS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; KINETICS; LUMINESCENT PROTEINS; METHOTREXATE; MUTAGENESIS, SITE-DIRECTED; NEOPLASM PROTEINS; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT FUSION PROTEINS;

EID: 70349782468     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900675v     Document Type: Article

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