In vitro testing for the diagnosis of anticonvulsant hypersensitivity syndrome: A systematic review

Molecular Diagnosis and Therapy

Volumn 13, Issue 5, 2009, Pages 313-330

  Elzagallaai, Abdelbaset A ^a,b   Knowles, Sandra R ^c   Rieder, Michael J ^a,b,d   Bend, John R ^a,b   Shear, Neil H ^c,e   Koren, Gideon ^a,b,d  

^a WESTERN UNIVERSITY   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^d CHILDREN S HOSPITAL OF WESTERN ONTARIO   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; ZONISAMIDE;

CELL ISOLATION; CELL PROLIFERATION; DIAGNOSTIC TEST; DRESS SYNDROME; DRUG HYPERSENSITIVITY; HUMAN; IN VITRO STUDY; LYMPHOCYTE TRANSFORMATION TEST; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

EID: 70349668597     PISSN: 11771062     EISSN: 11792000     Source Type: Journal    
DOI: 10.1007/BF03256336     Document Type: Review

References (132)

1. Shear NH, Spielberg SP. Anticonvulsant hypersensitivity syndrome: in vitro assessment of risk. J Clin Invest 1988 Dec; 82 (6): 1826-1832
2. Zaccara G, Franciotta D, Perucca E. Idiosyncratic adverse reactions to antiepileptic drugs. Epilepsia 2007 Jul; 48 (7): 1223-1244
3. Peyriere H, Dereure O, Breton H, et al. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol 2006 Aug; 155(2): 422-428
4. Shapiro LE, Shear NH. Mechanisms of drug reactions: the metabolic track. Semin Cutan Med Surg 1996 Dec; 15 (4): 217-227
5. Spielberg SP, Gordon GB, Blake DA, et al. Anticonvulsant toxicity in vitro: possible role of arene oxides. J Pharmacol Exp Ther 1981May; 217 (2): 386-389
6. Tennis P, Stern RS. Risk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: a record linkage study. Neurology 1997 Aug; 49 (2): 542-546
7. Primeau MN, Adkinson Jr NF. Recent advances in the diagnosis of drug allergy. Curr Opin Allergy Clin Immunol 2001 Aug; 1 (4): 337-341
8. Romano A, Demoly P. Recent advances in the diagnosis of drug allergy. Curr Opin Allergy Clin Immunol 2007 Aug; 7 (4): 299-303
9. Pourpak Z, Fazlollahi MR, Fattahi F. Understanding adverse drug reactions and drug allergies: principles, diagnosis and treatment aspects. Recent Pat Inflamm Allergy Drug Discov 2008; 2 (1): 24-46
10. Elzagallaai AA, Knowles SR, Rieder MJ, et al. Patch testing for the diagnosis of anticonvulsant hypersensitivity syndrome: a systematic review. Drug Saf 2009; 32 (5): 391-408
11. Naranjo CA, Shear NH, Lanctot KL. Advances in the diagnosis of adverse drug reactions. J Clin Pharmacol 1992 Oct; 32 (10): 897-904
12. Beeler A, Pichler WJ. In vitro tests of T-cell-mediated drug hypersensitivity. In: Pichler WJ, editor. Drug hypersensitivity. Basel: Karger, 2007: 380-390
13. LanCC,WuCS, Tsai PC, et al.Diagnostic role of soluble fas ligand secretion by peripheral blood mononuclear cells from patients with previous drug-induced blistering disease: a pilot study. Acta Derm Venereol 2006; 86 (3): 215-218
14. Wu Y, Sanderson JP, Farrell J, et al. Activation of T cells by carbamazepine and carbamazepine metabolites. J Allergy Clin Immunol 2006 Jul; 118 (1): 233-241
15. Beeler A, Engler O, Gerber BO, et al. Long-lasting reactivity and high frequency of drug-specific T cells after severe systemic drug hypersensitivity reactions. J Allergy Clin Immunol 2006 Feb; 117 (2): 455-462
16. Pentycross CR. Technique for lymphocyte transformation. J Clin Pathol 1968 Mar; 21 (2): 175-178
17. Böyum A. Isolation of leucocytes from human blood: further observations. Methylcellulose, dextran, and Ficoll as erythrocyte aggregating agents. Scand J Clin Lab Invest Suppl 1968; 97: 31-50
18. Rigas DA, Osgood EE. Purification and properties of the phytohemagglutinin of Phaseolus vulgaris. J Biol Chem 1955 Feb; 212 (2): 607-615
19. Minor AH, Burnett L. A method for obtaining living leukocytes from human peripheral blood by acceleration of erythrocyte sedimentation. Blood 1948 Jul; 3 (7): 799-802
20. Li JG, Osgood EE. A method for the rapid separation of leukocytes and nucleated erythrocytes from blood of marrow with a phytohemagglutinin from red beans (Phaseolus vulgaris). Blood 1949 May; 4 (5): 670-675
21. Nowell PC. Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. Cancer Res 1960 May; 20: 462-466
22. Pearmain G, Lycette RR, Fitzgerald PH. Tuberculin-induced mitosis in peripheral blood leucocytes. Lancet 1963 Mar 23; 1 (7282): 637-638
23. Holland P, Mauer AM. Drug-induced in-vitro stimulation of peripheral lymphocytes. Lancet 1964 Jun 20; 1 (7347): 1368-1369
24. Caron GA, Sarkany I. Lymphoblast transformation in sulphonamide sensitivity. Br J Dermatol 1965 Nov; 77 (11): 556-560
25. Vischer TL. Lymphocyte cultures in drug hypersensitivity. Lancet 1966 Aug 27; 2 (7461): 467-469
26. Leguit Jr P, Meinesz A, Zeijlemaker WP, et al. Immunological studies in burn patients: I. Lymphocyte transformation in vitro. Int Arch Allergy Appl Immunol 1973; 44 (1): 101-121
27. Schellekens PT, Eijsvoogel VP. Lymphocyte transformation in vitro: I. Tissue culture conditions and quantitative measurements. Clin Exp Immunol 1968 Jul; 3 (6): 571-584
28. Schellekens PT, Eijsvoogel VP. Lymphocyte transformation in vitro: III. Mechanism of stimulation in the mixed lymphocyte culture. Clin Exp Immunol 1970 Aug; 7 (2): 229-239
29. Schellekens PT, Eijsvoogel VP. Lymphocyte transformation in vitro: IV. Recruitment in antigen-stimulated cultures. Clin Exp Immunol 1971 Feb; 8 (2): 187-194
30. Schellekens PT, Vriesendorp B, Eijsvoogel VP, et al. Lymphocyte transformation in vitro: II. Mixed lymphocyte culture in relation to leucocyte antigens. Clin Exp Immunol 1970 Feb; 6 (2): 241-254
31. Pichler WJ, Tilch J. The lymphocyte transformation test in the diagnosis of drug hypersensitivity. Allergy 2004 Aug; 59 (8): 809-820
32. Sachs B, Erdmann S, Malte Baron J, et al. Determination of interleukin-5 secretion from drug-specific activated ex vivo peripheral blood mononuclear cells as a test system for the in vitro detection of drug sensitization. Clin Exp Allergy 2002 May; 32 (5): 736-744
33. Turcanu V, Maleki SJ, Lack G. Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts. J Clin Invest 2003 Apr; 111 (7): 1065-1072
34. OkumuraA, Tsuge I, Kubota T, et al. Phenytoin desensitization monitored by antigen specific T cell response using carboxyfluorescein succinimidyl ester dilution assay. Eur J Paediatr Neurol 2007 Nov; 11 (6): 385-388
35. Lyons AB. Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J Immunol Methods 2000 Sep 21; 243 (1-2): 147-154
36. Fulcher D, Wong S. Carboxyfluorescein succinimidyl ester-based proliferative assays for assessment of T cell function in the diagnostic laboratory. Immunol Cell Biol 1999 Dec; 77 (6): 559-564
37. Nyfeler B, Pichler WJ. The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity. Clin Exp Allergy 1997 Feb; 27 (2): 175-181
38. Spielberg SP. In vitro assessment of pharmacogenetic susceptibility to toxic drug metabolites in humans. Fed Proc 1984 May 15; 43 (8): 2308-2313
39. Spielberg SP. In vitro analysis of idiosyncratic drug reactions. Clin Biochem 1986 Apr; 19 (2): 142-144
40. Spielberg SP, Gordon GB, Blake DA, et al. Predisposition to phenytoin hepatotoxicity assessed in vitro. N Engl J Med 1981 Sep 24; 305 (13): 722-727
41. Spielberg SP. Acetaminophen toxicity in human lymphocytes in vitro. J Pharmacol Exp Ther 1980 May; 213 (2): 395-398
42. Knowles SR, Uetrecht J, Shear NH. Idiosyncratic drug reactions: the reactive metabolite syndromes. Lancet 2000 Nov 4; 356 (9241): 1587-1591
43. Uetrecht J. Idiosyncratic drug reactions: current understanding. Annu Rev Pharmacol Toxicol 2007; 47: 513-539
44. Uetrecht J. Idiosyncratic drug reactions: past, present, and future. Chem Res Toxicol 2008 Jan; 21 (1): 84-92
45. Kupfer A, Brilis GM, Watson JT, et al. A major pathway of mephenytoin metabolism in man: aromatic hydroxylation to p-hydroxymephenytoin. Drug Metab Dispos 1980 Jan-Feb; 8 (1): 1-4
46. Lertratanangkoon K, Horning MG. Metabolism of carbamazepine. Drug Metab Dispos 1982 Jan-Feb; 10 (1): 1-10
47. Karande S, Gogtay NJ, Kanchan S, et al. Anticonvulsant hypersensitivity syndrome to lamotrigine confirmed by lymphocyte stimulation in vitro. Indian J Med Sci 2006 Feb; 60 (2): 59-63
48. Aberer W. Drug hypersensitivities: the need for standardization. Eur Ann Allergy Clin Immunol 2005 Jun; 37 (6): 219-222
49. Wolkenstein P, Charue D, Laurent P, et al. Metabolic predisposition to cutaneous adverse drug reactions: role in toxic epidermal necrolysis caused by sulfonamides and anticonvulsants. Arch Dermatol 1995 May; 131 (5): 544-551
50. Hari Y, Frutig-Schnyder K, Hurni M, et al. T cell involvement in cutaneous drug eruptions. Clin Exp Allergy 2001 Sep; 31 (9): 1398-1408
51. Naisbitt DJ, Farrell J, WongG, et al. Characterization of drug-specific T cells in lamotrigine hypersensitivity. J Allergy Clin Immunol 2003 Jun; 111 (6): 1393-1403
52. Farrell J, Naisbitt DJ, Drummond NS, et al. Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and humans. J Pharmacol Exp Ther 2003 Jul; 306 (1): 229-237
53. Naisbitt DJ, Britschgi M, Wong G, et al. Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones. Mol Pharmacol 2003 Mar; 63 (3): 732-741
54. Berg PA, Becker EW. The lymphocyte transformation test: a debated method for the evaluation of drug allergic hepatic injury. J Hepatol 1995 Jan; 22 (1): 115-118
55. Beeler A, Zaccaria L, Kawabata T, et al. CD69 upregulation on T cells as an in vitro marker for delayed-type drug hypersensitivity.Allergy 2008 Feb; 63 (2): 181-188
56. Kano Y, Hirahara K, Mitsuyama Y, et al. Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption. Allergy 2007 Dec; 62 (12): 1439-1444
57. Tsuge I, Okumura A, Kondo Y, et al. Allergen-specific T-cell response in patients with phenytoin hypersensitivity: simultaneous analysis of proliferation and cytokine production by carboxyfluorescein succinimidyl ester (CFSE) dilution assay. Allergol Int 2007 Jun; 56 (2): 149-155
58. Romano A, Pettinato R, Andriolo M, et al. Hypersensitivity to aromatic anticonvulsants: in vivo and in vitro cross-reactivity studies. Curr PharmDes 2006; 12 (26): 3373-3381
59. Gex-Collet C, Helbling A, Pichler WJ. Multiple drug hypersensitivity: proof of multiple drug hypersensitivity by patch and lymphocyte transformation tests. J Investig Allergol Clin Immunol 2005; 15 (4): 293-296
60. Aihara Y, Ito SI, Kobayashi Y, et al. Carbamazepine-induced hypersensitivity syndrome associated with transient hypogammaglobulinaemia and reactivation of human herpesvirus 6 infection demonstrated by real-time quantitative polymerase chain reaction. Br J Dermatol 2003 Jul; 149 (1): 165-169
61. Neukomm CB, Yawalkar N, Helbling A, et al. T-cell reactions to drugs in distinct clinical manifestations of drug allergy. J Investig Allergol Clin Immunol 2001; 11 (4): 275-284
62. Mutoh K, Hidaka Y, Hirose Y, et al. Possible induction of systemic lupus erythematosus by zonisamide. Pediatr Neurol 2001 Oct; 25 (4): 340-343
63. Troger U, Brandt W, Rose W. Development of a pulmonary phenytoinassociated hypersensitivity reaction despite concomitant dexamethasone and prednisolone administration. Int J Clin Pharmacol Ther 2000 Sep; 38 (9): 452-456
64. Troger U, Brandt W, Rose W. A very early onset of respiratory failure due to phenytoin-associated hypersensitivity syndrome and concomitant glucocorticoid administration [letter]. Intensive Care Med 2000 Feb; 26 (2): 258
65. Chinen J, Piecuch S. Anticonvulsant hypersensitivity syndrome versus Kawasaki disease: a challenging clinical diagnosis with therapeutic implications. Clin Pediatr (Phila) 2000 Feb; 39 (2): 109-111
66. Schaub N, Bircher AJ. Severe hypersensitivity syndrome to lamotrigine confirmed by lymphocyte stimulation in vitro. Allergy 2000 Feb; 55 (2): 191-193
67. Brown KL, Henderson DC, Nadel S, et al. Carbamazepine hypersensitivity and the use of lymphocyte proliferation responses. Dev Med Child Neurol 1999 Apr; 41 (4): 267-269
68. Sachs B, Ronnau AC, von Schmiedeberg S, et al. Lamotrigine-induced Stevens-Johnson syndrome: demonstration of specific lymphocyte reactivity in vitro. Dermatology 1997; 195 (1): 60-64
69. Troost RJ, Van Parys JA, Hooijkaas H, et al. Allergy to carbamazepine: parallel in vivo and in vitro detection. Epilepsia 1996 Nov; 37 (11): 1093-1099
70. Okuyama R, Ichinohasama R, Tagami H. Carbamazepine induced erythroderma with systemic lymphadenopathy. J Dermatol 1996 Jul; 23 (7): 489-494
71. Mauri-Hellweg D, Bettens F, Mauri D, et al. Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine. J Immunol 1995 Jul 1; 155 (1): 462-472
72. Kimura M, Yoshino K, Maeoka Y, et al. Carbamazepine-induced thrombocytopenia and carbamazepine-10,11-epoxide: a case report. Psychiatry Clin Neurosci 1995 Mar; 49 (1): 69-70
73. Friedmann PS, Strickland I, Pirmohamed M, et al. Investigation of mechanisms in toxic epidermal necrolysis induced by carbamazepine. Arch Dermatol 1994 May; 130 (5): 598-604
74. Maria VA, Pinto L, Victorino RM. Lymphocyte reactivity to ex-vivo drug antigens in drug-induced hepatitis. J Hepatol 1994 Aug; 21 (2): 151-158
75. Takahashi N, Aizawa H, Takata S, et al. Acute interstitial pneumonitis induced by carbamazepine. Eur Respir J 1993 Oct; 6 (9): 1409-1411
76. Danno K, Kume M, Ohta M, et al. Erythroderma with generalized lymphadenopathy induced by phenytoin. J Dermatol 1989 Oct; 16 (5): 392-396
77. Zakrzewska JM, Ivanyi L. In vitro lymphocyte proliferation by carbamazepine, carbamazepine-10, 11-epoxide, and oxcarbazepine in the diagnosis of drug-induced hypersensitivity. J Allergy Clin Immunol 1988 Jul; 82 (1): 110-115
78. De Swert LF, Ceuppens JL, Teuwen D, et al. Acute interstitial pneumonitis and carbamazepine therapy. Acta Paediatr Scand 1984 Mar; 73 (2): 285-288
79. Houwerzijl J, De Gast GC, Nater JP, et al. Lymphocyte-stimulation tests and patch tests to carbamazepine hypersensitivity. Clin Exp Immunol 1977 Aug; 29 (2): 272-277
80. Cullinan SA, Bower GC. Acute pulmonary hypersensitivity to carbamazepine. Chest 1975 Oct; 68 (4): 580-581
81. Virolainen M. Blast transformation in vivo and in vitro in carbamazepin hypersensitivity. Clin Exp Immunol 1971 Sep; 9 (3): 429-435
82. Luque I, Leyva L, Jose Torres M, et al. In vitro T-cell responses to beta-lactam drugs in immediate and nonimmediate allergic reactions. Allergy 2001 Jul; 56 (7): 611-618
83. Shepherd GM. Hypersensitivity reactions to drugs: evaluation and management. Mt Sinai J Med 2003 Mar; 70 (2): 113-125
84. Sharma VK, Vatve M, Sawhney IM, et al. Clinical spectrum of drug rashes due to antiepileptics. J Assoc Physicians India 1998 Jul; 46 (7): 595-597
85. Kuechler PC, Britschgi M, Schmid S, et al. Cytotoxic mechanisms in different forms of T-cell-mediated drug allergies. Allergy 2004 Jun; 59 (6): 613-622
86. Posadas SJ, Pichler WJ. Delayed drug hypersensitivity reactions-new concepts. Clin Exp Allergy 2007 Jul; 37 (7): 989-999
87. Pichler WJ, Beeler A, Keller M, et al. Pharmacological interaction of drugs with immune receptors: the p-i concept. Allergol Int 2006 Mar; 55 (1): 17-25
88. Gerber BO, Pichler WJ. Noncovalent interactions of drugs with immune receptors may mediate drug-induced hypersensitivity reactions. AAPS J 2006; 8 (1): E160-5
89. Gerber BO, Pichler WJ. The p-i concept: evidence and implications. In: Pichler WJ, editor. Drug hypersensitivity. Basel: Karger, 2007: 66-73
90. Hashizume H, Takigawa M, Tokura Y. Characterization of drug-specific T cells in phenobarbital-induced eruption. J Immunol 2002 May 15; 168 (10): 5359-5368
91. Naisbitt DJ, Pirmohamed M, Park BK. Immunological principles of T-cellmediated adverse drug reactions in skin. Expert Opin Drug Saf 2007 Mar; 6 (2): 109-124
92. Pichler WJ. Delayed drug hypersensitivity reactions. Ann Intern Med 2003 Oct 21; 139 (8): 683-693
93. Matsuno O, Okubo T, Hiroshige S, et al. Drug-induced lymphocyte stimulation test is not useful for the diagnosis of drug-induced pneumonia. Tohoku J Exp Med 2007 May; 212 (1): 49-53
94. Mantani N, Kogure T, Tamura J, et al. Lymphocyte transformation test for medicinal herbs yields false-positive results for first-visit patients. Clin Diagn Lab Immunol 2003 May; 10 (3): 479-480
95. Ono E, Miyazaki E, Matsuno O, et al. Minocycline-induced acute eosinophilic pneumonia: controversial results of lymphocyte stimulation test and re-challenge test. Intern Med 2007; 46 (9): 593-595
96. Wu Y, Farrell J, Pirmohamed M, et al. Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazepine hypersensitivity. J Allergy Clin Immunol 2007 Apr; 119 (4): 973-981
97. Sachs B, Erdmann S, Al-Masaoudi T, et al. In vitro drug allergy detection system incorporating human liver microsomes in chlorazepate-induced skin rash: drug-specific proliferation associated with interleukin-5 secretion. Br J Dermatol 2001 Feb; 144 (2): 316-320
98. Merk HF. Diagnosis of drug hypersensitivity: lymphocyte transformation test and cytokines. Toxicology 2005 Apr 15; 209 (2): 217-220
99. Abe R, Shimizu T, Shibaki A, et al. Toxic epidermal necrolysis and Stevens- Johnson syndrome are induced by soluble Fas ligand. Am J Pathol 2003 May; 162 (5): 1515-1520
100. Krensky AM, Clayberger C. Granulysin: a novel host defense molecule. Am J Transplant 2005 Aug; 5 (8): 1789-1792
101. Chung WH, Hung SI, Yang JY, et al. Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nat Med 2008 Dec; 14 (12): 1343-1350
102. Neuman MG, Malkiewicz IM, Shear NH. A novel lymphocyte toxicity assay to assess drug hypersensitivity syndromes. Clin Biochem 2000 Oct; 33 (7): 517-524
103. Neuman MG, Shear NH, Malkiewicz IM, et al. Predicting possible zonisamide hypersensitivity syndrome. Exp Dermatol 2008 Dec; 17 (12): 1045-1051
104. Naranjo CA, Kwok MC, Lanctot KL, et al. Enhanced differential diagnosis of anticonvulsant hypersensitivity reactions by an integrated Bayesian and biochemical approach. Clin Pharmacol Ther 1994 Nov; 56 (5): 564-575
105. Dwivedi R, Gogtay N, Kharkar V, et al. In-vitro lymphocyte toxicity to a phenytoin metabolite in phenytoin induced cutaneous adverse drug eruptions. Indian J Dermatol Venereol Leprol 2004 Jul-Aug; 70 (4): 217-220
106. Bavdekar SB, Muranjan MN, Gogtay NJ, et al. Anticonvulsant hypersensitivity syndrome: lymphocyte toxicity assay for the confirmation of diagnosis and risk assessment. Ann Pharmacother 2004 Oct; 38 (10): 1648-1650
107. Gennis MA, Vemuri R, Burns EA, et al. Familial occurrence of hypersensitivity to phenytoin. Am J Med 1991 Dec; 91 (6): 631-634
108. Pirmohamed M, Graham A, Roberts P, et al. Carbamazepine-hypersensitivity: assessment of clinical and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine. Br J Clin Pharmacol 1991 Dec; 32 (6): 741-749
109. Hewitt CW, Sawyer S, Beck PA, et al. A simple method for the isolation of platelet-free lymphocyte suspensions from rat whole blood. J Immunol Methods 1980; 36 (3-4): 227-234
110. Rueda F, Marti F, Pinol G, et al. Artefactual low lymphocyte activity caused by platelet contamination in the mononuclear cell preparations. Am J Hematol 1989 Jun; 31 (2): 126-127
111. Casale TB, Kaliner M. A rapid method for isolation of human mononuclear cells free of significant platelet contamination. J ImmunolMethods 1982 Dec 30; 55 (3): 347-353
112. Hurwitz RL, Schreinemachers D, Kersey JH. Elimination of platelets from mononuclear cell preparations using heat-killed yeast. Exp Hematol 1979 Feb; 7 (2): 81-86
113. Lad PM, Easton J, Niedzin H, et al. A method for the preparation of mononuclear cells devoid of platelet contamination and its application to the evaluation of putative alpha-receptors in normal and asthmatic subjects. J Immunol Methods 1988 Jun 13; 110 (2): 193-202
114. Shibusawa Y, Suzuki K, Kinoshita H, et al. Selective separation of human peripheral platelets, granulocytes and lymphocytes by surface affinity chromatography. J Chromatogr B Biomed Appl 1995 Apr 21; 666 (2): 233-239
115. Martignoni M, Groothuis GM, deKanterR. Species differences betweenmouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol 2006 Dec; 2 (6): 875-894
116. Park BK, Pirmohamed M, Kitteringham NR. The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity. Pharmacol Ther 1995; 68 (3): 385-424
117. Rieder MJ, Uetrecht J, Shear NH, et al. Diagnosis of sulfonamide hypersensitivity reactions by in-vitro "rechallenge" with hydroxylamine metabolites. Ann Intern Med 1989 Feb 15; 110 (4): 286-289
118. Ting TY. Anticonvulsant hypersensitivity syndrome: identification and management. Curr Treat Options Neurol 2007 Jul; 9 (4): 243-248
119. Krauss G. Current understanding of delayed anticonvulsant hypersensitivity reactions. Epilepsy Curr 2006 Mar-Apr; 6 (2): 33-37
120. Gogtay NJ, Bavdekar SB, Kshirsagar NA. Anticonvulsant hypersensitivity syndrome: a review. Expert Opin Drug Saf 2005 May; 4 (3): 571-581
121. Bessmertny O, Pham T. Antiepileptic hypersensitivity syndrome: clinicians beware and be aware. Curr Allergy Asthma Rep 2002 Jan; 2 (1): 34-39
122. Quinones MD, Valero C, Salcedo M, et al. Phenytoin hypersensitivity syndrome with fatal evolution. Allergy 1999 Jan; 54 (1): 83-84
123. Huang LY, Liao WC, Chiou CC, et al. Fatal toxic epidermal necrolysis induced by carbamazepine treatment in a patient who previously had carbamazepine-induced Stevens-Johnson syndrome. J Formos Med Assoc 2007 Dec; 106 (12): 1032-1037
124. Kwan P, Brodie MJ. Effectiveness of first antiepileptic drug. Epilepsia 2001 Oct; 42 (10): 1255-1260
125. Toledano R, Gil-Nagel A. Adverse effects of antiepileptic drugs. Semin Neurol 2008 Jul; 28 (3): 317-327
126. Devi K, George S, Criton S, et al. Carbamazepine: the commonest cause of toxic epidermal necrolysis and Stevens-Johnson syndrome. A study of 7 years. Indian J Dermatol Venereol Leprol 2005 Sep-Oct; 71 (5): 325-328
127. Mathews KP. Clinical spectrum of allergic and pseudoallergic drug reactions. J Allergy Clin Immunol 1984 Oct; 74 (4 Pt 2): 558-566
128. Leeder JS. Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs. Epilepsia 1998; 39 Suppl. 7: S8-16
129. Shear NH, Spielberg SP, Grant DM, et al. Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity. Ann Intern Med 1986 Aug; 105 (2): 179-184
130. Lanctot KL, Ghajar BM, Shear NH, et al. Improving the diagnosis of hypersensitivity reactions associated with sulfonamides. J Clin Pharmacol 1994 Dec; 34 (12): 1228-1233
131. Neuman MG, Shear NH, Malkiewicz IM, et al. Immunopathogenesis of hypersensitivity syndrome reactions to sulfonamides. Transl Res 2007 May; 149 (5): 243-253
132. Tabatabaei AR, Thies RL, Abbott FS. Assessing the mechanism of metabolism- dependent valproic acid-induced in vitro cytotoxicity. Chem Res Toxicol 1999 Apr; 12 (4): 323-330