Allergen-specific T-cell response in patients with phenytoin hypersensitivity; simultaneous analysis of proliferation and cytokine production by Carboxyfluorescein Succinimidyl Ester (CFSE) dilution assay

Allergology International

Volumn 56, Issue 2, 2007, Pages 149-155

  Tsuge, Ikuya ^a   Okumura, Akihisa ^b   Kondo, Yasuto ^a   Itomi, Seiko ^b   Kakami, Michiko ^a   Kawamura, Makiko ^a   Nakajima, Yoichi ^a   Komatsubara, Ryo ^a   Urisu, Atsuo ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Allergen specific T cell; CFSE dilution assay; IFN ; Lymphocyte transformation test; Phenytoin hypersensitivity

Indexed keywords

ALLERGEN; CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; MONOCLONAL ANTIBODY; PHENYTOIN;

ARTICLE; CD4 LYMPHOCYTE COUNT; CELL CULTURE; CELL LABELING; CELL PROLIFERATION; CELL STIMULATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DILUTION; DRUG HYPERSENSITIVITY; ERYTHEMA; FEMALE; FEVER; HUMAN; MACULOPAPULAR RASH; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; STAINING; T LYMPHOCYTE;

EID: 34250840027     PISSN: 13238930     EISSN: 14401592     Source Type: Journal    
DOI: 10.2332/allergolint.O-06-457     Document Type: Article

References (19)

1. Scheinfeld N. Phenytoin in cutaneous medicine: its uses, mechanisms and side effects. Dermatol. Online J. 2003;9: 6.
2. Scheinfeld N. Impact of phenytoin therapy on the skin and skin disease. Expert Opin. Drug Saf. 2004;3:655-665.
3. Pichler WJ. Immune mechanism of drug hypersensitivity. Immunol. Allergy Clin. North Am. 2004;24:373-397.
4. Roujeau JC. Clinical heterogeneity of drug hypersensitivity. Toxicology 2005;209:123-129.
5. Lerch M, Pichler WJ. The immunological and clinical spectrum of delayed drug-induced exanthems. Curr. Opin. Allergy Clin. Immunol. 2004;4:411-419.
6. Martin E, Mayorga C, Rodriguez R et al. Drug hypersensitivity: insights into pathomechanisms. Allerg. Immunol. (Paris) 2005;37:207-212.
7. Pichler WJ. Delayed drug hypersensitivity reactions. Ann. Intern. Med. 2003;139:683-693.
8. Osawa J, Naito S, Aihara M et al. Evaluation of skin test reactions in patients with non-immediate type drug eruptions. J. Dermatol. 1990;17:235-239.
9. Barbaud A. Drug patch testing in systemic cutaneous drug allergy. Toxicology 2005;209:209-216.
10. Pichler WJ, Tilch J. The lymphocyte transformation test in the diagnosis of drug hypersensitivity. Allergy 2004;59: 809-820.
11. Merk HF. Diagnosis of drug hypersensitivity: lymphocyte transformation test and cytokines. Toxicology 2005;209: 217-220.
12. Sachs B, Erdmann S, Malte Baron J et al. Determination of interleukin-5 secretion from drug-specific activated ex vivo peripheral blood mononuclear cells as a test system for the in vitro detection of drug sensitization. Clin. Exp. Allergy 2002;32:736-744.
13. Turcanu V, Maleki SJ, Lack G. Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts. J. Clin. Invest. 2003;111:1065- 1072.
14. Nyfeler B, Pichler WJ. The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity. Clin. Exp. Allergy 1997;27:175-181.
15. Halevy S, Cohen A Livni E. Acute generalized exanthematous pustulosis associated with polysensitivity to paracetamol and bromhexine: the diagnostic role of in vitro interferon-gamma release test. Clin. Exp. Dermatol. 2000;25:652-654.
16. Mauri-Hellweg D, Bettens F, Mauri D et al. Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine. J. Immunol. 1995;155:462-472.
17. Hashizume H, Takigawa M, Tokura Y. Characterization of Drug-Specific T Cells in Phenobarbital-Induced Eruption. J. Immunol. 2002;168: 5359-5368.
18. Naisbitt DJ, Britschgi M, Wong G et al. Hypersensitivity Reactions to Carbamazepine: Characterization of the Specificity, Phenotype, and Cytokine Profile of Drug-Specific T Cell Clones. Mol. Pharmacol. 2003;63:732-741.
19. Demeure CE, Yang LP, Byun DG et al. Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th 2 phenotype upon repetitive stimulations in neutral conditions. Eur. J. Immunol. 1995;25:2722- 2725.