The lymphocyte transformation test for the diagnosis of drug allergy: Sensitivity and specificity

Clinical and Experimental Allergy

Volumn 27, Issue 2, 1997, Pages 175-181

  Nyfeler, B ^a   Pichler, W J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Drug allergy; Lymphocyte transformation test; Skin tests; T cell

Indexed keywords

AMOXICILLIN; AMPICILLIN; CARBAMAZEPINE; CEFAZOLIN; CERVICALETTEN; CIPROFLOXACIN; COTRIMOXAZOLE; DOXYCYCLINE; ERYTHROMYCIN; FANSIDAR; HETASTARCH; HUMAN INSULIN; ISOPHANE INSULIN; LOCAL ANESTHETIC AGENT; LYSOZYME; MEGLUMINE IOXITALAMATE PLUS SODIUM IOXITALAMATE; METHYLEPHEDRINE; MINOCYCLINE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PENICILLIN G; PYRAZOLONE DERIVATIVE; SULFAMETHOXAZOLE; TERFENADINE; THEOPHYLLINE; TOSSAMIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG HYPERSENSITIVITY; HUMAN; HUMAN CELL; LYMPHOCYTE TRANSFORMATION TEST; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SKIN TEST; T LYMPHOCYTE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DRUG HYPERSENSITIVITY; HUMANS; LYMPHOCYTE ACTIVATION; PENICILLINS; PREDICTIVE VALUE OF TESTS; PYRAZOLES; PYRAZOLONES; SENSITIVITY AND SPECIFICITY; SKIN TESTS; T-LYMPHOCYTES; TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION;

EID: 0031050054     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2222.1997.tb00690.x     Document Type: Article

References (32)

1. De Weck AL. Drugs as allergens. J Allergy Clin Immunol 1986; 78:1047.
2. Pichler WJ. Diagnostische Möglichkeiten bei Medikamentenallergien. Schweiz Med Wochenschrift 1993; 123:1183-92.
3. Matthews KP. Clinical spectrum of allergic and pseudo allergic drug reactions. J Allergy Clin Immunol 1984; 74:558-66.
4. Sullivan T. Drug allergy. In Midleton, C.E. Reed, E.F. Elliot, N.F. Adkinson. J.W. Yunginger eds. Allergy, principles and practice. 1988:1523.
5. Pichler WJ, Campi P. Allergy to lysozyme/egg white containing vaginal suppositories. Ann Allergy 1992; 69:521-5.
6. Lieberman Ph. Anaphylactoid reactions to radiocontrast material. Ann Allergy 1991; 67:91-100.
7. Jiang X, Kurshigara G, Rubin RL. Transformation of lupus-inducing drugs to cytotoxic products by activated neutrophils. Science 1994; 266:810-3.
8. Zürcher K, Krebs A. Cutaneous side effects of drugs. Karger Basel, 1994.
9. Mauri-Hellweg D, Bettens F, Mauri D et al. In vitro and in vivo T-cell response to drugs in drug allergic individuals. J Immunol 1995; 155:462-72.
10. Brander C, Mauri-Hellweg D, Rolli HP, Goldmann M, Pichler WJ. The T-cell response to betalactam modified self structures is heterogenous in penicillin allergic individuals. J Immunol 1995; 155:2670-8.
11. + T lymphocytes in bullous cutaneous reactions caused by beta lactam antibiotics. J Invest Dermatol 1993; 101:794-800.
12. + T cell clones from the peripheral blood of patients with cutaneous reactions to beta-lactam antibiotics. Br J Dermatol 1992; 128:619-25.
13. Koponen M, Pichler WJ, de Weck AL. T cell reactivity to penicillin: phenotopic analysis of in vitro activated cell subsets. J Allergy Clin Immunol 1986; 78:645-52.
14. Köstner B. Der Lymphozytentransformationstest in der Analyse arzneimittel-bedingter Nebenwirkungen: Möglichkeiten und Grenzen (doctoral thesis). Medical faculty, Bern, 1992.
15. Bell SJ, Pichler WJ. Penicillin-allergic patients react to penicillin-modified 'self'. Allergy 1989; 44:199-203.
16. Berg PA, Brattig N, Diao G-J, Schuff-Werner P. Diagnose arzneimittel-bedingter Nebenwirkungen mit Hilfe des Lymphozytentransformationstests. Allergologie 1983; 6:77-81.
17. Halpern B, Ky NT, Nouhal A. Diagnosis of drug allergy in vitro with the lymphocyte transformation test. J Allergy 1967; 47:168-81.
18. Sarkany I. Lymphocyte transformation in drug hypersensitivity. Lancet 1967; I:743-5.
19. Everness KM, Gawkrodger DJ, Botham PA, Hunter JAA. The discrimination between nickel-sensitive and non-nickel-sensitive subjects by an in vitro lymphocyte transformation test: Br J Dermatol 1990; 122:293-298.
20. Warrington RJ, Tse KS. Lymphocyte transformation studies in drug hypersensitivity. Can Med Assoc J 1979; 120:1089-94.
21. Barna BP, Gogate P, Deodhar SD, Moeder M. Lymphocyte transformation and radioallergosorbent tests in drug hypersensitivity. Am Soc Clin Pathol 1980; 73:172-6.
22. Bettens F, Kristensen F, Walker Ch et al. Lymphokine regulation of activated (G1) lymphocytes. II Glucocorticoid and anti TAC induced inhibition of human T lymphocyte proliferation. J Immunol 1984; 132:261-5.
23. Krishna DR, Klotz U. Extrahepatic metabolism of drugs in humans. Clin Pharmacokinet 1994; 26(2):144-60.
24. Steinsträsser I, Merkle HP. Dermal metabolism of topically applied drugs: pathways and models reconsidered. Pharmaceutica Acta Helvetiae 1995; 70:3-24.
25. Lamb KA, Denyer SP, Sanderson FD, Shaw PN. The metabolism of a series of ester pro-drugs by NCTC 2544 cells, skin homogenate and LDE testskin. J Pharm Pharmacol 1994; 46:965-73.
26. Merk H, Schneider R, Scholl P. Lymphocyte stimulation by drug modified microsomes. In: Eastabrook RW, Lindenlaub E, Oesch F, de Weck AL, eds. Toxicological and immunological aspects of drug metabolism and environmental chemicals. Stuttgart: F.K. Schattauer, 1988:211-220.
27. Cribb AE, Miller M, Tesoro A, Spielberg SP. Peroxidase-dependent oxidation of sulfonamides by monocytes and neutrophiles from humans and dogs. J Pharmacology 1990; 38:744-51.
28. Goebel C, Kubicka-Muranyi M, Tonn T, Gonzalez J, Gleichmann E. Phagocytes render chemicals immunogenic: oxidation of gold (I) to the T cell-sensitizing gold (III) metabolite generated by mononuclear phagocytes. Arch Toxicol 1995; 69:450-9.
29. Stejskal VDM, Forsbeck M, Olin R. Side chain-specific lymphocyte responses in workers with occupational allergy induced by penicillins. Int Archs Allergy Appl Immunol 1987; 82:461-7.
30. Blanca M, Vega JM, Garcia J et al. New aspects of allergic reactions to betalactams: crossreactions and unique specificities. Clin Exp Allergy 1994; 24:656-62.
31. Kalish RS, LaPorte A, Wood JA, Johnson KL. Sulfonamide-reactive lymphocytes detected at very low frequency in the peripheral blood of patients with drug-induced eruptions. J Allergy Clin Immunol 1994; 94:465-72.
32. De Vriese SP, Philippe J, van Renterghem DM et al. Carbamazepine hypersensitivity syndrome: report of 4 cases and review of the literature. Medicine 1995; 74:144-51.