Selective activation of mitomycin A by thiols to form DNA cross-links and monoadducts: Biochemical basis for the modulation of mitomycin cytotoxicity by the quinone redox potential

Journal of Medicinal Chemistry

Volumn 44, Issue 17, 2001, Pages 2834-2842

  Paz, M M ^a,b   Das, A ^b   Palom, Y ^b   He, Q Y ^b   Tomasz, M ^b  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM DERIVATIVE; AMMONIUM HYDROXIDE; DEOXYGUANOSINE; DITHIOTHREITOL; DNA; GLUTATHIONE; MERCAPTOETHANOL; MITOMYCIN A; MITOMYCIN C; QUINONE DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ABSORPTION SPECTROSCOPY; ARTICLE; CONTROLLED STUDY; DNA ADDUCT; DNA ALKYLATION; DNA CROSS LINKING; DNA DRUG COMPLEX; DNA SEQUENCE; DRUG ACTIVATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG TRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; OXIDATION REDUCTION POTENTIAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, ALKYLATING; BENZOQUINONES; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-LINKING REAGENTS; DITHIOTHREITOL; DNA; DNA ADDUCTS; HYDROXIDES; MITOMYCIN; MITOMYCINS; OLIGODEOXYRIBONUCLEOTIDES; OXIDATION-REDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; SULFHYDRYL COMPOUNDS;

EID: 0035899188     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010072g     Document Type: Article

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