Asymmetric synthesis of quaternary α-and β-amino acids and β-lactams via proline-catalyzed Mannich reactions with branched aldehyde donors

Organic Letters

Volumn 6, Issue 15, 2004, Pages 2507-2510

  Chowdari, Naidu S ^a   Suri, Jeff T ^a   Barbas III, Carlos F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; BETA AMINO ACID; BETA LACTAM;

ARTICLE; CATALYSIS; CATALYST; CHIRALITY; ENANTIOSELECTIVITY; MANNICH REACTION; SYNTHESIS;

ALDEHYDES; AMINO ACIDS; BETA-LACTAMS; CATALYSIS; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROLINE; STEREOISOMERISM;

EID: 4043170073     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol049248+     Document Type: Article

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45. 4), concentrated, and purified by flash column chromatography (silica gel, mixtures of hexanes/ethyl acetate) to afford the desired Mannich product.