In vitro drug allergy detection system incorporating human liver microsomes in chlorazepate-induced skin rash: Drug-specific proliferation associated with interleukin-5 secretion

British Journal of Dermatology

Volumn 144, Issue 2, 2001, Pages 316-320

  Sachs, B ^a   Erdmann, S ^a   Al Masaoudi, T ^a   Merk, H F ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Human liver microsomes; Interleukin 5; Lymphocyte transformation test; Patch test

Indexed keywords

CLORAZEPATE; INTERLEUKIN 5;

ADULT; ARTICLE; CASE REPORT; CELL CULTURE; CYTOKINE PRODUCTION; DRUG HYPERSENSITIVITY; DRUG SAFETY; FEMALE; HUMAN; HUMAN CELL; LIVER MICROSOME; LYMPHOCYTE TRANSFORMATION TEST; PATCH TEST; PRIORITY JOURNAL; RASH; T LYMPHOCYTE;

ADULT; CLORAZEPATE DIPOTASSIUM; CYTOKINES; DRUG ERUPTIONS; FEMALE; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-5; LYMPHOCYTE ACTIVATION; MICROSOMES, LIVER; SKIN TESTS;

EID: 0035110713     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.2001.04021.x     Document Type: Article

References (19)

1. Preoperative anxiolysis with minimal sedation in elderly patients: Bromazepam or chlorazepate-dipotassium?
2. Delayed hyper-sensitivity to tetrazepam
3. Cross-reactive type IV hypersensitivity reactions to benzodiazepines revealed by patch testing
4. Allergic and autoimmune reactions to xenobiotics: How do they start?
5. Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition
6. Effect of age and sex on disposition of desmethyldiazepam formed from its precursor chlorazepate
7. The lymphocyte transformation test for the diagnosis of drug allergy: Sensitivity and specificity
8. Anticonvulsant hypersensitivity syndrome
9. Propofol decreases the clearance of midazolam by inhibiting CYP3A4: An in vivo and in vitro study
10. Fentanyl inhibits metabolism of midazolam: Competitive inhibition of CYP3A4 in vitro
11. Covalent binding of carbamazepine reactive metabolites to P450 isoforms present in the skin
12. Cytochrome P450 1B1: A major P450 isoenzyme in human blood monocytes and macrophage subsets
13. IL-4 and IFN-γ mRNA induction in human peripheral lymphocytes specific for β-lactam antibiotics in immediate and delayed hypersensitivity reactions
14. Highly Th2-skewed cytokine profile of beta-lactam specific T cells from nonatopic subjects with adverse drug reactions
15. Antigen-dependent and -independent IFN-γ modulation by penicillins
16. Drug-induced linear IgA bullous dermatosis associated with ceftriaxone- and metronidazole-specific T cells
17. High IL-5 production by human drug-specific T cell clones
18. In vitro interleukin-5 (IL-5) production by peripheral blood mononuclear cells from patients with drug hypersensitivity