l-Proline catalyzed multicomponent reaction of 3,4-dihydro-(2H)-pyran, urea/thiourea, and aldehydes: diastereoselective synthesis of hexahydropyrano pyrimidinones (thiones)

Tetrahedron

Volumn 65, Issue 45, 2009, Pages 9350-9356

  Pandey, Jyoti ^a   Anand, Namrata ^a   Tripathi, Rama P ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Biginelli reaction; Hexahydropyrano pyrimidinones; L Proline; Multicomponent reaction; N Acyliminium ion; Organocatalyst

Indexed keywords

3,4 DIHYDRO (2H) PYRAN; 4 (2 CHLOROPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) ONE; 4 (2 NITROPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) ONE; 4 (3 NITROPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) ONE; 4 (3 NITROPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) THIONE; 4 (3,4 DIMETHOXYPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) THIONE; 4 (3,4,5 TRIMETHOXYPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) THIONE; 4 (4 BENZYLOXYPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) ONE; 4 (4 BENZYLOXYPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) THIONE; 4 (4 BROMOPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) ONE; 4 (4 BROMOPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) THIONE; 4 (4 CHLOROPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) ONE; 4 (4 CHLOROPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) THIONE; 4 (4 FLUOROPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) ONE; 4 (4 FLUOROPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) THIONE; 4 (4 NITROPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) ONE; 4 (4 NITROPHENYL)HEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) THIONE; 4 PHENYLHEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) ONE; 4 PHENYLHEXAHYDRO 1H PYRANO[2,3 D]PYRIMIDIN 2(8AH) THIONE; ALDEHYDE DERIVATIVE; PROLINE; PYRAN DERIVATIVE; PYRIMIDINONE DERIVATIVE; THIOUREA; UNCLASSIFIED DRUG; UREA;

ARTICLE; CATALYSIS; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; STEREOCHEMISTRY; THIN LAYER CHROMATOGRAPHY;

EID: 70349780559     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2009.09.002     Document Type: Article

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