Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazepine hypersensitivity

Journal of Allergy and Clinical Immunology

Volumn 119, Issue 4, 2007, Pages 973-981

  Wu, Ying ^a   Farrell, John ^a   Pirmohamed, Munir ^a   Park, B Kevin ^a   Naisbitt, Dean J ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

anticonvulsant hypersensitivity syndrome; Drug allergy; T cells

Indexed keywords

CARBAMAZEPINE; CD27 ANTIGEN; CELL SURFACE RECEPTOR; CHEMOKINE RECEPTOR CCR10; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR8; CHEMOKINE RECEPTOR CCR9; CHEMOKINE RECEPTOR CXCR4; GAMMA INTERFERON; INTERLEUKIN 5; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PERFORIN;

ADULT; AGED; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; CD4+ CD8+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DRUG ERUPTION; DRUG FEVER; DRUG HYPERSENSITIVITY; EOSINOPHILIA; EXFOLIATIVE DERMATITIS; FEMALE; HEPATOMEGALY; HUMAN; HUMAN CELL; JAUNDICE; LYMPHOCYTE CLONE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOSIS; MACULOPAPULAR RASH; MALE; PERIPHERAL CIRCULATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SWELLING; T LYMPHOCYTE; TARGET CELL;

ADULT; AGED; ANTIGEN PRESENTATION; CARBAMAZEPINE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; CLONE CELLS; CYTOTOXICITY, IMMUNOLOGIC; DRUG HYPERSENSITIVITY; EPITOPES, T-LYMPHOCYTE; FEMALE; HUMANS; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; MALE;

EID: 34047103842     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2006.12.617     Document Type: Article

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